Science Immunology

Article	Citations
Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5	334
DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling	310
Hypoxia-induced EGR1 remodels neutrophils to suppress antitumor immunity	273
Characterization of the mammalian prodefinitive angio-hematopoietic lineage	269
The HLA advantage: Why COVID-19 benched you but not your co-worker	237
Is one lymphocyte’s brake another lymphocyte’s gas?	200
The OAS–RNase L pathway: Insights from experiments of nature	195
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells	190
Intratumoral immunotherapy relies on B and T cell collaboration	188
Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics	151
HLA-E–restricted SARS-CoV-2–specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation	150
Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity	148
Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritis	146
Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells	144
Immunogenomic cancer evolution: A framework to understand cancer immunosuppression	143
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation	135
Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins	135
Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses	133
Structural variation tunes apoptotic responses to drive immune escape in melanoma	129
DNA-damaging chemotherapy reshapes cardiac-resident macrophage composition and function	125
Operation Nasal Vaccine—Lightning speed to counter COVID-19	119
CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity	113
RORγt-lineage APCs: The Aire apparent	113
T cell help induces Myc transcriptional bursts in germinal center B cells during positive selection	112
Neither naïve nor anergic, “autoimmune” not allergic	110

Antibody-mediated immunity against lung cancer goes retro	109
Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-γ	105
Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins	103
CD103 fate mapping reveals that intestinal CD103−tissue-resident memory T cells are the primary responders to secondary infection	102
Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis	102
SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens	100
The rise of spatial TCR profiling: Emerging technologies and open challenges	99
Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity	96
ILC2s—Bipartisan politicians in cancer	96
Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models	93
Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity	92
Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation	89
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination	89
Luck gone cold: A trifecta of B cell mutations associates with cryoglobulinemia	87
Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease	87
Dynamic STING repression orchestrates immune cell development and function	86
Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis	84
BCL6 is required for the thymic development of TCRαβ + CD8αα + intraepithelial lymphocyte lineage	83
Erratum for the Research Article “TGF-β specifies T FH versus T H 17 cell fates in murine CD4	83
RNA exosome drives early B cell development via noncoding RNA processing mechanisms	82
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing	82
Dissection of the immune landscape in psoriatic arthritis defines immunoproteasome up-regulation in treatment resistance	82
Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen	78
Immune determinants of chronic sequelae after respiratory viral infection	78
CD5 deletion enhances the antitumor activity of adoptive T cell therapies	77
Antigen-specific depletion of CD4 + T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity	77
CD39 + tissue-resident memory CD8 + T cells with a clonal overlap across compartments mediate antitumor immunity in breast cancer	77
Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling	77
Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life	76
Tissue origin and virus specificity shape human CD8 + T cell cytotoxicity	76
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis	74
Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer	74
Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1 + PD-1 + CD8 T cells	74
Gutsy memory T cells stand their ground against pathogens	73
Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos	71
Androgen effects cause sex-biased impairment of CD8 + T cell antitumor activity	71
Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors	71
Unearthing the Rosetta Stone of public antibody responses	71
Functional differences between rodent and human PD-1 linked to evolutionary divergence	70
Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system	69
Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells	69
Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis	69
Intratumoral T reg cell ablation elicits NK cell–mediated control of CD8 T cell–resistant tumors	69
IgE plasma cells are transcriptionally and functionally distinct from other isotypes	68
Early human lung immune cell development and its role in epithelial cell fate	68
An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence	67
Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses	66
Tissue-specific nonheritable influences drive endometrial immune system variation	66
Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1β secretion	65
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines	64

Long 3′UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation	64
Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice	64
NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis	64
Microbial uptake in oral mucosa–draining lymph nodes leads to rapid release of cytotoxic CD8 + T cells lacking a gut-homing phenotype	64
Mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge in seronegative adults	62
Histone demethylation tones down leukemia through innate immunity	61
An e-Xist-ential two-edged sword for women	61
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination	61
Contactin-4 suppresses antitumor T cell responses by engaging amyloid precursor protein	60
EBVerified TCRs and multiple sclerosis	60
Erratum for the Research Article “Circulating KLRG1 + long-lived effector memory T cells retain the flexibility to become tissue resident” by E. D. L	60
B cells drive CD4 T cell immunosenescence and age-associated health decline	59
Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis	59
Molecular scalpels dissect new GluN1 hot spots in anti–NMDA receptor encephalitis	59
The transcription factor Mef2d regulates B:T synapse–dependent GC-T FH differentiation and IL-21–mediated humoral immunity	59
Secondary infections rejuvenate the intestinal CD103+tissue-resident memory T cell pool	59
Gastrointestinal germinal center B cell depletion and reduction in IgA + plasma cells in HIV-1 infection	59
Combined Flt3L and CD40 agonism restores dendritic cell–driven T cell immunity in pancreatic cancer	58
Fibroblastic reticular cells form reactive myeloid cell niches in human lymph nodes	57
The tumor-intrinsic role of the m 6 A reader YTHDF2 in regulating immune evasion	57
Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis	56
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span	56
Stem-like tissue-resident memory T cells control functional heterogeneity and reactivation of T cell memory in the intestine	56
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity	56
Peyer’s patch T H 17 cells are dispensable for gut IgA responses to oral immunization	56
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity	55
Finding TB vaccine antigens: follow the TCRs	55
Ly6C hi monocytes balance regulatory and cytotoxic CD4 T cell responses to control virus-induced immunopathology	55
FOXP3 exon 2 controls T reg stability and autoimmunity	54
GM-CSF derived from alveolar type 2 cells promotes CD301b + cDC2 generation and allergic airway inflammation	54
C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire	54
The epitope tax: Antibody feedback and the economics of germinal center competition	54
Emergence and fate of stem cell–likeTcf7+CD8+T cells during a primary immune response to viral infection	53
Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity	53
The circadian immune system	53
Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells	52
Targeting TLR4 during vaccination boosts MAdCAM-1 + lymphoid stromal cell activation and promotes the aged germinal center response	52
Immune signature clues are key to unlocking the mystery of clinical responses	51
A SPARC-ling link to inflammaging	51
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome	50
B cells and dengue: A cat-and-mouse game	50
Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells	50
Plasmablasts from the past: Nostalgic B cells can’t let go	50
Local activation of mutant RIG-I by short noncoding Y-RNA in the kidney triggers lethal nephritis	50
EBV grants B cells a license for immortality in the CNS	49
TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells	49
Oncogenic KRAS drives immunosuppression of colorectal cancer by impairing DDX60-mediated dsRNA accumulation and viral mimicry	49
SARS-CoV-2 JN.1 variant evasion of IGHV3-53/3-66 B cell germlines	49
CD4 + T cell immunity against cutaneous melanoma encompasses multifaceted MHC II–dependent responses	49
LXR signaling controls homeostatic dendritic cell maturation	48
Pathogenic IgE-fated memory B cell responses retain functional plasticity	48
Divergent granulopoiesis at extramedullary sites safeguards antibacterial host defense	48
The gene regulatory basis of bystander activation in CD8 + T cells	48
Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome	47
Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells	46
An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif	46
STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy	46
CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model	46
AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans	46
An ILC2-chitinase circuit restores lung homeostasis after epithelial injury	46
MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles	46
Mast cells help organize the Peyer’s patch niche for induction of IgA responses	46
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection	45
Alternative splicing of GSDMB modulates killer lymphocyte–triggered pyroptosis	45
SARS-CoV-2 epitope–specific CD4 + memory T cell responses across COVID-19 disease severity and antibody durability	45
RORγt + dendritic cells are a distinct lymphoid-derived lineage	45
The 10 commandments of immunoregulation in lymphoma	44
TCRward personalized transplant therapies	44
Only pregnant moms can do it….	44
Tuft cells restrain intestinal type 2 immunity through the transcription factor Spi-B	44
How dengue defies dogma: An extrafollicular tale	44
Immunoglobulin A antibody composition is sculpted to bind the self gut microbiome	43
See no allergen, hear no allergen, speak no allergen!	43
Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages	43
Nuclear polarization to the immune synapse facilitates an early transcriptional burst	43
BCL6 promotes a stem-like CD8 + T cell program in cancer via antagonizing BLIMP1	43
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication	43
NuRD complex recruitment to Thpok mediates CD4 + T cell lineage differentiation	42
C/EBPα activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development	42
Bcl11b sustains multipotency and restricts effector programs of intestinal-resident memory CD8 + T cells	42

Erratum for the Research Article “Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium” by K. Liang et al .	42
Usp22 is an intracellular regulator of systemic emergency hematopoiesis	42
CD4 binding site immunogens elicit heterologous anti–HIV-1 neutralizing antibodies in transgenic and wild-type animals	41
MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection	41
Brain sensing of metabolic state regulates circulating monocytes	41
Signatures of recent activation identify a circulating T cell compartment containing tumor-specific antigen receptors with high avidity	41
CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration after radiation-induced injury	41
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes	41
NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages	41
Pre-vax metabolic clues: Cracking the code to a better dengue vaccine	40
Psychological stress increases skin infection through the action of TGFβ to suppress immune-acting fibroblasts	40
A new tolerogenic cell RORs onto the scene	40
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis	40
IMM-BCP-01, a patient-derived anti–SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2	40
LTβR deficiency causes lymph node aplasia and impaired B cell differentiation	40
Evolution of antigen-specific follicular helper T cell transcription from effector function to memory	40
Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells	40
DDX55 safeguards naïve T cell homeostasis by suppressing activation-promoting transposable elements	39
Skull-pting meningeal immunity: Skull bone channels shape neonatal meningeal immune cell trafficking	39
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern	39
Zfp281 and Zfp148 control CD4 + T cell thymic development and T H 2 functions	38
B cells targeting parasites capture spatially linked antigens to secure T cell help	38
mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models	38
Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines against SARS-CoV-2 BA.5 infection in nonhuman primates	37
Monocyte-derived IL-10 drives sex differences in pain duration	37
Recall of B cell memory depends on relative locations of prime and boost immunization	37
CD4 + T cells with convergent TCR recombination reprogram stroma and halt tumor progression in adoptive therapy	37
An engineered viral protein activates STAT5 to prevent T cell suppression	36
Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity	36
Human T follicular helper clones seed the germinal center–resident regulatory pool	36
Made to order tuft cells by an OCA-T1 isoform switch	36
Fishing with autoantibodies nets a gut bacteria that drives arthritis	36
A light-regulated circadian timer optimizes neutrophil bactericidal activity to boost daytime immunity	36
Size-dependent activation of CAR-T cells	36
Tricky Ts play possum to propagate autoimmune disease	36
Foxo1 regulates intestinal tissue–resident memory CD8 T cell biology in an anatomic compartment– and context-specific manner	35
CD19 CAR antigen engagement mechanisms and affinity tuning	35
Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis	34
Recruited atypical Ly6G + macrophages license alveolar regeneration after lung injury	34
Twin study identifies early immunological and metabolic dysregulation of CD8 + T cells in multiple sclerosis	34
A central role for STAT5 in the transcriptional programing of T helper cell metabolism	34
Stem-like and effector peripheral helper T cells comprise distinct subsets in rheumatoid arthritis	33
TGF-β specifies T FH versus T H 17 cell fates in murine CD4 + T cells through c-Maf	33
IL-10mpting T H 17 cell fate in the gut	32
Human life within a narrow range: The lethal ups and downs of type I interferons	32
“ILC2 it, but I can’t promise anything”	32
“Training immunity” against nosocomial pathogens	32
Immuno-amnesia: Without B cells, T cells cannot remember	32
Asparagine availability controls germinal center B cell homeostasis	32
Aldehyde and seek: Toxic aldehydes drive exhaustion in tumor-infiltrating T cells	32
A dynamic atlas of immunocyte migration from the gut	31
Genetic mapping reveals Pou2af2/ OCA-T1–dependent tuning of tuft cell differentiation and intestinal type 2 immunity	31
Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes	31
Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy	31
Transient disruption of T cell help impairs germinal center dynamics and memory responses	31
Age-associated CD4 + T cells with B cell–promoting functions are regulated by ZEB2 in autoimmunity	30
Gut bacteria–derived serotonin promotes immune tolerance in early life	30
Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy	30
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis	30
PPARβ/δ-orchestrated metabolic reprogramming supports the formation and maintenance of memory CD8 + T cells	30
Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8 + T cell formation	30
B cell– and T cell–intrinsic regulation of germinal centers by thymic stromal lymphopoietin signaling	30
Promoting (and targeting) alternative expression	29
The cold truth about TCR structure	29
CAR-ving away OX40L with engineered T regs	29
Bearing a grudge—How human natural killer cells remember past insults	29
Selfish antibodies target auto-antigens in cancer	29
SNIPR alert! Making T cells more precise killers	29
TB or not TB: That depends on the antibody Fc	29
B cells require DOCK8 to elicit and integrate T cell help when antigen is limiting	28
Immune recall improves antibody durability and breadth to SARS-CoV-2 variants	28
Anticancer immune responses are hindered by cis interaction of inhibitory checkpoint SIRPα	28
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein	28
Noncanonical MAVS signaling restrains dendritic cell–driven antitumor immunity by inhibiting IL-12	28
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression	28
Anti–immune complex antibodies are elicited during repeated immunization with HIV Env immunogens	28
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses	27
Cis interactions between CD2 and its ligands on T cells are required for T cell activation	27
TGFβ prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation	27
Metabolic challenges and interventions in CAR T cell therapy	27
IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells	27
T regs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis	27
CCR8 + decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy	27
Dampening type 2 properties of group 2 innate lymphoid cells by a gammaherpesvirus infection reprograms alveolar macrophages	26
Response to tumor-infiltrating lymphocyte adoptive therapy is associated with preexisting CD8 + T-myeloid cell networks in melanoma	26
Innate receptors with high specificity for HLA class I–peptide complexes	26
Sugar-coated CAR T for sweeter cell therapies	26
T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens	26
Suppression of thrombospondin-1–mediated inflammaging prolongs hematopoietic health span	25
Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes	25
SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19	25
NK cells restrain cytotoxic CD8 + T cells in the submandibular gland via PD-1–PD-L1	25
Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements	25
Immunization with germ line–targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques	24
Heart failure promotes multimorbidity through innate immune memory	24