OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Chemical Biology is 43. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas	148
Meet the Authors: Christopher R. Mansfield and Emily R. Derbyshire	144
Voices: Challenges and opportunities in regulating the immune system	114
Therapeutic potential of inhibiting the PI3Kγ complex for leukemia	111
Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1	105
A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer	99
Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation	98
A versatile residue numbering scheme for Nav and Cav channels	92
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection	91
Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations	91
Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development	90
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance	89
CBLs downregulation foretells T cell ubiquitination leading to autoimmunity	88
Next steps for targeted protein degradation	87
2′-OH as a universal handle for studying intracellular RNAs	85
An interactive resource mapping the proteome and reactive cysteine landscape across the NCI-60 reveals cell and tissue-specific profiles	81
RENBP inhibition amplifies metabolic glycan labeling efficiency of antigen-presenting cells in vitro and in vivo	81
Meet the Authors: Harkamal S. Jhajj and Peter M. Tessier	75
Meet the Cell Chemical Biology author and newest advisory board member: Marcus Conrad	74
Real-time non-invasive fluorescence imaging of gut commensal bacteria to detect dynamic changes in the microbiome of live mice	71
Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression	68
Targeting the endocannabinoid-eicosanoid axis to treat pain: Promise and pitfalls	67
Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy	65
A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation	65
Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration	62

A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation	62
Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions	61
Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria	58
Engineered pistol ribozymes selectively target KRAS G12V with enhanced efficacy by capping modification	58
N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis	57
Valence and avidity determine the agonistic activity of anti-TNFR2 nanobody fusion proteins	56
Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells	54
Catalytic spike antibodies: A new paradigm in neutralization	54
Pharmacological management of disease by overcoming structural adversity	53
A double whammy for KEAP1	53
De novo protein assembly enables drug-controlled cellular functions	50
Discovery of MARK2 as a physiological kinase for PER2 in the mammalian clock	49
PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication	47
A lipid brake on oncogenic signaling: 13-S-HODE inhibits mTOR activity	46
BLOC-1 and BORC: Complex regulators of endolysosomal dynamics	45
Targeting RNA with synthetic oligonucleotides: Clinical success invites new challenges	44
Structural basis for NONO-specific modification by the α-chloroacetamide compound (R)-SKBG-1	44
Metabolic tug-of-war: Microbial metabolism shapes colonization resistance against enteric pathogens	44
Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry	43