JACC-Basic to Translational Science

Article	Citations
Mechanisms of Cardiovascular Benefits of Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors	408
COVID-19 for the Cardiologist	203
Platelet and Endothelial Activation as Potential Mechanisms Behind the Thrombotic Complications of COVID-19 Patients	145
SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis	108
The Heart in COVID-19	73
Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition	72
Decentralized Clinical Trials	72
The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury	59
The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection	57
Targeting the Inflammasome in Cardiovascular Disease	55
Mutual Antagonism of Hypoxia-Inducible Factor Isoforms in Cardiac, Vascular, and Renal Disorders	54
Coronary Artery Disease Genetics Enlightened by Genome-Wide Association Studies	50
Intramyocardial Transplantation of Human iPS Cell–Derived Cardiac Spheroids Improves Cardiac Function in Heart Failure Animals	50
Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection	48
Optimizing Foundational Therapies in Patients With HFrEF	47
Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis	44
Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction	44
Innate Immune Receptors, Key Actors in Cardiovascular Diseases	44
Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction	43
Artificial Intelligence Discusses the Role of Artificial Intelligence in Translational Medicine	42
The Role of NLRP3 Inflammasome in Pericarditis	42
Treatment Targets for Right Ventricular Dysfunction in Pulmonary Arterial Hypertension	41
Dynamic Regulation of SARS-Cov-2 Binding and Cell Entry Mechanisms in Remodeled Human Ventricular Myocardium	40
Autosis	40
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury	39

Sex-Specific Effects of the Nlrp3 Inflammasome on Atherogenesis in LDL Receptor-Deficient Mice	39
In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves	38
Myopathic Cardiac Genotypes Increase Risk for Myocarditis	35
Antisense Inhibition of Angiotensinogen With IONIS-AGT-LRx	33
B Cells in Atherosclerosis	32
TNFR1 Contributes to Activation-Induced Cell Death of Pathological CD4+ T Lymphocytes During Ischemic Heart Failure	31
Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency	29
Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells	28
Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension	28
Optogenetic Stimulation of Vagal Efferent Activity Preserves Left Ventricular Function in Experimental Heart Failure	27
Large Animal Models of Heart Failure	27
Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction	26
Cardiac Fibrosis Is Associated With Decreased Circulating Levels of Full-Length CILP in Heart Failure	25
Neprilysin Inhibitors in Heart Failure	25
Erythrocytes Induce Vascular Dysfunction in COVID-19	25
Interleukin-1β, Oxidative Stress, and Abnormal Calcium Handling Mediate Diabetic Arrhythmic Risk	25
Bias in Medicine	24
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmonary Hypertension	24
Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities	24
Selective Interleukin-6 Trans-Signaling Blockade Is More Effective Than Panantagonism in Reperfused Myocardial Infarction	24
Proteomic Architecture of Valvular Extracellular Matrix	23
Artificial Intelligence Models Reveal Sex-Specific Gene Expression in Aortic Valve Calcification	23
Device-Based Solutions to Improve Cardiac Physiology and Hemodynamics in Heart Failure With Preserved Ejection Fraction	23
Role of Blood Oxygen Saturation During Post-Natal Human Cardiomyocyte Cell Cycle Activities	23
Micro-RNA Analysis in Pulmonary Arterial Hypertension	22
Effect of Crizanlizumab, a P-Selectin Inhibitor, in COVID-19	22
Cardio-Oncology	22
Characterization of Cardiac Sympathetic Nervous System and Inflammatory Activation in HFpEF Patients	21
Injectable Myocardial Matrix Hydrogel Mitigates Negative Left Ventricular Remodeling in a Chronic Myocardial Infarction Model	21
Precision Medicine in COVID-19: IL-1β a Potential Target	21
Translation of New and Emerging Therapies for Genetic Cardiomyopathies	21
Clinical Interpretation and Management of Genetic Variants	21
Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells	20
Lipoprotein(a) Cellular Uptake Ex Vivo and Hepatic Capture In Vivo Is Insensitive to PCSK9 Inhibition With Alirocumab	19
H2 Inhibits the Formation of Neutrophil Extracellular Traps	19
Differential Effects of Sacubitril/Valsartan on Diastolic Function in Mice With Obesity-Related Metabolic Heart Disease	19
In Mice Subjected to Chronic Stress, Exogenous cBIN1 Preserves Calcium-Handling Machinery and Cardiac Function	19
Genetic Risk Stratification	19
Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass	19
With No Lysine Kinase 1 Promotes Metabolic Derangements and RV Dysfunction in Pulmonary Arterial Hypertension	18
Paclitaxel Drug-Coated Balloon Angioplasty Suppresses Progression and Inflammation of Experimental Atherosclerosis in Rabbits	18
Cardiovascular Disease in Duchenne Muscular Dystrophy	18
Animal Models of Neointimal Hyperplasia and Restenosis	18
Human Dorsal Root Ganglion Stimulation Reduces Sympathetic Outflow and Long-Term Blood Pressure	18
Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction	18
Multiorgan Damage in Patients With COVID-19	18
Macrophage Polarization as a Novel Therapeutic Target for Endovascular Intervention in Peripheral Artery Disease	17
Glycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves	17
Clec4e-Receptor Signaling in Myocardial Repair After Ischemia-Reperfusion Injury	17
Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles	17

Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition	17
Rivaroxaban, a Direct Oral Factor Xa Inhibitor, Attenuates Atherosclerosis by Alleviating Factor Xa–PAR2-Mediated Autophagy Suppression	17
Metabolomic Signature of Human Aortic Valve Stenosis	17
HIV, Combination Antiretroviral Therapy, and Vascular Diseases in Men and Women	17
Prasugrel Versus Ticagrelor in Patients With CYP2C19 Loss-of-Function Genotypes	17
Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure	16
Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction	16
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction	16
Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation	16
Plasma Proteomics of COVID-19–Associated Cardiovascular Complications	16
Targeting Myocardial Mitochondria-STING-Polyamine Axis Prevents Cardiac Hypertrophy in Chronic Kidney Disease	15
Finding a Needle in a Haystack	15
Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model	14
Conduits’ Biology Regulates the Outcomes of Coronary Artery Bypass Grafting	14
Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models	14
Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis	14
Update on Cardioprotective Strategies for STEMI	14
Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension	14
A Phase 1 Dose-Escalation Study of the Cardiac Myosin Inhibitor Aficamten in Healthy Participants	14
Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection	13
Cardiac Endocrinology	13
Migraine in Patients Undergoing PFO Closure	13
Role of Oxidative Stress and Autophagy in Thoracic Aortic Aneurysms	13
Implications of Iron Deficiency in STEMI Patients and in a Murine Model of Myocardial Infarction	13
Translating Imaging Into 3D Printed Cardiovascular Phantoms	13
Long-Term Strenuous Exercise Promotes Vascular Injury by Selectively Damaging the Tunica Media	13
Genetic Ablation of the DNA Damage Response Pathway Attenuates Lamin-Associated Dilated Cardiomyopathy in Mice	13
Efficacy of a Novel Mitochondrial-Derived Peptide in a Porcine Model of Myocardial Ischemia/Reperfusion Injury	13
Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic Heart Failure	13
Cardiac Xenotransplantation	12
Molecular Signature of HFpEF	12
STOP-HF Trial	12
Exercise Training and Revascularization in the Management of Symptomatic Peripheral Artery Disease	12
Parkin Insufficiency Accentuates High-Fat Diet–Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca2+ Overload	12
Fir(e)ing the Rhythm	12
Cardiovascular Research in Friedreich Ataxia	11
Proteolysis of Von Willebrand Factor Influences Inflammatory Endothelial Activation and Vascular Compliance in Atherosclerosis	11
3-Dimensional Bioprinting of Cardiovascular Tissues	11
β-Arrestin–Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate	11
Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System	11
Inflammatory Macrophage Interleukin-1β Mediates High-Fat Diet-Induced Heart Failure With Preserved Ejection Fraction	11
PARP1-PKM2 Axis Mediates Right Ventricular Failure Associated With Pulmonary Arterial Hypertension	11
Landscape of Mentorship and its Effects on Success in Cardiology	11
TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis	11
Myocardial Injury and Altered Gene Expression Associated With SARS-CoV-2 Infection or mRNA Vaccination	11
Hyperadhesive von Willebrand Factor Promotes Extracellular Vesicle-Induced Angiogenesis	11
Update to Drugs, Devices, and the FDA	11
LncRNA-ZFAS1 Promotes Myocardial Ischemia-Reperfusion Injury Through DNA Methylation-Mediated Notch1 Down-Regulation in Mice	10
Immune Profiling Reveals Decreases in Circulating Regulatory and Exhausted T Cells in Human Hypertension	10
COVID-19 Clinical Trials	10
Novel IVC Doraya Catheter Provides Congestion Relief in Patients With Acute Heart Failure	10
Inefficient Batteries in Heart Failure	10
Utilization and Potential of RNA-Based Therapies in Cardiovascular Disease	10
Abnormalities in the Von Willebrand-Angiopoietin Axis Contribute to Dysregulated Angiogenesis and Angiodysplasia in Children With a Glenn Circulation	10
MLb-LDLr	10
PTP1B Inhibition Improves Mitochondrial Dynamics to Alleviate Calcific Aortic Valve Disease Via Regulating OPA1 Homeostasis	9
Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction	9
Heart Failure With Reduced Ejection Fraction Is Characterized by Systemic NEP Downregulation	9
Micro RNA-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice	9
Changes in Myocardial Microstructure and Mechanics With Progressive Left Ventricular Pressure Overload	9
Acute Ischemia Alters Human Pericardial Fluid Immune Cell Composition	9
Glucagon-Like Peptide-1 Receptor Regulates Thromboxane-Induced Human Platelet Activation	9
Comprehensive Assessment of High-Risk Plaques by Dual-Modal Imaging Catheter in Coronary Artery	8
SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function	8
Can a Biohybrid Patch Salvage Ventricular Function at a Late Time Point in the Post-Infarction Remodeling Process?	8
Association Between Thrombogenicity Indices and Coronary Microvascular Dysfunction in Patients With Acute Myocardial Infarction	8
Short-Chain Carbon Sources	8
The Effect of Estrogen on Intracellular Ca2+ and Na+ Regulation in Heart Failure	8
Cardiac Mesenchymal Stem Cells Promote Fibrosis and Remodeling in Heart Failure	8
Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury	8
β-Arrestin–Mediated Angiotensin II Type 1 Receptor Activation Promotes Pulmonary Vascular Remodeling in Pulmonary Hypertension	8
Transcatheter-Delivered Expandable Bioresorbable Polymeric Graft With Stenting Capacity Induces Vascular Regeneration	8
Splanchnic Nerve Ablation for Volume Management in Heart Failure	8
Western Diet Causes Heart Failure With Reduced Ejection Fraction and Metabolic Shifts After Diastolic Dysfunction and Novel Cardiac Lipid Derangements	8
High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3	8
Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules	8
RNA m6A-Regulated circ-ZNF609 Suppression Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating FTO	8
Phosphorylcholine Antibodies Preserve Cardiac Function and Reduce Infarct Size by Attenuating the Post-Ischemic Inflammatory Response	8
Immunometabolism at the Heart of Cardiovascular Disease	8
The Programmed Death-1 Signaling Axis Modulates Inflammation and LV Structure/Function in a Stress-Induced Cardiomyopathy Model	8

Cardiac Sympathetic-Parasympathetic Interaction	7
A Cardiac Amino-Terminal GRK2 Peptide Inhibits Maladaptive Adipocyte Hypertrophy and Insulin Resistance During Diet-Induced Obesity	7
Platelets	7
A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition	7
IGF-1 Therapy Improves Muscle Size and Function in Experimental Peripheral Arterial Disease	7
Sex-Dependent Effect of Platelet Nitric Oxide	7
Ketone Bodies Rescue Mitochondrial Dysfunction Via Epigenetic Remodeling	7
Abnormal Flow Conditions Promote Endocardial Fibroelastosis Via Endothelial-to-Mesenchymal Transition, Which Is Responsive to Losartan Treatment	7
COVID-19 and the Heart	7
Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca2+ Handling and NRF2 Activation	6
Loop Diuretics Inhibit Renal Excretion of Trimethylamine N-Oxide	6
Cardiac Pulmonary Nerve Stimulation (CPNSTM)	6
SARS-CoV-2 and Bats	6
DAPA-CKD	6
Acute Glycogen Synthase Kinase-3 Inhibition Modulates Human Cardiac Conduction	6
The National Institute of Allergy and Infectious Diseases Decision to Stop the Adaptive COVID-19 Trial	6
Septal Reduction Using Transvenous Intramyocardial Cerclage Radiofrequency Ablation	6
Linagliptin, A Xanthine-Based Dipeptidyl Peptidase-4 Inhibitor, Ameliorates Experimental Autoimmune Myocarditis	6
Fallacies of Using the Win Ratio in Cardiovascular Trials	6
Data Safety and Monitoring Boards Should Be Required for Both Early- and Late-Phase Clinical Trials	6
Inflammasome Signaling, Thromboinflammation, and Venous Thromboembolism	6
Dynamic Multiscale Regulation of Perfusion Recovery in Experimental Peripheral Arterial Disease	6
FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo	6
Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification	5
The Cardioprotective Effects of Semaglutide Exceed Those of Dietary Weight Loss in Mice With HFpEF	5
Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating	5
Spatial Distribution of Calcium Sparks Determines Their Ability to Induce Afterdepolarizations in Human Atrial Myocytes	5
Platelets and the Endothelium	5
Right Heart Failure in Mice Upon Pressure Overload Is Promoted by Mitochondrial Oxidative Stress	5
Coronary Flow Reserve, Inflammation, and Myocardial Strain	5
Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation	5
Vascular Inflammation and Hyperlipidemia	5
Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation	5
Novel GSK-3β Inhibitor Neopetroside A Protects Against Murine Myocardial Ischemia/Reperfusion Injury	5
Understanding HFpEF With Obesity	5
Circulating Progenitor Cells in Patients With Coronary Artery Disease and Renal Insufficiency	5
Transvalvular Unloading Mitigates Ventricular Injury Due to Venoarterial Extracorporeal Membrane Oxygenation in Acute Myocardial Infarction	5
RNA Vaccines for COVID-19	5
Genetic Catalytic Inactivation of GRK5 Impairs Cardiac Function in Mice Via Dysregulated P53 Levels	5