SLAS Discovery

Article	Citations
SLAS special issue editorial 2022: 3D cell culture approaches of microphysiologically relevant models	105
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei	69
Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay	54
Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies	45
Bioassay protocol metadata annotation: Proposed standards adoption	43
Outline and background for the EU-OS solubility prediction challenge	42
POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening	37
Protocol for 3D screening of lung cancer spheroids using natural products	36
FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery	31
Standards for reporting optical biosensor experiments (STROBE): Improving standards in the reporting of optical biosensor-based data in the literature	30
Genetically encoded fluorogenic RNA-based bioluminescence resonance energy transfer (BRET) sensors for cellular imaging and target detection	30
Ex vivo discovery of synergistic drug combinations for hematologic malignancies	28
Emerging drug discovery ecosystems	27
An efficient and scalable data analysis solution for automated electrophysiology platforms	26
Drug repurposing screen for the rare disease ataxia-telangiectasia	24
Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components	23
The Impact of Assay Design on Medicinal Chemistry: Case Studies	22
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening	21
Automation of Organoid Cultures: Current Protocols and Applications	21
Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease	21
Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells	21
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling	20
Role Of Vaccines Against COVID-19 Pandemic	19
Functional and Pharmacological Comparison of Human and Mouse Na+/Taurocholate Cotransporting Polypeptide (NTCP)	18
HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin	18

Nanobodies: A Game-Changer in Cell-Mediated Immunotherapy for Cancer	17
FocA: A deep learning tool for reliable, near-real-time imaging focus analysis in automated cell assay pipelines	16
Patient derived glioma stem cell spheroid reporter assays for live cell high content analysis	16
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice	15
Screening for molecular glues – Challenges and opportunities	14
High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals	13
In Memoriam	13
Overcoming a false-positive mechanism in RapidFire MRM-based high throughput screening	13
Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors	13
Highly scalable arrayed CRISPR mediated gene silencing in primary lung small airway epithelial cells	12
Screening for modulators of autism spectrum disorder using induced human neurons	12
Flexible Fitting of PROTAC Concentration–Response Curves with Changepoint Gaussian Processes	12
Protocol to develop A 3D tumor model for drug testing applications	12
High-Throughput cell-based immunofluorescence assays against influenza	11
A perspective on the discovery of enzyme activators	11
Development of a live cell assay for the zinc transporter ZnT8	11
Bonferroni’s method, not Tukey’s, should be used to control the total number of false positives when making multiple pairwise comparisons in experiments with few replicates	11
High-throughput screening for identifying acetylcholinesterase inhibitors: Insights on novel inhibitors and the use of liver microsomes	10
NF-kB oscillation profiles decode response to anti-EGFR monoclonal antibodies	10
Deep Learning Image Analysis of High-Throughput Toxicology Assay Images	10
Identification of tau-tubulin kinase 1 inhibitors by microfluidics-based mobility shift assay from a kinase inhibitor library	10
Corrigendum to “Varieties of Interactions of anti-CD133 Aptamers with Cell Cultures from Patient Glioblastoma” [SLAS Discov. 2024 Nov 16;29(8):100195]	10
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch	9
A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.	9
Automated high-throughput, high-content 3D imaging of intact pancreatic islets	9
Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine	9
3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons	9
A scalable human gut-immune co-culture model for evaluating inflammatory bowel disease anti-inflammatory therapies	8
Phenotypic Screening Following Transcriptomic Deconvolution to Identify Transcription Factors Mediating Axon Growth Induced by a Kinase Inhibitor	8
Identification of potent small molecule inhibitors of SARS-CoV-2 entry	8
A robust CETSA data analysis automation workflow for routine screening	8
Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate canc	8
Temperature-related intensity change (TRIC)-based high-throughput screening enables the discovery of small molecule CD28 binders	8
Publisher's Note	8
Creating a more strategic small molecule biophysical hit characterization workflow	8
Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	8
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	7
WITHDRAWN: Digital microfluidics as an emerging tool for bacterial protocols	7
New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase	7
Using chemical and biological data to predict drug toxicity	7
Absolute quantification of Neuron-specific enolase based on surface plasmon resonance	7
Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays	7
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant	7
SLAS Discovery – The Next Generation of Research	7
Protocol for kinetic mode potassium channel assays on common plate readers and microscopes	7
Protocols in drug discovery	6
Combinatorial screen with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids	6
Development of a continuous assay for high throughput screening to identify inhibitors of the purine salvage pathway in Plasmodium falciparum	6
Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell models	6
Application of human iPSC-derived macrophages in a miniaturized high-content-imaging-based efferocytosis assay	6

Characterisation of high throughput screening outputs for small molecule degrader discovery	6
WITHDRAWN: Towards robotic laboratory automation Plug & play: Survey and concept proposal on teaching-free robot integration with the lapp digital twin	6
An overview of drugging the bacterial cytoskeleton, rod, and divisome systems	6
Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma	6
A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency	6
Efficiency Improvements and Discovery of New Substrates for a SARS-CoV-2 Main Protease FRET Assay	6
SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening	6
Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology	6
Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Man	6
Towards Label-free detection of viral disease agents through their cell surface proteins: Rapid screening SARS-CoV-2 in biological specimens	6
A biochemical screening platform to target chromatin states using condensates as a tool	5
Genome-scale functional genomics screening highlights genes impacting protein fucosylation in Chinese hamster ovary cells	5
Thank You to Our 2021 Reviewers	5
Robustness of NanoBiT luciferase complementation technology in the presence of widely used kinase inhibitors	5
DeepTI: A deep learning-based framework decoding tumor-immune interactions for precision immunotherapy in oncology	5
Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ	5
NMR Reporter Assays for the Quantification of Weak-Affinity Receptor–Ligand Interactions	5
MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling	5
Antimicrobial resistance: Linking molecular mechanisms to public health impact	5
Addressing Unusual Assay Variability with Robust Statistics	5
Identification of Potential Modulators of the RGS7/Gβ5/R7BP Complex	5
Development of a time-resolved fluorescence resonance energy transfer ultra-high throughput screening assay targeting SYK and FCER1G interaction	4
High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS	4
Fast Mek1 Hit Identification with TRIC Technology Correlates Well with Other Biophysical Methods	4
The SLAS Discovery Editor's Top 10 for 2021	4
Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase	4
High throughput screening for drugs that inhibit 3C-like protease in SARS-CoV-2	4
Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors	4
Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors	4
Adipocyte-based high throughput screening for anti-obesity drug discovery: Current status and future perspectives	4
Compound management in a virtual research organization: The cornerstone of a reliable MMV discovery engine	4
Corelet™ platform: Precision high throughput screening for targeted drug discovery of biomolecular condensates	4
A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions	4
Optimized scaffold-free human 3D adipose tissue organoid culture for obesity and disease modeling	4
High-throughput approaches to uncover synergistic drug combinations in leukemia	4
Drug discovery efforts at George Mason University	4
Optimization and calibration of 384-well kinetic Ca2+ mobilization assays for the human transient receptor potential cation channels TRPM8, TRPV1, and TRPA1	3
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors	3
Enhancing throughput and robustness of the fibroblast to myofibroblast transition assay	3
Identification of unique binding mode anti-NTF3 antibodies from a novel long VH CDR3 phage display library	3
Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection	3
Epithelial 3D-spheroids as a tool to study air pollutant-induced lung pathology	3
High throughput screening for compounds to the orphan nuclear receptor NR2F6	3
Deep phenotyping of surface stimulatory and inhibitory co-receptors on cancer-resident T and NK cells reveals cell subsets within the tumor-reactive CTL population that are uniquely defined by NKG2A e	3
Point-of-use, automated fabrication of a 3D human liver model supplemented with human adipose microvessels	3
Development of a BRET based chloride biosensor for high throughput screening of KCC2 modulators	3
Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction	3
Alternate dyes for image-based profiling assays	3
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library	3
Grouping concentration response curves by features of their shape to aid rapid and consistent analysis of large data sets in high throughput screens	3
Fragment-based screening: A new paradigm for ligand and target discovery	3
Simultaneous screening for selective SARS-CoV-2, Lassa, and Machupo virus entry inhibitors	3
A “Failed” Assay Development for the Discovery of Rescuing Small Molecules from the Radiation Damage	3
Mathematical relationships between control group variability and assay quality metrics	3
Treating Cells as Reagents to Design Reproducible Assays	3
Orthogonal temperature-related intensity change (TRIC) and TR-FRET as a high-throughput screening platform for the discovery of SLIT2 binders: A proof-of-concept approach	3
A high throughput assay for phosphoribosylformylglycinamidine synthase	3
Lead identification using 3D models of pancreatic cancer	3
A multi-parametric high throughput assay for detecting beta-cell proliferation in dispersed primary islets	3
Optimising cell-based bioassays via integrated design of experiments (ixDoE) - A practical guide	3
Graph neural networks for the identification of novel inhibitors of a small RNA	3
The openOCHEM consensus model is the best-performing open-source predictive model in the First EUOS/SLAS joint compound solubility challenge	3
Profiling oncogenic KRAS mutant drugs with a cell-based Lumit p-ERK immunoassay	3
Automated quality control tool for high-content imaging data by building 2D prediction intervals on reference biosignatures	3
Development of an Image-Based HCS-Compatible Method for Endothelial Barrier Function Assessment	3
Advancing the development of TRIP13 inhibitors: A high-throughput screening approach	3
A mechanism of action-reflective, dual cell-based bioassay for determining the bioactivity of sclerostin-neutralizing antibodies	2
Micro/nano topological modification of TiO2 nanotubes activates Thy-1 signaling to control osteogenic differentiation of stem cells	2
Corrigendum to “Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology” [SLAS Discovery, Volume 27 (2022) P140-147/2472-5552]	2
Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors	2
1st EU-OPENSCREEN/SLAS data mining competition to predict compounds solubility	2
ATPase activity profiling of three human DExD/H-box RNA helicases	2
High-Throughput Affinity Selection Mass Spectrometry Using SAMDI-MS to Identify Small-Molecule Binders of the Human Rhinovirus 3C Protease	2
Utilising acoustic mist ionisation mass spectrometry to identify redox cycling compounds in high throughput screening outputs	2
Assay Guidance Manual for Drug Discovery: Robust or Go Bust	2
Green chemistry: Modern therapies using nanocarriers for treating rare brain cancer metastasis from colon cancer	2
WITHDRAWN: Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	2
High throughput screening for SARS-CoV-2 inhibitors targeting 5 helix bundle	2
High-throughput method to analyze the cytotoxicity of CAR-T Cells in a 3D tumor spheroid model using image cytometry	2
The role of m6A in lipid metabolism-related diseases	2

BRET measurement on CCD camera-based microtiter plate readers	2
DNA methylation-induced ablation of miR-133a accelerates cancer aggressiveness in glioma through upregulating peroxisome proliferator-activated receptor γ	2
Quantitative target engagement of RIPK1 in human whole blood via the cellular thermal shift assay for potential pre-clinical and clinical applications	2
Identification of chemicals breaking the USP8 interaction with its endocytic substrate CHMP1B	2
Combinatorial screen of targeted agents with the PI3K inhibitors inavolisib, alpelisib, duvelisib, and copanlisib in multi-cell type tumor spheroids	2
MT1G activation in dopaminergic neurons identifies chelators and their relationships to cytotoxicity	2
HTS discovery of PARP1-HPF1 complex inhibitors in cancer	2
A novel high-throughput screening strategy for targeting alpha-synuclein and other long-lived proteins	2
High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy	2
Magnetic three-dimensional bioprinting protocol for salivary gland mucoepidermoid carcinoma tumoroid culture	2
Structure-activity relationships of thiadiazole agonists of the human secretin receptor	2
Protocol for 3D drug sensitivity and resistance testing of patient-derived cancer cells in 384-well plates	2
Novel beta-glucocerebrosidase chaperone compounds identified from cell-based screening reduce pathologically accumulated glucosylsphingosine in iPS-derived neuronal cells	2
A neuronal cell-based reporter system for monitoring the activity of HDAC2	2
Toxicity evaluation of pharmaceutical drugs and quantum dots (QDs) using zebrafish embryos – A comprehensive review	2