OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Metabolism is 69. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Aldolase A: the broker of glycolysis	744
Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations	433
Targeting pancreatic β cells for diabetes treatment	375
Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response	310
Activation of GPR81 by lactate drives tumour-induced cachexia	285
Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound	265
Proteogenomic links to human metabolic diseases	264
Disrupting cholesterol homeostasis in T cells boosts antitumour responses	253
Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome	208
Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet–mitochondria tethering to enhance β-oxidation and tumor cell proliferation	186
Cellular and organismal function of choline metabolism	182
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells	182
NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis	171
Author Correction: Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	164
Intestinal plasticity and metabolism as regulators of organismal energy homeostasis	160
Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity	145
Phagocytosis in the retina promotes local insulin production in the eye	131
A subpopulation of lipogenic brown adipocytes drives thermogenic memory	130
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	128
Molecular consequences of SARS-CoV-2 liver tropism	126
Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes	123
Phenotypic profiling of solute carriers characterizes serine transport in cancer	117
O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production	113
Impaired cell surface expression of GLP1R variants determines T2D and obesity risk in humans	112
Lipids reroute mitochondria	111

Virtually unsocial	106
Overlooked confounding in studies of metabolite salts	105
Functional screening and rational design of compounds targeting GPR132 to treat diabetes	103
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	102
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages	101
Quantitative flux analysis in mammals	100
Science in times of conflict	100
HDAC6 inhibition overcomes leptin resistance in obesity	99
Systematic analysis of NDUFAF6 in complex I assembly and mitochondrial disease	99
Malaria thriving on steroids	98
There is more than one way to reach type 2 diabetes	96
Synthetic metabolism without the TCA cycle	95
ACBP orchestrates the metabolic phenotype in Cushing’s syndrome	93
Author Correction: Branched-chain α-ketoacids aerobically activate HIF1α signalling in vascular cells	93
The discovery of human agouti-induced obesity and its implication for genetic diagnosis	93
How cells flex their PEX to fine-tune lipolysis in NAFLD	92
GAPDH redox redux—rewiring pentose phosphate flux	91
Pentose phosphate pathway drives vascular maturation	91
A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells	90
A multi-omic trip through the human gut	88
Colchicine—an old dog with new tricks	88
Hypothalamus pre-optic area and metabolism regulation in humans	88
Astrocytic GABA in LHA is an obesity ‘thermostat’	86
Run to survive—how preoperative exercise could prevent major surgical complications	85
Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions	84
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation	83
Career pathways, part 6	83
Co-receptor regulation of insulin signaling	83
Umami taste—a novel mechanism driving food intake and obesity	83
Gut reaction: it’s not all about enzymes	82
nicX-ing bad habits with your microbial friends	82
Publisher Correction: Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism	81
Keeping ILCs in shape: PD-1 as a metabolic checkpoint	81
Glycolysis modulates efferocytosis in a noncanonical manner	80
MOF moves into mitochondria	78
Reply to: revisiting the role of serine metabolism in hepatic lipogenesis	78
Linking neuropsychiatric disease to neuronal metabolism	77
Big data and personalized nutrition: the key evidence gaps	74
A gut bacterium tackles atherosclerosis	73
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	72
A call for accessible tools to unlock single-cell immunometabolism research	71
Tissue-resident bacteria in metabolic diseases: emerging evidence and challenges	71
The cell cycle loops UTP around CAD	69
BCAT2–BCKDH metabolon maintains BCAA homeostasis	69
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	69