OOIR: Observatory of International Research

Papers

(The H4-Index of Geroscience is 37. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity	255
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice	101
Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction	93
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies	81
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years	78
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study	66
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease	66
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence	64
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	58
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile	57
Vitamin D supplementation is associated with slower epigenetic aging	56
Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults	56
Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease	55
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study	55
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease	54
Senolytic treatment rescues blunted muscle hypertrophy in old mice	52
Evidence for preserved insulin responsiveness in the aging rat brain	50
Lipidomic signatures from physically frail and robust older adults at hospital admission	49
Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists	49
Fast and slow skeletal myosin binding protein-C and aging	49
Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cell	48
Prediction of disability-free survival in healthy older people	47
Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome	47
The aging venous system: from varicosities to vascular cognitive impairment	46
Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow	46

Correction to: Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints	44
Associations between sociodemographic factors, health spending, disease burden, and life expectancy of older adults (70 + years old) in 22 countries in the Western Pacific Region, 1995–2019: estimates	43
Stringent public health measures during COVID-19 across ischemic stroke care systems: the potential impact of patient perceptions on health care-seeking behaviors	41
Physical activity reduces the risk of pneumonia: systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants	41
Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs	40
High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity	39
Is “cellular senescence” a misnomer?	39
Effect of simultaneous exercise and cognitive training on executive functions, baroreflex sensitivity, and pre-frontal cortex oxygenation in healthy older adults: a pilot study	38
Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain	37
Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life	37
Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury	37
Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways	37