Cell Chemical Biology

Article	Citations
CBLs downregulation foretells T cell ubiquitination leading to autoimmunity	125
A versatile residue numbering scheme for Nav and Cav channels	119
Antisense-mediated senseful regulation of orchestrated metabolic response	93
New sheriff in town: Cyclic peptide inhibitors of a DUB module	88
Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation	83
Meet the Authors: Christopher R. Mansfield and Emily R. Derbyshire	81
Therapeutic potential of inhibiting the PI3Kγ complex for leukemia	78
Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1	78
Voices: Challenges and opportunities in regulating the immune system	73
A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer	73
RENBP inhibition amplifies metabolic glycan labeling efficiency of antigen-presenting cells in vitro and in vivo	73
ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas	72
Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development	71
Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites	71
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection	69
2′-OH as a universal handle for studying intracellular RNAs	68
Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs	67
Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine	67
Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance	62
Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations	62
Next steps for targeted protein degradation	62
Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples	61
FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication	60
Meet the Authors: Harkamal S. Jhajj and Peter M. Tessier	55
Valence and avidity determine the agonistic activity of anti-TNFR2 nanobody fusion proteins	54

Meet the Cell Chemical Biology author and newest advisory board member: Marcus Conrad	54
Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions	51
Catalytic spike antibodies: A new paradigm in neutralization	50
Real-time non-invasive fluorescence imaging of gut commensal bacteria to detect dynamic changes in the microbiome of live mice	50
Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration	49
A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation	49
PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ	48
A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation	47
Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria	47
Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy	46
N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis	46
A double whammy for KEAP1	43
Metabolic tug-of-war: Microbial metabolism shapes colonization resistance against enteric pathogens	43
BLOC-1 and BORC: Complex regulators of endolysosomal dynamics	43
Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells	43
The art of designed coiled-coils for the regulation of mammalian cells	42
Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET	42
PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication	40
Targeting RNA with synthetic oligonucleotides: Clinical success invites new challenges	40
Pharmacological management of disease by overcoming structural adversity	40
Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry	40
Meet the authors: Aayushi Uberoi and Elizabeth A. Grice	39
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation	38
Enabling inclusion and looking ahead	37
Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis	36
Two sides of a co(i)ndensate	36
Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors	35
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy	35
A new chink in cancer’s armor: Unleashing cell death by selective PP5 inhibition	35
Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases	34
Arabinose- and xylose-modified analogs of 2′,3′-cGAMP act as STING agonists	34
Natural products chlorotonils exert a complex antibacterial mechanism and address multiple targets	34
Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns	34
Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs	33
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation	33
Induced proximity in biology and therapeutics	33
A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype	33
Cell-free production of personalized therapeutic phages targeting multidrug-resistant bacteria	33
Behavioral control through the direct, focal silencing of neuronal activity	33
Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome	33
Covalent inhibition of ACSL4 alleviates ferroptosis-induced acute liver injury	33
Identification of differential biological activity and synergy between the PARP inhibitor rucaparib and its major metabolite	32
Characterization of an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase to treat Candida albicans infections	32
Screening in serum-derived medium reveals differential response to compounds targeting metabolism	32
Boosting glycolysis to combat fragile bone in type 1 diabetes	32
No acetyl-CoA keeps Plasmodium at bay	32
Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates	31
S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons	31
Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators	30
D-aring to explore: New approaches to gasdermin D targeting	30

Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis	30
Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex	30
Meet the authors: Mitchel L. Tepe and Huiqing Zhou	30
Plant synthetic genomics: Big lessons from the little yeast	30
Feel the breeze: Opening the therapeutic window with RIPTACs and induced proximity	30
Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate	29
CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers	29
Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death	29
Mo’ m1A, mo’ problems	28
Structural basis of CD97 activation and G-protein coupling	28
Insights into lysophosphatidylserine recognition and Gα12/13-coupling specificity of P2Y10	28
Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells	27
PCNA degradation exhibits superior pharmacological effects over stoichiometric inhibition	27
Selective killing of the human gastric pathogen Helicobacter pylori by mitochondrial respiratory complex I inhibitors	27
In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin	27
Mapping the residue specificities of epigenome enzymes by yeast surface display	27
RNATACs: Multispecific small molecules targeting RNA by induced proximity	27
Small molecule targeting of transcription-replication conflict for selective chemotherapy	26
Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity	26
Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells	26
The physiological and pathological roles of RNA modifications in T cells	26
Discovery of a PROTAC degrader for METTL3-METTL14 complex	26
Mechanisms and functions of lysosomal lipid homeostasis	26
How to kill an ERKsome target: PROTACs deliver the deathblow	26
An N terminomics toolbox combining 2-pyridinecarboxaldehyde probes and click chemistry for profiling protease specificity	25
Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases	25
Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis	25
Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas	25
CRAGE-CRISPR facilitates rapid activation of secondary metabolite biosynthetic gene clusters in bacteria	25
Integrating inflammatory biomarker analysis and artificial-intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis	25
Lactylation of mTOR enhances autophagy in skeletal muscle during exercise	25
Excited to see you: New imaging approaches to detect ferrous iron in vivo	24
Voices: Challenges and opportunities for bioorthogonal chemistry	24
A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease	24
Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells	24
Identification of small molecules that strongly inhibit bacterial quorum sensing using a high-throughput lipid vesicle lysis assay	24
Identifying and antagonizing the interactions between layilin and glycosylated collagens	24
CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors	24
Targeting selective E3 ligase for healing cardiac fibrosis	24
Screening compound libraries for H2O2-mediated cancer therapeutics using a peroxiredoxin-based sensor	24
Tools to investigate the cell surface: Proximity as a central concept in glycoRNA biology	23
Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer	23
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells	23
Inhibitors of the ATPase p97/VCP: From basic research to clinical applications	23
The chemistry of electrical signaling in sodium channels from bacteria and beyond	23
Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling	23
PARP trapping is governed by the PARP inhibitor dissociation rate constant	23
Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input	23
Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders	22
Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor	22
Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseases	22
Host-like conditions validate nutrient transport as an antimalarial drug target	21
Monitoring autophagic flux in vivo revealed its physiological response and significance of heterogeneity in pancreatic beta cells	21
The dark side of circular RNA, a new driver of genome instability	21
Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells	21
Inhibiting GLUTtony in cancer	21
Phytate enhances gut Parasutterella colonization to alleviate radiation injury	20
The liquid lectin array detects compositional glycocalyx differences using multivalent DNA-encoded lectins on phage	20
Ligand discovery by activity-based protein profiling	20
Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model	20
MICU1 controls the sensitivity of the mitochondrial Ca2+ uniporter to activators and inhibitors	20
Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway	20
Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia	20
Quinoline-based compounds can inhibit diverse enzymes that act on DNA	20
Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation	20
Phosphorylation barcodes direct biased chemokine signaling at CXCR3	20
Development of D2HG biosensors inspired by the molecular mechanism of D2HG regulation of DhdR	20
Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120	20
Small-molecule allosteric inhibitors of GPX4	20
Facile generation of biepitopic antibodies with intrinsic agonism for activating tumor necrosis factor receptors	19
Meet the authors: Cydney N. Johnson, Shyra Wilde, Elaine Tuomanen, and Jason W. Rosch	19
One-pot trimodal mapping of unmethylated, hydroxymethylated, and open chromatin sites unveils distinctive 5hmC roles at dynamic chromatin loci	19
A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened	19
Identification of Pax protein inhibitors that suppress target gene expression and cancer cell proliferation	19
Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy	19
New twists in anti-malarial drug resistance	19
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells	19
The culinary chemist: Out of the lab and into the tent	19
Strategies of bacterial detection by inflammasomes	19
Targeted degradation of CDK9 potently disrupts the MYC-regulated network	18

Ligand-directed bias of G protein signaling at the dopamine D2 receptor	18
Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells	18
Meet the authors: Katerina Jones, Camila Bernardo de Brito, and Mariana Xavier Byndloss	18
Causes, functions, and therapeutic possibilities of RNA secondary structure ensembles and alternative states	18
Sharks give a handle to potent anti-tumor multiparatopic antibodies inducing membrane depletion of PD-L1	18
CBX4 acetoacetylation as an inhibitory mechanism of HIF-1α activity	18
A “light” touch on PI3K to interrogate cancer drug resistance	18
In vivo bioluminescence imaging of granzyme B activity in tumor response to cancer immunotherapy	18
STX-bpc: “Brightening” the path to neuronal inhibition	18
Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1	18
Pharmacologic activation of a compensatory integrated stress response kinase promotes mitochondrial remodeling in PERK-deficient cells	18
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir	18
Exploiting polypharmacology to dissect host kinases and kinase inhibitors that modulate endothelial barrier integrity	18
METTL3: Melting the tumor microenvironment for improved immunotherapy	18
Small-molecule inhibitors of ferrochelatase are antiangiogenic agents	18
One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade	18