Cell Chemical Biology

Article	Citations
CBLs downregulation foretells T cell ubiquitination leading to autoimmunity	129
A versatile residue numbering scheme for Nav and Cav channels	127
A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer	96
Voices: Challenges and opportunities in regulating the immune system	96
RENBP inhibition amplifies metabolic glycan labeling efficiency of antigen-presenting cells in vitro and in vivo	89
ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas	87
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection	81
Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation	79
Antisense-mediated senseful regulation of orchestrated metabolic response	77
Meet the Authors: Christopher R. Mansfield and Emily R. Derbyshire	77
New sheriff in town: Cyclic peptide inhibitors of a DUB module	75
Therapeutic potential of inhibiting the PI3Kγ complex for leukemia	75
Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1	74
Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs	71
2′-OH as a universal handle for studying intracellular RNAs	71
Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine	71
Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development	69
Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites	68
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance	65
Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples	64
Next steps for targeted protein degradation	64
Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations	62
An interactive resource mapping the proteome and reactive cysteine landscape across the NCI-60 reveals cell and tissue-specific profiles	57
FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication	56
Meet the Authors: Harkamal S. Jhajj and Peter M. Tessier	55

Valence and avidity determine the agonistic activity of anti-TNFR2 nanobody fusion proteins	53
PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ	51
Catalytic spike antibodies: A new paradigm in neutralization	51
A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation	50
Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria	50
Meet the Cell Chemical Biology author and newest advisory board member: Marcus Conrad	49
Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells	49
Real-time non-invasive fluorescence imaging of gut commensal bacteria to detect dynamic changes in the microbiome of live mice	48
Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy	48
A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation	46
Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions	45
Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration	44
Metabolic tug-of-war: Microbial metabolism shapes colonization resistance against enteric pathogens	44
N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis	44
A double whammy for KEAP1	43
BLOC-1 and BORC: Complex regulators of endolysosomal dynamics	43
Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry	42
Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET	42
Targeting RNA with synthetic oligonucleotides: Clinical success invites new challenges	40
PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication	40
Pharmacological management of disease by overcoming structural adversity	40
Meet the authors: Aayushi Uberoi and Elizabeth A. Grice	40
The art of designed coiled-coils for the regulation of mammalian cells	40
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation	39
Two sides of a co(i)ndensate	37
Enabling inclusion and looking ahead	37
A new chink in cancer’s armor: Unleashing cell death by selective PP5 inhibition	37
Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors	37
Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis	37
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy	36
Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns	36
Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome	35
Behavioral control through the direct, focal silencing of neuronal activity	35
Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases	35
A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype	34
Two genomes, one destiny: Mitophagy at the crossroads of inheritance and disease	34
Deciphering the opioid code	34
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation	33
Natural products chlorotonils exert a complex antibacterial mechanism and address multiple targets	33
Arabinose- and xylose-modified analogs of 2′,3′-cGAMP act as STING agonists	33
Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs	33
Linked-domain inhibitors designed to block UBE2D induce the unfolded protein response	33
Covalent inhibition of ACSL4 alleviates ferroptosis-induced acute liver injury	33
Cell-free production of personalized therapeutic phages targeting multidrug-resistant bacteria	33
Induced proximity in biology and therapeutics	32
Boosting glycolysis to combat fragile bone in type 1 diabetes	31
Screening in serum-derived medium reveals differential response to compounds targeting metabolism	31
Characterization of an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase to treat Candida albicans infections	31
No acetyl-CoA keeps Plasmodium at bay	31
S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons	31

Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis	30
In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin	30
Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates	30
Feel the breeze: Opening the therapeutic window with RIPTACs and induced proximity	30
Identification of differential biological activity and synergy between the PARP inhibitor rucaparib and its major metabolite	30
Selective killing of the human gastric pathogen Helicobacter pylori by mitochondrial respiratory complex I inhibitors	29
Plant synthetic genomics: Big lessons from the little yeast	29
Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate	29
RNATACs: Multispecific small molecules targeting RNA by induced proximity	29
Mo’ m1A, mo’ problems	28
D-aring to explore: New approaches to gasdermin D targeting	28
PCNA degradation exhibits superior pharmacological effects over stoichiometric inhibition	28
Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death	28
Insights into lysophosphatidylserine recognition and Gα12/13-coupling specificity of P2Y10	28
Meet the authors: Mitchel L. Tepe and Huiqing Zhou	28
Small molecule targeting of transcription-replication conflict for selective chemotherapy	28
Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators	27
Structural basis of CD97 activation and G-protein coupling	27
CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers	27
Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells	27
Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity	26
Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex	26
Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells	26
Discovery of a PROTAC degrader for METTL3-METTL14 complex	26
An N terminomics toolbox combining 2-pyridinecarboxaldehyde probes and click chemistry for profiling protease specificity	26
Mechanisms and functions of lysosomal lipid homeostasis	26
A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease	25
Integrating inflammatory biomarker analysis and artificial-intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis	25
How to kill an ERKsome target: PROTACs deliver the deathblow	25
Transcriptional restart: A new role for PARylation in overcoming DNA damage	25
Identifying and antagonizing the interactions between layilin and glycosylated collagens	25
The physiological and pathological roles of RNA modifications in T cells	25
CRAGE-CRISPR facilitates rapid activation of secondary metabolite biosynthetic gene clusters in bacteria	24
Lactylation of mTOR enhances autophagy in skeletal muscle during exercise	24
The chemistry of electrical signaling in sodium channels from bacteria and beyond	24
Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases	24
Targeting selective E3 ligase for healing cardiac fibrosis	24
Identification of small molecules that strongly inhibit bacterial quorum sensing using a high-throughput lipid vesicle lysis assay	24
Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas	24
Screening compound libraries for H2O2-mediated cancer therapeutics using a peroxiredoxin-based sensor	24
Excited to see you: New imaging approaches to detect ferrous iron in vivo	24
Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders	23
Voices: Challenges and opportunities for bioorthogonal chemistry	23
Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells	23
Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer	23
CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors	23
Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input	22
PARP trapping is governed by the PARP inhibitor dissociation rate constant	22
Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor	22
Photo-proximity labeling in live primary neurons identifies an AMPA-receptor signal transducer in homeostatic synaptic plasticity	22
Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling	22
Tools to investigate the cell surface: Proximity as a central concept in glycoRNA biology	22
Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseases	22
Inhibitors of the ATPase p97/VCP: From basic research to clinical applications	22
Host-like conditions validate nutrient transport as an antimalarial drug target	21
The liquid lectin array detects compositional glycocalyx differences using multivalent DNA-encoded lectins on phage	21
Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells	21
Phosphorylation barcodes direct biased chemokine signaling at CXCR3	21
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells	21
Immunity in motion: The role of mechanics in macrophage biology	20
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia	20
The dark side of circular RNA, a new driver of genome instability	20
Quinoline-based compounds can inhibit diverse enzymes that act on DNA	20
Small-molecule allosteric inhibitors of GPX4	20
Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation	20
Development of D2HG biosensors inspired by the molecular mechanism of D2HG regulation of DhdR	20
Inhibiting GLUTtony in cancer	20
Phytate enhances gut Parasutterella colonization to alleviate radiation injury	20
Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway	20
Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model	20
Ligand discovery by activity-based protein profiling	20
METTL3: Melting the tumor microenvironment for improved immunotherapy	19
Monitoring autophagic flux in vivo revealed its physiological response and significance of heterogeneity in pancreatic beta cells	19
The culinary chemist: Out of the lab and into the tent	19
CBX4 acetoacetylation as an inhibitory mechanism of HIF-1α activity	19
A “light” touch on PI3K to interrogate cancer drug resistance	19
MICU1 controls the sensitivity of the mitochondrial Ca2+ uniporter to activators and inhibitors	19
Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy	19
Facile generation of biepitopic antibodies with intrinsic agonism for activating tumor necrosis factor receptors	19
Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells	19

Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120	19
Meet the authors: Cydney N. Johnson, Shyra Wilde, Elaine Tuomanen, and Jason W. Rosch	19
A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened	19
Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1	18
New twists in anti-malarial drug resistance	18
One-pot trimodal mapping of unmethylated, hydroxymethylated, and open chromatin sites unveils distinctive 5hmC roles at dynamic chromatin loci	18
Meet the authors: Katerina Jones, Camila Bernardo de Brito, and Mariana Xavier Byndloss	18
Small-molecule inhibitors of ferrochelatase are antiangiogenic agents	18
In vivo bioluminescence imaging of granzyme B activity in tumor response to cancer immunotherapy	18
Peptide passports: Programmable import fuels novel protein building blocks	18
Identification of Pax protein inhibitors that suppress target gene expression and cancer cell proliferation	18
Strategies of bacterial detection by inflammasomes	18
STX-bpc: “Brightening” the path to neuronal inhibition	18
Targeted degradation of CDK9 potently disrupts the MYC-regulated network	18
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells	18
Ligand-directed bias of G protein signaling at the dopamine D2 receptor	18
Sharks give a handle to potent anti-tumor multiparatopic antibodies inducing membrane depletion of PD-L1	18
A proximity labeling-based orthogonal trap strategy identifies HDAC8 promotes cell motility by modulating cortactin acetylation	18
A collection of chemical biology strategies for visualization in live cells	17
Bivalent inhibitors of the BTB E3 ligase KEAP1 enable instant NRF2 activation to suppress acute inflammatory response	17
One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade	17
Robust antitumor treatment driven by lock-and-key biorecognition of dynamic cyclic diselenide-guided chiral prodrug self-assembly	17
Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling	17
Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis	17
Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers	17
Activation primes GPCRs for versatile coupling	17
Acylation probing of “generic” RNA libraries reveals critical influence of loop constraints on reactivity	17
Recognition of the tRNA structure: Everything everywhere but not all at once	17
Two birds, one stone: Non-canonical therapeutic effects of the PARP inhibitor Talazoparib	17
A method for the detection and enrichment of endogenous cereblon substrates	16
Specificity profiling of deubiquitylases against endogenously generated ubiquitin-protein conjugates	16
The cyclimids: Degron-inspired cereblon binders for targeted protein degradation	16
Pharmacologic activation of a compensatory integrated stress response kinase promotes mitochondrial remodeling in PERK-deficient cells	16
Repurposing AS1411 for constructing ANM-PROTACs	16
Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics	16
Spatiotemporally resolved GPCR interactome uncovers unique mediators of receptor agonism	16
Target protein localization and its impact on PROTAC-mediated degradation	16
Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation	16
TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor	16
Metabolic modulation of mitochondrial mass during CD4+ T cell activation	16
Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system	16
Causes, functions, and therapeutic possibilities of RNA secondary structure ensembles and alternative states	16
Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction	15
Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux	15
Chemical genomics reveals targetable programs of human cancers rooted in pluripotency	15
Targeted elimination of mutated mitochondrial DNA by a multi-functional conjugate capable of sequence-specific adenine alkylation	15
Discovery of compounds that reactivate p53 mutants in vitro and in vivo	15
A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis	15
High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface	14
Platelets accelerate lipid peroxidation and induce pathogenic neutrophil extracellular trap release	14
Ligand-induced assembly of antibody variable fragments for the chemical regulation of biological processes	14
Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics	14
CysDB: a human cysteine database based on experimental quantitative chemoproteomics	14
Generation of glycan-specific nanobodies	14
The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation	14
Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells	14
Context-dependent regulation of ferroptosis sensitivity	14
Engineering acyclovir-induced RNA nanodevices for reversible and tunable control of aptamer function	14
Degrading the signal amplifier: ITK as a target for targeted protein degradation	14
Genetically incorporated crosslinkers identify regulators of membrane protein PD-L1 in mammalian cells	14
Chemical approaches to unraveling the biology of mycobacteria	14
Regulation of bacterial gene expression by non-coding RNA: It is all about time!	14
Sensing within: Mitochondrial inside-out signal transduction	14
RPL22 links ribosome biogenesis, RNA splicing, and sensitivity to RNA polymerase I inhibition	14
Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome	14
Meet the authors: Xueqin Jin, Jian Huang, Huan Wang, Kan Wang, and Nieng Yan	13
3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis	13
When CDK4/6i meets GPX4i: Stop dividing to die iron hard	13
Engineering affinity-matured variants of an anti-polysialic acid monoclonal antibody with superior cytotoxicity-mediating potency	13
Raf protomers: Drug binding preferences in living cells	13
Modifying the antiviral innate immune response by selective writing, erasing, and reading of m6A on viral and cellular RNA	13
A sticky situation for targeted cancer therapy	13
Pantothenate kinase is an effective target for antifungal therapy	13
Site-resolved assessment of targeted protein degradation	13
Localization matters in targeted protein degradation	13
ND3 Cys39 in complex I is exposed during mitochondrial respiration	13
A base editor facilitates simultaneous purine and pyrimidine substitutions for ex vivo and in vivo mutagenesis screens	13
Engineering electrogenetic interfaces for mammalian cell control	12
Glycopeptidolipid glycosylation controls surface properties and pathogenicity in Mycobacterium abscessus	12
Targeting type I DED interactions at the DED filament serves as a sensitive switch for cell fate decisions	12
Disruption to the gut microbiome by non-antibiotics is linked to infection risk	12
Proteomics from compartment-specific APEX2 labeling in Mycobacterium tuberculosis reveals Type VII secretion substrates in the cell wall	12
Therapeutic potency of compound RMY-205 for pulmonary fibrosis induced by SARS-CoV-2 nucleocapsid protein	12
Integration of metabolism and regulation reveals rapid adaptability to growth on non-native substrates	12
Investigating the NRAS 5′ UTR as a target for small molecules	12
Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets	12
Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus	12
Getting in on the action: New tools to see SARS-CoV-2 infect a cell	12
AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms	12
Inhibiting cancer metastasis with water-solubilized membrane receptor CXCR4QTY-Fc as a molecular trap	12
Cell-selective bioorthogonal labeling	12
Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules	12
The next Nobel Prize in chemistry or in physiology or medicine	12
Multiplex miRNA reporting platform for real-time profiling of living cells	12
Proteasome inhibitors: The next generation of antimalarial drugs?	12