OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Metabolism is 74. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Glycolysis modulates efferocytosis in a noncanonical manner	917
The cell cycle loops UTP around CAD	525
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	460
Author Correction: Exercise hormone irisin is a critical regulator of cognitive function	367
What is the most appropriate covariate in ANCOVA when analysing metabolic rate?	336
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	332
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	304
Phagocytosis in the retina promotes local insulin production in the eye	270
NAD kinase essentiality in cancer: in real life, it is all about folates	270
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	218
Incretin-based therapeutics for the treatment of neurodegenerative diseases	217
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	198
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	177
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	170
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	165
The cyclic metabolic switching theory of intermittent fasting	148
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	143
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	140
The rs1421085 variant within FTO promotes brown fat thermogenesis	137
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	135
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	132
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	130
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	129
Best practices in collecting and reporting continuous glucose monitoring data in research settings	129
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	128

Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	127
Hypermetabolism and energetic constraints in mitochondrial disorders	121
The antitumour effects of caloric restriction are mediated by the gut microbiome	117
Shaping the future of cardiometabolic innovation: advances and opportunities	116
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide	115
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	113
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	112
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	110
TKT deficiency puts Tregs to rest	107
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	107
Fuelling the fire: de novo lipogenesis primes thermogenesis	106
The thyroid gland under Notch control	105
Gut bacteria thwart the blood sugar-lowering effect of acarbose	104
Hot news about temperature and lifespan	103
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	103
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	101
A BCAA–haem axis regulates brown fat function	101
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	100
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	100
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity	98
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	98
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	98
Spatial metabolomics: from a niche field towards a driver of innovation	97
Querying stool for dietary information	96
Why a good lab website matters	95
A systematic mutational framework for studying oxidative phosphorylation-related proteins	94
Hypometabolism with the speed of ultrasound	93
A RalA between high-fat diet and mitochondrial shape	92
Proline fuels ILC3s to maintain gut health	92
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8	92
Beyond Warburg: LDHA activates RAC for tumour growth	90
Methionine and H2S alter cancer–immune dialogue	86
Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation	85
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	85
A researcher’s guide to preclinical mouse NASH models	83
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis	82
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	82
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	81
Mitochondrial RNA stimulates beige adipocyte development in young mice	79
Fuelling synapses via lipid metabolism	78
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	77
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	77
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	77
Gases define redox signalling: NO, H2S, O2 … and cyanide	76
5-IP7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis	76
Illuminating the ‘healthy obese’ phenotype	76
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	75
A century of the Warburg effect	74
Neurometabolism in focus	74
Cancer metabolite blunts immunity	74