OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Systems is 38. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Evaluation of Peterson et al.: MAPK cascades don’t work in silos: MAP3K cross-activation of MAPKs and the effect of crosstalk on cellular responses	236
Statistical modeling and analysis of cell counts from multiplexed imaging data	173
Approaching deconvolution with Fermi’s mindset	126
Positional influence on cellular transcriptional identity revealed through spatially segmented single-cell transcriptomics	123
Engineering functional materials through bacteria-assisted living grafting	115
Probing enzyme-dependent pseudouridylation using direct RNA sequencing to assess epitranscriptome plasticity in a neuronal cell line	106
A framework for ultra-low-input spatial tissue proteomics	103
A digital CRISPR-dCas9-based gene remodeling biocomputer programmed by dietary compounds in mammals	101
Decoding the role of the arginine dihydrolase pathway in shaping human gut community assembly and health-relevant metabolites	89
What are the current bottlenecks in developing and applying CRISPR technologies?	87
Pitfalls of genotyping microbial communities with rapidly growing genome collections	87
Brain dynamics supported by a hierarchy of complex correlation patterns defining a robust functional architecture	85
Localization of signaling receptors maximizes cellular information acquisition in spatially structured natural environments	76
Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation	74
How can the protein design community best support biologists who want to harness AI tools for protein structure prediction and design?	73
Integrative, high-resolution analysis of single-cell gene expression across experimental conditions with PARAFAC2-RISE	73
Design, mutate, screen: Multiplexed creation and arrayed screening of synchronized genetic clocks	70
Accurate single-molecule spot detection for image-based spatial transcriptomics with weakly supervised deep learning	69
Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition	68
Homeostasis	67
Evolutionary paths that link orthogonal pairs of binding proteins	67
What differentiates a stress response from responsiveness in general?	64
The structure of the human cell cycle	63
A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation	62
How can concepts from ecology enable insights about cellular communities?	60

Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease	59
Allelic correlation is a marker of trade-offs between barriers to transmission of expression variability and signal responsiveness in genetic networks	58
Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation	54
The geometry of cell fate	52
Causal gene regulatory analysis with RNA velocity reveals an interplay between slow and fast transcription factors	51
Modeling elucidates context dependence in adipose regulation	49
Evaluating predictive patterns of antigen-specific B cells by single-cell transcriptome and antibody repertoire sequencing	48
The electrostatic landscape of MHC-peptide binding revealed using inception networks	46
The metallome and the biological periodic table: A metal atlas in cells	43
Deciphering tumor ecosystems at super resolution from spatial transcriptomics with TESLA	43
Redesign of an Escherichia coli Nissle treatment for phenylketonuria using insulated genomic landing pads and genetic circuits to reduce burden	41
Rugged fitness landscapes minimize promiscuity in the evolution of transcriptional repressors	40
Mapping combinatorial expression perturbations to growth in Escherichia coli	40
Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions	38