Nature Metabolism

Article	Citations
Aldolase A: the broker of glycolysis	744
Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations	433
Targeting pancreatic β cells for diabetes treatment	375
Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response	310
Activation of GPR81 by lactate drives tumour-induced cachexia	285
Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound	265
Proteogenomic links to human metabolic diseases	264
Disrupting cholesterol homeostasis in T cells boosts antitumour responses	253
Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome	208
Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet–mitochondria tethering to enhance β-oxidation and tumor cell proliferation	186
Cellular and organismal function of choline metabolism	182
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells	182
NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis	171
Author Correction: Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	164
Intestinal plasticity and metabolism as regulators of organismal energy homeostasis	160
Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity	145
Phagocytosis in the retina promotes local insulin production in the eye	131
A subpopulation of lipogenic brown adipocytes drives thermogenic memory	130
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	128
Molecular consequences of SARS-CoV-2 liver tropism	126
Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes	123
Phenotypic profiling of solute carriers characterizes serine transport in cancer	117
O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production	113
Impaired cell surface expression of GLP1R variants determines T2D and obesity risk in humans	112
Lipids reroute mitochondria	111

Virtually unsocial	106
Overlooked confounding in studies of metabolite salts	105
Functional screening and rational design of compounds targeting GPR132 to treat diabetes	103
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	102
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages	101
Quantitative flux analysis in mammals	100
Science in times of conflict	100
HDAC6 inhibition overcomes leptin resistance in obesity	99
Systematic analysis of NDUFAF6 in complex I assembly and mitochondrial disease	99
Malaria thriving on steroids	98
There is more than one way to reach type 2 diabetes	96
Synthetic metabolism without the TCA cycle	95
ACBP orchestrates the metabolic phenotype in Cushing’s syndrome	93
Author Correction: Branched-chain α-ketoacids aerobically activate HIF1α signalling in vascular cells	93
The discovery of human agouti-induced obesity and its implication for genetic diagnosis	93
How cells flex their PEX to fine-tune lipolysis in NAFLD	92
Pentose phosphate pathway drives vascular maturation	91
GAPDH redox redux—rewiring pentose phosphate flux	91
A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells	90
Hypothalamus pre-optic area and metabolism regulation in humans	88
A multi-omic trip through the human gut	88
Colchicine—an old dog with new tricks	88
Astrocytic GABA in LHA is an obesity ‘thermostat’	86
Run to survive—how preoperative exercise could prevent major surgical complications	85
Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions	84
Co-receptor regulation of insulin signaling	83
Umami taste—a novel mechanism driving food intake and obesity	83
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation	83
Career pathways, part 6	83
Gut reaction: it’s not all about enzymes	82
nicX-ing bad habits with your microbial friends	82
Keeping ILCs in shape: PD-1 as a metabolic checkpoint	81
Publisher Correction: Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism	81
Glycolysis modulates efferocytosis in a noncanonical manner	80
MOF moves into mitochondria	78
Reply to: revisiting the role of serine metabolism in hepatic lipogenesis	78
Linking neuropsychiatric disease to neuronal metabolism	77
Big data and personalized nutrition: the key evidence gaps	74
A gut bacterium tackles atherosclerosis	73
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	72
A call for accessible tools to unlock single-cell immunometabolism research	71
Tissue-resident bacteria in metabolic diseases: emerging evidence and challenges	71
The cell cycle loops UTP around CAD	69
BCAT2–BCKDH metabolon maintains BCAA homeostasis	69
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	69
Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function	68
Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue	68
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance	67
The dance of gut microbes on the keto diet	67
Methanol-tolerant yeast for biofuel production	67

Adipose glutaminolysis resurfaces in metabolic disease	67
Author Correction: An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	66
Human PERIOD3 variants lead to winter depression-like behaviours via glucocorticoid signalling	66
The pressure not to eat	65
Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing	65
Publisher Correction: Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation	64
Author Correction: Activation of GPR81 by lactate drives tumour-induced cachexia	64
Author Correction: PNPO–PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity	63
Publisher Correction: Reciprocal regulation of cellular mechanics and metabolism	63
Publisher Correction: Host–microbe interactions rewire metabolism in a C. elegans model of leucine breakdown deficiency	63
Enhanced branched-chain amino acid metabolism improves age-related reproduction in C. elegans	63
Publisher Correction: A new foe in folate metabolism	62
MYCL-mediated reprogramming expands pancreatic insulin-producing cells	61
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	60
PNPO–PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity	59
More protein in ultra-processed foods: no shortcut to eating less	59
S-acylation of ATGL is required for lipid droplet homoeostasis in hepatocytes	58
AI-driven framework to map the brain metabolome in three dimensions	58
What is the most appropriate covariate in ANCOVA when analysing metabolic rate?	58
Glycogen drives tumour initiation and progression in lung adenocarcinoma	58
GTTs and ITTs: aim for shorter fasting times	58
Vestibular nucleus mediation of motion sickness has implications for obesity control	57
Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis	57
Time of exercise differentially impacts bone growth in mice	57
mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1	57
Methylmalonic acid: an age-related metabolite that drives tumour aggressiveness	57
Broad-spectrum antibiotics disrupt homeostatic efferocytosis	57
Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity	56
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	55
Microviridae bacteriophages in the gut microbiome and food addiction in humans	55
Aberrant NAD+ metabolism underlies Zika virus–induced microcephaly	54
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	54
Alkaline taste sensation through the alkaliphile chloride channel in Drosophila	54
Obesity-induced inflammation: connecting the periphery to the brain	53
The cyclic metabolic switching theory of intermittent fasting	52
Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice	52
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	52
Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations	51
Independent phenotypic plasticity axes define distinct obesity sub-types	51
Exploring pancreatic beta-cell subgroups and their connectivity	51
Author Correction: Exercise hormone irisin is a critical regulator of cognitive function	51
Reciprocal regulation of cellular mechanics and metabolism	51
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	51
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	51
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production	51
Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity	50
Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis	50
Inhibition of the IL-17A axis in adipocytes suppresses diet-induced obesity and metabolic disorders in mice	50
The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding	49
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	48
Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype	48
Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis	48
Metabolic Messengers: bile acids	48
The rs1421085 variant within FTO promotes brown fat thermogenesis	48
SIRT5 slows skeletal muscle ageing by alleviating inflammation	48
Coordinated action of a gut–liver pathway drives alcohol detoxification and consumption	48
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	48
Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis	47
Publisher Correction: The glucose transporter 2 regulates CD8+ T cell function via environment sensing	47
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	46
Histone butyrylation in the mouse intestine is mediated by the microbiota and associated with regulation of gene expression	46
Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes	46
Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila	46
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma	46
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	46
Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+	46
Author Correction: Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase	45
Gut microbiome-derived ammonia modulates stress vulnerability in the host	45
Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas	45
Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells	45
The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions	44
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations	44
Obesity impairs brain responses to nutrients	43
APOE variants affect COVID-19 outcome	43
Functionally heterogeneous β cells regulate biphasic insulin secretion	43
A local source of insulin protects the retina against starvation	42
Suppression of CD8+ T cells by the metabolite itaconate	42
Non-mammalian metabolic models in the spotlight	42
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	42
Integration of epidemiological and blood biomarker analysis links haem iron intake to increased type 2 diabetes risk	42

Subcutaneous depth-selective spectral imaging with mμSORS enables noninvasive glucose monitoring	41
A future without needles: non-invasive glucose measurements in patients with diabetes	41
SERPINA3C as a mediator of metabolic health in offspring	41
GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation	40
Glial metabolism checkpoints memory	40
Human plasma proteomic profiles indicative of cardiorespiratory fitness	40
Affinity war: PSAT1 outcompetes the rest	40
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk	39
Mitochondrial DNA editing with mitoARCUS	39
Genetic susceptibility to diabetic kidney disease is linked to promoter variants of XOR	39
Macrophage vesicles starve bacteria of iron	39
Cancer tissue of origin constrains the growth and metabolism of metastases	38
Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption	38
Liver insulinization as a driver of triglyceride dysmetabolism	37
Hot news about temperature and lifespan	36
Astroglial clean-up of satiety synapses	36
A randomized clinical trial of lipid metabolism modulation with fenofibrate for acute coronavirus disease 2019	36
Raising the bar for sex and gender reporting in research	36
Ketones to the rescue of the starving fly	36
PD-1 signaling facilitates activation of lymphoid tissue inducer cells by restraining fatty acid oxidation	35
COVID-19 instigates adipose browning and atrophy through VEGF in small mammals	35
Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation	35
Reducing NAD(H) to amplify rhythms	34
Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure	34
A wild approach to obesity prevention	34
Gut bacteria thwart the blood sugar-lowering effect of acarbose	34
The dual action of basal forebrain in feeding regulation	33
Causal drivers of human proteome variation in health and disease	33
Depletion of JunB increases adipocyte thermogenic capacity and ameliorates diet-induced insulin resistance	33
Cold acclimation with shivering improves metabolic health in adults with overweight or obesity	33
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	33
Author Correction: Characterization of the genetic architecture of infant and early childhood body mass index	33
p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL	33
Diabetes, IL-10 and the brain’s microvascular crisis	33
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	32
A leucine–macrophage mTORC1 connection drives increased risk of atherosclerosis with high-protein diets	32
Gene-by-environment modulation of lifespan and weight gain in the murine BXD family	32
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	31
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2	31
Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity	31
A blood-to-brain delivery system to treat obesity	30
Upcycling the TCA cycle—rewiring tumour-associated fibroblasts	30
Publisher Correction: Revisiting energy expenditure: how to correct mouse metabolic rate for body mass	30
What about sex?	30
H2S as a metabolic saboteur	30
Metabolic Messengers: endocannabinoids	30
Humans without GDF15 reassure drug developers	30
Author Correction: Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	29
A microbial metabolite linked to fat accumulation	29
Considerations for designing and analysing inter-generational studies in rodents	29
Lipid cycling isn’t all futile	29
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis	28
Career pathways, part 10	28
Fuelling the fire: de novo lipogenesis primes thermogenesis	28
Author Correction: Proteogenomic links to human metabolic diseases	28
TKT deficiency puts Tregs to rest	27
Career pathways, part 14	27
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	27
Who knew? PPARs may act in the brain too	27
The thyroid gland under Notch control	27
Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency	27
Best practices in collecting and reporting continuous glucose monitoring data in research settings	27
Emerging tools and best practices for studying gut microbial community metabolism	27
Metformin induces a Lac-Phe gut–brain signalling axis	27
A CNS circuit that regulates gut motility	26
Time-restricted feeding makes the mouse run like a pro	26
Diabetes in China: epidemiology, pathophysiology and multi-omics	26
How to let your data shine	26
Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance	26
Inflamed macrophages sans mitochondrial pyruvate carrier?	26
Complex roles for mitochondrial complexes in microglia	26
Homeostatic feeding in hedonic centres	26
TrkB signalling regulates dopamine circuits and motor function through metabolic pathways	26
Farnesyl pyrophosphate modulates dendritic cell migration in lupus autoimmunity	26