OOIR: Observatory of International Research

Papers

(The median citation count of SLAS Discovery is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Outline and background for the EU-OS solubility prediction challenge	176
POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening	70
FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery	54
Bioassay protocol metadata annotation: Proposed standards adoption	54
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei	40
Ex vivo discovery of synergistic drug combinations for hematologic malignancies	38
Standards for reporting optical biosensor experiments (STROBE): Improving standards in the reporting of optical biosensor-based data in the literature	36
Genetically encoded fluorogenic RNA-based bioluminescence resonance energy transfer (BRET) sensors for cellular imaging and target detection	26
Protocol for 3D screening of lung cancer spheroids using natural products	25
HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin	24
Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay	24
Emerging drug discovery ecosystems	18
Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components	18
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling	17
Nanobodies: A Game-Changer in Cell-Mediated Immunotherapy for Cancer	17
Temperature-related intensity change (TRIC)-based high throughput screening platform for the discovery of CHI3L1-targeted small molecules	16
Role Of Vaccines Against COVID-19 Pandemic	16
Repurposing drug screen for the identification of helicase inhibitors from viruses of pandemic concern	16
FocA: A deep learning tool for reliable, near-real-time imaging focus analysis in automated cell assay pipelines	15
Drug repurposing screen for the rare disease ataxia-telangiectasia	15
Patient derived glioma stem cell spheroid reporter assays for live cell high content analysis	15
Screening for molecular glues – Challenges and opportunities	14
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice	14
Comparative analysis of antibody-mediated loss-of-function versus gene knock-out and knock-down	14
Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors	13

In Memoriam	13
Overcoming a false-positive mechanism in RapidFire MRM-based high throughput screening	12
High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals	12
Protocol to develop A 3D tumor model for drug testing applications	12
High-Throughput cell-based immunofluorescence assays against influenza	11
Highly scalable arrayed CRISPR mediated gene silencing in primary lung small airway epithelial cells	11
Bonferroni’s method, not Tukey’s, should be used to control the total number of false positives when making multiple pairwise comparisons in experiments with few replicates	10
Development of a live cell assay for the zinc transporter ZnT8	10
An MRC-5 cell based high-throughput, high-content imaging assay to identify hits against Trypanosoma cruzi intracellular parasites	10
A perspective on the discovery of enzyme activators	10
VOC analysis for rapid, early detection of bacteria, mold, and mycoplasma in cell and tissue cultures	9
Automated high-throughput, high-content 3D imaging of intact pancreatic islets	9
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch	9
Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate canc	9
A high throughput assay to identify modulators of Death Receptor 3 (DR3)	9
3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons	9
Identification of tau-tubulin kinase 1 inhibitors by microfluidics-based mobility shift assay from a kinase inhibitor library	9
Publisher's Note	9
A robust CETSA data analysis automation workflow for routine screening	9
Temperature-related intensity change (TRIC)-based high-throughput screening enables the discovery of small molecule CD28 binders	9
Corrigendum to “Varieties of Interactions of anti-CD133 Aptamers with Cell Cultures from Patient Glioblastoma” [SLAS Discov. 2024 Nov 16;29(8):100195]	9
NF-kB oscillation profiles decode response to anti-EGFR monoclonal antibodies	9
A scalable human gut-immune co-culture model for evaluating inflammatory bowel disease anti-inflammatory therapies	9
SLAS discovery - special issue - biomolecular condensate drug discovery	9
Creating a more strategic small molecule biophysical hit characterization workflow	8
An overview of drugging the bacterial cytoskeleton, rod, and divisome systems	8
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant	8
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	8
Using chemical and biological data to predict drug toxicity	8
WITHDRAWN: Towards robotic laboratory automation Plug & play: Survey and concept proposal on teaching-free robot integration with the lapp digital twin	7
Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma	7
Protocol for kinetic mode potassium channel assays on common plate readers and microscopes	7
Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays	7
Protocols in drug discovery	7
SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening	7
Binder2030: a quantitative membrane proteome binding dataset enabling AI-driven drug discovery	7
Absolute quantification of Neuron-specific enolase based on surface plasmon resonance	7
Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell models	7
Application of human iPSC-derived macrophages in a miniaturized high-content-imaging-based efferocytosis assay	7
Towards Label-free detection of viral disease agents through their cell surface proteins: Rapid screening SARS-CoV-2 in biological specimens	7
WITHDRAWN: Digital microfluidics as an emerging tool for bacterial protocols	7
New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase	7
Characterisation of high throughput screening outputs for small molecule degrader discovery	7
High-throughput screening of ALS patient iPSC-derived spinal motor neurons identifies novel compounds that increase neurofilament light chain expression	7
Genome-scale functional genomics screening highlights genes impacting protein fucosylation in Chinese hamster ovary cells	6
Robustness of NanoBiT luciferase complementation technology in the presence of widely used kinase inhibitors	6
High-throughput screening identifies non-nucleoside inhibitors of the SARS-CoV-2 polymerase with novel mechanisms	6
Antimicrobial resistance: Linking molecular mechanisms to public health impact	6
Combinatorial screen with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids	6
A biochemical screening platform to target chromatin states using condensates as a tool	6

MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling	6
Corelet™ platform: Precision high throughput screening for targeted drug discovery of biomolecular condensates	5
High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS	5
Optimising cell-based bioassays via integrated design of experiments (ixDoE) - A practical guide	5
Drug discovery efforts at George Mason University	5
High-throughput approaches to uncover synergistic drug combinations in leukemia	5
High throughput screening for drugs that inhibit 3C-like protease in SARS-CoV-2	5
Adipocyte-based high throughput screening for anti-obesity drug discovery: Current status and future perspectives	5
Graph neural networks for the identification of novel inhibitors of a small RNA	5
Validation, optimization, and quality assessment of a neuro-behavioral in vivo assay for phenotypic high-content evaluation of anesthetics	5
Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors	5
Development of a time-resolved fluorescence resonance energy transfer ultra-high throughput screening assay targeting SYK and FCER1G interaction	5
Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase	5
Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency	5
Compound management in a virtual research organization: The cornerstone of a reliable MMV discovery engine	5
PCIM: Learning pixel attributions via pixel-wise channel isolation mixing in high content imaging	5
Optimized scaffold-free human 3D adipose tissue organoid culture for obesity and disease modeling	5
Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ	5
Simultaneous screening for selective SARS-CoV-2, Lassa, and Machupo virus entry inhibitors	4
Alternate dyes for image-based profiling assays	4
Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction	4
Advancing the development of TRIP13 inhibitors: A high-throughput screening approach	4
Orthogonal temperature-related intensity change (TRIC) and TR-FRET as a high-throughput screening platform for the discovery of SLIT2 binders: A proof-of-concept approach	4
High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy	4
The openOCHEM consensus model is the best-performing open-source predictive model in the First EUOS/SLAS joint compound solubility challenge	4
Point-of-use, automated fabrication of a 3D human liver model supplemented with human adipose microvessels	4
Automated quality control tool for high-content imaging data by building 2D prediction intervals on reference biosignatures	4
Enhancing throughput and robustness of the fibroblast to myofibroblast transition assay	4
Optimization and calibration of 384-well kinetic Ca2+ mobilization assays for the human transient receptor potential cation channels TRPM8, TRPV1, and TRPA1	4
Development of a NanoBiT based high throughput screening assay for discovery of NOS1-NOS1AP interaction inhibitors	4
Development of a BRET based chloride biosensor for high throughput screening of KCC2 modulators	4
Mathematical relationships between control group variability and assay quality metrics	4
HTS discovery of PARP1-HPF1 complex inhibitors in cancer	4
1st EU-OPENSCREEN/SLAS data mining competition to predict compounds solubility	4
A high throughput assay for phosphoribosylformylglycinamidine synthase	4
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library	4
A multi-parametric high throughput assay for detecting beta-cell proliferation in dispersed primary islets	4
Identification of unique binding mode anti-NTF3 antibodies from a novel long VH CDR3 phage display library	4
Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors	4
The role of m6A in lipid metabolism-related diseases	4
A novel high-throughput screening strategy for targeting alpha-synuclein and other long-lived proteins	4
Magnetic three-dimensional bioprinting protocol for salivary gland mucoepidermoid carcinoma tumoroid culture	3
WITHDRAWN: Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	3
High-throughput method to analyze the cytotoxicity of CAR-T Cells in a 3D tumor spheroid model using image cytometry	3
Micro/nano topological modification of TiO2 nanotubes activates Thy-1 signaling to control osteogenic differentiation of stem cells	3
High throughput screening for SARS-CoV-2 inhibitors targeting 5 helix bundle	3
Green chemistry: Modern therapies using nanocarriers for treating rare brain cancer metastasis from colon cancer	3
Quantitative target engagement of RIPK1 in human whole blood via the cellular thermal shift assay for potential pre-clinical and clinical applications	3
Protocol for 3D drug sensitivity and resistance testing of patient-derived cancer cells in 384-well plates	3
MT1G activation in dopaminergic neurons identifies chelators and their relationships to cytotoxicity	3
BRET measurement on CCD camera-based microtiter plate readers	3
Streamlining cellular thermal shift assay for ultra-high throughput screening	3
Identification of a small molecule CAPON binder using affinity selection-mass spectrometry screening	3
Identification of chemicals breaking the USP8 interaction with its endocytic substrate CHMP1B	3
High-content immunofluorescence assay detecting PD-L1 expression changes in head and neck cancer patient-derived cultures	3
A neuronal cell-based reporter system for monitoring the activity of HDAC2	3
A mechanism of action-reflective, dual cell-based bioassay for determining the bioactivity of sclerostin-neutralizing antibodies	3
Beyond fluorescence: A critical look at AI-powered brightfield analysis for T-cell killing assays	3
Structure-activity relationships of thiadiazole agonists of the human secretin receptor	3
Corrigendum to “Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology” [SLAS Discovery, Volume 27 (2022) P140-147/2472-5552]	3
ATPase activity profiling of three human DExD/H-box RNA helicases	3
Toxicity evaluation of pharmaceutical drugs and quantum dots (QDs) using zebrafish embryos – A comprehensive review	3
Utilising acoustic mist ionisation mass spectrometry to identify redox cycling compounds in high throughput screening outputs	3
Combinatorial screen of targeted agents with the PI3K inhibitors inavolisib, alpelisib, duvelisib, and copanlisib in multi-cell type tumor spheroids	3