Science Immunology

Article	Citations
Anti–immune complex antibodies are elicited during repeated immunization with HIV Env immunogens	571
Linking vaccine adjuvant mechanisms of action to function	494
Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity	441
Cis interactions between CD2 and its ligands on T cells are required for T cell activation	374
Macrophage compartmentalization in the brain and cerebrospinal fluid system	326
The gene regulatory basis of bystander activation in CD8 + T cells	320
Mast cells help organize the Peyer’s patch niche for induction of IgA responses	260
Mast cell–derived BH4 and serotonin are critical mediators of postoperative pain	252
Sulfated bile acid is a host-derived ligand for MAIT cells	243
Welcoming c-MAF to the macrophage transcription factor VAM-ily	220
T cell help induces Myc transcriptional bursts in germinal center B cells during positive selection	209
Integrin α3 promotes T H 17 cell polarization and extravasation during autoimmune neuroinflammation	190
STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy	179
The acid-sensing receptor GPR65 on tumor macrophages drives tumor growth in obesity	177
Central memory T cells are the most effective precursors of resident memory T cells in human skin	173
Ikaros is a principal regulator of Aire + mTEC homeostasis, thymic mimetic cell diversity, and central tolerance	172
Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5	166
Type 2 immune predisposition results in accelerated neutrophil aging causing susceptibility to bacterial infection	165
Resident T H 2 cells orchestrate adipose tissue remodeling at a site adjacent to infection	160
Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics	159
The Benjamin Button effect on stem cells: Reversing the clock on aging immunity	159
T regs and inflammation—bring it on!	157
The HLA advantage: Why COVID-19 benched you but not your co-worker	154
MTHFD2, metabolic mastermind of CD4 + T cell destiny	153
Plasmablasts from the past: Nostalgic B cells can’t let go	148

A T-rojan horse strategy for cancer immunotherapy	146
It’s good to have Gremlins in the zone	142
Bearing a grudge—How human natural killer cells remember past insults	140
A three-stage developmental pathway for human Vγ9Vδ2 T cells within the postnatal thymus	134
Orientation-dependent CD45 inhibition with viral and engineered ligands	134
CAR-ving away OX40L with engineered T regs	130
Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity	128
Immune recall improves antibody durability and breadth to SARS-CoV-2 variants	127
Fractionating a COVID-19 Ad5-vectored vaccine improves virus-specific immunity	126
Immune memory from SARS-CoV-2 infection in hamsters provides variant-independent protection but still allows virus transmission	125
HLA-E–restricted SARS-CoV-2–specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation	121
Selfish antibodies target auto-antigens in cancer	116
The cold truth about TCR structure	116
A SPARC-ling link to inflammaging	113
The trouble with TRIBbles: TRIB3 blocks CD8 T cell homing to colorectal cancers	112
Promoting (and targeting) alternative expression	110
A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates	109
Getting toGether in Germinal centers	106
Is one lymphocyte’s brake another lymphocyte’s gas?	101
IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells	98
Afraid of needles? Try lotion: Engineering skin commensals for vaccination	96
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation	95
RORγt-lineage APCs: The Aire apparent	94
Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8 + T cell clone size and cytotoxicity	92
DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling	92
BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13–driven tuft cell hyperplasia	91
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome	86
Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β activation	85
B cells require DOCK8 to elicit and integrate T cell help when antigen is limiting	82
Erratum for the Research Article “GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing” by J. E. Heraud-Farlow et al .	81
Antigen-presenting cell activation requires intrinsic and extrinsic STING signaling after the phagocytosis of DNA-damaged cells	81
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses	80
Cytotoxic granzyme C–expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity	80
Virtual memory T cells orchestrate extralymphoid responses conducive to resident memory	77
Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening	76
TGFβ prevents IgE-mediated allergic disease by restraining T follicular helper 2 differentiation	75
Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses	75
A tetraspecific engager armed with a non-alpha IL-2 variant harnesses natural killer cells against B cell non-Hodgkin lymphoma	72
DNMT1 inhibition reprograms T cells to NK-like cells with potent antitumor activity	72
PD-1 blockade and vaccination provide therapeutic benefit against SIV by inducing broad and functional CD8 + T cells in lymphoid tissue	70
Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response	69
SNIPR alert! Making T cells more precise killers	68
Polyclonal expansion of TCR Vβ 21.3+CD4+and CD8+T cells is a hallmark of multisystem inflammatory syndrome in children	68
Distant antimetastatic effect of enterotropic colon cancer–derived α4β7 + CD8 + T cells	65
Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome	65
GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141	64
Rgs16 promotes antitumor CD8 + T cell exhaustion	64
The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation	63
Resident regulatory T cells reflect the immune history of individual lymph nodes	63
Erratum for the Research Article “TGF-β specifies T FH versus T H 17 cell fates in murine CD4 +	63

It’s the little things in life: Lymph node microniches drive T H 2 formation in allergic asthma	62
PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors	62
Removing “flavor” from pathogenic antibodies hits a therapeutic sweet spot	62
cGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation	61
SARS-CoV-2 JN.1 variant evasion of IGHV3-53/3-66 B cell germlines	60
IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage	59
ExtrathymicAire-expressing cells support maternal-fetal tolerance	58
Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins	58
Myeloid cell tropism enables MHC-E–restricted CD8 + T cell priming and vaccine efficacy by the RhCMV/SIV vaccine	58
A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity	58
Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA	58
AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans	58
Pannexin 1 drives efficient epithelial repair after tissue injury	58
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation	58
Noncanonical MAVS signaling restrains dendritic cell–driven antitumor immunity by inhibiting IL-12	58
Immunogenomic cancer evolution: A framework to understand cancer immunosuppression	57
Overexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironment	57
T regs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis	57
XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells	56
Lung dendritic cells migrate to the spleen to prime long-lived TCF1 hi memory CD8 + T cell precursors after influenza infection	56
Of bats and men: Immunomodulatory treatment options for COVID-19 guided by the immunopathology of SARS-CoV-2 infection	56
Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells	55
Intratumoral immunotherapy relies on B and T cell collaboration	54
Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood	54
Allergic airway recall responses require IL-9 from resident memory CD4 + T cells	53
NK-like CD8 + γδ T cells are expanded in persistent Mycobacterium tuberculosis infection	53
Metabolic challenges and interventions in CAR T cell therapy	52
Gasdermin D–mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma	52
Pharmacological activation of STING blocks SARS-CoV-2 infection	52
CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques	51
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses	51
Operation Nasal Vaccine—Lightning speed to counter COVID-19	50
Oncogenic KRAS drives immunosuppression of colorectal cancer by impairing DDX60-mediated dsRNA accumulation and viral mimicry	50
Local IL-23 is required for proliferation and retention of skin-resident memory T H 17 cells	50
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity	50
Activation of CD81 + skin ILC2s by cold-sensing TRPM8 + neuron-derived signals maintains cutaneous thermal homeostasis	49
TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells	49
LXR signaling controls homeostatic dendritic cell maturation	49
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein	49
Assembly of a spatial circuit of T-bet–expressing T and B lymphocytes is required for antiviral humoral immunity	48
A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression	47
CD4 + T cell immunity against cutaneous melanoma encompasses multifaceted MHC II–dependent responses	47
Clonally expanded CD38 hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritis	47
IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation	47
Response to tumor-infiltrating lymphocyte adoptive therapy is associated with preexisting CD8 + T-myeloid cell networks in melanoma	47
Clonally expanded, GPR15-expressing pathogenic effector T H 2 cells are associated with eosinophilic esophagitis	47
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19	46
NK cells restrain cytotoxic CD8 + T cells in the submandibular gland via PD-1–PD-L1	45
The expanding family of T follicular regulatory cells	44
Mitochondria—More than just ATP for CTLs	44
Myeloid cell–derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement	44
B cells on the brink	44
MBPeace treaty: How myelin self-peptides broker CNS tolerance	44
Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type–dependent effects of disease-risk variants	43
A CHip off the old block	43
Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosis	43
Suppression of thrombospondin-1–mediated inflammaging prolongs hematopoietic health span	43
Only pregnant moms can do it….	42
TAM-ing the beast with IL-34 blockade	42
An ILC2-chitinase circuit restores lung homeostasis after epithelial injury	42
Everlasting first impressions in B cells	42
Antibody-mediated immunity against lung cancer goes retro	42
A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses	42
Neither naïve nor anergic, “autoimmune” not allergic	41
Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19	41
Listen to your gut: Antibodies against gut commensals predict type 1 diabetes onset and therapeutic responses to T cell modulation	41
Don’t FRET—Antigens in the follicle are protected from degradation	41
TCRward personalized transplant therapies	41
Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9	40
Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis	40
Encephalitis and poor neuronal death–mediated control of herpes simplex virus in human inherited RIPK3 deficiency	40
Escape from the pore	40
Single-cell dissection of human hematopoietic reconstitution after allogeneic hematopoietic stem cell transplantation	39
Persistent CAD activity in memory CD8 + T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge	39
Throwing IL-1β for a loop	39
Un-BAFFling gray matter pathology in multiple sclerosis	39
ILC2s—Bipartisan politicians in cancer	39
GFI1B specifies developmental potential of innate lymphoid cell progenitors in the lungs	38
Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients	38
Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy	38

An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif	38
Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S -geranylgeranyl- l -glutathione	38
The chilling origin of germinal centers	37
CMV, MHC-E, and the quest for an unconventional AIDS vaccine	37
Selective control of transposable element expression during T cell exhaustion and anti–PD-1 treatment	37
The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity	37
Dampening type 2 properties of group 2 innate lymphoid cells by a gammaherpesvirus infection reprograms alveolar macrophages	37
Immunization with germ line–targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques	37
Context-dependent role of group 3 innate lymphoid cells in mucosal protection	37
Vaccine-driven lung TRM cells provide immunity against Klebsiella via fibroblast IL-17R signaling	36
Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements	36
Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity	36
Apolipoprotein E receptor 2 deficiency decreases endothelial adhesion of monocytes and protects against autoimmune encephalomyelitis	36
Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression	36
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication	36
A Stk4-Foxp3–NF-κB p65 transcriptional complex promotes T reg cell activation and homeostasis	36
Erratum for the Research Article “Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements” by M. Burbage et al.	36
Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus	36
CD36 family members are TCR-independent ligands for CD1 antigen–presenting molecules	36