Geroscience

Article	Citations
Glycolytic and Oxidative Phosphorylation Defects Precede the Development of Senescence in Primary Human Brain Microvascular Endothelial Cells	161
Cholinesterase inhibitors for the treatment of dementia: real-life data in Hungary	78
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependen	72
Greater habitual moderate-to-vigorous physical activity is associated with better executive function and higher prefrontal oxygenation in older adults	68
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary	67
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity	65
The Jackson Laboratory Nathan Shock Center: impact of genetic diversity on aging	65
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years	56
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence	54
Increased pulse wave velocity is related to impaired working memory and executive function in older adults with metabolic syndrome	54
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence	51
Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial	47
Acute cognitive impairment after traumatic brain injury predicts the occurrence of brain atrophy patterns similar to those observed in Alzheimer’s disease	46
University of Alabama at Birmingham Nathan Shock Center: comparative energetics of aging	46
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume	44
Interaction of aging with lipoxygenase deficiency initiates hypersplenism, cardiac dysfunction, and profound leukocyte directed non-resolving inflammation	44
The Nathan Shock Centers	44
Effects of aging on protein expression in mice brain microvessels: ROS scavengers, mRNA/protein stability, glycolytic enzymes, mitochondrial complexes, and basement membrane components	44
Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients	43
A COVID-19-association-dependent categorization of death causes in 100 autopsy cases	42
Correction to: Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	41
Telomere length and epigenetic clocks as markers of cellular aging: a comparative study	41
Epigenetic clock and methylation studies in vervet monkeys	40
Cerebral venous congestion exacerbates cerebral microhemorrhages in mice	40
T lymphocyte depletion ameliorates age-related metabolic impairments in mice	40

Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life	40
Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle	40
DNA damage-induced degradation of Sp1 promotes cellular senescence	39
Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults	39
University of Southern California and buck institute nathan shock center: multidimensional models of aging	38
Learning from machine learning: prediction of age-related athletic performance decline trajectories	38
Obesity paradox in joint replacement for osteoarthritis — truth or paradox?	38
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects	36
Early onset of aging phenotype in vascular repair by Mas receptor deficiency	36
Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels	36
Immune phenotype of the CD4+ T cells in the aged lymphoid organs and lacrimal glands	35
Different patterns of excess all-cause mortality by age and sex in Hungary during the 2nd and 3rd waves of the COVID-19 pandemic	35
Animal reservoirs of SARS-CoV-2: calculable COVID-19 risk for older adults from animal to human transmission	34
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice	34
Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain	34
HIV, pathology and epigenetic age acceleration in different human tissues	33
Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice	33
Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity	33
Use of convalescent plasma therapy in hospitalised adult patients with non-critical COVID-19: a focus on the elderly from Hungary	32
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease	31
Novel immortalization approach defers senescence of cultured canine adipose-derived mesenchymal stromal cells	31
Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles	30
Omicron variant of the SARS-CoV-2: a quest to define the consequences of its high mutational load	30
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies	30
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study	29
Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals	29
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies	28
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	28
Monkeypox: considerations for the understanding and containment of the current outbreak in non-endemic countries	28
Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction	28
Correction to: Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels	28
Correction to: Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline	27
Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males	27
Humoral immune response after COVID-19 infection or BNT162b2 vaccine among older adults: evolution over time and protective thresholds	26
Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease	26
Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	26
Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging	25
Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability	25
A sex-stratified analysis of neuroimmune gene expression signatures in Alzheimer’s disease brains	25
Familial aggregation of the aging process: biological age measured in young adult offspring as a predictor of parental mortality	25
The role of age-associated autonomic dysfunction in inflammation and endothelial dysfunction	24
Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices	24
Association of rs3027178 polymorphism in the circadian clock gene PER1 with susceptibility to Alzheimer’s disease and longevity in an Italian population	23
Generation and characterization of a tractable C. elegans model of tauopathy	23
Serological and viral genetic features of patients with COVID-19 in a selected German patient cohort—correlation with disease characteristics	23
Human centenarian–associated SIRT6 mutants modulate hepatocyte metabolism and collagen deposition in multilineage hepatic 3D spheroids	23
The Combined Oral Stable Isotope Assessment of Muscle (COSIAM) reveals D-3 creatine derived muscle mass as a standout cross-sectional biomarker of muscle physiology vitality in older age	23
Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians	23
Plant-based diets and risk of frailty in community-dwelling older adults: the Seniors-ENRICA-1 cohort	23
The association of proBNPage with manifestations of age-related cardiovascular, physical, and psychological impairment in community-dwelling older adults	22

Effect of environmental enrichment and isolation on behavioral and histological indices following focal ischemia in old rats	22
Higher-order resting state network association with the useful field of view task in older adults	22
Evidence for preserved insulin responsiveness in the aging rat brain	22
Modeling human gray hair by irradiation as a valuable tool to study aspects of tissue aging	22
Task-based functional connectivity of the Useful Field of View (UFOV) fMRI task	22
Canine Cognitive Dysfunction (CCD) scores correlate with amyloid beta 42 levels in dog brain tissue	22
Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases	21
Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults	21
Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata	21
Renoprotective effects of empagliflozin in type 1 and type 2 models of diabetic nephropathy superimposed with hypertension	21
White matter hyperintensity load varies depending on subjective cognitive decline criteria	21
Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats	20
Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus	20
Longitudinal association of executive function and structural network controllability in the aging brain	20
Effect of longevity genetic variants on the molecular aging rate	20
Age and sex modify cellular proliferation responses to oxidative stress and glucocorticoid challenges in baboon cells	20
Apolipoprotein E ɛ4–related effects on cognition are limited to the Alzheimer’s disease spectrum	20
Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment	20
Is an MRI-derived anatomical measure of dementia risk also a measure of brain aging?	20
Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice	19
Lipidomics profiling of biological aging in American Indians: the Strong Heart Family Study	19
Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease	19
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile	19
Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice	19
Editorial: Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans	19
Metabolic syndrome and Growth Differentiation Factor 15 in older adults	19
Liver frailty and all-cause mortality in the older participants of the Salus in Apulia Study	19
Lipid and metabolite correlation networks specific to clinical and biochemical covariate show differences associated with sexual dimorphism in a cohort of nonagenarians	18
Age-related expression of prominent regulatory elements in mouse brain: catastrophic decline of FOXO3a	18
Growth hormone increases DNA damage in ovarian follicles and macrophage infiltration in the ovaries	18
Topographical differences in white matter hyperintensity burden and cognition in aging, MCI, and AD	18
Strategies and cognitive reserve to preserve lexical production in aging	18
Metabolic pathways and therapeutics to promote resilience, rehabilitation and delayed aging	17
50 years of the “war on cancer”: lessons for public health and geroscience	17
The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA)	17
Retraction Note to: Omega-3 fatty acid levels in red blood cell membranes and physical decline over 3 years: longitudinal data from the MAPT study	17
Strategies for handling missing data that improve Frailty Index estimation and predictive power: lessons from the NHANES dataset	17
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study	17
Angiotensin receptor blocker use is associated with upregulation of the memory-protective angiotensin type 4 receptor (AT4R) in the postmortem brains of individuals without cognitive impairment	17
Eat like an athlete: insights of sports nutrition science to support active aging in healthy older adults	17
Regulation of TDP-43 phosphorylation in aging and disease	17
Imaging retinal microvascular manifestations of carotid artery disease in older adults: from diagnosis of ocular complications to understanding microvascular contributions to cognitive impairment	17
Proximal improvement and higher-order resting state network change after multidomain cognitive training intervention in healthy older adults	17
Elevated skin senescence in young mice causes delayed wound healing	17
Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study	17
Are fat and sugar just as detrimental in old age?	17
Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice	17
Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue	16
Old plasma dilution reduces human biological age: a clinical study	16
Epigenetic clock and methylation studies in the rhesus macaque	16
Attentional focus effect on dual-task walking in Parkinson’s disease with and without freezing of gait	16
Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach	16
Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range	16
Hypothalamic microstructure and function are related to body mass, but not mental or cognitive abilities across the adult lifespan	16
Vitamin D supplementation is associated with slower epigenetic aging	16
Senolytic treatment rescues blunted muscle hypertrophy in old mice	15
Bioenergetic and vascular predictors of potential super-ager and cognitive decline trajectories—a UK Biobank Random Forest classification study	15
Early manifestation of gait alterations in the Tg2576 mouse model of Alzheimer’s disease	15
Blood–brain barrier leakage at baseline and cognitive decline in cerebral small vessel disease: a 2-year follow-up study	15
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease	15
Systemic inflammatory markers in relation to cognitive function and measures of brain atrophy: a Mendelian randomization study	15
Cell therapy rescues aging-induced beta-1 adrenergic receptor and GRK2 dysfunction in the coronary microcirculation	14
Prognosis of the non-ST elevation myocardial infarction complicated with early ventricular fibrillation at higher age	14
Brain cellular senescence in mouse models of Alzheimer’s disease	14
Which components of the Mediterranean diet are associated with dementia? A UK Biobank cohort study	14
Using lipid profiling to better characterize metabolic differences in apolipoprotein E (APOE) genotype among community-dwelling older Black men	14
University of Washington Nathan Shock Center: innovation to advance aging research	14
Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17	14
Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model	14
Metabolomics of aging in primary fibroblasts from small and large breed dogs	14
A neuromuscular perspective of sarcopenia pathogenesis: deciphering the signaling pathways involved	14
Divergent regulation of lncRNA expression by ischemia in adult and aging mice	14
A quantitative yeast aging proteomics analysis reveals novel aging regulators	14
An energetics perspective on geroscience: mitochondrial protonmotive force and aging	14
SARS-CoV-2 interacts with renin-angiotensin system: impact on the central nervous system in elderly patients	13
Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cell	13
Effects of task prioritization on a postural-motor task in early-stage Parkinson’s disease: EEG connectivity and clinical implication	13
Tau and TDP-43 synergy: a novel therapeutic target for sporadic late-onset Alzheimer’s disease	13
Epigenetic clock and methylation studies in cats	13
Changes in the SARS-CoV-2 cellular receptor ACE2 levels in cardiovascular patients: a potential biomarker for the stratification of COVID-19 patients	13

The Instrumented Stand and Walk (ISAW) test to predict falls in older men	13
Vitamin D3 promotes longevity in Caenorhabditis elegans	13
Modeling of nursing care-associated airborne transmission of SARS-CoV-2 in a real-world hospital setting	13
Lipidomic signatures from physically frail and robust older adults at hospital admission	13
Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration	13
Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics	12
Optimising the selection of outcomes for healthy ageing trials: a mixed methods study	12
From 1901 to 2022, how far are we from truly understanding the pathogenesis of age-related dementia?	12
Modulation of nigral dopamine signaling mitigates parkinsonian signs of aging: evidence from intervention with calorie restriction or inhibition of dopamine uptake	12
Inhibition of the 3-mercaptopyruvate sulfurtransferase—hydrogen sulfide system promotes cellular lipid accumulation	12
Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals	12
Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer’s disease risk	12
Evidence that conserved essential genes are enriched for pro-longevity factors	12
Grip strength performance from 9431 participants of the GenoFit study: normative data and associated factors	12
Cognitive control, interference inhibition, and ordering of information during working memory in younger and older healthy adults	12
Handgrip strength is associated with learning and verbal fluency in older men without dementia: insights from the NHANES	12
The association of measures of body shape and adiposity with incidence of cardiometabolic disease from an ageing perspective	12
Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation	12
A long-term obesogenic high-fat diet in mice partially dampens the anti-frailty benefits of late-life intermittent fasting	12
Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans	12
Aging: working memory capacity and spatial strategies in a virtual orientation task	12
The pathophysiology of chronic subdural hematoma revisited: emphasis on aging processes as key factor	11
Senescent macrophages in the human adipose tissue as a source of inflammaging	11
Altered T cell infiltration and enrichment of leukocyte regulating pathways within aged skeletal muscle are associated impaired muscle function following influenza infection	11
Focus group study on perceptions and information needs regarding vaccines targeting the older population: a cross-country comparison in four European countries	11
Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease	11
Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists	11
Fast and slow skeletal myosin binding protein-C and aging	11
Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling	11
Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis	11
Selective brain regional changes in lipid profile with human aging	11