OOIR: Observatory of International Research

Papers

(The median citation count of SLAS Discovery is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Bioassay protocol metadata annotation: Proposed standards adoption	142
Protocol for 3D screening of lung cancer spheroids using natural products	47
Genetically encoded fluorogenic RNA-based bioluminescence resonance energy transfer (BRET) sensors for cellular imaging and target detection	42
Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies	41
POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening	32
FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery	31
SLAS special issue editorial 2022: 3D cell culture approaches of microphysiologically relevant models	30
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei	29
Ex vivo discovery of synergistic drug combinations for hematologic malignancies	26
Standards for reporting optical biosensor experiments (STROBE): Improving standards in the reporting of optical biosensor-based data in the literature	25
Outline and background for the EU-OS solubility prediction challenge	24
Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay	23
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling	20
Development of high-throughput lacrimal gland organoid platforms for drug discovery in dry eye disease	19
HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin	18
Emerging drug discovery ecosystems	17
Role Of Vaccines Against COVID-19 Pandemic	16
Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components	15
An efficient and scalable data analysis solution for automated electrophysiology platforms	15
Nanobodies: A Game-Changer in Cell-Mediated Immunotherapy for Cancer	15
Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells	15
Temperature-related intensity change (TRIC)-based high throughput screening platform for the discovery of CHI3L1-targeted small molecules	14
Drug repurposing screen for the rare disease ataxia-telangiectasia	14
Patient derived glioma stem cell spheroid reporter assays for live cell high content analysis	13
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice	13

FocA: A deep learning tool for reliable, near-real-time imaging focus analysis in automated cell assay pipelines	13
Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors	12
High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals	12
Comparative analysis of antibody-mediated loss-of-function versus gene knock-out and knock-down	12
Screening for molecular glues – Challenges and opportunities	12
In Memoriam	12
Development of a live cell assay for the zinc transporter ZnT8	11
Highly scalable arrayed CRISPR mediated gene silencing in primary lung small airway epithelial cells	11
Screening for modulators of autism spectrum disorder using induced human neurons	11
Overcoming a false-positive mechanism in RapidFire MRM-based high throughput screening	11
A perspective on the discovery of enzyme activators	10
Bonferroni’s method, not Tukey’s, should be used to control the total number of false positives when making multiple pairwise comparisons in experiments with few replicates	10
High-Throughput cell-based immunofluorescence assays against influenza	10
Protocol to develop A 3D tumor model for drug testing applications	10
High-throughput screening for identifying acetylcholinesterase inhibitors: Insights on novel inhibitors and the use of liver microsomes	10
NF-kB oscillation profiles decode response to anti-EGFR monoclonal antibodies	9
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch	9
Identification of tau-tubulin kinase 1 inhibitors by microfluidics-based mobility shift assay from a kinase inhibitor library	9
Corrigendum to “Varieties of Interactions of anti-CD133 Aptamers with Cell Cultures from Patient Glioblastoma” [SLAS Discov. 2024 Nov 16;29(8):100195]	9
Automated high-throughput, high-content 3D imaging of intact pancreatic islets	9
Deep Learning Image Analysis of High-Throughput Toxicology Assay Images	8
VOC analysis for rapid, early detection of bacteria, mold, and mycoplasma in cell and tissue cultures	8
Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines	8
A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.	8
Creating a more strategic small molecule biophysical hit characterization workflow	8
3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons	8
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant	7
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	7
New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase	7
Temperature-related intensity change (TRIC)-based high-throughput screening enables the discovery of small molecule CD28 binders	7
Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate canc	7
A scalable human gut-immune co-culture model for evaluating inflammatory bowel disease anti-inflammatory therapies	7
Absolute quantification of Neuron-specific enolase based on surface plasmon resonance	7
WITHDRAWN: Digital microfluidics as an emerging tool for bacterial protocols	7
Publisher's Note	7
Using chemical and biological data to predict drug toxicity	7
Identification of potent small molecule inhibitors of SARS-CoV-2 entry	7
A robust CETSA data analysis automation workflow for routine screening	7
An overview of drugging the bacterial cytoskeleton, rod, and divisome systems	6
Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays	6
Development of a continuous assay for high throughput screening to identify inhibitors of the purine salvage pathway in Plasmodium falciparum	6
Application of human iPSC-derived macrophages in a miniaturized high-content-imaging-based efferocytosis assay	6
SLAS Discovery – The Next Generation of Research	6
Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma	6
Protocols in drug discovery	6
Combinatorial screen with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids	6
Protocol for kinetic mode potassium channel assays on common plate readers and microscopes	6
Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology	6
Characterisation of high throughput screening outputs for small molecule degrader discovery	6
Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell models	6

Towards Label-free detection of viral disease agents through their cell surface proteins: Rapid screening SARS-CoV-2 in biological specimens	5
Robustness of NanoBiT luciferase complementation technology in the presence of widely used kinase inhibitors	5
Genome-scale functional genomics screening highlights genes impacting protein fucosylation in Chinese hamster ovary cells	5
Corelet™ platform: Precision high throughput screening for targeted drug discovery of biomolecular condensates	5
A biochemical screening platform to target chromatin states using condensates as a tool	5
MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling	5
Antimicrobial resistance: Linking molecular mechanisms to public health impact	5
High throughput screening for drugs that inhibit 3C-like protease in SARS-CoV-2	5
WITHDRAWN: Towards robotic laboratory automation Plug & play: Survey and concept proposal on teaching-free robot integration with the lapp digital twin	5
DeepTI: A deep learning-based framework decoding tumor-immune interactions for precision immunotherapy in oncology	5
SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening	5
Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ	5
High-throughput screening identifies non-nucleoside inhibitors of the SARS-CoV-2 polymerase with novel mechanisms	5
Optimized scaffold-free human 3D adipose tissue organoid culture for obesity and disease modeling	4
The SLAS Discovery Editor's Top 10 for 2021	4
Graph neural networks for the identification of novel inhibitors of a small RNA	4
Automated quality control tool for high-content imaging data by building 2D prediction intervals on reference biosignatures	4
High-throughput approaches to uncover synergistic drug combinations in leukemia	4
Adipocyte-based high throughput screening for anti-obesity drug discovery: Current status and future perspectives	4
High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS	4
Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency	4
PCIM: Learning pixel attributions via pixel-wise channel isolation mixing in high content imaging	4
Validation, optimization, and quality assessment of a neuro-behavioral in vivo assay for phenotypic high-content evaluation of anesthetics	4
Compound management in a virtual research organization: The cornerstone of a reliable MMV discovery engine	4
Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors	4
Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors	4
Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase	4
Optimising cell-based bioassays via integrated design of experiments (ixDoE) - A practical guide	4
Drug discovery efforts at George Mason University	4
Identification of unique binding mode anti-NTF3 antibodies from a novel long VH CDR3 phage display library	4
Development of a time-resolved fluorescence resonance energy transfer ultra-high throughput screening assay targeting SYK and FCER1G interaction	4
A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions	4
Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction	3
Alternate dyes for image-based profiling assays	3
Lead identification using 3D models of pancreatic cancer	3
Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors	3
High throughput screening for SARS-CoV-2 inhibitors targeting 5 helix bundle	3
The role of m6A in lipid metabolism-related diseases	3
High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy	3
Mathematical relationships between control group variability and assay quality metrics	3
Epithelial 3D-spheroids as a tool to study air pollutant-induced lung pathology	3
Fragment-based screening: A new paradigm for ligand and target discovery	3
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library	3
Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection	3
Grouping concentration response curves by features of their shape to aid rapid and consistent analysis of large data sets in high throughput screens	3
Point-of-use, automated fabrication of a 3D human liver model supplemented with human adipose microvessels	3
1st EU-OPENSCREEN/SLAS data mining competition to predict compounds solubility	3
A novel high-throughput screening strategy for targeting alpha-synuclein and other long-lived proteins	3
Corrigendum to “Automation of high-throughput mRNA-seq library preparation: a robust, hands-free and time efficient methodology” [SLAS Discovery, Volume 27 (2022) P140-147/2472-5552]	3
High throughput screening for compounds to the orphan nuclear receptor NR2F6	3
Deep phenotyping of surface stimulatory and inhibitory co-receptors on cancer-resident T and NK cells reveals cell subsets within the tumor-reactive CTL population that are uniquely defined by NKG2A e	3
Simultaneous screening for selective SARS-CoV-2, Lassa, and Machupo virus entry inhibitors	3
Advancing the development of TRIP13 inhibitors: A high-throughput screening approach	3
A high throughput assay for phosphoribosylformylglycinamidine synthase	3
Enhancing throughput and robustness of the fibroblast to myofibroblast transition assay	3
Orthogonal temperature-related intensity change (TRIC) and TR-FRET as a high-throughput screening platform for the discovery of SLIT2 binders: A proof-of-concept approach	3
Micro/nano topological modification of TiO2 nanotubes activates Thy-1 signaling to control osteogenic differentiation of stem cells	3
High-throughput method to analyze the cytotoxicity of CAR-T Cells in a 3D tumor spheroid model using image cytometry	3
HTS discovery of PARP1-HPF1 complex inhibitors in cancer	3
Structure-activity relationships of thiadiazole agonists of the human secretin receptor	3
Profiling oncogenic KRAS mutant drugs with a cell-based Lumit p-ERK immunoassay	3
Optimization and calibration of 384-well kinetic Ca2+ mobilization assays for the human transient receptor potential cation channels TRPM8, TRPV1, and TRPA1	3
The openOCHEM consensus model is the best-performing open-source predictive model in the First EUOS/SLAS joint compound solubility challenge	3
Development of a BRET based chloride biosensor for high throughput screening of KCC2 modulators	3
A multi-parametric high throughput assay for detecting beta-cell proliferation in dispersed primary islets	3