OOIR: Observatory of International Research

Papers

(The median citation count of SLAS Discovery is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
SLAS special issue editorial 2022: 3D cell culture approaches of microphysiologically relevant models	95
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei	67
Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay	51
Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies	44
Bioassay protocol metadata annotation: Proposed standards adoption	42
Outline and background for the EU-OS solubility prediction challenge	41
Standards for reporting optical biosensor experiments (STROBE): Improving standards in the reporting of optical biosensor-based data in the literature	36
POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening	31
Protocol for 3D screening of lung cancer spheroids using natural products	30
FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery	29
In Vitro Ubiquitination Platform Identifies Methyl Ellipticiniums as Ubiquitin Ligase Inhibitors	29
Emerging drug discovery ecosystems	26
Ex vivo discovery of synergistic drug combinations for hematologic malignancies	26
An efficient and scalable data analysis solution for automated electrophysiology platforms	25
Drug repurposing screen for the rare disease ataxia-telangiectasia	24
Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components	22
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling	21
Role Of Vaccines Against COVID-19 Pandemic	21
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening	21
Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells	21
The Impact of Assay Design on Medicinal Chemistry: Case Studies	20
Functional and Pharmacological Comparison of Human and Mouse Na+/Taurocholate Cotransporting Polypeptide (NTCP)	20
HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin	19
Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease	18
Automation of Organoid Cultures: Current Protocols and Applications	18

Nanobodies: A Game-Changer in Cell-Mediated Immunotherapy for Cancer	17
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice	17
Screening for molecular glues – Challenges and opportunities	17
Patient derived glioma stem cell spheroid reporter assays for live cell high content analysis	15
In Memoriam	15
FocA: A deep learning tool for reliable, near-real-time imaging focus analysis in automated cell assay pipelines	15
Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors	14
Protocol to develop A 3D tumor model for drug testing applications	13
High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals	13
High-Throughput cell-based immunofluorescence assays against influenza	12
Screening for modulators of autism spectrum disorder using induced human neurons	12
Flexible Fitting of PROTAC Concentration–Response Curves with Changepoint Gaussian Processes	12
A perspective on the discovery of enzyme activators	12
Highly scalable arrayed CRISPR mediated gene silencing in primary lung small airway epithelial cells	12
High-throughput screening for identifying acetylcholinesterase inhibitors: Insights on novel inhibitors and the use of liver microsomes	11
NF-kB oscillation profiles decode response to anti-EGFR monoclonal antibodies	11
Development of a live cell assay for the zinc transporter ZnT8	11
Identification of tau-tubulin kinase 1 inhibitors by microfluidics-based mobility shift assay from a kinase inhibitor library	11
Corrigendum to “Varieties of Interactions of anti-CD133 Aptamers with Cell Cultures from Patient Glioblastoma” [SLAS Discov. 2024 Nov 16;29(8):100195]	11
3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons	10
Automated high-throughput, high-content 3D imaging of intact pancreatic islets	10
Deep Learning Image Analysis of High-Throughput Toxicology Assay Images	9
A robust CETSA data analysis automation workflow for routine screening	9
A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.	9
Publisher's Note	9
Creating a more strategic small molecule biophysical hit characterization workflow	9
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch	9
Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine	9
Phenotypic Screening Following Transcriptomic Deconvolution to Identify Transcription Factors Mediating Axon Growth Induced by a Kinase Inhibitor	9
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	8
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant	8
Identification of potent small molecule inhibitors of SARS-CoV-2 entry	8
Using chemical and biological data to predict drug toxicity	8
Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	8
SLAS Discovery – The Next Generation of Research	8
A Scalable Human Gut-Immune Co-Culture Model for Evaluating Inflammatory Bowel Disease Anti-Inflammatory Therapies	8
Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate canc	8
New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase	7
Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology	7
A High-Content Screening Assay for Small Molecules That Stabilize Mutant Triose Phosphate Isomerase (TPI) as Treatments for TPI Deficiency	7
WITHDRAWN: Digital microfluidics as an emerging tool for bacterial protocols	7
Absolute quantification of Neuron-specific enolase based on surface plasmon resonance	7
Development of a continuous assay for high throughput screening to identify inhibitors of the purine salvage pathway in Plasmodium falciparum	7
Protocol for kinetic mode potassium channel assays on common plate readers and microscopes	7
Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma	7
MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling	6
Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell models	6
Combinatorial screen with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids	6
Protocols in drug discovery	6
Robustness of NanoBiT luciferase complementation technology in the presence of widely used kinase inhibitors	6

A biochemical screening platform to target chromatin states using condensates as a tool	6
Discovery of Novel HCN4 Blockers with Unique Blocking Kinetics and Binding Properties	6
Towards Label-free detection of viral disease agents through their cell surface proteins: Rapid screening SARS-CoV-2 in biological specimens	6
Application of human iPSC-derived macrophages in a miniaturized high-content-imaging-based efferocytosis assay	6
Development of a High-Throughput, Compound-Multiplexed Fluorescence Polarization Assay to Identify ATG5–ATG16L1 Protein–Protein Interaction Inhibitors	6
Genome-scale functional genomics screening highlights genes impacting protein fucosylation in Chinese hamster ovary cells	6
Efficiency Improvements and Discovery of New Substrates for a SARS-CoV-2 Main Protease FRET Assay	6
Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Man	6
WITHDRAWN: Towards robotic laboratory automation Plug & play: Survey and concept proposal on teaching-free robot integration with the lapp digital twin	6
SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening	6
Characterisation of high throughput screening outputs for small molecule degrader discovery	6
Identification of Potential Modulators of the RGS7/Gβ5/R7BP Complex	5
Epithelial Barrier Integrity Profiling: Combined Approach Using Cellular Junctional Complex Imaging and Transepithelial Electrical Resistance	5
Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ	5
High throughput screening for drugs that inhibit 3C-like protease in SARS-CoV-2	5
A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions	5
Addressing Unusual Assay Variability with Robust Statistics	5
Antimicrobial resistance: Linking molecular mechanisms to public health impact	5
NMR Reporter Assays for the Quantification of Weak-Affinity Receptor–Ligand Interactions	5
Corelet™ platform: Precision high throughput screening for targeted drug discovery of biomolecular condensates	5
High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS	5
DeepTI: A deep learning-based framework decoding tumor-immune interactions for precision immunotherapy in oncology	5
Thank You to Our 2021 Reviewers	5
Development of a time-resolved fluorescence resonance energy transfer ultra-high throughput screening assay targeting SYK and FCER1G interaction	5
Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors	5
Optimized scaffold-free human 3D adipose tissue organoid culture for obesity and disease modeling	4
Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase	4
Optimising cell-based bioassays via integrated design of experiments (ixDoE) - A practical guide	4
Graph neural networks for the identification of novel inhibitors of a small RNA	4
The SLAS Discovery Editor's Top 10 for 2021	4
Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors	4
Fast Mek1 Hit Identification with TRIC Technology Correlates Well with Other Biophysical Methods	4
Compound management in a virtual research organization: The cornerstone of a reliable MMV discovery engine	4
Grouping concentration response curves by features of their shape to aid rapid and consistent analysis of large data sets in high throughput screens	4
Adipocyte-based high throughput screening for anti-obesity drug discovery: Current status and future perspectives	4
High-throughput approaches to uncover synergistic drug combinations in leukemia	4
A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications	4
Drug discovery efforts at George Mason University	4
A high throughput assay for phosphoribosylformylglycinamidine synthase	4
A “Failed” Assay Development for the Discovery of Rescuing Small Molecules from the Radiation Damage	3
Mathematical relationships between control group variability and assay quality metrics	3
Development of an Image-Based HCS-Compatible Method for Endothelial Barrier Function Assessment	3
A multi-parametric high throughput assay for detecting beta-cell proliferation in dispersed primary islets	3
Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction	3
Enhancing throughput and robustness of the fibroblast to myofibroblast transition assay	3
Lead identification using 3D models of pancreatic cancer	3
Simultaneous screening for selective SARS-CoV-2, Lassa, and Machupo virus entry inhibitors	3
Treating Cells as Reagents to Design Reproducible Assays	3
Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors	3
Profiling oncogenic KRAS mutant drugs with a cell-based Lumit p-ERK immunoassay	3
Brief Guide: Experimental Strategies for High-Quality Hit Selection from Small-Molecule Screening Campaigns	3
Advancing the development of TRIP13 inhibitors: A high-throughput screening approach	3
Optimization and calibration of 384-well kinetic Ca2+ mobilization assays for the human transient receptor potential cation channels TRPM8, TRPV1, and TRPA1	3
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library	3
Identification of unique binding mode anti-NTF3 antibodies from a novel long VH CDR3 phage display library	3
Point-of-use, automated fabrication of a 3D human liver model supplemented with human adipose microvessels	3
1st EU-OPENSCREEN/SLAS data mining competition to predict compounds solubility	3
High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy	3
High throughput screening for compounds to the orphan nuclear receptor NR2F6	3
Deep phenotyping of surface stimulatory and inhibitory co-receptors on cancer-resident T and NK cells reveals cell subsets within the tumor-reactive CTL population that are uniquely defined by NKG2A e	3
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors	3
Epithelial 3D-spheroids as a tool to study air pollutant-induced lung pathology	3
Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection	3
Automated quality control tool for high-content imaging data by building 2D prediction intervals on reference biosignatures	3
Fragment-based screening: A new paradigm for ligand and target discovery	3
Corrigendum to “Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology” [SLAS Discovery, Volume 27 (2022) P140-147/2472-5552]	3
High-throughput method to analyze the cytotoxicity of CAR-T Cells in a 3D tumor spheroid model using image cytometry	3
The openOCHEM consensus model is the best-performing open-source predictive model in the First EUOS/SLAS joint compound solubility challenge	3