Cell Chemical Biology

Article	Citations
PROTACs: An Emerging Therapeutic Modality in Precision Medicine	249
Targeted protein degradation: A promise for undruggable proteins	120
The Chemical Biology of Ferroptosis in the Central Nervous System	109
MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells	101
Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras	96
Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function	93
Targeted degradation of the enhancer lysine acetyltransferases CBP and p300	86
Haven't got a glue: Protein surface variation for the design of molecular glue degraders	81
The Chemical Biology of Reversible Lysine Post-translational Modifications	80
Recent advances in identifying protein targets in drug discovery	74
Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC	69
Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2	67
Chemical Tools for Endogenous Protein Labeling and Profiling	65
Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming	64
Development of a potent and selective chemical probe for the pleiotropic kinase CK2	64
Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation	63
Seeing (and Using) the Light: Recent Developments in Bioluminescence Technology	63
Illuminating RNA Biology: Tools for Imaging RNA in Live Mammalian Cells	62
Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis	61
Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP	59
Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases	58
An E3 ligase guide to the galaxy of small-molecule-induced protein degradation	57
Eradicating Bacterial Persisters with Combinations of Strongly and Weakly Metabolism-Dependent Antibiotics	56
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity	55
The role of reversible and irreversible covalent chemistry in targeted protein degradation	54

FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication	53
A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders	52
Development of Potent, Selective Surrogate WNT Molecules and Their Application in Defining Frizzled Requirements	52
An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor	48
How to untie G-quadruplex knots and why?	48
A biaryl-linked tripeptide from Planomonospora reveals a widespread class of minimal RiPP gene clusters	47
Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity	45
A Robust, GFP-Orthogonal Photoswitchable Inhibitor Scaffold Extends Optical Control over the Microtubule Cytoskeleton	45
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors	45
Context-dependent regulation of ferroptosis sensitivity	44
HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins	44
Chemo-proteomics exploration of HDAC degradability by small molecule degraders	44
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention	44
Lanthanide-Based Optical Probes of Biological Systems	44
Strategies for Tuning the Selectivity of Chemical Probes that Target Serine Hydrolases	43
CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes	42
Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System	42
Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System	42
Systematic Chemogenetic Library Assembly	40
The proteasome and its role in the nervous system	40
Morphological profiling of small molecules	40
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2	39
Degradation from the outside in: Targeting extracellular and membrane proteins for degradation through the endolysosomal pathway	39
Nuisance compounds in cellular assays	38
A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants	38
Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A	38
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth	36
Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors	36
Ubiquitin ligases in cancer: Functions and clinical potentials	35
Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB	35
A fine-tuned azobenzene for enhanced photopharmacology in vivo	34
Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy	34
A Clickable APEX Probe for Proximity-Dependent Proteomic Profiling in Yeast	34
Optical control of targeted protein degradation	34
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses	34
Identification and selectivity profiling of small-molecule degraders via multi-omics approaches	33
Hit Triage and Validation in Phenotypic Screening: Considerations and Strategies	33
Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy	33
Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3	33
Exploring the target scope of KEAP1 E3 ligase-based PROTACs	32
Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation	32
Decoding the messaging of the ubiquitin system using chemical and protein probes	31
Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis	31
DogCatcher allows loop-friendly protein-protein ligation	30
Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth	30
A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells	29
Targeted In Situ Protein Diversification and Intra-organelle Validation in Mammalian Cells	29
Quantitative Imaging of Labile Zn2+ in the Golgi Apparatus Using a Localizable Small-Molecule Fluorescent Probe	29
Small molecule targeting of biologically relevant RNA tertiary and quaternary structures	28
Polynuclear Ruthenium Amines Inhibit K2P Channels via a “Finger in the Dam” Mechanism	28

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity	28
Proteomics-Based Identification of DUB Substrates Using Selective Inhibitors	28
Small Substrate or Large? Debate Over the Mechanism of Glycation Adduct Repair by DJ-1	27
Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering	27
Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein	27
Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase	27
Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification	27
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis	27
Chemical Biology Tools for Examining the Bacterial Cell Wall	27
High-content phenotypic and pathway profiling to advance drug discovery in diseases of unmet need	27
Cell-free production of personalized therapeutic phages targeting multidrug-resistant bacteria	27
Targeting Two-Component Systems Uncovers a Small-Molecule Inhibitor of Salmonella Virulence	26
The chemical tools for imaging dopamine release	26
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death	26
Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A	25
Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia	25
ND3 Cys39 in complex I is exposed during mitochondrial respiration	25
CysDB: a human cysteine database based on experimental quantitative chemoproteomics	25
3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis	25
Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds	24
Bifunctional modalities for repurposing protein function	24
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells	24
Chemoproteomic-enabled phenotypic screening	24
An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity	24
Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth	24
The future of phenotypic drug discovery	24
A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex	23
Rational Design of Bioavailable Photosensitizers for Manipulation and Imaging of Biological Systems	23
An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals	23
Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis	23
Mechanism of Cell Penetration by Permeabilization of Late Endosomes: Interplay between a Multivalent TAT Peptide and Bis(monoacylglycero)phosphate	23
Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology	23
Human iPSC modeling of heart disease for drug development	23
A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex	23
Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin	23
Inhibition of Nonfunctional Ras	23
Piperlongumine conjugates induce targeted protein degradation	23
Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor	22
Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome	22
Small-molecule allosteric inhibitors of GPX4	22
A photo-cross-linking GlcNAc analog enables covalent capture of N-linked glycoprotein-binding partners on the cell surface	22
Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies	22
Formation of an aminovinyl-cysteine residue in thioviridamides occurs through a path independent of known lanthionine synthetase activity	21
Identification of a PCSK9-LDLR disruptor peptide with in vivo function	21
Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions	21
A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin	21
Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer	21
Target protein localization and its impact on PROTAC-mediated degradation	21
Selective Modulation of Dynamic Protein Complexes	21
Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism	21
Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel	21
A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA	21
Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality	21
Making the cut with protease engineering	21
CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity	20
Engineering DNA-Templated Nonribosomal Peptide Synthesis	20
Quantitative chemoproteomics reveals O-GlcNAcylation of cystathionine γ-lyase (CSE) represses trophoblast syncytialization	20
The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors	20
Selective autophagy as the basis of autophagy-based degraders	20
Light-controllable RNA-protein devices for translational regulation of synthetic mRNAs in mammalian cells	20
Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling	19
tRNAArg-Derived Fragments Can Serve as Arginine Donors for Protein Arginylation	19
Identification and validation of selective deubiquitinase inhibitors	19
Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator	19
Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1	19
A synthetic diterpene analogue inhibits mycobacterial persistence and biofilm formation by targeting (p)ppGpp synthetases	19
Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors	19
TK216 targets microtubules in Ewing sarcoma cells	19
Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis	19
Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities	18
Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing	18
Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I	18
PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ	18
Peptide-Based PROTAC: The Predator of Pathological Proteins	18
Re-wiring the regulation of the formicamycin biosynthetic gene cluster to enable the development of promising antibacterial compounds	18
Site-Specific Incorporation of Genetically Encoded Photo-Crosslinkers Locates the Heteromeric Interface of a GPCR Complex in Living Cells	18
Periplasmic expression of SpyTagged antibody fragments enables rapid modular antibody assembly	18
Mechanism-Based Personalized Medicine for Cystic Fibrosis by Suppressing Pseudo Exon Inclusion	18
Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex	18
Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs	18

Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis	18
A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity	17
Metabolic targeting of cancer by a ubiquinone uncompetitive inhibitor of mitochondrial complex I	17
Ligand-induced interactions between butyrophilin 2A1 and 3A1 internal domains in the HMBPP receptor complex	17
Re-defining synthetic lethality by phenotypic profiling for precision oncology	17
A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader	17
Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling	17
Modulation of lanosterol synthase drives 24,25-epoxysterol synthesis and oligodendrocyte formation	17
In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement	17
A PROTAC targets splicing factor 3B1	16
Phenotypic screening with target identification and validation in the discovery and development of E3 ligase modulators	16
Proteostasis Regulators Restore Function of Epilepsy-Associated GABAA Receptors	16
Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum	16
Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190	16
Discovery of an Inhibitor for Bacterial 3-Mercaptopyruvate Sulfurtransferase that Synergistically Controls Bacterial Survival	16
The rise of degrader drugs	16
Sulfotyrosine-Mediated Recognition of Human Thrombin by a Tsetse Fly Anticoagulant Mimics Physiological Substrates	16
Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers	16