OOIR: Observatory of International Research

Papers

(The H4-Index of Geroscience is 37. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Early onset of aging phenotype in vascular repair by Mas receptor deficiency	220
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies	88
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence	80
Correction to: Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels	78
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	75
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years	74
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study	72
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice	60
Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction	57
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity	57
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease	56
Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults	54
Evidence for preserved insulin responsiveness in the aging rat brain	53
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study	52
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease	52
Vitamin D supplementation is associated with slower epigenetic aging	51
Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease	49
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile	49
Fast and slow skeletal myosin binding protein-C and aging	48
Senolytic treatment rescues blunted muscle hypertrophy in old mice	48
Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists	47
Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cell	46
Lipidomic signatures from physically frail and robust older adults at hospital admission	46
Prediction of disability-free survival in healthy older people	45
Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome	45

Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17	45
Leukocyte-derived ratios are associated with late-life any type dementia: a cross-sectional analysis of the Mugello study	43
The aging venous system: from varicosities to vascular cognitive impairment	42
Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain	42
Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury	42
High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity	41
Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs	40
Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow	39
Correction to: Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints	38
Stringent public health measures during COVID-19 across ischemic stroke care systems: the potential impact of patient perceptions on health care-seeking behaviors	38
Physical activity reduces the risk of pneumonia: systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants	38
Associations between sociodemographic factors, health spending, disease burden, and life expectancy of older adults (70 + years old) in 22 countries in the Western Pacific Region, 1995–2019: estimates	37