Cell Chemical Biology

Article	Citations
30th anniversary celebrations: Inspiring innovation in biology and medicine	171
Covalent targeting of splicing in T cells	137
Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases	129
Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway	128
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2	121
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation	107
Therapeutic potential of inhibiting the PI3Kγ complex for leukemia	93
Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB	89
The physiological and pathological roles of RNA modifications in T cells	89
Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs	88
A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader	85
Host specific sphingomyelin is critical for replication of diverse RNA viruses	75
Engineered protein-small molecule conjugates empower selective enzyme inhibition	73
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection	67
New sheriff in town: Cyclic peptide inhibitors of a DUB module	65
Antisense-mediated senseful regulation of orchestrated metabolic response	60
Identification of proteomic landscape of drug-binding proteins in live cells by proximity-dependent target ID	59
Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1	57
Next steps for targeted protein degradation	55
Generation of glycan-specific nanobodies	55
Shining light on reprogramming Tregs for cancer therapy	55
Interrogating direct NLRP3 engagement and functional inflammasome inhibition using cellular assays	54
ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas	54
Advances and opportunities in targeted protein degradation	54
A versatile residue numbering scheme for Nav and Cav channels	53

Degrading the signal amplifier: ITK as a target for targeted protein degradation	51
Carolyn Bertozzi: Building new bonds between molecules, fields, and communities	51
An N terminomics toolbox combining 2-pyridinecarboxaldehyde probes and click chemistry for profiling protease specificity	50
A transcriptional relationship with a natural product disrupts mitochondrial biogenesis	50
Voices: Challenges and opportunities in regulating the immune system	48
Multi-protein complexes as drug targets	48
Peptidoglycan NlpC/P60 peptidases in bacterial physiology and host interactions	47
Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras	47
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance	46
Structural and mechanistic investigations of protein S-glycosyltransferases	46
How to kill an ERKsome target: PROTACs deliver the deathblow	45
Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin	45
Help! I need a WNT antibody. Help! Not just any antibody	44
Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis	43
Meet the Authors: Christopher R. Mansfield and Emily R. Derbyshire	43
Bioorthogonal dissection of the replicase assembly of hepatitis C virus	40
Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons	40
Regulation of the endocytosis and prion-chaperoning machineries by yeast E3 ubiquitin ligase Rsp5 as revealed by orthogonal ubiquitin transfer	39
Targeting allostery in the Dynein motor domain with small molecule inhibitors	39
HER2-targeted antibody-drug conjugate induces host immunity against cancer stem cells	39
Avoid the trap: Targeting PARP1 beyond human malignancy	38
ND3 Cys39 in complex I is exposed during mitochondrial respiration	38
Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples	37
Screening compound libraries for H2O2-mediated cancer therapeutics using a peroxiredoxin-based sensor	37
Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine	37
3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis	37
Restoring two tumor suppressor pathways with one PAWI	37
The role of SERPIN citrullination in thrombosis	37
Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells	37
2′-OH as a universal handle for studying intracellular RNAs	36
Advancing protein therapeutics through proximity-induced chemistry	36
Synthetic gene circuit evolution: Insights and opportunities at the mid-scale	35
Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth	35
Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics	34
CBLs downregulation foretells T cell ubiquitination leading to autoimmunity	34
A new light on PLCβ!	33
Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas	33
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria	33
FLEX: genetically encodable enzymatic fluorescence signal amplification using engineered peroxidase	32
Development of a potent and selective chemical probe for the pleiotropic kinase CK2	32
Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development	32
Engineering acyclovir-induced RNA nanodevices for reversible and tunable control of aptamer function	32
Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation	31
An engineered cereblon optimized for high-throughput screening and molecular glue discovery	31
Potent macrocycle inhibitors of the human SAGA deubiquitinating module	30
Making the cut with protease engineering	30
Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction	30
Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2	29
NAPE-PLD is target of thiazide diuretics	29
Motif-dependent immune co-receptor interactome profiling by photoaffinity chemical proteomics	28

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor	28
New advisory board members speak on challenges and opportunities in chemical biology	28
A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease	28
Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (−)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice	27
Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations	27
Genetically incorporated crosslinkers identify regulators of membrane protein PD-L1 in mammalian cells	27
Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome	26
VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation	26
IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization	26
Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells	26
A split-luciferase lysate-based approach to identify small-molecule modulators of phosphatase subunit interactions	25
Development of potent dimeric inhibitors of GAS41 YEATS domain	25
Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation	25
HER-096 is a CDNF-derived brain-penetrating peptidomimetic that protects dopaminergic neurons in a mouse synucleinopathy model of Parkinson’s disease	25
CRAGE-CRISPR facilitates rapid activation of secondary metabolite biosynthetic gene clusters in bacteria	25
HATS off to KAT6A/B inhibitors: A new way to target estrogen-receptor-positive breast cancer	25
The chemical tools for imaging dopamine release	25
Modifying the antiviral innate immune response by selective writing, erasing, and reading of m6A on viral and cellular RNA	25
Identifying and antagonizing the interactions between layilin and glycosylated collagens	25
How to untie G-quadruplex knots and why?	24
Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology	24
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses	24
TK216 targets microtubules in Ewing sarcoma cells	24
Integrating inflammatory biomarker analysis and artificial-intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis	24
Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues	24
Identification of two repurposed drugs targeting GSDMD oligomerization interface I to block pyroptosis	24
Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites	24
Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth	23
Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis	23
Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity	23
Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to inverse agonism	23
A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin	23
FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication	23
Tumor microenvironmental nutrients, cellular responses, and cancer	23
A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening	23
An E3 ligase guide to the galaxy of small-molecule-induced protein degradation	23
The impact of iron and heme availability on the healthy human gut microbiome in vivo and in vitro	23
Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors	23
Visualization of calpain-1 activation during cell death and its role in GSDMD cleavage using chemical probes	23
Localization matters in targeted protein degradation	22
Early DNA damage detection and cellular autophagy as drivers of stress-adaptive H2S production: A paradox resolved	22
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance	22
Development of an intracellular quantitative assay to measure compound binding kinetics	22
Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells	21
Meet the Authors: Harkamal S. Jhajj and Peter M. Tessier	21
PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ	21
Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules	21
Lockdown, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion	21
Targeting biomolecular condensates: The rise of engineered chaperones	20
Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking	20
Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor	20
Disrupting neuron-tumor networking connections	20
Sweet sensation: Developing a single-cell fluorescent reporter of glycolytic heterogeneity	20
Using chemical biology for targeting cancer	20
An affinity-based depletion strategy for evaluating the effects of ergothioneine on bacterial physiology	20
Targeting selective E3 ligase for healing cardiac fibrosis	20
Identification of small molecules that strongly inhibit bacterial quorum sensing using a high-throughput lipid vesicle lysis assay	19
Serotonin is a common thread linking different classes of antidepressants	19
Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome	19
Chemical proteomics to study metabolism, a reductionist approach applied at the systems level	19
Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration	19
Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics	19
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain	19
Chemoproteomic profiling to identify activity changes and functional inhibitors of DNA-binding proteins	19
Development of an intracellular quantitative assay to measure compound binding kinetics	19
Investigating the NRAS 5′ UTR as a target for small molecules	19
The chemistry of electrical signaling in sodium channels from bacteria and beyond	18
Induced proximity labeling and editing for epigenetic research	18
Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation	18
When CDK4/6i meets GPX4i: Stop dividing to die iron hard	18
Membrane remodeling via ubiquitin-mediated pathways	18
Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria	18
Identification of clickable HIV-1 capsid-targeting probes for viral replication inhibition	18
Break Away: FKBP12 sequestration as a target for increasing BMP activity	17
A synthetic RNA-based biosensor for fructose-1,6-bisphosphate that reports glycolytic flux	17
Raf protomers: Drug binding preferences in living cells	17
Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage	17
Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input	17
Chemical control of multidomain acetyltransferase activity	17
NAD reloaded: Hacking bacterial defenses	17

Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors	16
Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation	16
Proteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substrates and assess enzyme specificity	16
Voices: Challenges and opportunities for bioorthogonal chemistry	16
Periplasmic expression of SpyTagged antibody fragments enables rapid modular antibody assembly	16
Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality	16
A sticky situation for targeted cancer therapy	16
Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer	16
Combating the myth of “innate genius” in science	16
Meet the authors: Xueqin Jin, Jian Huang, Huan Wang, Kan Wang, and Nieng Yan	16
Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A	16
Fishing for a balance: Toward promyelinating drug discovery	16
Catalytic spike antibodies: A new paradigm in neutralization	16
Excited to see you: New imaging approaches to detect ferrous iron in vivo	16
Light-controllable RNA-protein devices for translational regulation of synthetic mRNAs in mammalian cells	16
Targeting type I DED interactions at the DED filament serves as a sensitive switch for cell fate decisions	15
Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders	15
Un-FASN-ing cancer’s seat belt: Linking lipid metabolism and antigen presentation	15
Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer	15
A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation	15
Decoding retrons: Breakthroughs in RT-DNA production and genome editing	15
Anaerobic purinolytic enzymes enable dietary purine clearance by engineered gut bacteria	15
Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I	15
The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis	15
TPC2 targeting evolution: Leveraging therapeutic opportunities for cancer	15
CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors	15
Integration of metabolism and regulation reveals rapid adaptability to growth on non-native substrates	15
Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen	14
Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions	14
Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter	14
Tools to investigate the cell surface: Proximity as a central concept in glycoRNA biology	14
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells	14
A phospholipid mimetic targeting LRH-1 ameliorates colitis	14
Antiplasmodial peptaibols act through membrane directed mechanisms	14
Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation	14
Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy	14
Utilizing directed evolution to interrogate and optimize CRISPR/Cas guide RNA scaffolds	14
Resident and elicited murine macrophages differ in expression of their glycomes and glycan-binding proteins	14
Cell-selective bioorthogonal labeling	14
A double on the Rocs with a twist: Rocaglamide A targets multiple DEAD-box helicases to inhibit translation initiation	14
The role of reversible and irreversible covalent chemistry in targeted protein degradation	14
Inhibitors of the ATPase p97/VCP: From basic research to clinical applications	14
Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization	14
A fine-tuned azobenzene for enhanced photopharmacology in vivo	14
Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors	13
Autotaxin facilitates selective LPA receptor signaling	13
In-depth characterization of ubiquitin turnover in mammalian cells by fluorescence tracking	13
AspSnFR: A genetically encoded biosensor for real-time monitoring of aspartate in live cells	13
Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling	13
Real-time non-invasive fluorescence imaging of gut commensal bacteria to detect dynamic changes in the microbiome of live mice	13
Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseases	13
Dissecting the neuroprotective interaction between the BH4 domain of BCL-w and the IP3 receptor	13
Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity	13
Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury	13
Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells	13
Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions	13
PARP trapping is governed by the PARP inhibitor dissociation rate constant	13
N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis	13
Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs	13
A histone deacetylase network regulates epigenetic reprogramming and viral silencing in HIV-infected cells	13
Genome- and metabolome-guided discovery of marine BamA inhibitors revealed a dedicated darobactin halogenase	13
Identification of covalent inhibitors that disrupt M. tuberculosis growth by targeting multiple serine hydrolases involved in lipid metabolism	12
Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation	12
Multiplexed bioluminescence imaging with a substrate unmixing platform	12
Taming transcription factors with TRAFTACs	12
Dual-action compounds unleash a one-two punch against tuberculosis	12
Cell Chemical Biology announces changes to the editorial team	12
Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function	12
Getting in on the action: New tools to see SARS-CoV-2 infect a cell	12
Finding my leadership style	12
TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2	12
Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation	12
Ferroptosis execution: Is it all about ACSL4?	12
Glycopeptidolipid glycosylation controls surface properties and pathogenicity in Mycobacterium abscessus	12
How do you mend inactive tumor suppressor mutants? You glue them!	12
Proteasome inhibitors: The next generation of antimalarial drugs?	12
Human nuclear hormone receptor activity contributes to malaria parasite liver stage development	12
The next Nobel Prize in chemistry or in physiology or medicine	12
Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer	12
Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling	12
Small molecules as tools for functional assessment of deubiquitinating enzyme function	11
Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome	11
Pharmacological management of disease by overcoming structural adversity	11
Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor	11
Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production	11
Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein	11
Convergent impact of vaccination and antibiotic pressures on pneumococcal populations	11
Genetic retargeting of E3 ligases to enhance CAR T cell therapy	11
Inhibiting GLUTtony in cancer	11
Challenges and opportunities in targeting metabolism	11
A non-rational approach to optimized targeting of CRISPR-Cas9 complexes	11
The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond	11
Velcrin compounds activate the SLFN12 tRNase to induce tomoptosis	10
AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms	10
A game of networks: Do different lipids interact to orchestrate inflammatory homeostasis?	10