Cell Chemical Biology

Article	Citations
Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1	143
A versatile residue numbering scheme for Nav and Cav channels	138
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance	130
A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer	109
Next steps for targeted protein degradation	107
Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations	98
FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication	95
Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation	91
Voices: Challenges and opportunities in regulating the immune system	90
Meet the Authors: Christopher R. Mansfield and Emily R. Derbyshire	88
RENBP inhibition amplifies metabolic glycan labeling efficiency of antigen-presenting cells in vitro and in vivo	88
ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas	87
An interactive resource mapping the proteome and reactive cysteine landscape across the NCI-60 reveals cell and tissue-specific profiles	86
Therapeutic potential of inhibiting the PI3Kγ complex for leukemia	85
2′-OH as a universal handle for studying intracellular RNAs	82
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection	79
Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development	78
Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine	77
CBLs downregulation foretells T cell ubiquitination leading to autoimmunity	74
Meet the Authors: Harkamal S. Jhajj and Peter M. Tessier	68
Catalytic spike antibodies: A new paradigm in neutralization	67
Valence and avidity determine the agonistic activity of anti-TNFR2 nanobody fusion proteins	66
Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration	65
Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells	61
Meet the Cell Chemical Biology author and newest advisory board member: Marcus Conrad	60

A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation	60
N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis	57
Engineered pistol ribozymes selectively target KRAS G12V with enhanced efficacy by capping modification	57
Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy	57
Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions	54
Targeting the endocannabinoid-eicosanoid axis to treat pain: Promise and pitfalls	54
Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression	54
Real-time non-invasive fluorescence imaging of gut commensal bacteria to detect dynamic changes in the microbiome of live mice	54
Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria	53
A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation	51
Pharmacological management of disease by overcoming structural adversity	50
A double whammy for KEAP1	50
The art of designed coiled-coils for the regulation of mammalian cells	48
De novo protein assembly enables drug-controlled cellular functions	47
Discovery of MARK2 as a physiological kinase for PER2 in the mammalian clock	47
Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry	46
BLOC-1 and BORC: Complex regulators of endolysosomal dynamics	43
PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication	42
Metabolic tug-of-war: Microbial metabolism shapes colonization resistance against enteric pathogens	42
Targeting RNA with synthetic oligonucleotides: Clinical success invites new challenges	42
Structural basis for NONO-specific modification by the α-chloroacetamide compound (R)-SKBG-1	41
A new chink in cancer’s armor: Unleashing cell death by selective PP5 inhibition	40
Enabling inclusion and looking ahead	39
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy	38
Two sides of a co(i)ndensate	38
Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases	38
Arabinose- and xylose-modified analogs of 2′,3′-cGAMP act as STING agonists	38
Two genomes, one destiny: Mitophagy at the crossroads of inheritance and disease	37
Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome	37
Deciphering the opioid code	37
Meet the authors: Aayushi Uberoi and Elizabeth A. Grice	37
Linked-domain inhibitors designed to block UBE2D induce the unfolded protein response	37
Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis	36
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation	35
Covalent inhibition of ACSL4 alleviates ferroptosis-induced acute liver injury	35
Natural products chlorotonils exert a complex antibacterial mechanism and address multiple targets	35
Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors	35
Behavioral control through the direct, focal silencing of neuronal activity	34
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation	34
Sorting out extracellular proteins: SORTACs harness sortilin for targeted protein degradation	33
The membrane strikes back: A mechanical force awakens antiviral defense	33
Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs	33
IAP-based biodegraders can convert necroptosis to apoptosis and eliminate cancer driving protein complexes	33
Cell-free production of personalized therapeutic phages targeting multidrug-resistant bacteria	33
Screening in serum-derived medium reveals differential response to compounds targeting metabolism	32
S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons	32
Identification of differential biological activity and synergy between the PARP inhibitor rucaparib and its major metabolite	32
Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates	32
Characterization of an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase to treat Candida albicans infections	32
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis	31

PCNA degradation exhibits superior pharmacological effects over stoichiometric inhibition	31
Boosting glycolysis to combat fragile bone in type 1 diabetes	31
Induced proximity in biology and therapeutics	31
Feel the breeze: Opening the therapeutic window with RIPTACs and induced proximity	31
Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO	31
Mo’ m1A, mo’ problems	31
Insights into lysophosphatidylserine recognition and Gα12/13-coupling specificity of P2Y10	30
Selective killing of the human gastric pathogen Helicobacter pylori by mitochondrial respiratory complex I inhibitors	30
Meet the authors: Mitchel L. Tepe and Huiqing Zhou	30
Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex	30
D-aring to explore: New approaches to gasdermin D targeting	30
Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death	29
In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin	29
Structural basis of CD97 activation and G-protein coupling	28
Small molecule targeting of transcription-replication conflict for selective chemotherapy	28
Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators	28
Plant synthetic genomics: Big lessons from the little yeast	28
Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells	28
Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases	27
Discovery of a PROTAC degrader for METTL3-METTL14 complex	27
Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate	27
Decoding E1-E2 specificity: How UBA6 prioritizes BIRC6 for ubiquitin conjugation	27
Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity	27
Mechanisms and functions of lysosomal lipid homeostasis	27
Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells	27
The physiological and pathological roles of RNA modifications in T cells	27
CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers	27
RNATACs: Multispecific small molecules targeting RNA by induced proximity	27
Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas	26
How to kill an ERKsome target: PROTACs deliver the deathblow	26
Transcriptional restart: A new role for PARylation in overcoming DNA damage	26
Integrating inflammatory biomarker analysis and artificial-intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis	25
An N terminomics toolbox combining 2-pyridinecarboxaldehyde probes and click chemistry for profiling protease specificity	25
Targeting selective E3 ligase for healing cardiac fibrosis	25
Lactylation of mTOR enhances autophagy in skeletal muscle during exercise	25
Inhibitors of the ATPase p97/VCP: From basic research to clinical applications	25
Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells	25
A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease	25
De novo design of Ras isoform selective binders	25
Membrane lipids regulate the STING pathway and type I interferon responses	25
PARP trapping is governed by the PARP inhibitor dissociation rate constant	25
Transcending cell death – The diverse roles of necroptosis signal adaptors in pathogen infection	24
Voices: Challenges and opportunities for bioorthogonal chemistry	24
The chemistry of electrical signaling in sodium channels from bacteria and beyond	24
CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors	24
Photo-proximity labeling in live primary neurons identifies an AMPA-receptor signal transducer in homeostatic synaptic plasticity	24
Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling	24
Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseases	23
Tools to investigate the cell surface: Proximity as a central concept in glycoRNA biology	23
Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders	23
Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input	23
Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells	23
Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor	23
Host-like conditions validate nutrient transport as an antimalarial drug target	22
Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway	22
The liquid lectin array detects compositional glycocalyx differences using multivalent DNA-encoded lectins on phage	22
Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation	22
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia	22
MICU1 controls the sensitivity of the mitochondrial Ca2+ uniporter to activators and inhibitors	22
Quinoline-based compounds can inhibit diverse enzymes that act on DNA	21
Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120	21
The dark side of circular RNA, a new driver of genome instability	21
Monitoring autophagic flux in vivo revealed its physiological response and significance of heterogeneity in pancreatic beta cells	21
Development of D2HG biosensors inspired by the molecular mechanism of D2HG regulation of DhdR	21
A small molecule PTER-selective inhibitor reduces food intake and body weight	21
Immunity in motion: The role of mechanics in macrophage biology	21
Phosphorylation barcodes direct biased chemokine signaling at CXCR3	20
Phytate enhances gut Parasutterella colonization to alleviate radiation injury	20
Small-molecule allosteric inhibitors of GPX4	20
CryoSeek identification of glycofibrils with diverse compositions and structural assemblies	20
Identification of an STING inhibitor targeting the allosteric transmembrane domains	20
Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1	19
Meet the authors: Cydney N. Johnson, Shyra Wilde, Elaine Tuomanen, and Jason W. Rosch	19
Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells	19
A “light” touch on PI3K to interrogate cancer drug resistance	19
METTL3: Melting the tumor microenvironment for improved immunotherapy	19
The culinary chemist: Out of the lab and into the tent	19
Ligand discovery by activity-based protein profiling	19
One-pot trimodal mapping of unmethylated, hydroxymethylated, and open chromatin sites unveils distinctive 5hmC roles at dynamic chromatin loci	19
Facile generation of biepitopic antibodies with intrinsic agonism for activating tumor necrosis factor receptors	19

Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy	19
Peptide passports: Programmable import fuels novel protein building blocks	19
New twists in anti-malarial drug resistance	19
Beyond a degrader: VHL reprograms hypoxic metabolism	19
Targeted degradation of CDK9 potently disrupts the MYC-regulated network	18
A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened	18
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells	18
One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade	18
Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling	18
In vivo bioluminescence imaging of granzyme B activity in tumor response to cancer immunotherapy	18
Assessing the suitability of deubiquitylases as substrates for targeted protein degradation	18
Robust antitumor treatment driven by lock-and-key biorecognition of dynamic cyclic diselenide-guided chiral prodrug self-assembly	18
Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers	18
Meet the authors: Katerina Jones, Camila Bernardo de Brito, and Mariana Xavier Byndloss	18
Strategies of bacterial detection by inflammasomes	18
CBX4 acetoacetylation as an inhibitory mechanism of HIF-1α activity	18
Sharks give a handle to potent anti-tumor multiparatopic antibodies inducing membrane depletion of PD-L1	18
STX-bpc: “Brightening” the path to neuronal inhibition	18
Activation primes GPCRs for versatile coupling	18
A method for the detection and enrichment of endogenous cereblon substrates	17
The cyclimids: Degron-inspired cereblon binders for targeted protein degradation	17
Intracellular cyclization-coupled peptide library screening yields potent transcription factor antagonists	17
Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system	17
Target protein localization and its impact on PROTAC-mediated degradation	17
Pharmacologic activation of a compensatory integrated stress response kinase promotes mitochondrial remodeling in PERK-deficient cells	17
Small-molecule inhibitors of ferrochelatase are antiangiogenic agents	17
Cytoplasmic tail diversity determines the effector bias of the adhesion GPCR ADGRL2	17
A proximity labeling-based orthogonal trap strategy identifies HDAC8 promotes cell motility by modulating cortactin acetylation	17
Bivalent inhibitors of the BTB E3 ligase KEAP1 enable instant NRF2 activation to suppress acute inflammatory response	17
Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation	17
Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics	17
Recognition of the tRNA structure: Everything everywhere but not all at once	16
Acylation probing of “generic” RNA libraries reveals critical influence of loop constraints on reactivity	16
Ligand-induced assembly of antibody variable fragments for the chemical regulation of biological processes	16
Causes, functions, and therapeutic possibilities of RNA secondary structure ensembles and alternative states	16
Platelets accelerate lipid peroxidation and induce pathogenic neutrophil extracellular trap release	16
Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis	16
Repurposing AS1411 for constructing ANM-PROTACs	16
Chemical approaches to unraveling the biology of mycobacteria	16
Degrading TBK1 to disarm VHL-deficient renal cancer	15
Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux	15
Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells	15
Spatiotemporally resolved GPCR interactome uncovers unique mediators of receptor agonism	15
Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins	15
Metabolic modulation of mitochondrial mass during CD4+ T cell activation	15
Mechanosensation promotes broad-spectrum antiviral defense through membrane remodeling	15
A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis	14
The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation	14
Sensing within: Mitochondrial inside-out signal transduction	14
Context-dependent regulation of ferroptosis sensitivity	14
Specificity profiling of deubiquitylases against endogenously generated ubiquitin-protein conjugates	14
Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction	14
Discovery of compounds that reactivate p53 mutants in vitro and in vivo	14
Chemical genomics reveals targetable programs of human cancers rooted in pluripotency	14
Degrading the signal amplifier: ITK as a target for targeted protein degradation	14
High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface	14
Regulation of bacterial gene expression by non-coding RNA: It is all about time!	14
CysDB: a human cysteine database based on experimental quantitative chemoproteomics	14
Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics	14
The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation	13
Genetically encoded manipulation of ATP/ADP ratio in human cells uncovers proteomic and physiological signatures of energy stress	13
Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome	13
RPL22 links ribosome biogenesis, RNA splicing, and sensitivity to RNA polymerase I inhibition	13
Targeting type I DED interactions at the DED filament serves as a sensitive switch for cell fate decisions	13
Site-resolved assessment of targeted protein degradation	13
Modifying the antiviral innate immune response by selective writing, erasing, and reading of m6A on viral and cellular RNA	13
Engineering acyclovir-induced RNA nanodevices for reversible and tunable control of aptamer function	13
Meet the authors: Xueqin Jin, Jian Huang, Huan Wang, Kan Wang, and Nieng Yan	13
A sticky situation for targeted cancer therapy	13
A base editor facilitates simultaneous purine and pyrimidine substitutions for ex vivo and in vivo mutagenesis screens	13
Generation of glycan-specific nanobodies	13
Genetically incorporated crosslinkers identify regulators of membrane protein PD-L1 in mammalian cells	13
When CDK4/6i meets GPX4i: Stop dividing to die iron hard	13
Raf protomers: Drug binding preferences in living cells	13
Integration of metabolism and regulation reveals rapid adaptability to growth on non-native substrates	12
Localization matters in targeted protein degradation	12
Advances in degradomics technologies to assess proteolytic cleavage events	12
Structural insights into inhibition mechanism of the helicase-primase complex from human herpesvirus 1	12
Anaerobic purinolytic enzymes enable dietary purine clearance by engineered gut bacteria	12
The next Nobel Prize in chemistry or in physiology or medicine	12
Genome- and metabolome-guided discovery of marine BamA inhibitors revealed a dedicated darobactin halogenase	12
Targeting biomolecular condensates: The rise of engineered chaperones	12
Cell-selective bioorthogonal labeling	12
Inhibiting cancer metastasis with water-solubilized membrane receptor CXCR4QTY-Fc as a molecular trap	12
Pantothenate kinase is an effective target for antifungal therapy	12
Engineering electrogenetic interfaces for mammalian cell control	12
Disruption to the gut microbiome by non-antibiotics is linked to infection risk	12
Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules	12
Chemical proteomics to study metabolism, a reductionist approach applied at the systems level	12
Fluorogenic CRISPR for DNA imaging in live mammalian cells	12
Engineering affinity-matured variants of an anti-polysialic acid monoclonal antibody with superior cytotoxicity-mediating potency	12
Glycopeptidolipid glycosylation controls surface properties and pathogenicity in Mycobacterium abscessus	12
Investigating the NRAS 5′ UTR as a target for small molecules	12
Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation	11
Genetic retargeting of E3 ligases to enhance CAR T cell therapy	11