OOIR: Observatory of International Research

Papers

(The median citation count of Geroscience is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Early onset of aging phenotype in vascular repair by Mas receptor deficiency	220
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies	88
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence	80
Correction to: Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels	78
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	75
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years	74
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study	72
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice	60
Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction	57
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity	57
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease	56
Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults	54
Evidence for preserved insulin responsiveness in the aging rat brain	53
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease	52
Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study	52
Vitamin D supplementation is associated with slower epigenetic aging	51
High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile	49
Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease	49
Senolytic treatment rescues blunted muscle hypertrophy in old mice	48
Fast and slow skeletal myosin binding protein-C and aging	48
Aging alters antiviral signaling pathways resulting in functional impairment in innate immunity in response to pattern recognition receptor agonists	47
Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cell	46
Lipidomic signatures from physically frail and robust older adults at hospital admission	46
Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17	45
Prediction of disability-free survival in healthy older people	45

Clonal hematopoiesis is not prevalent in Hutchinson-Gilford progeria syndrome	45
Leukocyte-derived ratios are associated with late-life any type dementia: a cross-sectional analysis of the Mugello study	43
Brain age estimation reveals older adults’ accelerated senescence after traumatic brain injury	42
The aging venous system: from varicosities to vascular cognitive impairment	42
Aging compromises oligodendrocyte precursor cell maturation and efficient remyelination in the monkey brain	42
High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity	41
Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs	40
Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow	39
Physical activity reduces the risk of pneumonia: systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants	38
Correction to: Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints	38
Stringent public health measures during COVID-19 across ischemic stroke care systems: the potential impact of patient perceptions on health care-seeking behaviors	38
Associations between sociodemographic factors, health spending, disease burden, and life expectancy of older adults (70 + years old) in 22 countries in the Western Pacific Region, 1995–2019: estimates	37
Is “cellular senescence” a misnomer?	36
Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men	35
Effect of simultaneous exercise and cognitive training on executive functions, baroreflex sensitivity, and pre-frontal cortex oxygenation in healthy older adults: a pilot study	35
DNA methylation age analysis of rapamycin in common marmosets	35
Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary	35
Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways	35
Age-associated changes in circulatory fatty acids: new insights on adults and long-lived individuals	34
Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life	33
Continent-wide evolutionary trends of emerging SARS-CoV-2 variants: dynamic profiles from Alpha to Omicron	33
Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring	33
Diabetic patients treated with metformin during early stages of Alzheimer’s disease show a better integral performance: data from ADNI study	33
Correction to: Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	32
SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice	32
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence	31
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies	31
Epigenetic clock and methylation studies in vervet monkeys	31
Animal reservoirs of SARS-CoV-2: calculable COVID-19 risk for older adults from animal to human transmission	30
Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial	30
Different patterns of excess all-cause mortality by age and sex in Hungary during the 2nd and 3rd waves of the COVID-19 pandemic	30
Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals	30
A COVID-19-association-dependent categorization of death causes in 100 autopsy cases	29
Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity	29
Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging	29
Telomere length and epigenetic clocks as markers of cellular aging: a comparative study	28
Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults	28
Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease	28
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependen	27
Elevated skin senescence in young mice causes delayed wound healing	27
Liver frailty and all-cause mortality in the older participants of the Salus in Apulia Study	27
Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment	26
Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases	26
Higher-order resting state network association with the useful field of view task in older adults	25
Bioenergetic and vascular predictors of potential super-ager and cognitive decline trajectories—a UK Biobank Random Forest classification study	25
Longitudinal association of executive function and structural network controllability in the aging brain	24
Modulation of nigral dopamine signaling mitigates parkinsonian signs of aging: evidence from intervention with calorie restriction or inhibition of dopamine uptake	24
Strategies for handling missing data that improve Frailty Index estimation and predictive power: lessons from the NHANES dataset	24
Attentional focus effect on dual-task walking in Parkinson’s disease with and without freezing of gait	24
The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA)	24

Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range	24
Modeling of nursing care-associated airborne transmission of SARS-CoV-2 in a real-world hospital setting	23
Senescent macrophages in the human adipose tissue as a source of inflammaging	23
Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation	23
Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics	23
Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer’s disease risk	23
Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals	23
Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis	23
Rapamycin not dietary restriction improves resilience against pathogens: a meta-analysis	22
Favipiravir treatment does not influence disease progression among adult patients hospitalized with moderate-to-severe COVID-19: a prospective, sequential cohort study from Hungary	22
Aging results in DNA damage and telomere dysfunction that is greater in endothelial versus vascular smooth muscle cells and is exacerbated in atheroprone regions	22
Diabetes mellitus correlates with increased biological age as indicated by clinical biomarkers	22
Correction to: Pterocarpus marsupium extract extends replicative lifespan in budding yeast	22
Emergence of heartbeat frailty in advanced age I: perspectives from life-long EKG recordings in adult mice	22
Examination of pituitary adenylate cyclase-activating polypeptide in Parkinson’s disease focusing on correlations with motor symptoms	21
Replenishment of myeloid-derived suppressor cells (MDSCs) overrides CR-mediated protection against tumor growth in a murine model of triple-negative breast cancer	21
The understudied links of the retromer complex to age-related pathways	21
Higher white matter hyperintensity load adversely affects pre-post proximal cognitive training performance in healthy older adults	21
miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes	21
Reversal of deficits in aged skeletal muscle during disuse and recovery in response to treatment with a secrotome product derived from partially differentiated human pluripotent stem cells	21
Data-driven health deficit assessment improves a frailty index’s prediction of current cognitive status and future conversion to dementia: results from ADNI	20
Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration	20
A metabolomic signature of the APOE2 allele	20
Once-daily feeding is associated with better health in companion dogs: results from the Dog Aging Project	20
Correction to: Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration	20
The elderly at risk: aldosterone as modulator of the immune response to SARS-CoV-2 infection	19
Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles	19
Resistance exercise intervention on muscular strength and power, and functional capacity in acute hospitalized older adults: a systematic review and meta-analysis of 2498 patients in 7 randomized clin	19
Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults	19
Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men	19
Einstein-Nathan Shock Center: translating the hallmarks of aging to extend human health span	19
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects	18
Humoral immune response after COVID-19 infection or BNT162b2 vaccine among older adults: evolution over time and protective thresholds	18
Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients	18
Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice	18
Cerebral venous congestion exacerbates cerebral microhemorrhages in mice	18
Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices	18
Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life	18
Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	18
Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease	17
Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice	17
Proximal improvement and higher-order resting state network change after multidomain cognitive training intervention in healthy older adults	17
Poly(A) RNA sequencing reveals age-related differences in the prefrontal cortex of dogs	17
Handgrip strength is associated with learning and verbal fluency in older men without dementia: insights from the NHANES	17
Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians	17
Lipidomics profiling of biological aging in American Indians: the Strong Heart Family Study	17
Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment	17
SARS-CoV-2 interacts with renin-angiotensin system: impact on the central nervous system in elderly patients	17
Canine Cognitive Dysfunction (CCD) scores correlate with amyloid beta 42 levels in dog brain tissue	17
Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype	16
A comprehensive analysis of the mutational landscape of the newly emerging Omicron (B.1.1.529) variant and comparison of mutations with VOCs and VOIs	16
Methylation studies in Peromyscus: aging, altitude adaptation, and monogamy	16
Poliomyelitis is a current challenge: long-term sequelae and circulating vaccine-derived poliovirus	16
Liver alterations and detection of SARS-CoV-2 RNA and proteins in COVID-19 autopsies	16
Carotid disease, cognition, and aging: time to redefine asymptomatic disease?	16
Remember NIBS? tACS improves memory performance in elders with subjective memory complaints	15
Potassium-chelating drug sodium polystyrene sulfonate enhances lysosomal function and suppresses proteotoxicity	15
Causal influences of salience/cerebellar networks on dorsal attention network subserved age-related cognitive slowing	15
Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain	15
Neuronavigated Magnetic Stimulation combined with cognitive training for Alzheimer’s patients: an EEG graph study	15
Intrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults	15
Metabolic and molecular responses of human patellar tendon to concentric- and eccentric-type exercise in youth and older age	15
Hippocampus is more susceptible to hypoxic injury: has the Rosetta Stone of regional variation in neurovascular coupling been deciphered?	15
Decreased lifespan in female “Munchkin” actors from the cast of the 1939 film version of The Wizard of Oz does not support the hypothesis linking hypopituitary dwarfism to longevity	15
Biomarkers of aging in real life: three questions on aging and the comprehensive geriatric assessment	15
Pleiotropic predisposition to Alzheimer’s disease and educational attainment: insights from the summary statistics analysis	15
Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults	15
Accumulation of C-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged mice	15
Multiple myeloma, a quintessential malignant disease of aging: a geroscience perspective on pathogenesis and treatment	14
The effect of systemic factors on retinal blood flow in patients with carotid stenosis: an optical coherence tomography angiography study	14
Omicron variant of the SARS-CoV-2: a quest to define the consequences of its high mutational load	14
Longitudinal associations between blood lysophosphatidylcholines and skeletal muscle mitochondrial function	14
How size and genetic diversity shape lifespan across breeds of purebred dogs	14
Immune phenotype of the CD4+ T cells in the aged lymphoid organs and lacrimal glands	14
Microbiota mitochondria disorders as hubs for early age-related macular degeneration	14
HIV, pathology and epigenetic age acceleration in different human tissues	14