OOIR: Observatory of International Research

Papers

(The median citation count of Geroscience is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity	255
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice	101
Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction	93
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies	81
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years	78
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease	66
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study	66
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence	64
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	58
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile	57
Vitamin D supplementation is associated with slower epigenetic aging	56
Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults	56
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study	55
Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease	55
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease	54
Senolytic treatment rescues blunted muscle hypertrophy in old mice	52
Evidence for preserved insulin responsiveness in the aging rat brain	50
Fast and slow skeletal myosin binding protein-C and aging	49
Lipidomic signatures from physically frail and robust older adults at hospital admission	49
Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists	49
Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cell	48
Prediction of disability-free survival in healthy older people	47
Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome	47
The aging venous system: from varicosities to vascular cognitive impairment	46
Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow	46

Correction to: Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints	44
Associations between sociodemographic factors, health spending, disease burden, and life expectancy of older adults (70 + years old) in 22 countries in the Western Pacific Region, 1995–2019: estimates	43
Stringent public health measures during COVID-19 across ischemic stroke care systems: the potential impact of patient perceptions on health care-seeking behaviors	41
Physical activity reduces the risk of pneumonia: systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants	41
Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs	40
High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity	39
Is “cellular senescence” a misnomer?	39
Effect of simultaneous exercise and cognitive training on executive functions, baroreflex sensitivity, and pre-frontal cortex oxygenation in healthy older adults: a pilot study	38
Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways	37
Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain	37
Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life	37
Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury	37
Continent-wide evolutionary trends of emerging SARS-CoV-2 variants: dynamic profiles from Alpha to Omicron	36
SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice	36
Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary	35
Age-associated changes in circulatory fatty acids: new insights on adults and long-lived individuals	35
Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring	35
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence	34
Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men	34
Diabetic patients treated with metformin during early stages of Alzheimer’s disease show a better integral performance: data from ADNI study	34
Different patterns of excess all-cause mortality by age and sex in Hungary during the 2nd and 3rd waves of the COVID-19 pandemic	34
Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging	32
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependen	31
Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial	31
Correction to: Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	29
Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals	29
Telomere length and epigenetic clocks as markers of cellular aging: a comparative study	29
The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA)	29
Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease	29
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies	29
Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases	28
Attentional focus effect on dual-task walking in Parkinson’s disease with and without freezing of gait	28
Longitudinal association of executive function and structural network controllability in the aging brain	28
Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment	28
Strategies for handling missing data that improve Frailty Index estimation and predictive power: lessons from the NHANES dataset	27
Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range	27
Elevated skin senescence in young mice causes delayed wound healing	27
Bioenergetic and vascular predictors of potential super-ager and cognitive decline trajectories—a UK Biobank Random Forest classification study	27
Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals	26
Modeling of nursing care-associated airborne transmission of SARS-CoV-2 in a real-world hospital setting	26
Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics	25
Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation	25
Senescent macrophages in the human adipose tissue as a source of inflammaging	25
Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer’s disease risk	25
Modulation of nigral dopamine signaling mitigates parkinsonian signs of aging: evidence from intervention with calorie restriction or inhibition of dopamine uptake	24
Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis	24
Rapamycin not dietary restriction improves resilience against pathogens: a meta-analysis	24
Correction to: Pterocarpus marsupium extract extends replicative lifespan in budding yeast	24
Diabetes mellitus correlates with increased biological age as indicated by clinical biomarkers	23
miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes	23

Higher white matter hyperintensity load adversely affects pre-post proximal cognitive training performance in healthy older adults	23
Aging results in DNA damage and telomere dysfunction that is greater in endothelial versus vascular smooth muscle cells and is exacerbated in atheroprone regions	23
Replenishment of myeloid-derived suppressor cells (MDSCs) overrides CR-mediated protection against tumor growth in a murine model of triple-negative breast cancer	23
Emergence of heartbeat frailty in advanced age I: perspectives from life-long EKG recordings in adult mice	23
Examination of pituitary adenylate cyclase-activating polypeptide in Parkinson’s disease focusing on correlations with motor symptoms	22
The elderly at risk: aldosterone as modulator of the immune response to SARS-CoV-2 infection	21
Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men	21
Data-driven health deficit assessment improves a frailty index’s prediction of current cognitive status and future conversion to dementia: results from ADNI	21
A metabolomic signature of the APOE2 allele	21
Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults	21
Once-daily feeding is associated with better health in companion dogs: results from the Dog Aging Project	20
Correction to: Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration	20
Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration	20
Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	19
Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life	19
Humoral immune response after COVID-19 infection or BNT162b2 vaccine among older adults: evolution over time and protective thresholds	19
Cerebral venous congestion exacerbates cerebral microhemorrhages in mice	19
Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients	19
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects	19
Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles	19
Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices	19
Lipidomics profiling of biological aging in American Indians: the Strong Heart Family Study	18
Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians	18
Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice	18
SARS-CoV-2 interacts with renin-angiotensin system: impact on the central nervous system in elderly patients	18
Proximal improvement and higher-order resting state network change after multidomain cognitive training intervention in healthy older adults	18
Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease	18
Liver alterations and detection of SARS-CoV-2 RNA and proteins in COVID-19 autopsies	17
Poliomyelitis is a current challenge: long-term sequelae and circulating vaccine-derived poliovirus	17
Carotid disease, cognition, and aging: time to redefine asymptomatic disease?	17
Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment	17
A comprehensive analysis of the mutational landscape of the newly emerging Omicron (B.1.1.529) variant and comparison of mutations with VOCs and VOIs	17
Poly(A) RNA sequencing reveals age-related differences in the prefrontal cortex of dogs	17
Handgrip strength is associated with learning and verbal fluency in older men without dementia: insights from the NHANES	17
Decreased lifespan in female “Munchkin” actors from the cast of the 1939 film version of The Wizard of Oz does not support the hypothesis linking hypopituitary dwarfism to longevity	16
Biomarkers of aging in real life: three questions on aging and the comprehensive geriatric assessment	16
How size and genetic diversity shape lifespan across breeds of purebred dogs	16
Longitudinal associations between blood lysophosphatidylcholines and skeletal muscle mitochondrial function	16
Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults	16
Neuronavigated Magnetic Stimulation combined with cognitive training for Alzheimer’s patients: an EEG graph study	16
Microbiota mitochondria disorders as hubs for early age-related macular degeneration	16
Metabolic and molecular responses of human patellar tendon to concentric- and eccentric-type exercise in youth and older age	16
Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain	16
Remember NIBS? tACS improves memory performance in elders with subjective memory complaints	16
Pleiotropic predisposition to Alzheimer’s disease and educational attainment: insights from the summary statistics analysis	16
Causal influences of salience/cerebellar networks on dorsal attention network subserved age-related cognitive slowing	16