OOIR: Observatory of International Research

Papers

(The H4-Index of Bioactive Materials is 77. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Outside Front Cover	373
Primary and Re-exposure effects of D-enantiomeric peptide on metabolism, diversity, and composition of oral biofilms at different stages of recovery	323
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery	309
Avoiding artefacts in MicroCT imaging of collagen scaffolds: Effect of phosphotungstic acid (PTA)-staining and crosslink density	244
Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model	228
Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response	217
Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration	214
High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure	210
ROS-responsive nanoparticle delivery of ferroptosis inhibitor prodrug to facilitate mesenchymal stem cell-mediated spinal cord injury repair	202
Platinum-crosslinking polymeric nanoparticle for synergetic chemoradiotherapy of nasopharyngeal carcinoma	180
Zwitterionic betaines over HEPES as the new generation biocompatible pH buffers for cell culture	167
Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating	162
In situ implantation of type II collagen-based double-layer scaffolds for Articular Osteochondral Regeneration comprising hyaline cartilage and vascularized subchondral bones	159
From hard tissues to beyond: Progress and challenges of strontium-containing biomaterials in regenerative medicine applications	158
Artificial cilia for soft and stable surface covalent immobilization of bone morphogenetic protein-2	154
Advances and applications of biomimetic biomaterials for endogenous skin regeneration	154
Promoting lacunar bone regeneration with an injectable hydrogel adaptive to the microenvironment	151
Biomimetic integration of functionally controlled modular tissue building blocks for engineering 3D vascularized adipose tissue	151
In situ engineered magnesium alloy implant for preventing postsurgical tumor recurrence	147
Application of bioactive materials primary cilia as a novel delivery vehicle	144
Enhancing PD-1 blockade in NSCLC: Reprogramming tumor immune microenvironment with albumin-bound statins targeting lipid rafts and mitochondrial respiration	144
Corrigendum to “Surface modification of electrospun fibers with mechano-growth factor for mitigating the foreign-body reaction” [Bioact. Mater. 6 (9) (2021) 2983–2998]	137
Electrically conductive biopolymer-based hydrogels and fibrous materials fabricated using 3D printing and electrospinning for cardiac tissue engineering	135
Dual-pathway targeted therapy for Parkinson's disease: Biomimetic nanosomes inhibit ferroptosis and pyroptosis through NLRP3 inflammasome regulation	131
Reprogramming macrophages via immune cell mobilized hydrogel microspheres for osteoarthritis treatments	130

MoS2-based nanocomposites for cancer diagnosis and therapy	128
Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis	122
T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance	121
Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway	121
Cryo-shocked cancer cell microgels for tumor postoperative combination immunotherapy and tissue regeneration	120
Delivery of therapeutic oligonucleotides in nanoscale	116
Structure-function integrated biodegradable Mg/polymer composites: Design, manufacturing, properties, and biomedical applications	115
Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction	113
Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor	112
Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF/NOX2-associated ferroptosis while repairing bone defects	111
Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy	109
Bio-integrated scaffold facilitates large bone regeneration dominated by endochondral ossification	106
Biochemical hallmarks-targeting antineoplastic nanotherapeutics	103
Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment	103
Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing	102
Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation	100
Chinese herb microneedle patch for wound healing	100
Surface charge adaptive nitric oxide nanogenerator for enhanced photothermal eradication of drug-resistant biofilm infections	97
Bioprinted constructs that simulate nerve–bone crosstalk to improve microenvironment for bone repair	97
Bimetallic clusterzymes-loaded dendritic mesoporous silica particle regulate arthritis microenvironment via ROS scavenging and YAP1 stabilization	96
Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation	94
Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures	94
Rationally designed approaches to augment CAR-T therapy for solid tumor treatment	94
Light-activated nanoclusters with tunable ROS for wound infection treatment	93
Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration	91
Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy	90
3D bio-printed living nerve-like fibers refine the ecological niche for long-distance spinal cord injury regeneration	89
Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade	88
Nitric-oxide enriched plasma-activated water inactivates 229E coronavirus and alters antiviral response genes in human lung host cells	88
Engineering mesoporous bioactive glasses for emerging stimuli-responsive drug delivery and theranostic applications	87
Advances in biomaterial-based tissue engineering for peripheral nerve injury repair	86
Bioinspired porous microspheres for sustained hypoxic exosomes release and vascularized bone regeneration	85
An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation	85
A gel microparticle-based self-thickening strategy for 3D printing high-modulus hydrogels skeleton cushioned with PNAGA hydrogel mimicking anisotropic mechanics of meniscus	85
3D printed silk-gelatin hydrogel scaffold with different porous structure and cell seeding strategy for cartilage regeneration	84
Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts	84
Exploring the degradation behavior of MgXAg alloys by in vitro electrochemical methods	82
Next-generation finely controlled graded porous antibacterial bioceramics for high-efficiency vascularization in orbital reconstruction	82
In situ phosphorus-modified Mg2Ge/Zn-Cu composite with improved mechanical, degradation, biotribological properties, and in vitro and in vivo osteogenesis and osteointegration performance for biodegra	82
Exosomes loaded a smart bilayer-hydrogel scaffold with ROS-scavenging and macrophage-reprogramming properties for repairing cartilage defect	81
Corrigendum to “3D-printed tri-element-doped hydroxyapatite/ polycaprolactone composite scaffolds with antibacterial potential for osteosarcoma therapy and bone regeneration” [Bioact. Mater. 31 (Janua	81
Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regeneration	81
Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategy	81
Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content	80
Highly efficient semiconductor modules making controllable parallel microchannels for non-compressible hemorrhages	80
Virus-inspired surface-nanoengineered antimicrobial liposome: A potential system to simultaneously achieve high activity and selectivity	79
Advancements in adoptive CAR immune cell immunotherapy synergistically combined with multimodal approaches for tumor treatment	79
Magnetic bioassembly platforms towards the generation of extracellular vesicles from human salivary gland functional organoids for epithelial repair	79
Combination of biodegradable hydrogel and antioxidant bioadhesive for treatment of breast cancer recurrence and radiation skin injury	79
Janus piezoelectric adhesives regulate macrophage TRPV1/Ca2+/cAMP axis to stimulate tendon-to-bone healing by multi-omics analysis	79

Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization	78
Facile fabrication of a biocompatible composite gel with sustained release of aspirin for bone regeneration	78
Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity	77
Enhanced bone regeneration via endochondral ossification using Exendin-4-modified mesenchymal stem cells	77