OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Chemical Biology is 42. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
PROTACs: An Emerging Therapeutic Modality in Precision Medicine	249
Targeted protein degradation: A promise for undruggable proteins	120
The Chemical Biology of Ferroptosis in the Central Nervous System	109
MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells	101
Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras	96
Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function	93
Targeted degradation of the enhancer lysine acetyltransferases CBP and p300	86
Haven't got a glue: Protein surface variation for the design of molecular glue degraders	81
The Chemical Biology of Reversible Lysine Post-translational Modifications	80
Recent advances in identifying protein targets in drug discovery	74
Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC	69
Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2	67
Chemical Tools for Endogenous Protein Labeling and Profiling	65
Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming	64
Development of a potent and selective chemical probe for the pleiotropic kinase CK2	64
Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation	63
Seeing (and Using) the Light: Recent Developments in Bioluminescence Technology	63
Illuminating RNA Biology: Tools for Imaging RNA in Live Mammalian Cells	62
Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis	61
Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP	59
Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases	58
An E3 ligase guide to the galaxy of small-molecule-induced protein degradation	57
Eradicating Bacterial Persisters with Combinations of Strongly and Weakly Metabolism-Dependent Antibiotics	56
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity	55
The role of reversible and irreversible covalent chemistry in targeted protein degradation	54

FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication	53
A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders	52
Development of Potent, Selective Surrogate WNT Molecules and Their Application in Defining Frizzled Requirements	52
An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor	48
How to untie G-quadruplex knots and why?	48
A biaryl-linked tripeptide from Planomonospora reveals a widespread class of minimal RiPP gene clusters	47
Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity	45
A Robust, GFP-Orthogonal Photoswitchable Inhibitor Scaffold Extends Optical Control over the Microtubule Cytoskeleton	45
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors	45
Context-dependent regulation of ferroptosis sensitivity	44
HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins	44
Chemo-proteomics exploration of HDAC degradability by small molecule degraders	44
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention	44
Lanthanide-Based Optical Probes of Biological Systems	44
Strategies for Tuning the Selectivity of Chemical Probes that Target Serine Hydrolases	43
CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes	42
Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System	42
Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System	42