OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Metabolism is 75. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	1064
Glycolysis modulates efferocytosis in a noncanonical manner	452
The cell cycle loops UTP around CAD	399
NAD kinase essentiality in cancer: in real life, it is all about folates	371
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	370
The rs1421085 variant within FTO promotes brown fat thermogenesis	246
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	229
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	228
Phagocytosis in the retina promotes local insulin production in the eye	217
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	175
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	173
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	168
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	168
Incretin-based therapeutics for the treatment of neurodegenerative diseases	162
The cyclic metabolic switching theory of intermittent fasting	155
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	153
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	153
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	149
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	149
Hot news about temperature and lifespan	148
A BCAA–haem axis regulates brown fat function	142
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	141
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	140
The antitumour effects of caloric restriction are mediated by the gut microbiome	139
Shaping the future of cardiometabolic innovation: advances and opportunities	137

A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals	133
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	131
Hypermetabolism and energetic constraints in mitochondrial disorders	129
Best practices in collecting and reporting continuous glucose monitoring data in research settings	129
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	129
Fuelling the fire: de novo lipogenesis primes thermogenesis	127
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	127
The thyroid gland under Notch control	122
TKT deficiency puts Tregs to rest	120
Gut bacteria thwart the blood sugar-lowering effect of acarbose	120
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	120
Common genetic variants modify disease risk and clinical presentation in monogenic diabetes	119
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide	118
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	115
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	114
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	113
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	111
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	108
Spatial metabolomics: from a niche field towards a driver of innovation	106
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	101
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	101
Fuelling synapses via lipid metabolism	98
Querying stool for dietary information	96
Methionine and H2S alter cancer–immune dialogue	95
Why a good lab website matters	95
A RalA between high-fat diet and mitochondrial shape	94
Hypometabolism with the speed of ultrasound	94
Illuminating the ‘healthy obese’ phenotype	93
A systematic mutational framework for studying oxidative phosphorylation-related proteins	93
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	93
Proline fuels ILC3s to maintain gut health	93
Gases define redox signalling: NO, H2S, O2 … and cyanide	90
Sweet signals for myelin: glucose sensing redirected to regeneration	89
Mitochondrial RNA stimulates beige adipocyte development in young mice	89
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	88
A century of the Warburg effect	87
Beyond Warburg: LDHA activates RAC for tumour growth	87
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8	86
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	86
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	84
Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia	84
Fat sensory cues in early life program central response to food and obesity	83
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	83
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	82
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	82
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis	81
A researcher’s guide to preclinical mouse NASH models	79
Neurometabolism in focus	79
Human basal metabolic rate has declined over the past 30 years	78
An integrated single-cell islet atlas in health and disease	78

Cancer metabolite blunts immunity	75
Lighting up targets of dual agonist therapies for diabetes and obesity	75