OOIR: Observatory of International Research

Papers

(The H4-Index of Bioactive Materials is 77. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Outside Front Cover	358
Structure-function integrated biodegradable Mg/polymer composites: Design, manufacturing, properties, and biomedical applications	315
Enhanced healing of critical-sized bone defects using degradable scaffolds with tailored composition through immunomodulation and angiogenesis	305
Primary and Re-exposure effects of D-enantiomeric peptide on metabolism, diversity, and composition of oral biofilms at different stages of recovery	237
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery	234
Avoiding artefacts in MicroCT imaging of collagen scaffolds: Effect of phosphotungstic acid (PTA)-staining and crosslink density	219
Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model	214
Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response	212
Delivery of therapeutic oligonucleotides in nanoscale	206
Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration	193
High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure	177
Surface charge adaptive nitric oxide nanogenerator for enhanced photothermal eradication of drug-resistant biofilm infections	164
ROS-responsive nanoparticle delivery of ferroptosis inhibitor prodrug to facilitate mesenchymal stem cell-mediated spinal cord injury repair	159
Platinum-crosslinking polymeric nanoparticle for synergetic chemoradiotherapy of nasopharyngeal carcinoma	158
Cryo-shocked cancer cell microgels for tumor postoperative combination immunotherapy and tissue regeneration	155
Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF/NOX2-associated ferroptosis while repairing bone defects	154
Zwitterionic betaines over HEPES as the new generation biocompatible pH buffers for cell culture	149
Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating	147
Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction	146
T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance	145
In situ implantation of type II collagen-based double-layer scaffolds for Articular Osteochondral Regeneration comprising hyaline cartilage and vascularized subchondral bones	144
Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation	140
From hard tissues to beyond: Progress and challenges of strontium-containing biomaterials in regenerative medicine applications	131
Enhancing PD-1 blockade in NSCLC: Reprogramming tumor immune microenvironment with albumin-bound statins targeting lipid rafts and mitochondrial respiration	129
Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing	127

Artificial cilia for soft and stable surface covalent immobilization of bone morphogenetic protein-2	126
Advances and applications of biomimetic biomaterials for endogenous skin regeneration	125
Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy	122
Reprogramming macrophages via immune cell mobilized hydrogel microspheres for osteoarthritis treatments	120
Chinese herb microneedle patch for wound healing	116
In situ engineered magnesium alloy implant for preventing postsurgical tumor recurrence	116
Bio-integrated scaffold facilitates large bone regeneration dominated by endochondral ossification	115
Biochemical hallmarks-targeting antineoplastic nanotherapeutics	114
Biomimetic integration of functionally controlled modular tissue building blocks for engineering 3D vascularized adipose tissue	109
MoS2-based nanocomposites for cancer diagnosis and therapy	109
Piezoresistive MXene/Silk fibroin nanocomposite hydrogel for accelerating bone regeneration by Re-establishing electrical microenvironment	109
Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway	106
Bimetallic clusterzymes-loaded dendritic mesoporous silica particle regulate arthritis microenvironment via ROS scavenging and YAP1 stabilization	102
Promoting lacunar bone regeneration with an injectable hydrogel adaptive to the microenvironment	101
Bioprinted constructs that simulate nerve–bone crosstalk to improve microenvironment for bone repair	101
Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor	101
Nitric-oxide enriched plasma-activated water inactivates 229E coronavirus and alters antiviral response genes in human lung host cells	100
Spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure	99
Rationally designed approaches to augment CAR-T therapy for solid tumor treatment	99
Strategies of functionalized GelMA-based bioinks for bone regeneration: Recent advances and future perspectives	98
Conformationally regulated “nanozyme-like” cerium oxide with multiple free radical scavenging activities for osteoimmunology modulation and vascularized osseointegration	94
Enhancing biocompatibility of the brain-machine interface: A review	93
3D cell-printing of gradient multi-tissue interfaces for rotator cuff regeneration	92
Exploring the degradation behavior of MgXAg alloys by in vitro electrochemical methods	91
Engineering functional electroconductive hydrogels for targeted therapy in myocardial infarction repair	91
Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures	91
Next-generation finely controlled graded porous antibacterial bioceramics for high-efficiency vascularization in orbital reconstruction	89
In situ phosphorus-modified Mg2Ge/Zn-Cu composite with improved mechanical, degradation, biotribological properties, and in vitro and in vivo osteogenesis and osteointegration performance for biodegra	89
Corrigendum to “3D-printed tri-element-doped hydroxyapatite/ polycaprolactone composite scaffolds with antibacterial potential for osteosarcoma therapy and bone regeneration” [Bioact. Mater. 31 (Janua	88
Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis	87
Engineering anti-thrombogenic and anti-infective catheters through a stepwise metal-catechol-(amine) surface engineering strategy	87
Janus piezoelectric adhesives regulate macrophage TRPV1/Ca2+/cAMP axis to stimulate tendon-to-bone healing by multi-omics analysis	86
A gel microparticle-based self-thickening strategy for 3D printing high-modulus hydrogels skeleton cushioned with PNAGA hydrogel mimicking anisotropic mechanics of meniscus	86
Enhanced bone regeneration via endochondral ossification using Exendin-4-modified mesenchymal stem cells	84
Polymer-modified DNA hydrogels for living mitochondria and nanozyme delivery in the treatment of rheumatoid arthritis	84
Hydroxyapatite reinforced inorganic-organic hybrid nanocomposite as high-performance adsorbents for bilirubin removal in vitro and in pig models	83
Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity	82
Hypoxia-inducing cryogels uncover key cancer-immune cell interactions in an oxygen-deficient tumor microenvironment	82
Antimicrobial properties of dental cements modified with zein-coated magnesium oxide nanoparticles	81
Tumor microenvironment-responsive self-assembly of barium titanate nanoparticles with enhanced piezoelectric catalysis capabilities for efficient tumor therapy	81
Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation	80
Intrinsically bioactive and biomimetic nanoparticle-derived therapies alleviate asthma by regulating multiple pathological cells	80
Engineering mesoporous bioactive glasses for emerging stimuli-responsive drug delivery and theranostic applications	80
Immunomodulation and osseointegration activities of Na2TiO3 nanorods-arrayed coatings doped with different Sr content	80
Facile fabrication of a biocompatible composite gel with sustained release of aspirin for bone regeneration	80
Highly efficient semiconductor modules making controllable parallel microchannels for non-compressible hemorrhages	79
Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts	79
Exosomes loaded a smart bilayer-hydrogel scaffold with ROS-scavenging and macrophage-reprogramming properties for repairing cartilage defect	79
Fabrication and functional validation of a hybrid biomimetic nanovaccine (HBNV) against Kit-mutant melanoma	79
An adhesive and resilient hydrogel for the sealing and treatment of gastric perforation	79

Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regeneration	78
Magnetic bioassembly platforms towards the generation of extracellular vesicles from human salivary gland functional organoids for epithelial repair	77
Combination of biodegradable hydrogel and antioxidant bioadhesive for treatment of breast cancer recurrence and radiation skin injury	77
Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation	77