Epilepsia Open

Papers
(The median citation count of Epilepsia Open is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)
ArticleCitations
Total posterior quadrant disconnection for drug‐resistant epilepsy in children66
Epilepsy following neonatal encephalopathy—Future directions58
Evaluation of the International League Against Epilepsy 1981, 1989, and 2017 classifications of seizure semiology and etiology in a population‐based cohort of children and adults with epilepsy56
Commentary on “The epileptogenic zone in children with tuberous sclerosis complex is characterized by prominent features of focal cortical dysplasia”53
Microglia and status epilepticus in the immature brain45
Patient complexity, depression, and quality of life in patients with epilepsy at an epilepsy center in Japan40
An interview with Ifrah Zawar, 2023 Epilepsia Open prize winner for clinical research38
Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges33
One‐year seizure freedom and quality of life in patients with drug‐resistant epilepsy receiving adjunctive vagus nerve stimulation in Japan30
Clinical characteristics and outcomes after new‐onset seizure among Zambian children with HIV during the antiretroviral therapy era26
Characterization of low‐grade epilepsy‐associated tumor from implanted stereoelectroencephalography electrodes26
Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches25
Astrocyte reactivity in a mouse model of SCN8A epileptic encephalopathy25
Building a dashboard to inform policy and clinical practice using the Irish epilepsy electronic patient record: Towards a learning health system22
Key steps and barriers in the journey of patients with epilepsy through the National Healthcare System in Spain: The EPIPASS qualitative study21
Longitudinal hippocampal diffusion‐weighted imaging and T2 relaxometry demonstrate regional abnormalities which are stable and predict subfield pathology in temporal lobe epilepsy21
Alterations of apparent diffusion coefficient from ultra high b‐values in the bilateral thalamus and striatum in MRI‐negative drug‐resistant epilepsy20
Risk of COVID‐19 infection and seizure exacerbation among patients with epilepsy during the peak of Omicron wave20
Effectiveness of perampanel as the only add‐on: Retrospective, multicenter, observational real‐life study on epilepsy patients19
Assessment of tau phosphorylation and β‐amyloid pathology in human drug‐resistant epilepsy19
A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint tra19
Comparative efficacy and safety of stiripentol, cannabidiol and fenfluramine as first‐line add‐on therapies for seizures in Dravet syndrome: A network meta‐analysis18
Long‐term effectiveness and tolerability of ketogenic diet therapy in patients with genetic developmental and epileptic encephalopathy onset within the first 6 months of life18
Direct visualization of microwires in hybrid depth electrodes using high‐resolution photon‐counting CT18
Deficiency of nNOS in adult‐born dentate granule cells causes epilepsy17
Neonatal seizures: Advances in diagnosis and management17
Efficacy and Safety of adjunctive Perampanel in a prospective, real‐world, Phase IV study in Indian patients aged ≥12 years for Treatment of focal‐onset Epilepsy: Study 50817
Drug‐resistant epilepsy and the hypothesis of intrinsic severity: What about the high‐frequency oscillations?17
Integration of interictal EEG source localization in presurgical epilepsy evaluation – A single‐center prospective study17
Sleep architecture in drug‐naïve adult patients with epilepsy: Comparison between focal and generalized epilepsy17
Timing differences between HFOs and interictal epileptiform discharges generated in vitro by different mechanisms in rat hippocampal slices: A novel approach17
Thank you to our reviewers of 202317
Bilateral pulvinar responsive neurostimulation for bilateral multifocal posteriorly dominant drug resistant epilepsy17
Exploring the impact of hippocampal sclerosis on white matter tracts and memory in individuals with mesial temporal lobe epilepsy16
Ex‐SPECTing success: Predictors of successful SPECT radiotracer injection during presurgical video‐EEG admissions16
A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3WG2 Neuropathology Working Group o16
Outcomes of resective surgery in pediatric patients with drug‐resistant epilepsy: A single‐center study from the Eastern Mediterranean Region16
Longitudinal EpiTrack assessment of executive functions following vagus nerve stimulation therapy in patients with drug‐resistant epilepsy15
Gingival enlargement following levetiracetam treatment: A clinical case analysis15
Letter on: 3D figure of epilepsy syndromes15
Epilepsia Open—June 2023—Announcements15
A multicenter, cross‐sectional analysis to assess the safety and usage pattern of brivaracetam in the management of partial‐onset seizure with BAEsBREEZE study: A post‐hoc analy14
Intravenous perampanel as an alternative to the oral formulations in Japanese patients with epilepsy14
Interrater reliability of interictal EEG waveforms in Lennox–Gastaut Syndrome14
Emotional experience elicited by direct electrical stimulation: Case series and literature review14
Experience of perampanel monotherapy beyond initial titration to achieve seizure freedom in patients with focal‐onset seizures with newly diagnosed or currently untreated recurrent epilepsy: A post ho14
Analysis of clinical characteristics and histopathological transcription in 40 patients afflicted by epilepsy stemming from focal cortical dysplasia14
User involvement in the design and development of medical devices in epilepsy: A systematic review14
Bilateral ictal EEG is associated with better memory outcome after hippocampal sclerosis surgery14
An interview with Ondřej Strýček, 2025 Epilepsia Open prize winner for clinical research13
EEG‐based spatiotemporal dynamics of fast ripple networks and hubs in infantile epileptic spasms13
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Intravenous lacosamide for acute repetitive seizures and convulsive status epilepticus in critically ill children13
Acetazolamide: Old drug, new evidence?13
Discovery ofE2730, a novel selective uncompetitiveGAT1inhibitor, as a candidate for anti‐seizure medication13
Analysis of epilepsy‐associated variants in HCN3 – Functional implications and clinical observations13
Reflections on the first 8 years of Epilepsia Open13
Epilepsy surgery in early infancy: A retrospective, multicenter study13
Epilepsia Open—December 2022—Announcements13
Treatment with brivaracetam has no apparent long‐term effects on body weight in pediatric patients with epilepsy13
Safety and efficacy of rapid withdrawal of antiseizure medications during long‐term video‐electroencephalogram monitoring in children with drug‐resistant epilepsy: A retrospective study12
Epilepsia Open: Welcome to the inaugural lived experience editor and editorial interns12
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Epilepsia Open – April 2025 Announcements12
Correspondence: FKBP5 blockade may provide a new horizon for the treatment of stress‐associated disorders: An in silico study12
Fenfluramine treatment in pediatric patients with Dravet syndrome reduces seizure burden and overall healthcare costs: A retrospective and observational real‐world study12
Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures12
Response: Safety and adverse events following COVID‐19 vaccination among people with epilepsy: Correspondence12
Thank you to our reviewers of 202412
Communicating a diagnosis of Dravet syndrome to parents/caregivers: An international Delphi consensus12
Thank you to the outgoing Editor in Chief of Epilepsia Open, Aristea Galanopoulou12
Long‐term outcomes of corpus callosotomy in adult patients with drug‐resistant epilepsy: Results from a single neurosurgical center in Mexico11
Antiseizure medication discovery: Recent and future paradigm shifts11
Evaluating depression in Indonesian adolescents with epilepsy: Comprehensive validation and reliability assessment of the neurological disorders depression inventory‐epilepsy for youth Indonesian vers11
Effectiveness of add‐on acetazolamide in children with drug‐resistant CHD2‐related epilepsy and in a zebrafish CHD2 model11
The cenobamate KORK study—A prospective monocenter observational study investigating cenobamate as an adjunctive therapy in refractory epilepsy, with comparisons to historical cohorts treated with add11
Status of epilepsy in the tropics: An overlooked perspective11
Epilepsy is an important feature of KBG syndrome associated with poorer developmental outcome11
Chemical analysis and concentrations of cannabidiol substances used for refractory epilepsy in Chilean patients. An underestimated worldwide risk11
Long‐term efficacy and safety of cannabidiol in patients with tuberous sclerosis complex: 3‐year results from the cannabidiol expanded access program11
Predictive value of traditional laboratory parameters and inflammatory indices for same‐day seizure recurrence in patients with epileptic seizures11
Brain temperature, brain metabolites, and immune system phenotypes in temporal lobe epilepsy11
Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysis11
Successful management of refractory epilepsy in creatine transporter deficiency with cannabidiol and clobazam: A case report11
Drosophila melanogaster as a rapid in vivo assay system for preclinical anti‐seizure medication testing10
Commentary on “Antiseizure activity by opioid receptor antagonism, new evidence”10
First report of Tunisian patients with CDKL5‐related encephalopathy10
A multicenter randomized controlled feasibility trial of a digital self‐management intervention for adults with epilepsy10
The effect of epilepsy awareness on attitudes toward individuals with epilepsy in Turkish society: A case study from Northern Turkey10
SEEG‐based reevaluation of epileptogenic networks and the predictive role for reoperation in MTLE patients with surgical failure10
PERPRISE: A prospective non‐interventional study of PERampanel as only adjunctive treatment in patients with PRImary or SEcondarily generalized tonic–clonic10
An exploratory study of brain temperature and choline abnormalities in temporal lobe epilepsy patients with depressive symptoms10
Resting‐state functional connectivity changes with microburst vagus nerve stimulation therapy10
An interview with Fabienne Kühne, 2024 Epilepsia Open prize winner for clinical research10
An interview with Lyndsey Anderson, 2024 Epilepsia Open prize winner for basic science research10
Reactive oxygen species in status epilepticus10
Issue Information10
AI‐based localization of the epileptogenic zone using intracranial EEG9
Serotonin receptors in epilepsy: Novel treatment targets?9
Anti‐seizure efficacy and retention rate of carbamazepine is highly variable in randomized controlled trials: A meta‐analysis9
Support vector machines predict postoperative memory outcomes in temporal lobe epilepsies9
Peri‐ictal yawning: A potential lateralizing sign in temporal lobe epilepsy9
Medications used for seizure‐emergency management in the UK community: A clinical practice research datalink retrospective database study9
Epilepsia Open—September 2022—Announcements9
Potential role of FKBP5 single‐nucleotide polymorphisms in functional seizures9
In vitro human cell culture models in a bench‐to‐bedside approach to epilepsy9
Transcranial direct current stimulation treatment reduces, while repetitive transcranial magnetic stimulation treatment increases electroencephalography spike rates with refractory occipital lobe epil9
Impact of length of stay on diagnostic yield in the epilepsy monitoring unit: A multi‐center retrospective 12‐year Veterans Health Administration study9
Epilepsia Open–December 2021–Announcements9
Impact of hippocampectomy on seizure freedom in temporal encephaloceles: A systematic review and individual participant data meta‐analysis9
Factors influencing seizure control of patients with convulsive epilepsy in rural areas of northwest China9
Epileptic Status in a PEDiatric cohort (ESPED) requiring intensive care treatment: A multicenter, national, two‐year prospective surveillance study9
First‐in‐human microelectrode recordings from the vagus nerve during clinical vagus nerve stimulation9
BRIVA‐ONE study: 12‐month outcomes of brivaracetam monotherapy in clinical practice9
Hypometabolic patterns are related to post‐surgical seizure outcomes in focal cortical dysplasia: A semi‐quantitative study9
Verbal paired associates learning lateralizes left hippocampal sclerosis in temporal lobe epilepsy9
Effectiveness of perampanel as the only adjunctive anti‐seizure medication in adults: Final results from the observational PERPRISE study in Germany9
Feasibility of cardiac‐based seizure detection and prediction: A systematic review of non‐invasive wearable sensor‐based studies9
Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug‐refractory epilepsy8
Status epilepticus and early development: Neuronal injury, neurodegeneration, and their consequences8
Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder8
Decreased homovanillic acid and 5‐hydroxyindoleacetic acid levels in the cerebrospinal fluid of patients with Dravet syndrome with parkinsonism8
The effects of COVID‐19 measures on the hospitalization of patients with epilepsy and status epilepticus in Thailand: An interrupted time series analysis8
Epilepsy surgery program in a resource‐limited setting in Vietnam: A multicentered collaborative model8
Evaluation of self‐stigma in patients with epilepsy: Validation of the self‐stigma scale to Spanish (ESSS‐S)8
An examination of the efficacy and safety of fenfluramine in adults, children, and adolescents with Dravet syndrome in a real‐world practice setting: A report from the Fenfluramine European8
Early genetic testing in pediatric epilepsy: Diagnostic and cost implications8
Cannabidiol for functional seizures (psychogenic nonepileptic seizures/attacks) and other stress‐associated disorders8
Mendelian randomization reveals no causal relationship between COVID‐19 susceptibility, hospitalization, or severity and epilepsy8
Confirmation of infantile spasms resolution by prolonged outpatient EEGs8
A study of factors influencing self‐stigma in people with epilepsy: A nationwide online questionnaire survey in Japan8
Antiepileptogenesis after stroke—trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate8
Thank you to our Reviewers of 20218
HMGB1 blood levels and neurological outcomes after traumatic brain injury: Insights from an exploratory study8
Multimodal non‐invasive evaluation in MRI‐negative epilepsy patients7
Issue Information7
Epilepsy care pathway: The Finnish model7
Parvalbumin neurons in the anterior nucleus of thalamus control absence seizures7
The mechanism of mitochondrial autophagy regulating Clathrin‐mediated endocytosis in epilepsy7
Real‐world data on cannabidiol treatment of various epilepsy subtypes: A retrospective, multicenter study7
Issue Information7
High FGF‐21 level in a cohort of 22 patients with Dravet Syndrome—Possible relationship with the disease outcomes7
Long‐term outcomes after NORSE: Treatment with vagus nerve stimulation7
Late‐onset asystole associated with vagal nerve stimulation7
Febrile status epilepticus and epileptogenesis: The FEBSTAT study7
Impact of COVID‐19 pandemic on epilepsy care in Japan: A national‐level multicenter retrospective cohort study7
Scalp high‐frequency oscillations differentiate neonates with seizures from healthy neonates7
Ordinal regression increases statistical power to predict epilepsy surgical outcomes7
Parsing neuronal circuits involved in comorbidities of epilepsy: A commentary on “Focal impaired awareness seizures in a rodent model: A functional anatomy”7
Factors not considered in the study of drug‐resistant epilepsy: Drug‐resistant epilepsy: Assessment of neuroinflammation7
Cardiovascular risk factor assessment in late‐onset seizures: A study protocol to assess the value of structured intervention7
Medical treatment in infants and young children with epilepsy: Off‐label use of antiseizure medications. Survey Report of ILAE Task Force Medical Therapies in Children7
Prospective multisite cohort study of patient‐reported outcomes in adults with new‐onset seizures6
Antiseizure medication withdrawal risk estimation and recommendations: A survey of American Academy of Neurology and EpiCARE members6
Self‐limited familial focal epilepsy caused by ANK2 variants: A potentially under‐recognized condition6
Limited cerebellar gradient extension in temporal lobe epilepsy with dystonic posturing6
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Issue Information6
Evaluating the impact of an AI‐powered chatbot on epilepsy education and stigma reduction: A pre‐post intervention study using EpiloBot6
Effect of levetiracetam on cognition in patients with cognitive decline: A systematic review and meta‐analysis of randomized controlled trials6
Clinical features of unilateral multilobar and hemispheric polymicrogyria (PMG)‐related epilepsy and seizure outcome with different treatment options6
A retrospective, real‐world experience of perampanel monotherapy in patient with first new onset focal seizure: A Thailand experience6
Italian report on RARE epilepsies (i‐RARE): A consensus on multidisciplinarity6
Issue Information6
Neurologists' perspectives on SUDEP communication: A comparative study across five European countries6
Comparing late‐onset epileptic spasm outcomes after corpus callosotomy and subsequent disconnection surgery between post‐encephalitis/encephalopathy and non‐encephalitis/encephalopathy6
Bradycardia is induced by hyperactivity of the vagus nerve and nucleus ambiguus during seizures propagating into the brainstem6
Comparison of magnetic resonance‐guided laser interstitial thermal therapy corpus callosum ablation to open microsurgical corpus callosotomy: A single‐center retrospective cohort study6
Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low‐dose kainic acid systemic injection paradigm in mice6
Cardiac structural and functional abnormalities in epilepsy: A systematic review and meta‐analysis6
Epilepsia Open—December 2024 announcements6
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Creativity and its link to epilepsy6
The National Comprehensive Governance for epilepsy prevention and control in China6
Real‐world use of adjunctive perampanel for focal‐onset seizures in Italy: A mirroring clinical practice study of perampanel in adults and adolescents (AMPA)6
Customized targeted massively parallel sequencing enables the identification of novel pathogenic variants in Tunisian patients with developmental and epileptic encephalopathy5
Epilepsia Open—March 2022—Announcements5
Role of the glymphatic system and perivascular spaces as a potential biomarker for post‐stroke epilepsy5
Attention‐deficit/hyperactivity disorder in children with epilepsy: A systematic review and meta‐analysis of prevalence and risk factors5
Determinants of successful ictal SPECT injection in phase 1 epilepsy presurgical evaluation: Findings from the pediatric epilepsy research consortium surgery database project5
The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia5
Impact of theCOVID‐19 pandemic on people with epilepsy: Findings from theUSarm of theCOV‐Estudy5
Epileptic spasms relapse is associated with response latency but not conventional attributes of post‐treatment EEG5
Clinical phenotype and functional influence of GRIN2A variants in epilepsy‐aphasia syndrome5
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Antiseizure medication choice in diffuse glioma: A single‐center population‐based experience5
General mental ability (Spearman's g) in Juvenile Myoclonic Epilepsy5
Huperzine A suppresses absence seizures in the genetic absence epilepsy rat from Strasbourg (GAERS) model of genetic generalized epilepsy with absence seizures5
Polymorphism of glucocorticoid receptor gene (rs41423247) in functional seizures (psychogenic nonepileptic seizures/attacks)5
The appearance of scalp high‐frequency oscillations is associated with poor seizure control in pediatric epilepsy patients5
Serum perampanel levels in patients with seizures are not affected by hemodialysis5
Ivermectin as a promising therapeutic option for onchocerciasis‐associated epilepsy5
Efficacy and tolerability of perampanel as add‐on therapy in Dravet syndrome: A prospective real‐world study5
Psychiatric disorders in children and adolescents with temporal lobe epilepsy: A narrative review5
Cerebrospinal fluid metabolites as potential biomarkers for epilepsy: Insights from genome‐wide association studies5
Successful use of cannabidiol in nonconvulsive status epilepticus in Angelman syndrome5
The diagnostic value of ictal SPECT—A retrospective, semiquantitative monocenter study5
Preliminary development and validation of the Indonesian Pediatric Epilepsy Questionnaire (INA‐PEPSI) to determine epilepsy and distinguish focal and generalized epilepsy in infants and children with 5
Efficacy of anti‐seizure medications and alternative therapies (ketogenic diet, CBD, and quinidine) in KCNT1‐related epilepsy: A systematic review5
Exploring ketogenic diet resistance in glucose transporter type 1 deficiency syndrome: A comprehensive review and critical appraisal5
NORSE secondary to anti‐GAD65 antibody‐positive encephalitis treated with novel adjunctive rapid titration VNS protocol5
Issue Information5
Dynamics of glucose concentration during the initiation of ketogenic diet treatment in children with refractory epilepsy: Results of continuous glucose monitoring5
Preclinical common data elements for general pharmacological studies (pharmacokinetic sample collection, tolerability, and drug administration). A report of the TASK3‐WG1A General Pharmacology Working5
Epilepsy in inmate patients seen in a high complexity reference hospital in Colombia: A cross‐sectional study5
Brain network entropy, depression, and quality of life in people with traumatic brain injury and seizure disorders5
A model‐based cost‐effectiveness estimates of hormonal therapy in Indian children with infantile epileptic spasms syndrome5
Different pharmacoresistance of focal epileptic spasms, generalized epileptic spasms, and generalized epileptic spasms combined with focal seizures5
Bromodomain‐containing protein 2 gene polymorphism among patients with photosensitive epilepsy in Indonesia5
The bidirectional role of music effect in epilepsy: Friend or foe?5
Issue Information5
Treatment of status epilepticus: Physiology, pharmacology, and future directions5
Embracing a new chapter at Epilepsia Open: A message from the incoming Editor‐in‐Chief5
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Exploration of epileptic networks in temporal lobe encephaloceles with stereotactic EEG: Electroclinical characteristics and surgical outcomes4
One‐year cost‐effectiveness of callosotomy vs vagus nerve stimulation for drug‐resistant seizures in Lennox‐Gastaut Syndrome: A decision analytic model4
An interview with Morgan Sturgeon, 2022 Epilepsia Open prize winner for basic science research4
Correspondence between scalp‐EEG and stereoelectroencephalography seizure‐onset patterns in patients with MRI‐negative drug‐resistant focal epilepsy4
The upside of epilepsy: Theories of an evolutionary paradox4
Validity of the MoCA as a cognitive screening tool in epilepsy: Are there implications for global care and research?4
Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy4
Factors not considered in the study of drug‐resistant epilepsy: Psychiatric comorbidities, age, and gender4
Use of ketogenic dietary therapy for drug‐resistant epilepsy in early infancy4
Transient global amnesia after the right temporal epilepsy surgery: A case report4
Sex‐based structural and functional MRI outcomes in the rat brain after soman (GD) exposure‐induced status epilepticus4
Effectiveness of perampanel for focal seizures determined by interictal gamma oscillation regularity analysis4
Epilepsia Open—August 2024 Announcements4
Differences in the topographical distribution of sleep spindles among adult epilepsy with cognitive impairment4
Issue Information4
Prospective multicenter cohort study of possible psychogenic nonepileptic seizure cases—Results at 1‐year follow‐up examinations4
Systemic inflammation as a biomarker of seizure propensity and a target for treatment to reduce seizure propensity4
A public benchmark for human performance in the detection of focal cortical dysplasia4
Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs4
How are they doing as adults? Psychosocial and socioeconomic outcomes 11‐30 years after pediatric epilepsy surgery4
Classifying etiology of infantile spasms syndrome in resource‐limited settings: A study from the South Asian region4
Perampanel monotherapy in pediatric epilepsy: Emphasizing the need for comprehensive safety evaluation4
FIRDA, refractory epilepsy, and SEEG‐guided RF: A case report4
Efficacy and tolerability of add‐on stiripentol in real‐world clinical practice: An observational study in Dravet syndrome and non‐Dravet developmental and epileptic encephalopathies4
Response to amoxicillin and perampanel in infantile Alexander disease4
Changes in public attitude toward epilepsy in Hungary since 1994. A multicriteria weighting analysis4
Systemic lupus erythematosus and epilepsy: A Mendelian randomization study4
Review of epilepsy care in the Democratic Republic of the Congo4
Utility and limitations of homemade videos in differentiating functional seizures from other paroxysmal events: An Italian cohort study4
Genetic etiologies with a large NGS panel in a monocentric cohort of 1000 patients with pediatric onset epilepsies4
ECG‐based epileptic seizure prediction: Challenges of current data‐driven models4
In the fast lane: Receptor trafficking during status epilepticus4
Frequency‐specific network changes in mesial temporal lobe epilepsy: Analysis of chronic and transient dysfunctions in the temporo‐amygdala‐orbitofrontal network using magnetoencephalography4
Adaptation of the disease‐related apathy scale in adults with epilepsy into Turkish: A methodological study4
Compound heterozygosity of a De novo 16q24.1 deletion and missense mutation in COX4I1 leads to developmental regression, intellectual disability, and seizures4
Antiseizure medication prescribing in people with Dravet syndrome: An analysis of real‐time administrative data4
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