Epilepsia Open

Article	Citations
Total posterior quadrant disconnection for drug‐resistant epilepsy in children	89
Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges	64
Comparative efficacy and safety of stiripentol, cannabidiol and fenfluramine as first‐line add‐on therapies for seizures in Dravet syndrome: A network meta‐analysis	54
Epilepsy following neonatal encephalopathy—Future directions	51
Risk of COVID‐19 infection and seizure exacerbation among patients with epilepsy during the peak of Omicron wave	47
Alterations of apparent diffusion coefficient from ultra high b‐values in the bilateral thalamus and striatum in MRI‐negative drug‐resistant epilepsy	41
Long‐term effectiveness and tolerability of ketogenic diet therapy in patients with genetic developmental and epileptic encephalopathy onset within the first 6 months of life	38
Evaluation of the International League Against Epilepsy 1981, 1989, and 2017 classifications of seizure semiology and etiology in a population‐based cohort of children and adults with epilepsy	34
Commentary on “The epileptogenic zone in children with tuberous sclerosis complex is characterized by prominent features of focal cortical dysplasia”	32
Patient complexity, depression, and quality of life in patients with epilepsy at an epilepsy center in Japan	26
Microglia and status epilepticus in the immature brain	26
An interview with Ifrah Zawar, 2023 Epilepsia Open prize winner for clinical research	26
Building a dashboard to inform policy and clinical practice using the Irish epilepsy electronic patient record: Towards a learning health system	25
Characterization of low‐grade epilepsy‐associated tumor from implanted stereoelectroencephalography electrodes	24
Clinical characteristics and outcomes after new‐onset seizure among Zambian children with HIV during the antiretroviral therapy era	21
Assessment of tau phosphorylation and β‐amyloid pathology in human drug‐resistant epilepsy	21
Astrocyte reactivity in a mouse model of SCN8A epileptic encephalopathy	20
One‐year seizure freedom and quality of life in patients with drug‐resistant epilepsy receiving adjunctive vagus nerve stimulation in Japan	20
Key steps and barriers in the journey of patients with epilepsy through the National Healthcare System in Spain: The EPIPASS qualitative study	20
Effectiveness of perampanel as the only add‐on: Retrospective, multicenter, observational real‐life study on epilepsy patients	19
Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches	19
Thank you to our reviewers of 2023	17
A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint tra	17
Exploring the impact of hippocampal sclerosis on white matter tracts and memory in individuals with mesial temporal lobe epilepsy	17
Longitudinal hippocampal diffusion‐weighted imaging and T2 relaxometry demonstrate regional abnormalities which are stable and predict subfield pathology in temporal lobe epilepsy	17

Efficacy and Safety of adjunctive Perampanel in a prospective, real‐world, Phase IV study in Indian patients aged ≥12 years for Treatment of focal‐onset Epilepsy: Study 508	17
Bilateral pulvinar responsive neurostimulation for bilateral multifocal posteriorly dominant drug resistant epilepsy	17
Direct visualization of microwires in hybrid depth electrodes using high‐resolution photon‐counting CT	17
Timing differences between HFOs and interictal epileptiform discharges generated in vitro by different mechanisms in rat hippocampal slices: A novel approach	17
Drug‐resistant epilepsy and the hypothesis of intrinsic severity: What about the high‐frequency oscillations?	16
Neonatal seizures: Advances in diagnosis and management	16
A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3WG2 Neuropathology Working Group o	16
Ex‐SPECTing success: Predictors of successful SPECT radiotracer injection during presurgical video‐EEG admissions	16
Integration of interictal EEG source localization in presurgical epilepsy evaluation – A single‐center prospective study	16
Outcomes of resective surgery in pediatric patients with drug‐resistant epilepsy: A single‐center study from the Eastern Mediterranean Region	16
Longitudinal EpiTrack assessment of executive functions following vagus nerve stimulation therapy in patients with drug‐resistant epilepsy	15
Epilepsia Open—June 2023—Announcements	15
Letter on: 3D figure of epilepsy syndromes	15
Sleep architecture in drug‐naïve adult patients with epilepsy: Comparison between focal and generalized epilepsy	15
Bilateral ictal EEG is associated with better memory outcome after hippocampal sclerosis surgery	14
Discovery ofE2730, a novel selective uncompetitiveGAT1inhibitor, as a candidate for anti‐seizure medication	14
Interrater reliability of interictal EEG waveforms in Lennox–Gastaut Syndrome	14
Epilepsy surgery in early infancy: A retrospective, multicenter study	14
Reflections on the first 8 years of Epilepsia Open	14
Acetazolamide: Old drug, new evidence?	14
Analysis of clinical characteristics and histopathological transcription in 40 patients afflicted by epilepsy stemming from focal cortical dysplasia	14
An interview with Ondřej Strýček, 2025 Epilepsia Open prize winner for clinical research	13
Intravenous perampanel as an alternative to the oral formulations in Japanese patients with epilepsy	13
Intravenous lacosamide for acute repetitive seizures and convulsive status epilepticus in critically ill children	13
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A multicenter, cross‐sectional analysis to assess the safety and usage pattern of brivaracetam in the management of partial‐onset seizure with BAEs—BREEZE study: A post‐hoc analy	13
EEG‐based spatiotemporal dynamics of fast ripple networks and hubs in infantile epileptic spasms	13
Thank you to the outgoing Editor in Chief of Epilepsia Open, Aristea Galanopoulou	13
Experience of perampanel monotherapy beyond initial titration to achieve seizure freedom in patients with focal‐onset seizures with newly diagnosed or currently untreated recurrent epilepsy: A post ho	13
User involvement in the design and development of medical devices in epilepsy: A systematic review	13
Emotional experience elicited by direct electrical stimulation: Case series and literature review	13
Analysis of epilepsy‐associated variants in HCN3 – Functional implications and clinical observations	13
Epilepsia Open—December 2022—Announcements	13
Brain temperature, brain metabolites, and immune system phenotypes in temporal lobe epilepsy	12
Response: Safety and adverse events following COVID‐19 vaccination among people with epilepsy: Correspondence	12
Communicating a diagnosis of Dravet syndrome to parents/caregivers: An international Delphi consensus	12
Treatment with brivaracetam has no apparent long‐term effects on body weight in pediatric patients with epilepsy	12
Correspondence: FKBP5 blockade may provide a new horizon for the treatment of stress‐associated disorders: An in silico study	12
Antiseizure medication discovery: Recent and future paradigm shifts	12
Thank you to our reviewers of 2024	12
Epilepsia Open – April 2025 Announcements	12
Safety and efficacy of rapid withdrawal of antiseizure medications during long‐term video‐electroencephalogram monitoring in children with drug‐resistant epilepsy: A retrospective study	12
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Epilepsy is an important feature of KBG syndrome associated with poorer developmental outcome	11
Epilepsia Open: Welcome to the inaugural lived experience editor and editorial interns	11
Hypometabolic patterns are related to post‐surgical seizure outcomes in focal cortical dysplasia: A semi‐quantitative study	11
Status of epilepsy in the tropics: An overlooked perspective	11
Incidence and Predictors of Later Epilepsy in Neonates with Encephalopathy: The Impact of Electrographic Seizures	11
Fenfluramine treatment in pediatric patients with Dravet syndrome reduces seizure burden and overall healthcare costs: A retrospective and observational real‐world study	11
The cenobamate KORK study—A prospective monocenter observational study investigating cenobamate as an adjunctive therapy in refractory epilepsy, with comparisons to historical cohorts treated with add	11

Long‐term outcomes of corpus callosotomy in adult patients with drug‐resistant epilepsy: Results from a single neurosurgical center in Mexico	11
Chemical analysis and concentrations of cannabidiol substances used for refractory epilepsy in Chilean patients. An underestimated worldwide risk	10
An interview with Fabienne Kühne, 2024 Epilepsia Open prize winner for clinical research	10
The effect of epilepsy awareness on attitudes toward individuals with epilepsy in Turkish society: A case study from Northern Turkey	10
An exploratory study of brain temperature and choline abnormalities in temporal lobe epilepsy patients with depressive symptoms	10
SEEG‐based reevaluation of epileptogenic networks and the predictive role for reoperation in MTLE patients with surgical failure	10
Drosophila melanogaster as a rapid in vivo assay system for preclinical anti‐seizure medication testing	10
Resting‐state functional connectivity changes with microburst vagus nerve stimulation therapy	10
Issue Information	10
Evaluating depression in Indonesian adolescents with epilepsy: Comprehensive validation and reliability assessment of the neurological disorders depression inventory‐epilepsy for youth Indonesian vers	10
In vitro human cell culture models in a bench‐to‐bedside approach to epilepsy	10
Reactive oxygen species in status epilepticus	10
An interview with Lyndsey Anderson, 2024 Epilepsia Open prize winner for basic science research	10
Effectiveness of add‐on acetazolamide in children with drug‐resistant CHD2‐related epilepsy and in a zebrafish CHD2 model	10
Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysis	10
A multicenter randomized controlled feasibility trial of a digital self‐management intervention for adults with epilepsy	10
Successful management of refractory epilepsy in creatine transporter deficiency with cannabidiol and clobazam: A case report	10
First report of Tunisian patients with CDKL5‐related encephalopathy	10
Epileptic Status in a PEDiatric cohort (ESPED) requiring intensive care treatment: A multicenter, national, two‐year prospective surveillance study	10
Commentary on “Antiseizure activity by opioid receptor antagonism, new evidence”	10
PERPRISE: A prospective non‐interventional study of PERampanel as only adjunctive treatment in patients with PRImary or SEcondarily generalized tonic–clonic	10
Decreased homovanillic acid and 5‐hydroxyindoleacetic acid levels in the cerebrospinal fluid of patients with Dravet syndrome with parkinsonism	9
Transcranial direct current stimulation treatment reduces, while repetitive transcranial magnetic stimulation treatment increases electroencephalography spike rates with refractory occipital lobe epil	9
Anti‐seizure efficacy and retention rate of carbamazepine is highly variable in randomized controlled trials: A meta‐analysis	9
Long‐term efficacy and safety of cannabidiol in patients with tuberous sclerosis complex: 3‐year results from the cannabidiol expanded access program	9
Epilepsy surgery program in a resource‐limited setting in Vietnam: A multicentered collaborative model	9
Impact of hippocampectomy on seizure freedom in temporal encephaloceles: A systematic review and individual participant data meta‐analysis	9
First‐in‐human microelectrode recordings from the vagus nerve during clinical vagus nerve stimulation	9
Serotonin receptors in epilepsy: Novel treatment targets?	9
Potential role of FKBP5 single‐nucleotide polymorphisms in functional seizures	9
Verbal paired associates learning lateralizes left hippocampal sclerosis in temporal lobe epilepsy	9
HMGB1 blood levels and neurological outcomes after traumatic brain injury: Insights from an exploratory study	9
Peri‐ictal yawning: A potential lateralizing sign in temporal lobe epilepsy	9
Impact of length of stay on diagnostic yield in the epilepsy monitoring unit: A multi‐center retrospective 12‐year Veterans Health Administration study	9
BRIVA‐ONE study: 12‐month outcomes of brivaracetam monotherapy in clinical practice	9
Epilepsia Open—September 2022—Announcements	9
Thank you to our Reviewers of 2021	9
Epilepsia Open–December 2021–Announcements	9
Early genetic testing in pediatric epilepsy: Diagnostic and cost implications	8
Factors influencing seizure control of patients with convulsive epilepsy in rural areas of northwest China	8
An examination of the efficacy and safety of fenfluramine in adults, children, and adolescents with Dravet syndrome in a real‐world practice setting: A report from the Fenfluramine European	8
A study of factors influencing self‐stigma in people with epilepsy: A nationwide online questionnaire survey in Japan	8
Issue Information	8
Evaluation of self‐stigma in patients with epilepsy: Validation of the self‐stigma scale to Spanish (ESSS‐S)	8
Mendelian randomization reveals no causal relationship between COVID‐19 susceptibility, hospitalization, or severity and epilepsy	8
Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug‐refractory epilepsy	8
Feasibility of cardiac‐based seizure detection and prediction: A systematic review of non‐invasive wearable sensor‐based studies	8
Status epilepticus and early development: Neuronal injury, neurodegeneration, and their consequences	8
Antiepileptogenesis after stroke—trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate	8
Parvalbumin neurons in the anterior nucleus of thalamus control absence seizures	8
The effects of COVID‐19 measures on the hospitalization of patients with epilepsy and status epilepticus in Thailand: An interrupted time series analysis	8
Multimodal non‐invasive evaluation in MRI‐negative epilepsy patients	8
Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder	8
Cannabidiol for functional seizures (psychogenic nonepileptic seizures/attacks) and other stress‐associated disorders	8
Confirmation of infantile spasms resolution by prolonged outpatient EEGs	8
Issue Information	8
High FGF‐21 level in a cohort of 22 patients with Dravet Syndrome—Possible relationship with the disease outcomes	8
Medications used for seizure‐emergency management in the UK community: A clinical practice research datalink retrospective database study	8
Scalp high‐frequency oscillations differentiate neonates with seizures from healthy neonates	7
Parsing neuronal circuits involved in comorbidities of epilepsy: A commentary on “Focal impaired awareness seizures in a rodent model: A functional anatomy”	7
The mechanism of mitochondrial autophagy regulating Clathrin‐mediated endocytosis in epilepsy	7
Real‐world data on cannabidiol treatment of various epilepsy subtypes: A retrospective, multicenter study	7
Italian report on RARE epilepsies (i‐RARE): A consensus on multidisciplinarity	7
Late‐onset asystole associated with vagal nerve stimulation	7
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Ordinal regression increases statistical power to predict epilepsy surgical outcomes	7
Medical treatment in infants and young children with epilepsy: Off‐label use of antiseizure medications. Survey Report of ILAE Task Force Medical Therapies in Children	7
Epilepsy care pathway: The Finnish model	7
Limited cerebellar gradient extension in temporal lobe epilepsy with dystonic posturing	7
Epilepsia Open—December 2024 announcements	7
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Cardiovascular risk factor assessment in late‐onset seizures: A study protocol to assess the value of structured intervention	7
Long‐term outcomes after NORSE: Treatment with vagus nerve stimulation	7
Factors not considered in the study of drug‐resistant epilepsy: Drug‐resistant epilepsy: Assessment of neuroinflammation	7
Impact of COVID‐19 pandemic on epilepsy care in Japan: A national‐level multicenter retrospective cohort study	7
Issue Information	7
Issue Information	7
Epileptic spasms relapse is associated with response latency but not conventional attributes of post‐treatment EEG	6
The bidirectional role of music effect in epilepsy: Friend or foe?	6
Issue Information	6

Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low‐dose kainic acid systemic injection paradigm in mice	6
Effect of levetiracetam on cognition in patients with cognitive decline: A systematic review and meta‐analysis of randomized controlled trials	6
Self‐limited familial focal epilepsy caused by ANK2 variants: A potentially under‐recognized condition	6
Clinical features of unilateral multilobar and hemispheric polymicrogyria (PMG)‐related epilepsy and seizure outcome with different treatment options	6
Prospective multisite cohort study of patient‐reported outcomes in adults with new‐onset seizures	6
Psychiatric disorders in children and adolescents with temporal lobe epilepsy: A narrative review	6
Ivermectin as a promising therapeutic option for onchocerciasis‐associated epilepsy	6
Cardiac structural and functional abnormalities in epilepsy: A systematic review and meta‐analysis	6
Antiseizure medication withdrawal risk estimation and recommendations: A survey of American Academy of Neurology and EpiCARE members	6
The National Comprehensive Governance for epilepsy prevention and control in China	6
The diagnostic value of ictal SPECT—A retrospective, semiquantitative monocenter study	6
Real‐world use of adjunctive perampanel for focal‐onset seizures in Italy: Amirroring clinical practice study of perampanel in adults and adolescents (AMPA)	6
A retrospective, real‐world experience of perampanel monotherapy in patient with first new onset focal seizure: A Thailand experience	6
Comparison of magnetic resonance‐guided laser interstitial thermal therapy corpus callosum ablation to open microsurgical corpus callosotomy: A single‐center retrospective cohort study	6
Antiseizure medication choice in diffuse glioma: A single‐center population‐based experience	6
Preliminary development and validation of the Indonesian Pediatric Epilepsy Questionnaire (INA‐PEPSI) to determine epilepsy and distinguish focal and generalized epilepsy in infants and children with	6
Clinical phenotype and functional influence of GRIN2A variants in epilepsy‐aphasia syndrome	6
Evaluating the impact of an AI‐powered chatbot on epilepsy education and stigma reduction: A pre‐post intervention study using EpiloBot	6
Efficacy of anti‐seizure medications and alternative therapies (ketogenic diet, CBD, and quinidine) in KCNT1‐related epilepsy: A systematic review	6
Comparing late‐onset epileptic spasm outcomes after corpus callosotomy and subsequent disconnection surgery between post‐encephalitis/encephalopathy and non‐encephalitis/encephalopathy	6
Creativity and its link to epilepsy	6
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Impact of theCOVID‐19 pandemic on people with epilepsy: Findings from theUSarm of theCOV‐Estudy	5
Issue Information	5
Serum perampanel levels in patients with seizures are not affected by hemodialysis	5
Dynamics of glucose concentration during the initiation of ketogenic diet treatment in children with refractory epilepsy: Results of continuous glucose monitoring	5
Polymorphism of glucocorticoid receptor gene (rs41423247) in functional seizures (psychogenic nonepileptic seizures/attacks)	5
Determinants of successful ictal SPECT injection in phase 1 epilepsy presurgical evaluation: Findings from the pediatric epilepsy research consortium surgery database project	5
NORSE secondary to anti‐GAD65 antibody‐positive encephalitis treated with novel adjunctive rapid titration VNS protocol	5
Different pharmacoresistance of focal epileptic spasms, generalized epileptic spasms, and generalized epileptic spasms combined with focal seizures	5
Systemic inflammation as a biomarker of seizure propensity and a target for treatment to reduce seizure propensity	5
Validity of the MoCA as a cognitive screening tool in epilepsy: Are there implications for global care and research?	5
Review of epilepsy care in the Democratic Republic of the Congo	5
Exploring ketogenic diet resistance in glucose transporter type 1 deficiency syndrome: A comprehensive review and critical appraisal	5
Huperzine A suppresses absence seizures in the genetic absence epilepsy rat from Strasbourg (GAERS) model of genetic generalized epilepsy with absence seizures	5
Attention‐deficit/hyperactivity disorder in children with epilepsy: A systematic review and meta‐analysis of prevalence and risk factors	5
Frequency‐specific network changes in mesial temporal lobe epilepsy: Analysis of chronic and transient dysfunctions in the temporo‐amygdala‐orbitofrontal network using magnetoencephalography	5
Role of the glymphatic system and perivascular spaces as a potential biomarker for post‐stroke epilepsy	5
Brain network entropy, depression, and quality of life in people with traumatic brain injury and seizure disorders	5
Cerebrospinal fluid metabolites as potential biomarkers for epilepsy: Insights from genome‐wide association studies	5
Efficacy and tolerability of perampanel as add‐on therapy in Dravet syndrome: A prospective real‐world study	5
Factors not considered in the study of drug‐resistant epilepsy: Psychiatric comorbidities, age, and gender	5
Classifying etiology of infantile spasms syndrome in resource‐limited settings: A study from the South Asian region	5
A public benchmark for human performance in the detection of focal cortical dysplasia	5
How are they doing as adults? Psychosocial and socioeconomic outcomes 11‐30 years after pediatric epilepsy surgery	5
Customized targeted massively parallel sequencing enables the identification of novel pathogenic variants in Tunisian patients with developmental and epileptic encephalopathy	5
Preclinical common data elements for general pharmacological studies (pharmacokinetic sample collection, tolerability, and drug administration). A report of the TASK3‐WG1A General Pharmacology Working	5
The appearance of scalp high‐frequency oscillations is associated with poor seizure control in pediatric epilepsy patients	5
Successful use of cannabidiol in nonconvulsive status epilepticus in Angelman syndrome	5
Treatment of status epilepticus: Physiology, pharmacology, and future directions	5
The AMPA receptor antagonist perampanel suppresses epileptic activity in human focal cortical dysplasia	5
Epilepsy in inmate patients seen in a high complexity reference hospital in Colombia: A cross‐sectional study	5
Bromodomain‐containing protein 2 gene polymorphism among patients with photosensitive epilepsy in Indonesia	5
Epilepsia Open—March 2022—Announcements	5
Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs	5
In the fast lane: Receptor trafficking during status epilepticus	5
Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy	5
Embracing a new chapter at Epilepsia Open: A message from the incoming Editor‐in‐Chief	5