OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Metabolism is 72. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Glycolysis modulates efferocytosis in a noncanonical manner	882
The cell cycle loops UTP around CAD	501
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	439
Author Correction: Exercise hormone irisin is a critical regulator of cognitive function	352
What is the most appropriate covariate in ANCOVA when analysing metabolic rate?	325
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	312
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	295
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	250
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	250
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	235
The rs1421085 variant within FTO promotes brown fat thermogenesis	213
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	212
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	187
NAD kinase essentiality in cancer: in real life, it is all about folates	172
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	162
Phagocytosis in the retina promotes local insulin production in the eye	160
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	142
The cyclic metabolic switching theory of intermittent fasting	140
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	134
Incretin-based therapeutics for the treatment of neurodegenerative diseases	132
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	131
Best practices in collecting and reporting continuous glucose monitoring data in research settings	129
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	129
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	125
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	124

Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	121
TKT deficiency puts Tregs to rest	118
Shaping the future of cardiometabolic innovation: advances and opportunities	118
Fuelling the fire: de novo lipogenesis primes thermogenesis	114
The thyroid gland under Notch control	111
Hot news about temperature and lifespan	111
Gut bacteria thwart the blood sugar-lowering effect of acarbose	111
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	110
A BCAA–haem axis regulates brown fat function	106
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	106
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	104
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	104
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	101
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	101
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	101
Hypermetabolism and energetic constraints in mitochondrial disorders	98
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	98
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	98
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity	96
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	96
The antitumour effects of caloric restriction are mediated by the gut microbiome	95
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	94
Illuminating the ‘healthy obese’ phenotype	94
Methionine and H2S alter cancer–immune dialogue	94
Spatial metabolomics: from a niche field towards a driver of innovation	94
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	93
Fuelling synapses via lipid metabolism	91
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis	91
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8	90
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	89
Gases define redox signalling: NO, H2S, O2 … and cyanide	89
Querying stool for dietary information	88
Why a good lab website matters	87
A systematic mutational framework for studying oxidative phosphorylation-related proteins	86
A RalA between high-fat diet and mitochondrial shape	80
Hypometabolism with the speed of ultrasound	80
Proline fuels ILC3s to maintain gut health	80
Beyond Warburg: LDHA activates RAC for tumour growth	79
Mitochondrial RNA stimulates beige adipocyte development in young mice	76
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	75
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	75
A century of the Warburg effect	75
5-IP7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis	74
Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation	73
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	73
Cancer metabolite blunts immunity	72
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	72
A researcher’s guide to preclinical mouse NASH models	72