OOIR: Observatory of International Research

Papers

(The TQCC of Geroscience is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Glycolytic and Oxidative Phosphorylation Defects Precede the Development of Senescence in Primary Human Brain Microvascular Endothelial Cells	161
Cholinesterase inhibitors for the treatment of dementia: real-life data in Hungary	78
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependen	72
Greater habitual moderate-to-vigorous physical activity is associated with better executive function and higher prefrontal oxygenation in older adults	68
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary	67
Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity	65
The Jackson Laboratory Nathan Shock Center: impact of genetic diversity on aging	65
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years	56
Rapid emergence of transcriptional heterogeneity upon molecular stress predisposes cells to two distinct states of senescence	54
Increased pulse wave velocity is related to impaired working memory and executive function in older adults with metabolic syndrome	54
Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence	51
Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial	47
University of Alabama at Birmingham Nathan Shock Center: comparative energetics of aging	46
Acute cognitive impairment after traumatic brain injury predicts the occurrence of brain atrophy patterns similar to those observed in Alzheimer’s disease	46
Interaction of aging with lipoxygenase deficiency initiates hypersplenism, cardiac dysfunction, and profound leukocyte directed non-resolving inflammation	44
The Nathan Shock Centers	44
Effects of aging on protein expression in mice brain microvessels: ROS scavengers, mRNA/protein stability, glycolytic enzymes, mitochondrial complexes, and basement membrane components	44
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume	44
Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients	43
A COVID-19-association-dependent categorization of death causes in 100 autopsy cases	42
Correction to: Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	41
Telomere length and epigenetic clocks as markers of cellular aging: a comparative study	41
Cerebral venous congestion exacerbates cerebral microhemorrhages in mice	40
T lymphocyte depletion ameliorates age-related metabolic impairments in mice	40
Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life	40

Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle	40
Epigenetic clock and methylation studies in vervet monkeys	40
Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults	39
DNA damage-induced degradation of Sp1 promotes cellular senescence	39
Learning from machine learning: prediction of age-related athletic performance decline trajectories	38
Obesity paradox in joint replacement for osteoarthritis — truth or paradox?	38
University of Southern California and buck institute nathan shock center: multidimensional models of aging	38
Early onset of aging phenotype in vascular repair by Mas receptor deficiency	36
Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels	36
Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects	36
Different patterns of excess all-cause mortality by age and sex in Hungary during the 2nd and 3rd waves of the COVID-19 pandemic	35
Immune phenotype of the CD4+ T cells in the aged lymphoid organs and lacrimal glands	35
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice	34
Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain	34
Animal reservoirs of SARS-CoV-2: calculable COVID-19 risk for older adults from animal to human transmission	34
Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice	33
Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity	33
HIV, pathology and epigenetic age acceleration in different human tissues	33
Use of convalescent plasma therapy in hospitalised adult patients with non-critical COVID-19: a focus on the elderly from Hungary	32
Novel immortalization approach defers senescence of cultured canine adipose-derived mesenchymal stromal cells	31
Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease	31
Omicron variant of the SARS-CoV-2: a quest to define the consequences of its high mutational load	30
Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies	30
Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles	30
Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study	29
Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals	29
Monkeypox: considerations for the understanding and containment of the current outbreak in non-endemic countries	28
Evaluation of a blood-based geroscience biomarker index in a randomized trial of caloric restriction and exercise in older adults with heart failure with preserved ejection fraction	28
Correction to: Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels	28
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies	28
Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions	28
Correction to: Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline	27
Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males	27
Accelerated epigenetic aging and inflammatory/immunological profile (ipAGE) in patients with chronic kidney disease	26
Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis	26
Humoral immune response after COVID-19 infection or BNT162b2 vaccine among older adults: evolution over time and protective thresholds	26
Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability	25
A sex-stratified analysis of neuroimmune gene expression signatures in Alzheimer’s disease brains	25
Familial aggregation of the aging process: biological age measured in young adult offspring as a predictor of parental mortality	25
Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging	25
Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices	24
The role of age-associated autonomic dysfunction in inflammation and endothelial dysfunction	24
Serological and viral genetic features of patients with COVID-19 in a selected German patient cohort—correlation with disease characteristics	23
Human centenarian–associated SIRT6 mutants modulate hepatocyte metabolism and collagen deposition in multilineage hepatic 3D spheroids	23
The Combined Oral Stable Isotope Assessment of Muscle (COSIAM) reveals D-3 creatine derived muscle mass as a standout cross-sectional biomarker of muscle physiology vitality in older age	23
Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians	23
Plant-based diets and risk of frailty in community-dwelling older adults: the Seniors-ENRICA-1 cohort	23
Association of rs3027178 polymorphism in the circadian clock gene PER1 with susceptibility to Alzheimer’s disease and longevity in an Italian population	23
Generation and characterization of a tractable C. elegans model of tauopathy	23
Evidence for preserved insulin responsiveness in the aging rat brain	22

Modeling human gray hair by irradiation as a valuable tool to study aspects of tissue aging	22
Task-based functional connectivity of the Useful Field of View (UFOV) fMRI task	22
Canine Cognitive Dysfunction (CCD) scores correlate with amyloid beta 42 levels in dog brain tissue	22
The association of proBNPage with manifestations of age-related cardiovascular, physical, and psychological impairment in community-dwelling older adults	22
Effect of environmental enrichment and isolation on behavioral and histological indices following focal ischemia in old rats	22
Higher-order resting state network association with the useful field of view task in older adults	22
Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults	21
Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata	21
Renoprotective effects of empagliflozin in type 1 and type 2 models of diabetic nephropathy superimposed with hypertension	21
White matter hyperintensity load varies depending on subjective cognitive decline criteria	21
Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases	21
Effect of longevity genetic variants on the molecular aging rate	20
Age and sex modify cellular proliferation responses to oxidative stress and glucocorticoid challenges in baboon cells	20
Apolipoprotein E ɛ4–related effects on cognition are limited to the Alzheimer’s disease spectrum	20
Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment	20
Is an MRI-derived anatomical measure of dementia risk also a measure of brain aging?	20
Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats	20
Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus	20
Longitudinal association of executive function and structural network controllability in the aging brain	20