OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Chemical Biology is 42. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1	143
A versatile residue numbering scheme for Nav and Cav channels	138
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance	130
A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer	109
Next steps for targeted protein degradation	107
Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations	98
FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication	95
Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation	91
Voices: Challenges and opportunities in regulating the immune system	90
Meet the Authors: Christopher R. Mansfield and Emily R. Derbyshire	88
RENBP inhibition amplifies metabolic glycan labeling efficiency of antigen-presenting cells in vitro and in vivo	88
ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas	87
An interactive resource mapping the proteome and reactive cysteine landscape across the NCI-60 reveals cell and tissue-specific profiles	86
Therapeutic potential of inhibiting the PI3Kγ complex for leukemia	85
2′-OH as a universal handle for studying intracellular RNAs	82
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection	79
Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development	78
Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine	77
CBLs downregulation foretells T cell ubiquitination leading to autoimmunity	74
Meet the Authors: Harkamal S. Jhajj and Peter M. Tessier	68
Catalytic spike antibodies: A new paradigm in neutralization	67
Valence and avidity determine the agonistic activity of anti-TNFR2 nanobody fusion proteins	66
Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration	65
Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells	61
Meet the Cell Chemical Biology author and newest advisory board member: Marcus Conrad	60

A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation	60
Engineered pistol ribozymes selectively target KRAS G12V with enhanced efficacy by capping modification	57
Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy	57
N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis	57
Real-time non-invasive fluorescence imaging of gut commensal bacteria to detect dynamic changes in the microbiome of live mice	54
Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions	54
Targeting the endocannabinoid-eicosanoid axis to treat pain: Promise and pitfalls	54
Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression	54
Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria	53
A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation	51
Pharmacological management of disease by overcoming structural adversity	50
A double whammy for KEAP1	50
The art of designed coiled-coils for the regulation of mammalian cells	48
De novo protein assembly enables drug-controlled cellular functions	47
Discovery of MARK2 as a physiological kinase for PER2 in the mammalian clock	47
Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry	46
BLOC-1 and BORC: Complex regulators of endolysosomal dynamics	43
Metabolic tug-of-war: Microbial metabolism shapes colonization resistance against enteric pathogens	42
Targeting RNA with synthetic oligonucleotides: Clinical success invites new challenges	42
PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication	42