Nature Metabolism

Article	Citations
Incretin-based therapeutics for the treatment of neurodegenerative diseases	992
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	555
Glycolysis modulates efferocytosis in a noncanonical manner	401
The cell cycle loops UTP around CAD	368
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	358
What is the most appropriate covariate in ANCOVA when analysing metabolic rate?	326
NAD kinase essentiality in cancer: in real life, it is all about folates	315
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	232
The cyclic metabolic switching theory of intermittent fasting	232
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	212
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	201
Phagocytosis in the retina promotes local insulin production in the eye	200
The rs1421085 variant within FTO promotes brown fat thermogenesis	177
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	154
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	153
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	148
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	147
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	145
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	144
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	143
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	141
Hot news about temperature and lifespan	138
A BCAA–haem axis regulates brown fat function	137
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	134
Fuelling the fire: de novo lipogenesis primes thermogenesis	127

The thyroid gland under Notch control	127
Best practices in collecting and reporting continuous glucose monitoring data in research settings	127
Gut bacteria thwart the blood sugar-lowering effect of acarbose	126
TKT deficiency puts Tregs to rest	121
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	121
A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals	119
Shaping the future of cardiometabolic innovation: advances and opportunities	119
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	118
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	116
Common genetic variants modify disease risk and clinical presentation in monogenic diabetes	113
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide	113
Spatial metabolomics: from a niche field towards a driver of innovation	110
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	108
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	107
Hypermetabolism and energetic constraints in mitochondrial disorders	106
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	106
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	106
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	104
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	103
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity	101
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	100
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	97
The antitumour effects of caloric restriction are mediated by the gut microbiome	97
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	94
Fuelling synapses via lipid metabolism	92
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	91
Gases define redox signalling: NO, H2S, O2 … and cyanide	91
Proline fuels ILC3s to maintain gut health	90
Why a good lab website matters	90
Querying stool for dietary information	90
Beyond Warburg: LDHA activates RAC for tumour growth	88
Hypometabolism with the speed of ultrasound	86
A RalA between high-fat diet and mitochondrial shape	86
Methionine and H2S alter cancer–immune dialogue	85
Illuminating the ‘healthy obese’ phenotype	85
A systematic mutational framework for studying oxidative phosphorylation-related proteins	85
Sweet signals for myelin: glucose sensing redirected to regeneration	83
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis	82
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	82
A century of the Warburg effect	82
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	82
Mitochondrial RNA stimulates beige adipocyte development in young mice	82
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	80
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	79
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	79
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	78
A researcher’s guide to preclinical mouse NASH models	78
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8	78
Neurometabolism in focus	77
An integrated single-cell islet atlas in health and disease	77

Human basal metabolic rate has declined over the past 30 years	76
Lighting up targets of dual agonist therapies for diabetes and obesity	75
Cancer metabolite blunts immunity	75
Regulated insulin secretion from human and mouse islets exclusively composed of β-cells	75
Author Correction: Metabolic reconfiguration enables synthetic reductive metabolism in yeast	73
Asters: rising stars in the cholesterol universe	73
Central regulation of the anorexigenic receptor GFRAL	72
Feeding the hippocampus … with specific nutrients	69
Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis	68
GLP-2 attenuates antipsychotics’ adverse metabolic effects	68
Retraction Note: Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice	68
Itaconate boosts type I IFN response by disrupting cytoprotection	68
A yeast vacuolar pH ‘heartbeat’ coordinates amino acid metabolism and the cell cycle	67
Mapping the plasma metabolome to human health and disease in 274,241 adults	67
Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging	67
Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes	67
Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control	66
Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	66
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc	66
Intracellular metabolic gradients dictate dependence on exogenous pyruvate	66
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism	65
Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth	63
Sclerostin secreted from bone mediates cognitive decline in the brains of aged and Alzheimer’s disease mice	63
Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation	62
The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice	61
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function	61
Do not overlook the role of fructose in obesity	61
Insulin induces insulin receptor degradation in the liver through EphB4	61
Principles and functions of metabolic compartmentalization	61
TM6SF2 as new intestinal lipid player	60
MCT1 helps brown fat suck up succinate	60
Small intestinal protein sensing pathways regulate food intake and glucose homeostasis	60
A common framework for mouse hypothalamic cell atlases	59
Bile acid binds heart failure and inflammation	58
Career pathways, part 12	58
Proteogenomic mapping sets stage for precision medicine	58
ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP	57
Odour-imagery ability is linked to food craving, intake, and adiposity change in humans	56
A food-sensitive olfactory circuit drives anticipatory satiety	56
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells	56
Identification of a regulatory pathway inhibiting adipogenesis via RSPO2	56
Iron at the intersection of macrophage–adipocyte interactions	55
NAD+ precursor supplementation in human ageing: clinical evidence and challenges	55
Systemic proteome adaptions to 7-day complete caloric restriction in humans	55
Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons	55
Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis	54
Serine catabolism generates liver NADPH and supports hepatic lipogenesis	54
AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids	54
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration	53
Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease	52
Career pathways, part 9	51
Divergent roles for propionate and butyrate in colorectal cancer epigenetics	51
NAD+ regeneration drives cancer cell proliferation	51
Differential mechanisms affecting weight loss and weight loss maintenance	50
Revisiting the role of serine metabolism in hepatic lipogenesis	49
Publisher Correction: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function	49
The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming	49
GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice	49
Mitochondrial function and phenotype are defined by bioenergetics	49
d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1	49
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism	49
Author Correction: Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer	49
Anaplerosis in action	49
The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation	48
Liraglutide restores impaired associative learning in individuals with obesity	48
Hypothalamic Grb10 enhances leptin signalling and promotes weight loss	48
The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade	47
Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota	47
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness	47
Metabolic Messengers: itaconate	47
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair	46
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia	46
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity	46
Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment	46
AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation	46
Pentose phosphate pathway drives vascular maturation	45
Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth	45
Adipose glutaminolysis resurfaces in metabolic disease	44
Keeping ILCs in shape: PD-1 as a metabolic checkpoint	44
A multi-omic trip through the human gut	44

Publisher Correction: A new foe in folate metabolism	44
Disrupting cholesterol homeostasis in T cells boosts antitumour responses	43
Reply to: revisiting the role of serine metabolism in hepatic lipogenesis	43
O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production	43
Vestibular nucleus mediation of motion sickness has implications for obesity control	43
Science in times of conflict	43
Signalling from adipose tissue to the brain is not just about leptin	43
A derivative of the ancient drug salicylate for obesity treatment	42
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production	42
Phenotypic profiling of solute carriers characterizes serine transport in cancer	42
Overlooked confounding in studies of metabolite salts	42
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	42
Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis	42
Activation of GPR81 by lactate drives tumour-induced cachexia	41
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells	41
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance	41
GAPDH redox redux—rewiring pentose phosphate flux	41
Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome	41
The insulin signalling network	40
Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations	40
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations	40
Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations	40
Obesity-induced inflammation: connecting the periphery to the brain	39
Mitochondrial DNA editing with mitoARCUS	39
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages	39
A local source of insulin protects the retina against starvation	39
NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis	39
Raising the bar for sex and gender reporting in research	38
Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency	38
Mitochondrial and psychosocial stress-related regulation of FGF21 in humans	38
SERPINA3C as a mediator of metabolic health in offspring	38
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix	38
Subcellular quantitative imaging of metabolites at the organelle level	38
Author Correction: Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	38
Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke	37
What about sex?	37
Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer	37
Innate metabolic responses against viral infections	37
Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol	37
Metabolic Messengers: endocannabinoids	36
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss	36
Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia	36
H2S as a metabolic saboteur	36
A brief guide to statistical analysis of grouped data in preclinical research	36
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction	35
Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD	35
Cancer tissue of origin constrains the growth and metabolism of metastases	35
Early-life ketone body signalling promotes beige fat biogenesis through changes in histone acetylome and β-hydroxybutyrylome	35
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis	35
Cold acclimation with shivering improves metabolic health in adults with overweight or obesity	35
Considerations for designing and analysing inter-generational studies in rodents	35
Author Correction: ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response	34
A monolysocardiolipin–cytochrome c peroxidase causes defects in Barth syndrome	34
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus	34
NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection	33
Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization	33
Serine synthesis promotes bone degradation	33
β-hydroxybutyrate inhibits Plasmodium falciparum development and confers protection against malaria in mice	33
Itaconate trims the fat	33
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health	33
Publisher Correction: The endothelial Dll4–muscular Notch2 axis regulates skeletal muscle mass	33
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics	33
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth	32
Artificial intelligence in metabolic research	32
Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer	32
Epitranscriptomics in metabolic disease	32
Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature	32
Five years on	31
Metabolic engineering for optimized CAR-T cell therapy	31
Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21	31
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis	31
Maternal diet disrupts the placenta–brain axis in a sex-specific manner	31
Considering co-submissions	31
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity	31
Triglycerides are an important fuel reserve for synapse function in the brain	31