OOIR: Observatory of International Research

Papers

(The median citation count of Human Reproduction Open is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Follicle-stimulating hormone stimulates free radical generation without inducing substantial oxidative stress in human granulosa cells	724
Paternal age and neonatal outcomes: a population-based cohort study	159
Birth defects reporting and the use of dydrogesterone: a disproportionality analysis from the World Health Organization pharmacovigilance database (VigiBase)	119
Unmasking the risk: clinical trials versus real-world evidence on dydrogesterone and birth defects	104
Association between maternal MTHFR C677T/A1298C combination polymorphisms and IVF/ICSI outcomes: a retrospective cohort study	99
Finding truth in an ocean of evidence	87
ESHRE guideline: medically assisted reproduction in patients with a viral infection/disease	74
The prevalence of SARS-CoV-2 antibodies in triage-negative patients and staff of a fertility setting from lockdown release throughout 2020	64
A systematic review of outcome reporting and outcome measures in studies investigating uterine-sparing treatment for adenomyosis	61
Outcome reporting across randomized controlled trials evaluating potential treatments for male infertility: a systematic review	53
Conventional outcome reporting per IVF cycle/embryo transfer may systematically underestimate chances of success for women undergoing ART: relevant biases in registries, epidemiological studies, and g	45
Reproductive outcomes following recurrent first-trimester miscarriage: a retrospective cohort study	42
A concise infertility work-up results in fewer pregnancies	39
Pretreatment with oral contraceptive pills in women with PCOS scheduled for IVF: a randomized clinical trial	35
COVID-19 pandemic and the consequential effect on patients with endometriosis	34
Risk factors associated with monozygotic twinning in offspring conceived by assisted reproductive technology	34
Endometriosis classification systems: an international survey to map current knowledge and uptake	33
Lab-based semen parameters as predictors of long-term health in men—a systematic review	33
Gamete donation: anti-anonymity does not equate to anti-donation	33
Women’s preferences concerning IVF treatment: a discrete choice experiment with particular focus on embryo transfer policy	33
Infertility and pregnancy outcomes among adults with primary ciliary dyskinesia	33
Uterine fluid cytokine/chemokine levels of women undergoing ART with and without oral Vitamin D supplementation	33
Predicting serum hormone concentration by estimation of urinary hormones through a home-use device	30
HROpen—open, accessible and now with an impact factor!	20
The lack of evidence behind over-the-counter antioxidant supplements for male fertility patients: a scoping review	19

Reply to: ‘Hiding in plain sight’ and ‘Caution is needed when communicating analyses based on an apple to orange comparison’	18
Extracellular vesicles secreted by human aneuploid embryos present a distinct transcriptomic profile and upregulate MUC1 transcription in decidualised endometrial stromal cells	17
Speaking up for the safety of the children following frozen embryo transfer	17
Reply: Emerging evidence of endometrial compaction in predicting ART outcomes	16
Women’s reproductive span: a systematic scoping review	15
Preconception depression reduces fertility: a couple-based prospective preconception cohort	15
Anxiety in couples undergoing IVF: evidence from E-Freeze randomised controlled trial	15
Will a government subsidy increase couples’ further fertility intentions? A real-world study from a large-scale online survey in Eastern China	15
Is retrograde menstruation a universal, recurrent, physiological phenomenon? A systematic review of the evidence in humans and non-human primates	15
Financial costs of assisted reproductive technology for patients in low- and middle-income countries: a systematic review	14
Lifestyle intervention prior to IVF does not improve embryo utilization rate and cumulative live birth rate in women with obesity: a nested cohort study	14
Associations between synthetic phenols, phthalates, and placental growth/function: a longitudinal cohort with exposure assessment in early pregnancy	14
Pronuclear transfer rescues poor embryo development of in vitro-grown secondary mouse follicles	14
ESGO/ESHRE/ESGE Guidelines for the fertility-sparing treatment of patients with endometrial carcinoma,	13
Endometriosis and oocyte quality: an analysis of 13 614 donor oocyte recipient and autologous IVF cycles	13
The microbiome in reproductive health: protocol for a systems biology approach using a prospective, observational study design	13
Evidence-based guideline: premature ovarian insufficiency,	12
A comparison of perinatal outcomes following fresh blastocyst or cleavage stage embryo transfer in singletons and twins and between singleton siblings	12
Good practice recommendations for information provision for those involved in reproductive donation†	12
Visceral and subcutaneous adipose tissue in children born after assisted reproductive technology with frozen and fresh embryo transfers	11
The forgotten group of donor-conceived persons	10
Infertility prevalence and the methods of estimation from 1990 to 2021: a systematic review and meta-analysis	10
Blastocyst quality and perinatal outcomes in women undergoing single blastocyst transfer in frozen cycles	9
The needs of subfertile couples continuing to attempt natural conception: in-depth interviews	9
Adolescent attachment to parents and peers in singletons and twins born with assisted and natural conception	9
The risk of Type 1 diabetes in children born after ART: a Nordic cohort study from the CoNARTaS group	9
Situating commercialization of assisted reproduction in its socio-political context: a critical interpretive synthesis	9
The effect of frozen embryo transfer regimen on the association between serum progesterone and live birth: a multicentre prospective cohort study (ProFET)	9
Birth outcomes in mothers with hypertensive disorders and polycystic ovary syndrome: a population-based cohort study	8
‘There will be blood’† A proof of concept for the role of haemorrhagic corpora lutea in the pathogenesis of endometriosis	8
Toxic elements in follicular fluid adversely influence the likelihood of pregnancy and live birth in women undergoing IVF	8
Blastocyst telomere length predicts successful implantation after frozen-thawed embryo transfer	8
No additional risk of congenital anomalies after first-trimester dydrogesterone use: a systematic review and meta-analysis	7
Characteristics of menstrual cycles with or without intercourse in women with no known subfertility	7
Endometrial compaction to predict pregnancy outcomes in patients undergoing assisted reproductive technologies: a systematic review and meta-analysis	7
The risk of asthma in singletons conceived by ART: a retrospective cohort study	7
Clinical and ethical perspectives of ovarian stimulation and oocyte cryopreservation in adolescents: 6 years experience from a tertiary centre	7
Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application	7
In infertile women with subclinical hypothyroidism, with or without thyroid peroxidase antibodies, serum TSH during pregnancy follows preconception values and thyroid hormones remain stable	7
Reply: Inaccurate measures of outcomes in the two-sample Mendelian randomization of vitamin D with miscarriage	7
Human Reproduction Open, a wild mustang in the prairie of science	7
The interplay between mitochondrial DNA genotypes, female infertility, ovarian response, and mutagenesis in oocytes	7
The long and winding road leading to evidence-based medicine	7
Caution is needed when communicating analyses based on an apple to orange comparison	7
Binucleated embryos at the two-cell stage show higher blastocyst formation rates and higher pregnancy and live birth rates compared to non-multinucleated embryos	7
A comprehensive study of common and rare genetic variants in spermatogenesis-related loci identifies new risk factors for idiopathic severe spermatogenic failure	7
Dysregulation of endometrial stromal serotonin homeostasis leading to abnormal phosphatidylcholine metabolism impairs decidualization in patients with recurrent implantation failure	7
Biallelic mutations in RNA-binding protein ADAD2 cause spermiogenic failure and non-obstructive azoospermia in humans	6
Health-related quality of life in women with endometriosis: psychometric validation of the Endometriosis Health Profile 30 questionnaire using confirmatory factor analysis	6
Ovarian ferroptosis induced by androgen is involved in pathogenesis of PCOS	6

ESHRE PGT Consortium data collection XIX–XX: PGT analyses from 2016 to 2017	6
Non-invasive imaging techniques for diagnosis of pelvic deep endometriosis and endometriosis classification systems: an International Consensus Statement,	6
Current global status of male reproductive health	6
Bi-allelic variants in DNAH3 cause male infertility with asthenoteratozoospermia in humans and mice	6
Knowledge, anxiety levels and attitudes of infertile couples towards COVID-19 and its impact on self-funded fertility treatment: a cross-sectional questionnaire survey	6
Building a family at advanced parental age: a systematic review on the risks and opportunities for parents and their offspring	5
Genetic architecture of congenital hypogonadotropic hypogonadism: insights from analysis of a Portuguese cohort	5
Influence of ovarian stromal cells on human ovarian follicle growth in a 3D environment	5
‘A sorrow shared …’: a qualitative content analysis of what couples with recurrent miscarriages expect from one another and their families and friends	5
Effects of Tcte1 knockout on energy chain transportation and spermatogenesis: implications for male infertility	5
Plasma level of mannose-binding lectin is associated with the risk of recurrent pregnancy loss but not pregnancy outcome after the diagnosis	5
Facilitators and barriers for home-based monitoring to time frozen embryo transfers in IVF among women and healthcare providers	5
Reply to: Anti-anonymity should not be taken more seriously than other positions on gamete donation	5
Absence of evidence is not evidence of absence for first trimester dydrogesterone-induced birth defects	5
The mid-secretory endometrial transcriptomic landscape in endometriosis: a meta-analysis	5
Attenuation of palmitic acid-induced lysyl oxidase overexpression in the ovary contributes to the improvement of ovulation in obesity by metformin	5
Technical specificities of the study of the mitochondrial genome	5
Association between uterine artery embolization for postpartum hemorrhage and second delivery on maternal and offspring outcomes: a nationwide cohort study	5
The role of endometrial B cells in normal endometrium and benign female reproductive pathologies: a systematic review	5
Women may not benefit from repeated frozen embryo transfers: a retrospective analysis of the cumulative live birth rate of 43 972 women	5
Reply: Performance indicators in ART: time for a reappraisal?	4
Significantly increased load of hereditary cancer-linked germline variants in infertile men	4
ESHRE certification of ART centres for good laboratory and clinical practice	4
Fertility preservation in women with endometriosis	4
Multi-omics analysis of uterine fluid extracellular vesicles reveals a resemblance with endometrial tissue across the menstrual cycle: biological and translational insights	4
Extended versus conventional letrozole regimen in patients with polycystic ovary syndrome undergoing their first ovulation induction cycle: a prospective randomized controlled trial	4
Endometriosis: from iron and macrophages to exosomes. Is the sky clearing?	4
Trial characteristics, geographic distribution, and selected methodological issues of 1425 infertility trials published from 2012 to 2023: a systematic review	4
Fertility preservation in adult male patients with cancer: a systematic review and meta-analysis	3
Association of ambient air pollutant mixtures with IVF/ICSI-ET clinical pregnancy rates during critical exposure periods	3
Preliminary report of intraovarian injections of autologous platelet-rich plasma (PRP) in extremely poor prognosis patients with only oocyte donation as alternative: a prospective cohort study	3
mtDNA content in cumulus cells does not predict development to blastocyst or implantation	3
Clinical perspectives on the menstrual pictogram for the assessment of heavy menstrual bleeding	3
A 3D endometrial organotypic model simulating the acute inflammatory decidualisation initiation phase with epithelial induction of the key endometrial receptivity marker, integrin αVβ3	3
Sperm and leukocyte telomere length are related to sperm quality parameters in healthy men from the Led-Fertyl study	3
ESHRE good practice recommendations on recurrent implantation failure	3
Extracellular vesicles from human Fallopian tubal fluid benefit embryo developmentin vitro	3
Reply: A paradox? Which paradox?	3
Training and competency assessment of Clinical Embryologists and licensing of the profession in European countries	3
Why the hypothesis of embryo selection in IVF/ICSI must finally be reconsidered	3
The International Fertility Education Initiative: research and action to improve fertility awareness	3
Enzymatic tissue processing after testicular biopsy in non-obstructive azoospermia enhances sperm retrieval	3
Dynamic peripheral blood microRNA expression landscape during the peri-implantation stage in women with successful pregnancy achieved by single frozen-thawed blastocyst transfer	3
Measurement of changes in uterine and fibroid volume during treatment of heavy menstrual bleeding (HMB)	3
Rapamycin improves the developmental competence of human oocytes by alleviating DNA damage during IVM	3