OOIR: Observatory of International Research

Papers

(The TQCC of JACC-Basic to Translational Science is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Recognizing Early Career Translational Investigators	124
Is Laser Doppler Perfusion Imaging Truly a “Gold Standard” for Preclinical Peripheral Artery Disease Research?	108
Validation of a Novel Renal Denervation System With Cryoablation	86
Electroanatomical Navigation to Minimize Contrast Medium or X-Rays During Stenting	74
Editorial Board	71
New Insights Into the Role of GSK-3 in the Regulation of Human Cardiac Electrophysiology	66
Mitochondrial DNA in Uremia and New Targets to Treat Myocardial Hypertrophy in the Cardiorenal Syndrome	66
Right Heart Failure in Mice Upon Pressure Overload Is Promoted by Mitochondrial Oxidative Stress	59
Targeting Syntaxin 17 to Improve Mitophagy in Heart Failure	55
Reading a Good Transcript Soothes MYZAPed Heart	50
PD-1 Checkmate and the 2-Edged Sword of the Immune System	50
Is it Time to Abandon the Use of P-Values in Early Phase Translational Trials: Why (Effect) Size Matters	48
FULL ISSUE PDF	47
A Potential New Therapeutic Direction for Fibrosis in the Injured Heart Orchestrated by Cardiac MSCs	46
Reducing Plasma Factor XI Concentration With siRNA Technology	44
CXC-Chemokine-Receptor-Type-5 Expression on Circulating Naive B Cells Predicts Improvement After Cardiac Resynchronization Therapy	43
Full Issue PDF	39
When Off-Target Is the Target	39
Evaluation of Treatment Effect of Sirolimus on Pediatric Pulmonary Vein Stenosis Using a Neonatal Rat Model Induced by Bilateral Pulmonary Vein Banding	38
JACC: Basic to Translational Science 2016-2025	38
Low-Grade Inflammation in Long COVID Syndrome Sustains a Persistent Platelet Activation Associated With Lung Impairment	37
Therapeutic CCR2 Blockade Prevents Inflammation and Alleviates Myxomatous Valve Disease in Marfan Syndrome	37
Unveiling the PGAM5-ANGPTL3 Axis	37
H2 Inhibits the Formation of Neutrophil Extracellular Traps	36
1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model	35

Full Issue PDF	34
New Drug-Coated Balloons on the Horizon	32
The Reduction of COMP Serves as a Predictor for Warning of Aortic Dissection Progression	32
Addressing the Reproducibility Crisis in Science	32
Recognizing Early Career Translational Investigators	31
Is Endogenous Fibrinolysis a Major Player in Occurrence of Atherothrombotic Events Following Acute Myocardial Infarction?	31
Full Issue PDF	31
Cardiomyocyte Alpha-1A Adrenergic Receptors Mitigate Postinfarct Remodeling and Mortality by Constraining Necroptosis	30
Inflammasome Signaling, Thromboinflammation, and Venous Thromboembolism	30
6-Month Evaluation of a Transcatheter Aortic Valve (Myval) in a Novel Ovine, Supra-Aortic Banding Model	30
Antibody Matrimony in a Duel of Hearts	30
SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction by Promoting Mitochondrial Bioenergetics	30
TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms	30
PDGF-AB Reduces Myofibroblast Differentiation Without Increasing Proliferation After Myocardial Infarction	30
ApoM Activates Autophagy and Suppresses Lyosomal Lethargy to Combat Doxorubicin Cardiomyopathy	30
Therapeutic Efficacy of a Novel Pharmacologic GRK2 Inhibitor in Multiple Animal Models of Heart Failure	29
Characterizing Adrenergic Regulation of Glucose Transporter 4-Mediated Glucose Uptake and Metabolism in the Heart	29
Interferon Interrupted	28
Shear-Thinning Hydrogel for Delayed Delivery of a Small Molecule Metalloproteinase Inhibitor Attenuates Myocardial Infarction Remodeling	27
Soluble Programmed Death-1 Predicts Clinical Outcome After STEMI	27
Editorial Board	27
Endocardial Fibrosis Elastosis	26
Lower Extremity Lymphatic Flow/Drainage Assessment by Indocyanine Green Fluorescent Lymphography in Heart Failure Patients	25
ATP-Citrate Lyase in Heart Failure	25
When Facts Become Forbidden	25
TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis	25
Pulsatile ECMO	24
Fir(e)ing the Rhythm	24
Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules	24
From Risk to Remedy?	24
Nitric Oxide Releasing Nanomaterials for Cardiovascular Applications	24
C-Type Natriuretic Peptide in Essential Hypertension	24
Inhibiting Serotonin to Treat Pulmonary Arterial Hypertension	23
Should All Translational Scientists Be Swifties?	22
The Farm to Table HFpEF Kitchen	22
Reply	22
Phosphoglycerate Mutase 5 Is Important Mediator for Instigating Arterial Lipid Accumulation and Aggravating Atherosclerosis	22
A Differentiated Approach Delivering Targeted Thrombectomy for VTE	22
Full Issue Pdf	21
Large Animal Models for Transcatheter Heart Valve Prosthesis Development	21
Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction	21
Reply	21
Exosome-Mediated Angiogenesis Underlies LVAD-Induced Bleeding in Patients With End-Stage Heart Failure	21
From Colon to Aortic Aneurysm: Trek of the Treg	20
Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation	20
Editorial Board	19
Glucagon-Like Peptide-1 Receptor Regulates Thromboxane-Induced Human Platelet Activation	19
Red Blood Cell-Mediated Cardioprotection Is Impaired in ST-Segment Elevation Myocardial Infarction Patients With Anemia	19
Epigenetic Regulation of Heart-ECHS	19
A Novel LncRNA SNHG3 Promotes Osteoblast Differentiation Through BMP2 Upregulation in Aortic Valve Calcification	19

Full Issue PDF	18
Proteomics of Large Artery Stiffness	18
A Novel Pathway of Platelet Activation in ACS Mediated by LL-37 Immunoglobulin G Autoantibody Immune Complexes	17
The Impact of Semaglutide on Cardiac Mass and Function Requires Further Investigation	17
Small Molecule Activators of Mitochondrial Fusion Prevent Congenital Heart Defects Induced by Maternal Diabetes	17
The Virtual Patient Simulator	17
Tissue Engineered Vascular Grafts	17
Real-Time Revolution	17
Full Issue Pdf	16
Pleiotropic, Cellular Effects of Rivaroxaban on Autophagy Explain Atheroprotective Effects	16
Acute Glycogen Synthase Kinase-3 Inhibition Modulates Human Cardiac Conduction	16
Full Issue PDF	16
Full Issue PDF	16
The Past, Present, and Promising Future of Direct Cardiac Compression Devices	16
Reduced Proteolytic Cleavage of von Willebrand Factor Leads to Aortic Valve Stenosis and Load-Dependent Ventricular Remodeling	15
Neuregulin-1β Improves Uremic Cardiomyopathy and Renal Dysfunction in Rats	15
Full Issue PDF	15
JACC: Basic to Translational Science Top Reviewers 2022: With Appreciation and Gratitude	15
Noninvasive Cardiovascular Imaging in Preclinical Research	15
Introducing the 2024 Transcatheter Cardiovascular Therapeutics (TCT) Shark Tank Presentations	14
Reassessing the Mechanisms of PLN-R14del Cardiomyopathy	14
Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation	14
IL-6 Inhibitors and TNF Inhibitors	14
Full Issue Pdf	14
Pulsatile Ventricular Assist Platform	14
Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 2	14
Where Comity in Science Goes to Die	14
Ticagrelor Antibiotic Effect	14
CD14 Blockade Modulates Macrophage-Mediated Immunological Injury in a Translational Model of Reperfused ST-Segment Elevation Myocardial Infarction	14
Full Issue PDF	13
Targeting Myocardial Mitochondria-STING-Polyamine Axis Prevents Cardiac Hypertrophy in Chronic Kidney Disease	13
Editorial Board	13
Editorial Board	13
Quality Over Quantity	13
Reverse Translation of Pericardial Access	13
Synbiotics and Gut-Heart Axis in Cardiometabolic Disease	13
A Cardiac Amino-Terminal GRK2 Peptide Inhibits Maladaptive Adipocyte Hypertrophy and Insulin Resistance During Diet-Induced Obesity	13
TIMD4hiMHCⅡhi Macrophages Preserve Heart Function Through Retnla	12
Turn(over) the Page	12
JACC: Basic to Translational Science 2024 Thomas Force Young Investigator Award Winner	12
Structural and Functional Adaptations to Exercise Training	12
Partial Heart Transplant Growth and Hemodynamic Function in Piglets	12
Editorial Board	12
FNDC4 Prevents Aging-Related Cardiac Dysfunction	11
Iron Overload via Heme Degradation in the Endoplasmic Reticulum Triggers Ferroptosis in Myocardial Ischemia-Reperfusion Injury	11
Full Issue PDF	11
Atrial Metabolic Stress	11
Autonomic Modulation of Atrial Fibrillation	11
Experimental Models of Hypertrophic Cardiomyopathy	11
GLP-1 Receptor Agonists, the Holy Grail Preventing Atrial Fibrillation in Patients With T2D?	11
Remembering Ada L. Steininger	11
Decoding MTSS1	11
Charting New Real Estate	11
Mesenchymal Stromal Cell Delivery Via Cardiopulmonary Bypass Provides Neuroprotection in a Juvenile Porcine Model	11
Towards Metabolomic-Based Precision Approaches for Classifying and Treating Heart Failure	11
Publisher's Note	11
Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation	10
Parkin Insufficiency Accentuates High-Fat Diet–Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca2+ Overload	10
Effect of Semaglutide on Epicardial Adipogenesis and hiPSC-Atrial Cardiomyocytes New Hope in Targeting Epicardial Adipose Tissue	10
Recurrent Adrenergic Stress Provokes Persistent Myocarditis in PD-1–Deficient Mice	10
Recognizing Early Career Translational Investigators	10
Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis	10
Shielding the Heart	10
Myocardial Infarction Platelet Gene Expression Signatures in Women	10
Development of a Peripherally Restricted 5-HT2B Partial Agonist for Treatment of Pulmonary Arterial Hypertension	10
Inhibition of Factor XI Using RBD4059	10
Negative Impact of TET2 Mutations on Long-Term Survival After Transcatheter Aortic Valve Replacement	10
BAG3 in the Heart	10
Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification	10
In Vivo Efficacy of an Adhesive Bioresorbable Patch to Treat Aortic Dissections	10
Tit for TAK1	9
Full Issue PDF	9
Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction	9
High Maternal Glycine Levels Increase the Risk of Developing Atrial Septal Defect in the Offspring	9
Translating Imaging Into 3D Printed Cardiovascular Phantoms	9
Introducing the 2024 THT Shark Tank Edition of JACC: Basic to Translational Science	9
Who Should Be Accountable for Scientific Accountability?	9
The Cardiac Circadian Clock	9
Continuous Monitoring of Blood Pressure and Vascular Hemodynamic Properties With Miniature Extravascular Hall-Based Magnetic Sensor	9
The Imperative to Enhance Cost-Effectiveness for Cardiovascular Therapeutic Development	9

Full Issue PDF	9
Minimally Invasive Aortic Regurgitation Surgery	9
Paradoxical Effect of Caloric Restriction on Overload-Induced Muscle Growth in Diastolic Heart Failure	9
Left Atrial Glucose Metabolism Evaluation by 18F-FDG-PET in Persistent Atrial Fibrillation and in Sinus Rhythm	9
Full Issue PDF	9
Recognizing Early Career Translational Investigators	9
Editorial Board	9
New Insights in the Pathology of Chronic Thromboembolic Pulmonary Hypertension	8
Platelets	8
Platelet Gene Expression in Systemic Lupus Erythematosus and Cardiovascular Health	8
Intrinsic and Extrinsic Contributors to the Cardiac Benefits of Exercise	8
The Quest for an Early Marker of Anthracycline-Induced Cardiotoxicity	8
Low-Grade Inflammation	8
Erythrocytes Induce Vascular Dysfunction in COVID-19	8
A (Alpha1-Adrenergic Receptors), B (Blocking Alpha1-Adrenergic Receptors), C (Catecholamines)	8
Cardiac Adrenergic Activation in Heart Failure With Preserved Ejection Fraction	8
Cardiovascular Disease in Duchenne Muscular Dystrophy	8
New Insights Into the Therapy for Lamin-Associated Dilated Cardiomyopathy	8
Full Issue PDF	7
Controlled Right Ventricular Pressure Overload Can Rescue Left Ventricular Dysfunction by Promoting Biventricular Adaptive Hypertrophy	7
Deleterious Anti-Inflammatory Macrophage Recruitment in Early Post-Infarction Phase	7
Editorial Board	7
Mitophagy Regulators as Novel Targets in Sepsis-Induced Myocardial Dysfunction	7
Associations of Epigenetic Age Acceleration With CVD Risks Across the Lifespan	7
Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation	7
Estrogen Influences Human Microvascular Endothelial Function Via Sex-Specific Regulation of Sphingolipids	7
Heart Failure Solutions	7
Editorial Board	7
Proteome-Wide Genetic Investigation of Large Artery Stiffness	7
Syntaxin 17 Protects Against Heart Failure Through Recruitment of CDK1 to Promote DRP1-Dependent Mitophagy	7
Editorial Board	7
Editorial Board	6
Clonal Hematopoiesis and Transcatheter Aortic Valve Replacement	6
JACC Journals’ Pathway Forward With AI Tools	6
The Emerging Role of Circular RNAs in Cardio-Oncology	6
PCSK9 Inhibition	6
Are 3 Aorta Pumps Better Than 1 Transaortic to Preserve Von Willebrand Factor?	6
Decreased FAM13B Expression Increases Atrial Fibrillation Susceptibility by Regulating Sodium Current and Calcium Handling	6
In Memory of Dr Gary D. Lopaschuk, PhD (1955–2025)	6
INKing the Cardiotoxicity Out of Doxorubicin	6
Inhibition of Soluble Epoxide Hydrolase Reduces Inflammation and Myocardial Injury in Arrhythmogenic Cardiomyopathy	6
Platelet-Derived Growth Factors	6
The Antioxidant Vitamin B12 Analogue Cobinamide as a Treatment for Marfan Syndrome	6
Red Blood Cell Transfusion and Cardiac Surgery–Associated Acute Kidney Injury	6
Transvalvular Unloading Mitigates Ventricular Injury Due to Venoarterial Extracorporeal Membrane Oxygenation in Acute Myocardial Infarction	6
Stimulation of Erythrocyte Soluble Guanylyl Cyclase Induces cGMP Export and Cardioprotection in Type 2 Diabetes	6
Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury	6
Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis	6
A Novel Device for Tricuspid Regurgitation Reduction Featuring 3-Dimensional Leaflet and Atraumatic Anchor	6
Full Issue PDF	6
Will Gene Editing Orphanize Rare Diseases?	6
Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models	6
Deep Image Segmentation for Cardiomyocyte Proliferation	6
Targeting the Autophagy-Lysosome Pathway in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure	5
Cardiovascular Research in Friedreich Ataxia	5
Electrogram Morphology Recurrence	5
Serum Anti-Heart and Antinuclear Autoantibodies Are Independent Predictors of Response to Immunosuppressive Therapy in Autoimmune Biopsy-Proven Inflammatory Cardiomyopathy	5
Translating Translation	5
Editorial Board	5
Exploring Mechanisms of Pulmonary Artery Banding in a Rat Model of Dilated Cardiomyopathy	5
Vagus Nerve Stimulation for Myocardial Ischemia	5
Mitochondrial Targeted Therapies to Prevent Maternal Diabetes–Induced Congenital Heart Defects	5
Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF	5
Caloric Restriction Rejuvenates Skeletal Muscle Growth in Heart Failure With Preserved Ejection Fraction	5
Serum cFAS Content Correlates With Incidence of Peripheral Arterial Disease	5
Revitalizing Innovation	5
Mitochondrial Calcium Flux—Friend or Foe in Chronic Heart Failure?	5
A New Ex Vivo Model to Study Cardiac Fibrosis in Whole Mouse Hearts	5
Dysregulation of IL-6/MCP-1/STAT3 Axis	5
The Pathology of Primary Mitral Regurgitation	5
Natriuretic Peptides and Metabolic Hypertension	5
Abnormal Flow Conditions Promote Endocardial Fibroelastosis Via Endothelial-to-Mesenchymal Transition, Which Is Responsive to Losartan Treatment	5
Correction	5
Recognizing Early Career Translational Investigators	5
Full Issue PDF	5
Transvalvular Mechanical Circulatory Support Reverse Remodels the Ischemic Chronic Failing Heart in an Ovine Model	5
Cardiac TRPM7 Causes Diabetic Heart Failure With Preserved Ejection Fraction	5
The Enigmata of Cardioprotection With SGLT2 Inhibition	5
Maintaining Success for Patients With Dilated Cardiomyopathy and Remission of Heart Failure	5