Nature Metabolism

Article	Citations
Glycolysis modulates efferocytosis in a noncanonical manner	882
The cell cycle loops UTP around CAD	501
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	439
Author Correction: Exercise hormone irisin is a critical regulator of cognitive function	352
What is the most appropriate covariate in ANCOVA when analysing metabolic rate?	325
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	312
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen	295
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	250
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	250
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	235
The rs1421085 variant within FTO promotes brown fat thermogenesis	213
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	212
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	187
NAD kinase essentiality in cancer: in real life, it is all about folates	172
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	162
Phagocytosis in the retina promotes local insulin production in the eye	160
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	142
The cyclic metabolic switching theory of intermittent fasting	140
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	134
Incretin-based therapeutics for the treatment of neurodegenerative diseases	132
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	131
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	129
Best practices in collecting and reporting continuous glucose monitoring data in research settings	129
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	125
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	124

Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	121
TKT deficiency puts Tregs to rest	118
Shaping the future of cardiometabolic innovation: advances and opportunities	118
Fuelling the fire: de novo lipogenesis primes thermogenesis	114
The thyroid gland under Notch control	111
Hot news about temperature and lifespan	111
Gut bacteria thwart the blood sugar-lowering effect of acarbose	111
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	110
A BCAA–haem axis regulates brown fat function	106
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	106
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	104
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	104
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	101
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	101
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	101
Hypermetabolism and energetic constraints in mitochondrial disorders	98
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	98
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	98
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity	96
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	96
The antitumour effects of caloric restriction are mediated by the gut microbiome	95
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	94
Illuminating the ‘healthy obese’ phenotype	94
Methionine and H2S alter cancer–immune dialogue	94
Spatial metabolomics: from a niche field towards a driver of innovation	94
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	93
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis	91
Fuelling synapses via lipid metabolism	91
Abnormal exocrine–endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8	90
Gases define redox signalling: NO, H2S, O2 … and cyanide	89
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	89
Querying stool for dietary information	88
Why a good lab website matters	87
A systematic mutational framework for studying oxidative phosphorylation-related proteins	86
Hypometabolism with the speed of ultrasound	80
Proline fuels ILC3s to maintain gut health	80
A RalA between high-fat diet and mitochondrial shape	80
Beyond Warburg: LDHA activates RAC for tumour growth	79
Mitochondrial RNA stimulates beige adipocyte development in young mice	76
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	75
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	75
A century of the Warburg effect	75
5-IP7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis	74
Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation	73
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	73
Cancer metabolite blunts immunity	72
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	72
A researcher’s guide to preclinical mouse NASH models	72
Neurometabolism in focus	71
An integrated single-cell islet atlas in health and disease	70

Sclerostin secreted from bone mediates cognitive decline in the brains of aged and Alzheimer’s disease mice	70
Regulated insulin secretion from human and mouse islets exclusively composed of β-cells	69
Human basal metabolic rate has declined over the past 30 years	69
Feeding the hippocampus … with specific nutrients	69
Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes	68
Fixing lymphatics improves glucose metabolism	67
Asters: rising stars in the cholesterol universe	67
Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation	67
Author Correction: Metabolic reconfiguration enables synthetic reductive metabolism in yeast	67
GLP-2 attenuates antipsychotics’ adverse metabolic effects	67
Central regulation of the anorexigenic receptor GFRAL	67
Insulin induces insulin receptor degradation in the liver through EphB4	66
Itaconate boosts type I IFN response by disrupting cytoprotection	66
A yeast vacuolar pH ‘heartbeat’ coordinates amino acid metabolism and the cell cycle	66
The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice	65
Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation	64
Retraction Note: Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice	64
Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging	64
Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	63
Principles and functions of metabolic compartmentalization	63
Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth	63
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism	62
Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis	61
Intracellular metabolic gradients dictate dependence on exogenous pyruvate	61
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc	60
Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function	60
Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity	59
Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control	59
MCT1 helps brown fat suck up succinate	58
Small intestinal protein sensing pathways regulate food intake and glucose homeostasis	58
TM6SF2 as new intestinal lipid player	58
ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP	58
Do not overlook the role of fructose in obesity	58
Systemic proteome adaptions to 7-day complete caloric restriction in humans	57
Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease	57
A common framework for mouse hypothalamic cell atlases	57
Proteogenomic mapping sets stage for precision medicine	56
Career pathways, part 12	56
Iron at the intersection of macrophage–adipocyte interactions	56
Bile acid binds heart failure and inflammation	56
A food-sensitive olfactory circuit drives anticipatory satiety	55
AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids	54
Nuclear PHGDH protects cancer cells from nutrient stress	54
Identification of a regulatory pathway inhibiting adipogenesis via RSPO2	54
Odour-imagery ability is linked to food craving, intake, and adiposity change in humans	54
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells	54
Serine catabolism generates liver NADPH and supports hepatic lipogenesis	53
Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons	52
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration	52
Career pathways, part 9	52
Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis	52
NAD+ regeneration drives cancer cell proliferation	52
Anaplerosis in action	51
Author Correction: Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer	50
GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice	50
Publisher Correction: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function	50
The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming	49
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity	49
Mitochondrial function and phenotype are defined by bioenergetics	49
The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation	48
Revisiting the role of serine metabolism in hepatic lipogenesis	47
Divergent roles for propionate and butyrate in colorectal cancer epigenetics	46
Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota	46
The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade	45
Differential mechanisms affecting weight loss and weight loss maintenance	45
AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation	45
Hypothalamic Grb10 enhances leptin signalling and promotes weight loss	44
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair	44
Liraglutide restores impaired associative learning in individuals with obesity	44
Glutamine synthetase licenses APC/C-mediated mitotic progression to drive cell growth	43
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia	43
Adipose glutaminolysis resurfaces in metabolic disease	43
Keeping ILCs in shape: PD-1 as a metabolic checkpoint	43
Metabolic Messengers: itaconate	43
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism	43
A multi-omic trip through the human gut	43
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness	43
Umami taste—a novel mechanism driving food intake and obesity	43
Publisher Correction: A new foe in folate metabolism	43
Pentose phosphate pathway drives vascular maturation	42

Science in times of conflict	41
Disrupting cholesterol homeostasis in T cells boosts antitumour responses	41
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production	40
Reply to: revisiting the role of serine metabolism in hepatic lipogenesis	40
GAPDH redox redux—rewiring pentose phosphate flux	40
Signalling from adipose tissue to the brain is not just about leptin	40
Vestibular nucleus mediation of motion sickness has implications for obesity control	40
O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production	40
Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome	39
Activation of GPR81 by lactate drives tumour-induced cachexia	39
A derivative of the ancient drug salicylate for obesity treatment	39
Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis	39
Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations	39
Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations	39
Overlooked confounding in studies of metabolite salts	39
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations	39
Obesity-induced inflammation: connecting the periphery to the brain	38
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages	38
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance	38
NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis	38
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells	38
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	38
A local source of insulin protects the retina against starvation	37
Phenotypic profiling of solute carriers characterizes serine transport in cancer	37
Mitochondrial DNA editing with mitoARCUS	36
Author Correction: Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	36
SERPINA3C as a mediator of metabolic health in offspring	36
Raising the bar for sex and gender reporting in research	36
A blood-to-brain delivery system to treat obesity	36
What about sex?	36
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix	35
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2	35
Considerations for designing and analysing inter-generational studies in rodents	35
Gene-by-environment modulation of lifespan and weight gain in the murine BXD family	35
Innate metabolic responses against viral infections	35
A brief guide to statistical analysis of grouped data in preclinical research	35
Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency	35
Metabolic Messengers: endocannabinoids	34
H2S as a metabolic saboteur	34
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss	34
Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol	34
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis	34
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus	33
Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia	33
Subcellular quantitative imaging of metabolites at the organelle level	33
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction	33
Cold acclimation with shivering improves metabolic health in adults with overweight or obesity	33
Cancer tissue of origin constrains the growth and metabolism of metastases	33
Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer	33
Itaconate trims the fat	32
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics	32
Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization	32
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication	32
Serine synthesis promotes bone degradation	32
NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection	32
A monolysocardiolipin–cytochrome c peroxidase causes defects in Barth syndrome	32
Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature	31
Author Correction: ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response	31
Triglycerides are an important fuel reserve for synapse function in the brain	31
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health	31
β-hydroxybutyrate inhibits Plasmodium falciparum development and confers protection against malaria in mice	31
Publisher Correction: The endothelial Dll4–muscular Notch2 axis regulates skeletal muscle mass	31
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis	30
Metabolic engineering for optimized CAR-T cell therapy	30
Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth	30
Publisher Correction: A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis	30
Five years on	30
Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21	30
Maternal diet disrupts the placenta–brain axis in a sex-specific manner	30
Considering co-submissions	30
Short-term effects of high-protein, lower-carbohydrate ultra-processed foods on human energy balance	30
Epitranscriptomics in metabolic disease	30
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity	30
Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer	30
Mitochondrial superoxide regulates pro-inflammatory macrophages	30
Long-term exercise training has positive effects on adipose tissue in overweight or obesity	30