OOIR: Observatory of International Research

Papers

(The TQCC of Epilepsia Open is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Implantation/explantation of sEEG electrodes and takotsubo syndrome: Plausible merits of some additions to the protocol	75
A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the	58
The impact of ketogenic diet on the frequency of psychogenic non‐epileptic seizures (PNES): A feasibility randomized pilot study	43
Disparities in the utilization of genetic testing for non‐acquired infantile epileptic spasms syndrome in a single healthcare center in North Carolina	42
GATAD2B‐related developmental and epileptic encephalopathy (DEE): Extending the epilepsy phenotype and a literature appraisal	38
Ictal and interictalSPECTwith^99mTc‐HMPAOin presurgical epilepsy. I: Predictive value and methodological considerations	36
Quantitative EEG signatures in patients with and without epilepsy development after a first seizure	34
Interim analysis of the long‐term efficacy and safety of azetukalner in an ongoing open‐label extension study following a phase 2b clinical trial (X‐TOLE) in adults with focal epilepsy	30
An interview with Ifrah Zawar, 2023 Epilepsia Open prize winner for clinical research	25
An interview with Nadia Adotevi, 2023 Epilepsia Open Prize winner for basic science	24
Decreased serum concentrations of antiseizure medications in children with drug resistant epilepsy following treatment with ketogenic diet	21
Astrocyte reactivity in a mouse model of SCN8A epileptic encephalopathy	20
Factors not considered in the study of drug‐resistant epilepsy: Drug‐resistant epilepsy: Assessment of neuroinflammation	20
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Neuropsychiatric profile in average intelligent individuals with coexisting epilepsy and psychogenic non‐epileptic seizures	19
Programmed mechanisms of status epilepticus‐induced neuronal necrosis	19
Phosphatidylserine enriched with polyunsaturated n‐3 fatty acid supplementation for attention‐deficit hyperactivity disorder in children and adolescents with epilepsy: A randomized p	18
Insulo‐opercular stereoelectroencephalography exploration in children and young adults: Indications, techniques, and safety	17
Ettore Beghi (1947–2022): A farewell	17
Management and outcomes among older adults with generalized epilepsy in routine clinical practice	17
Issue Information	17
Issue Information	16
Rapid response electroencephalography decreases time to seizure diagnosis in pediatric acute care patients	16
Epilepsy care pathway: The Finnish model	15
High FGF‐21 level in a cohort of 22 patients with Dravet Syndrome—Possible relationship with the disease outcomes	14

Parsing neuronal circuits involved in comorbidities of epilepsy: A commentary on “Focal impaired awareness seizures in a rodent model: A functional anatomy”	14
Status epilepticus in BRAF‐related cardio‐facio‐cutaneous syndrome: Focus on neuroimaging clues to physiopathology	13
Survey of an online system for information to women with epilepsy of childbearing age and management during pregnancy: A 3‐year evaluation	13
E = mc²: Education (E), medication (m), and conditional cash (c²) to improve uptake of antiseizure medications in a low‐resource pop	13
Efficacy and safety of a smartphone application‐based treatment of ketogenic diet in pediatric refractory epilepsy	13
Readability and content gaps in online epilepsy surgery materials as potential health literacy and shared‐decision‐making barriers	13
A 5‐year‐old boy with super‐refractory status epilepticus and RANBP2 variant warranting life‐saving hemispherotomy	13
Epilepsy and neurocysticercosis in rural areas of the Bolivian Chaco: What has changed during the last 30 years?	13
Epilepsies with onset during the first year of life: A prospective study on syndromes, etiologies, and outcomes	12
Tolerance, adherence, and acceptability of a ketogenic 2.5:1 ratio, nutritionally complete, medium chain triglyceride‐containing liquid feed in children and adults with drug‐resistant epilepsy followi	12
Hospital‐acquired infections as a risk factor for post‐traumatic epilepsy: A registry‐based cohort study	12
Risk of COVID‐19 infection and seizure exacerbation among patients with epilepsy during the peak of Omicron wave	12
The mechanism of mitochondrial autophagy regulating Clathrin‐mediated endocytosis in epilepsy	12
Characterization of alcohol‐related seizures in withdrawal syndrome	12
Alterations of apparent diffusion coefficient from ultra high b‐values in the bilateral thalamus and striatum in MRI‐negative drug‐resistant epilepsy	11
Prospective study of epilepsy with generalized tonic–clonic seizures alone: Clinical features, response to treatment, and likelihood of medication withdrawal	11
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Development of a novel dosing paradigm to model diazepam rescue therapy in preclinical seizure and epilepsy models	11
Commentary on “The epileptogenic zone in children with tuberous sclerosis complex is characterized by prominent features of focal cortical dysplasia”	11
Cardiovascular risk factor assessment in late‐onset seizures: A study protocol to assess the value of structured intervention	11
Epilepsia Open—June 2024 Announcements	11
Epilepsy in Niger: An overview of the current situation	10
3D figure of epilepsy syndromes	10
Association of patent foramen ovale with epilepsy: A hospital‐based case–control study	10
Issue Information	10
Microglia and status epilepticus in the immature brain	10
Response: Letter to FKBP5 blockade may provide a new horizon for the treatment of stress‐associated disorders: An in silico study	10
Medical treatment in infants and young children with epilepsy: Off‐label use of antiseizure medications. Survey Report of ILAE Task Force Medical Therapies in Children	10
Prevalence of epilepsy in Morocco: A population‐based study	10
Identification and clinical characteristics of a novel missense ADGRG1 variant in bilateral Frontoparietal Polymicrogyria: The electroclinical change from infancy to adulthood after Calloso	10
The efficacy and safety of ganaxolone for the treatment of refractory epilepsy: A meta‐analysis from randomized controlled trials	10
Epilepsia Open – September 2021 – Announcements	10
Availability, affordability, and quality of essential anti‐seizure medication in Cambodia	10
Long‐term effectiveness and tolerability of ketogenic diet therapy in patients with genetic developmental and epileptic encephalopathy onset within the first 6 months of life	10
Feasibility, tolerability and efficacy of the ketogenic diet in children with drug‐resistant epilepsy in Vietnam	10
Parvalbumin neurons in the anterior nucleus of thalamus control absence seizures	10
Experimental status epilepticus, COX‐2 and BDNF: Connecting the dots	10
Seizure‐related injuries in people with epilepsy: A cohort study from Saudi Arabia	10
Safety and effectiveness of diazepam nasal spray in male and female patients: Post hoc analysis of data from a phase 3 safety study	10
Real‐world antiseizure medication treatment outcomes in drug‐resistant focal epilepsy patients	9
Comparative efficacy and safety of stiripentol, cannabidiol and fenfluramine as first‐line add‐on therapies for seizures in Dravet syndrome: A network meta‐analysis	9
Implantation and reimplantation of intracranial EEG electrodes in patients considering epilepsy surgery	9
Ordinal regression increases statistical power to predict epilepsy surgical outcomes	9
Diagnostic yield of utilizing 24–72‐hour video electroencephalographic monitoring in the diagnosis of seizures presenting as paroxysmal events in resource‐limited settings	9
Drugs acting at TRPM7 channels inhibit seizure‐like activity	9
Temporal encephaloceles and coexisting epileptogenic lesions	9
Pregabalin as adjunctive therapy in adult and pediatric patients with generalized tonic‐clonic seizures: A randomized, placebo‐controlled trial	9
Influence of extent and age at corpus callosotomy on seizure outcomes. A single center experience	9
Causal relationship between telomere length and epilepsy: A bidirectional Mendelian randomization study	9
Evaluation of the International League Against Epilepsy 1981, 1989, and 2017 classifications of seizure semiology and etiology in a population‐based cohort of children and adults with epilepsy	9

The causal effect of serum 25‐hydroxyvitamin D levels on epilepsy: A two‐sample Mendelian randomization study	9
Memory compromise at extended delays in people with new‐onset epilepsy	8
Efficacy and tolerability of low versus standard daily doses of antiseizure medications in newly diagnosed focal epilepsy. A multicenter, randomized, single‐blind, non‐inferiority trial (STANDLOW	8
Drug‐resistant epilepsy: Drug target hypothesis and beyond the receptors	8
Seizures in Sotos syndrome: Phenotyping in 49 patients	8
Navigating Dravet syndrome in Spain: A cross‐sectional study of diagnosis, management, and care coordination	8
Epilepsy following neonatal encephalopathy—Future directions	8
A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint tra	8
Sevoflurane as bridge therapy for plasma exchange and Anakinra in febrile infection–related epilepsy syndrome	8
Early rehabilitation and improved outcomes in patients with status epilepticus: Evidence from cases presenting to the emergency department	8
Key steps and barriers in the journey of patients with epilepsy through the National Healthcare System in Spain: The EPIPASS qualitative study	8
The hidden link between late‐onset seizures and cerebral amyloid angiopathy: A case–control study	8
Effectiveness of perampanel as the only add‐on: Retrospective, multicenter, observational real‐life study on epilepsy patients	8
Impact of COVID‐19 pandemic on epilepsy care in Japan: A national‐level multicenter retrospective cohort study	8
Experience with the ketogenic diet in premature neonates	7
The clinical analysis of new‐onset status epilepticus	7
Total posterior quadrant disconnection for drug‐resistant epilepsy in children	7
Development and validation of a peripheral cell ratio and lactate score for differentiating status epilepticus from prolonged psychogenic nonepileptic seizures	7
A cross‐sectional study of COVID‐19 vaccination patterns among patients with epilepsy in Hong Kong	7
Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory	7
Patient complexity, depression, and quality of life in patients with epilepsy at an epilepsy center in Japan	7
Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges	7
Deep‐learning predicted PET can be subtracted from the true clinical fluorodeoxyglucose PET co‐registered to MRI to identify the epileptogenic zone in focal epilepsy	7
WRAPPER study: Real‐world effectiveness and tolerability of adjunctive perampanel for people with drug–resistant epilepsy in Hong Kong	7
Type 2 diabetes mellitus facilitates status epilepticus in adult rats: Seizure severity, neurodegeneration, and oxidative stress	7
Variation in seizure risk increases from antiseizure medication withdrawal among patients with well‐controlled epilepsy: A pooled analysis	7
Characteristics of deceased subjects transported to a postmortem imaging center due to unusual death related to epilepsy	7
A companion to the preclinical common data elements for rodent genetic epilepsy models. A report of the TASK3‐WG1B: Paediatric and genetic models working group of the ILAE/A	7
Surgical management of status epilepticus: A systematic review	7
Erratum: To “the clinical analysis of new‐onset status epilepticus”Deng B, Dai Y, Wang Q, Yang J, Chen X, Liu T–T, et al. The clinical analysis of new‐onset status epilepticus. Epilepsia Open. 2022;7:	7
Assessment of tau phosphorylation and β‐amyloid pathology in human drug‐resistant epilepsy	7
Multi‐omic strategies applied to the study of pharmacoresistance in mesial temporal lobe epilepsy	7
Clinical characteristics and outcomes after new‐onset seizure among Zambian children with HIV during the antiretroviral therapy era	7
Effect of transcutaneous vagus nerve stimulation on stress‐reactive neuroendocrine measures in a sample of persons with temporal lobe epilepsy	6
Sleep disturbances in SCN8A‐related disorders	6
Lateralization of memory function in temporal lobe epilepsy using scene memory fMRI	6
The long‐term surgical outcomes of low‐grade epilepsy‐associated neuroepithelial tumors	6
Remote effects of temporal lobe epilepsy surgery: Long‐term morphological changes after surgical resection	6
Characterization of low‐grade epilepsy‐associated tumor from implanted stereoelectroencephalography electrodes	6
Radiofrequency thermocoagulation in focal epilepsy: A retrospective cohort study	6
Vaccination against COVID‐19 and potential protective effects on seizure recurrence in children with epilepsy: A cross‐sectional survey	6
The causal relationship of DTI phenotypes and epilepsy: A two sample mendelian randomization study	6
The origins and early development of the ILAE/IBE/WHO global campaign against epilepsy: Out of the shadows	6
Myoclonus: Differential diagnosis and current management	6
Longitudinal hippocampal diffusion‐weighted imaging and T2 relaxometry demonstrate regional abnormalities which are stable and predict subfield pathology in temporal lobe epilepsy	6
Scalp high‐frequency oscillations differentiate neonates with seizures from healthy neonates	6
One‐year seizure freedom and quality of life in patients with drug‐resistant epilepsy receiving adjunctive vagus nerve stimulation in Japan	6
The thickness of the retinal nerve fiber layer, macula, and ganglion cell‐inner plexiform layer in people with drug‐resistant epilepsy	6
Electroclinical features and phenotypic differences in adenylosuccinate lyase deficiency: Long‐term follow‐up of seven patients from four families and appraisal of the literature	6
Subjective cognition is linked to everyday functioning in epilepsy	6
Report of the ILAE SUDEP Task Force on national recommendations and practices around the world regarding the use of wearable seizure detection devices: A global survey	6
Real‐world data on cannabidiol treatment of various epilepsy subtypes: A retrospective, multicenter study	6
Long‐term outcomes after NORSE: Treatment with vagus nerve stimulation	6
Clinical and genetic analysis of 23 Chinese children with epilepsy associated with KCNQ2 gene mutations	6
Issue Information	6
EEG datasets for seizure detection and prediction— A review	6
Left‐sided epileptiform activity influences language lateralization in right mesial temporal sclerosis	5
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Ex‐SPECTing success: Predictors of successful SPECT radiotracer injection during presurgical video‐EEG admissions	5
Outcomes of resective surgery in pediatric patients with drug‐resistant epilepsy: A single‐center study from the Eastern Mediterranean Region	5
Targeted continuous EEG monitoring in critically ill patients: The long and the short of a scalability problem	5
The efficacy and safety of adjunctive perampanel for the treatment of refractory focal‐onset seizures in patients with epilepsy: A meta‐analysis	5
Human herpesvirus 6 DNA was not detected in a brain specimen from a patient with mesial temporal sclerosis after status epilepticus due to human herpesvirus 6 infection	5
Diagnosis and treatment of growth hormone deficiency in children on the ketogenic diet: A case series	5
Initial combination versus early sequential standard therapies for Infantile Epileptic Spasms Syndrome—Feedback from stakeholders	5
Italian report on RARE epilepsies (i‐RARE): A consensus on multidisciplinarity	5
Increased susceptibility to kainate‐induced seizures in a mouse model of tuberous sclerosis complex: Importance of sex and circadian cycle	5
Eye closure sensitivity as a novel EEG marker of MERRF	5
Clinical and genetic analysis of infants with pontocerebellar hypoplasia type 6 caused by RARS2 variations	5
Therapeutic drug monitoring of perampanel in children diagnosed with epilepsy: Focus on influencing factors on the plasma concentration‐to‐dose ratio	5
A disease concept model for STXBP1‐related disorders	5
Accessibility, availability and common practices regarding genetic testing for epilepsy across Europe: A survey of the European Reference Network EpiCARE	5
Leveraging multiple approaches for the detection of pathogenic deep intronic variants in developmental and epileptic encephalopathies: A case report	5
Baseline characteristics and predictors for early implantation of vagus nerve stimulation therapy in people with drug‐resistant epilepsy: Observations from an international prospective outcomes regist	5
Long‐term outcomes and adaptive behavior in adult patients with Lennox–Gastaut syndrome	5
Efficacy of anti‐seizure medications and alternative therapies (ketogenic diet, CBD, and quinidine) in KCNT1‐related epilepsy: A systematic review	5
Transporter hypothesis in pharmacoresistant epilepsies. Is it at the central or peripheral level?	5
Self‐limited familial focal epilepsy caused by ANK2 variants: A potentially under‐recognized condition	5
Three cases of atypical Rasmussen's encephalitis with delayed‐onset seizures	5
COVID‐19 response in a long‐term care facility for people with epilepsy	5

A European pilot study in Dravet Syndrome to delineate what really matters for the patients and families	4
Synchronous heart rate reduction with suppression‐burst pattern in KCNT1‐related developmental and epileptic encephalopathies	4
Epilepsy duration is an independent factor for electrocardiographic changes in pediatric epilepsy	4
Seizure prophylaxis in pneumococcal meningitis, cohort study	4
Work productivity, quality of life, and care needs: An unfolding epilepsy burden revealed in the Australian Epilepsy Project pilot study	4
Efficacy and Safety of adjunctive Perampanel in a prospective, real‐world, Phase IV study in Indian patients aged ≥12 years for Treatment of focal‐onset Epilepsy: Study 508	4
Epilepsia Open – February 2024 Announcements	4
Creativity and its link to epilepsy	4
An international survey of SEEG cortical stimulation practices	4
An interview with Ying Yu, 2021 EpilepsiaOpen Prize Winner for Basic Science Research	4
A novel FAME1 repeat configuration in a European family identified using a combined genomics approach	4
NORSE seasonality may vary geographically in adults	4
May anti‐seizure medications alter brain structure in temporal lobe epilepsy? A prospective study	4
Prevalence of non‐convulsive seizures and electroencephalographic abnormalities in critically ill patients—A retrospective observational study	4
A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3WG2 Neuropathology Working Group o	4
Prospective multisite cohort study of patient‐reported outcomes in adults with new‐onset seizures	4
Comparing late‐onset epileptic spasm outcomes after corpus callosotomy and subsequent disconnection surgery between post‐encephalitis/encephalopathy and non‐encephalitis/encephalopathy	4
Interictal magnetic signals in new‐onset Rolandic epilepsy may help with timing of treatment selection	4
Thank you to our reviewers of 2023	4
The goal of explaining black boxes in EEG seizure prediction is not to explain models' decisions	4
Cenobamate in refractory epilepsy: Overview of treatment options and practical considerations	4
Leukotriene antagonists reduce epileptic seizures‐related hospitalization in older adult populations with allergic rhinitis or asthma: A population‐based cohort study using the Shizuoka Kokuho databas	4
Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low‐dose kainic acid systemic injection paradigm in mice	4
Comparison of magnetic resonance‐guided laser interstitial thermal therapy corpus callosum ablation to open microsurgical corpus callosotomy: A single‐center retrospective cohort study	4