OOIR: Observatory of International Research

Papers

(The TQCC of SLAS Discovery is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei	159
Ex vivo discovery of synergistic drug combinations for hematologic malignancies	56
Outline and background for the EU-OS solubility prediction challenge	51
POLARISED views and FRETting about probe modulation assays: Learning from High Throughput Screening	43
Magnetic 3D bioprinting of skeletal muscle spheroid for a spheroid-based screening assay	33
Genetically encoded fluorogenic RNA-based bioluminescence resonance energy transfer (BRET) sensors for cellular imaging and target detection	29
FLECS technology for high-throughput screening of hypercontractile cellular phenotypes in fibrosis: A function-first approach to anti-fibrotic drug discovery	24
Bioassay protocol metadata annotation: Proposed standards adoption	24
Protocol for 3D screening of lung cancer spheroids using natural products	22
Standards for reporting optical biosensor experiments (STROBE): Improving standards in the reporting of optical biosensor-based data in the literature	21
Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells	17
Nanobodies: A Game-Changer in Cell-Mediated Immunotherapy for Cancer	16
HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin	16
Emerging drug discovery ecosystems	16
Drug repurposing screen for the rare disease ataxia-telangiectasia	15
Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components	15
Role Of Vaccines Against COVID-19 Pandemic	15
An efficient and scalable data analysis solution for automated electrophysiology platforms	15
Temperature-related intensity change (TRIC)-based high throughput screening platform for the discovery of CHI3L1-targeted small molecules	14
Single-plate kinome screening in live-cells to enable highly cost-efficient kinase inhibitor profiling	14
FocA: A deep learning tool for reliable, near-real-time imaging focus analysis in automated cell assay pipelines	13
Patient derived glioma stem cell spheroid reporter assays for live cell high content analysis	13
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice	13
Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors	12
Screening for molecular glues – Challenges and opportunities	12

In Memoriam	12
Comparative analysis of antibody-mediated loss-of-function versus gene knock-out and knock-down	11
Overcoming a false-positive mechanism in RapidFire MRM-based high throughput screening	11
High-Throughput cell-based immunofluorescence assays against influenza	11
High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals	11
Development of a live cell assay for the zinc transporter ZnT8	10
Protocol to develop A 3D tumor model for drug testing applications	10
Highly scalable arrayed CRISPR mediated gene silencing in primary lung small airway epithelial cells	10
A perspective on the discovery of enzyme activators	9
Corrigendum to “Varieties of Interactions of anti-CD133 Aptamers with Cell Cultures from Patient Glioblastoma” [SLAS Discov. 2024 Nov 16;29(8):100195]	9
Automated high-throughput, high-content 3D imaging of intact pancreatic islets	9
Development and validation of a generic methyltransferase enzymatic assay based on an SAH riboswitch	9
An MRC-5 cell based high-throughput, high-content imaging assay to identify hits against Trypanosoma cruzi intracellular parasites	9
A multiparametric calcium signal screening platform using iPSC-derived cortical neural spheroids.	9
VOC analysis for rapid, early detection of bacteria, mold, and mycoplasma in cell and tissue cultures	9
Bonferroni’s method, not Tukey’s, should be used to control the total number of false positives when making multiple pairwise comparisons in experiments with few replicates	9
Identification of tau-tubulin kinase 1 inhibitors by microfluidics-based mobility shift assay from a kinase inhibitor library	9
3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons	9
Using chemical and biological data to predict drug toxicity	8
Creating a more strategic small molecule biophysical hit characterization workflow	8
NF-kB oscillation profiles decode response to anti-EGFR monoclonal antibodies	8
WITHDRAWN: Digital microfluidics as an emerging tool for bacterial protocols	7
Protocol for kinetic mode potassium channel assays on common plate readers and microscopes	7
Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays	7
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant	7
A scalable human gut-immune co-culture model for evaluating inflammatory bowel disease anti-inflammatory therapies	7
Protocol for high throughput 3D drug screening of patient derived melanoma and renal cell carcinoma	7
An overview of drugging the bacterial cytoskeleton, rod, and divisome systems	7
Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell models	7
In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models	7
Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for metastatic castration resistant prostate canc	7
Temperature-related intensity change (TRIC)-based high-throughput screening enables the discovery of small molecule CD28 binders	7
Binder2030: a quantitative membrane proteome binding dataset enabling AI-driven drug discovery	7
Absolute quantification of Neuron-specific enolase based on surface plasmon resonance	7
New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase	7
Publisher's Note	7
A robust CETSA data analysis automation workflow for routine screening	7
Application of human iPSC-derived macrophages in a miniaturized high-content-imaging-based efferocytosis assay	6
SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening	6
Robustness of NanoBiT luciferase complementation technology in the presence of widely used kinase inhibitors	6
Genome-scale functional genomics screening highlights genes impacting protein fucosylation in Chinese hamster ovary cells	6
Protocols in drug discovery	6
Combinatorial screen with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids	6
Characterisation of high throughput screening outputs for small molecule degrader discovery	6
MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling	6
Towards Label-free detection of viral disease agents through their cell surface proteins: Rapid screening SARS-CoV-2 in biological specimens	6
WITHDRAWN: Towards robotic laboratory automation Plug & play: Survey and concept proposal on teaching-free robot integration with the lapp digital twin	6
High-throughput screening identifies non-nucleoside inhibitors of the SARS-CoV-2 polymerase with novel mechanisms	6
A biochemical screening platform to target chromatin states using condensates as a tool	6