Science Immunology

Article	Citations
Anti–immune complex antibodies are elicited during repeated immunization with HIV Env immunogens	571
Linking vaccine adjuvant mechanisms of action to function	494
Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity	441
Cis interactions between CD2 and its ligands on T cells are required for T cell activation	374
Macrophage compartmentalization in the brain and cerebrospinal fluid system	326
The gene regulatory basis of bystander activation in CD8 + T cells	320
Mast cells help organize the Peyer’s patch niche for induction of IgA responses	260
Mast cell–derived BH4 and serotonin are critical mediators of postoperative pain	252
Sulfated bile acid is a host-derived ligand for MAIT cells	243
Welcoming c-MAF to the macrophage transcription factor VAM-ily	220
T cell help induces Myc transcriptional bursts in germinal center B cells during positive selection	209
Integrin α3 promotes T H 17 cell polarization and extravasation during autoimmune neuroinflammation	190
STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy	179
The acid-sensing receptor GPR65 on tumor macrophages drives tumor growth in obesity	177
Central memory T cells are the most effective precursors of resident memory T cells in human skin	173
Ikaros is a principal regulator of Aire + mTEC homeostasis, thymic mimetic cell diversity, and central tolerance	172
Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5	166
Type 2 immune predisposition results in accelerated neutrophil aging causing susceptibility to bacterial infection	165
Resident T H 2 cells orchestrate adipose tissue remodeling at a site adjacent to infection	160
Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics	159
The Benjamin Button effect on stem cells: Reversing the clock on aging immunity	159
T regs and inflammation—bring it on!	157
The HLA advantage: Why COVID-19 benched you but not your co-worker	154
MTHFD2, metabolic mastermind of CD4 + T cell destiny	153
Plasmablasts from the past: Nostalgic B cells can’t let go	148

A T-rojan horse strategy for cancer immunotherapy	146
It’s good to have Gremlins in the zone	142
Bearing a grudge—How human natural killer cells remember past insults	140
A three-stage developmental pathway for human Vγ9Vδ2 T cells within the postnatal thymus	134
Orientation-dependent CD45 inhibition with viral and engineered ligands	134
CAR-ving away OX40L with engineered T regs	130
Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity	128
Immune recall improves antibody durability and breadth to SARS-CoV-2 variants	127
Fractionating a COVID-19 Ad5-vectored vaccine improves virus-specific immunity	126
Immune memory from SARS-CoV-2 infection in hamsters provides variant-independent protection but still allows virus transmission	125
HLA-E–restricted SARS-CoV-2–specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation	121
The cold truth about TCR structure	116
Selfish antibodies target auto-antigens in cancer	116
A SPARC-ling link to inflammaging	113
The trouble with TRIBbles: TRIB3 blocks CD8 T cell homing to colorectal cancers	112
Promoting (and targeting) alternative expression	110
A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates	109
Getting toGether in Germinal centers	106
Is one lymphocyte’s brake another lymphocyte’s gas?	101
IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells	98
Afraid of needles? Try lotion: Engineering skin commensals for vaccination	96
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation	95
RORγt-lineage APCs: The Aire apparent	94
Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8 + T cell clone size and cytotoxicity	92
DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling	92
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13–driven tuft cell hyperplasia	91
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome	86
Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β activation	85
B cells require DOCK8 to elicit and integrate T cell help when antigen is limiting	82
Erratum for the Research Article “GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing” by J. E. Heraud-Farlow et al .	81
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells	81
Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity	80
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses	80
Virtual memory T cells orchestrate extralymphoid responses conducive to resident memory	77
Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening	76
TGFβ prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation	75
Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses	75
DNMT1 inhibition reprograms T cells to NK-like cells with potent antitumor activity	72
A tetraspecific engager armed with a non-alpha IL-2 variant harnesses natural killer cells against B cell non-Hodgkin lymphoma	72
PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8 + T cells in lymphoid tissue	70
Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response	69
SNIPR alert! Making T cells more precise killers	68
Polyclonal expansion of TCR Vβ 21.3+CD4+and CD8+T cells is a hallmark of multisystem inflammatory syndrome in children	68
Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome	65
Distant antimetastatic effect of enterotropic colon cancer–derived α4β7 + CD8 + T cells	65
GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141	64
Rgs16 promotes antitumor CD8 + T cell exhaustion	64
The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation	63
Resident regulatory T cells reflect the immune history of individual lymph nodes	63
Erratum for the Research Article “TGF-β specifies T FH versus T H 17 cell fates in murine CD4 +	63

It’s the little things in life: Lymph node microniches drive T H 2 formation in allergic asthma	62
PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors	62
Removing “flavor” from pathogenic antibodies hits a therapeutic sweet spot	62
cGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation	61
SARS-CoV-2 JN.1 variant evasion of IGHV3-53/3-66 B cell germlines	60
IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage	59
Myeloid cell tropism enables MHC-E–restricted CD8 + T cell priming and vaccine efficacy by the RhCMV/SIV vaccine	58
ExtrathymicAire-expressing cells support maternal-fetal tolerance	58
A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity	58
Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA	58
AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans	58
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation	58
Noncanonical MAVS signaling restrains dendritic cell–driven antitumor immunity by inhibiting IL-12	58
Pannexin 1 drives efficient epithelial repair after tissue injury	58
Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins	58
Immunogenomic cancer evolution: A framework to understand cancer immunosuppression	57
Overexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironment	57
T regs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis	57
XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells	56
Lung dendritic cells migrate to the spleen to prime long-lived TCF1 hi memory CD8 + T cell precursors after influenza infection	56
Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection	56
Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells	55
Intratumoral immunotherapy relies on B and T cell collaboration	54
Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood	54
Allergic airway recall responses require IL-9 from resident memory CD4 + T cells	53
NK-like CD8 + γδ T cells are expanded in persistent Mycobacterium tuberculosis infection	53
Pharmacological activation of STING blocks SARS-CoV-2 infection	52
Metabolic challenges and interventions in CAR T cell therapy	52
Gasdermin D–mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma	52
CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques	51
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses	51
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity	50
Operation Nasal Vaccine—Lightning speed to counter COVID-19	50
Oncogenic KRAS drives immunosuppression of colorectal cancer by impairing DDX60-mediated dsRNA accumulation and viral mimicry	50
Local IL-23 is required for proliferation and retention of skin-resident memory T H 17 cells	50
Activation of CD81 + skin ILC2s by cold-sensing TRPM8 + neuron-derived signals maintains cutaneous thermal homeostasis	49
TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells	49
LXR signaling controls homeostatic dendritic cell maturation	49
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein	49
Assembly of a spatial circuit of T-bet–expressing T and B lymphocytes is required for antiviral humoral immunity	48
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression	47
CD4 + T cell immunity against cutaneous melanoma encompasses multifaceted MHC II–dependent responses	47
Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritis	47
IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation	47
Response to tumor-infiltrating lymphocyte adoptive therapy is associated with preexisting CD8 + T-myeloid cell networks in melanoma	47
Clonally expanded, GPR15-expressing pathogenic effector T H 2 cells are associated with eosinophilic esophagitis	47
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19	46
NK cells restrain cytotoxic CD8 + T cells in the submandibular gland via PD-1–PD-L1	45
The expanding family of T follicular regulatory cells	44
Mitochondria—More than just ATP for CTLs	44
Myeloid cell–derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement	44
B cells on the brink	44
MBPeace treaty: How myelin self-peptides broker CNS tolerance	44
Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants	43
A CHip off the old block	43
Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosis	43
Suppression of thrombospondin-1–mediated inflammaging prolongs hematopoietic health span	43
A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses	42
Only pregnant moms can do it….	42
TAM-ing the beast with IL-34 blockade	42
An ILC2-chitinase circuit restores lung homeostasis after epithelial injury	42
Everlasting first impressions in B cells	42
Antibody-mediated immunity against lung cancer goes retro	42
TCRward personalized transplant therapies	41
Neither naïve nor anergic, “autoimmune” not allergic	41
Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19	41
Listen to your gut: Antibodies against gut commensals predict type 1 diabetes onset and therapeutic responses to T cell modulation	41
Don’t FRET—Antigens in the follicle are protected from degradation	41
Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9	40
Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis	40
Encephalitis and poor neuronal death–mediated control of herpes simplex virus in human inherited RIPK3 deficiency	40
Escape from the pore	40
Single-cell dissection of human hematopoietic reconstitution after allogeneic hematopoietic stem cell transplantation	39
Persistent CAD activity in memory CD8 + T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge	39
Throwing IL-1β for a loop	39
Un-BAFFling gray matter pathology in multiple sclerosis	39
ILC2s—Bipartisan politicians in cancer	39
GFI1B specifies developmental potential of innate lymphoid cell progenitors in the lungs	38
Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients	38
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy	38

An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif	38
Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S -geranylgeranyl- l -glutathione	38
The chilling origin of germinal centers	37
CMV, MHC-E, and the quest for an unconventional AIDS vaccine	37
Selective control of transposable element expression during T cell exhaustion and anti–PD-1 treatment	37
The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity	37
Dampening type 2 properties of group 2 innate lymphoid cells by a gammaherpesvirus infection reprograms alveolar macrophages	37
Immunization with germ line–targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques	37
Context-dependent role of group 3 innate lymphoid cells in mucosal protection	37
Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus	36
CD36 family members are TCR-independent ligands for CD1 antigen–presenting molecules	36
Vaccine-driven lung TRM cells provide immunity against Klebsiella via fibroblast IL-17R signaling	36
Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements	36
Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity	36
Apolipoprotein E receptor 2 deficiency decreases endothelial adhesion of monocytes and protects against autoimmune encephalomyelitis	36
Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression	36
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication	36
A Stk4-Foxp3–NF-κB p65 transcriptional complex promotes T reg cell activation and homeostasis	36
Erratum for the Research Article “Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements” by M. Burbage et al.	36
Expansion of tumor-reactive CD8 + T cell clonotypes occurs in the spleen in response to immune checkpoint blockade	35
BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype	35
The expansion of human T-bet high CD21 low B cells is T cell dependent	35
Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes	35
Cytolytic CD8 + T cells infiltrate germinal centers to limit ongoing HIV replication in spontaneous controller lymph nodes	35
All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages	35
Human plasmacytoid dendritic cells mount a distinct antiviral response to virus-infected cells	35
Regulatory T cells shield muscle mitochondria from interferon-γ–mediated damage to promote the beneficial effects of exercise	34
A circulating subset of iNKT cells mediates antitumor and antiviral immunity	34
Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation	34
LITAF protects against pore-forming protein–induced cell death by promoting membrane repair	34
CD103 fate mapping reveals that intestinal CD103−tissue-resident memory T cells are the primary responders to secondary infection	34
Transmembrane domain–driven PD-1 dimers mediate T cell inhibition	34
MHC heterozygosity limits T cell receptor variability in CD4 T cells	34
Single-cell deletion analyses show control of pro–T cell developmental speed and pathways by Tcf7, Spi1, Gata3, Bcl11a, Erg, and Bcl11b	33
In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 + T H 1 cell response	33
Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2	33
Atypical B cells up-regulate costimulatory molecules during malaria and secrete antibodies with T follicular helper cell support	33
Pulmonary BCG induces lung-resident macrophage activation and confers long-term protection against tuberculosis	33
Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation	32
BCL6 promotes a stem-like CD8 + T cell program in cancer via antagonizing BLIMP1	32
Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease	32
Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization	32
A common framework of monocyte-derived macrophage activation	32
SARS-CoV-2 epitope–specific CD4 + memory T cell responses across COVID-19 disease severity and antibody durability	32
KIR3DS1 directs NK cell–mediated protection against human adenovirus infections	31
T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens	31
Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation	31
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection	31
Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants	31
CD8 + T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19	31
Heart failure promotes multimorbidity through innate immune memory	30
Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche	30
NLRP3 inflammasome activation triggers gasdermin D–independent inflammation	30
MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles	30
Hexokinase dissociation from mitochondria promotes oligomerization of VDAC that facilitates NLRP3 inflammasome assembly and activation	30
ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer	30
Alternative splicing of GSDMB modulates killer lymphocyte–triggered pyroptosis	30
Human γδ T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2	30
NF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity	29
Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation	29
SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19	29
A mast cell–thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis	29
Anti–PD-1 antibodies recognizing the membrane-proximal region are PD-1 agonists that can down-regulate inflammatory diseases	29
Innate receptors with high specificity for HLA class I–peptide complexes	29
A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma	29
TWEAK functions with TNF and IL-17 on keratinocytes and is a potential target for psoriasis therapy	28
Cold-blooded vertebrates evolved organized germinal center–like structures	28
3D chromatin reprogramming primes human memory T H 2 cells for rapid recall and pathogenic dysfunction	28
SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens	28
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection	28
A reservoir of stem-like CD8 + T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response	28
Immunoglobulin A antibody composition is sculpted to bind the self gut microbiome	28
Lymph node–resident dendritic cells drive T H 2 cell development involving MARCH1	28
Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination	28
A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors	28
Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24	28
Lung epithelial cell–derived C3 protects against pneumonia-induced lung injury	28
CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection	28
Identity thieves: T cells steal CD20 from B cells but mark themselves for certain death	27
Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion	27
Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity	27
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis	27
An antibody from single human V H -rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion	27
Tumor-draining lymph nodes: At the crossroads of metastasis and immunity	27
Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8 + T cell metabolic fitness and function in tumors	26
DuraBle tolerance to CNS antigens	26
Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation	26
In a wild germinal center, what determines survival of the fittest?	26
Can we teach a tired cell new tricks?	26
GABA-cadabra: autoantibodies trick neurotransmitter receptors and induce seizures	26
Too much and not enough: tuning human primary T cell cytokine signaling networks	26
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells	26
Anti-body antibodies in COVID-19	25
Lost in post-translational modification—Dengue virus writes its own sequel	25
Three residues in the BTB domain promote a good partnership between NuRD and Thpok	25