Nature Metabolism

Article	Citations
The cell cycle loops UTP around CAD	1275
NAD kinase essentiality in cancer: in real life, it is all about folates	563
Publisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	516
Glycolysis modulates efferocytosis in a noncanonical manner	513
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation	498
The rs1421085 variant within FTO promotes brown fat thermogenesis	292
Improved polyketide production in C. glutamicum by preventing propionate-induced growth inhibition	253
Epigenetic adaptation of beta cells across lifespan and disease	219
Heterogeneous sympathetic control of brown adipose tissue	213
An ATP-sensitive phosphoketolase regulates carbon fixation in cyanobacteria	203
Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis	200
DGAT1 mediates sex-specific CD8+ T cell antitumour responses	195
PFKM governs metabolic shifts throughout skeletal muscle differentiation	192
Publisher Correction: Gut mucosal mycobiome profiling in Crohn’s disease uncovers an AMP-mediated anti-inflammatory effect of Cladosporium sphaerospermum	189
Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota	188
The cyclic metabolic switching theory of intermittent fasting	180
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation	177
Total parenteral nutrition impairs glucose metabolism by modifying the gut microbiome	174
Incretin-based therapeutics for the treatment of neurodegenerative diseases	173
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle	167
Recommendations for mitochondria transfer and transplantation nomenclature and characterization	163
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes	157
Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice	153
Phagocytosis in the retina promotes local insulin production in the eye	151
GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management	151

A BCAA–haem axis regulates brown fat function	150
A conserved role for PCYT2-regulated lipid biosynthesis in muscle health and ageing	148
Fuelling the fire: de novo lipogenesis primes thermogenesis	145
Methylation, acetylation and cell fate	145
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence	140
The thyroid gland under Notch control	140
The antitumour effects of caloric restriction are mediated by the gut microbiome	137
Gut bacteria thwart the blood sugar-lowering effect of acarbose	137
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA	134
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress	134
Skeletal muscle, not adipose tissue, mediates cold-induced metabolic benefits	129
Common genetic variants modify disease risk and clinical presentation in monogenic diabetes	127
Shaping the future of cardiometabolic innovation: advances and opportunities	123
A salute to innovation: exenatide in diabetes and obesity drug development at Amylin Pharmaceuticals	121
GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice	118
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions	117
Hypermetabolism and energetic constraints in mitochondrial disorders	117
Spatial metabolomics: from a niche field towards a driver of innovation	116
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid	115
Best practices in collecting and reporting continuous glucose monitoring data in research settings	115
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide	112
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice	112
Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	111
Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states	111
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury	108
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice	108
Why a good lab website matters	104
Fat sensory cues in early life program central response to food and obesity	103
Hypometabolism with the speed of ultrasound	102
Cysteine depletion triggers adipose tissue thermogenesis and weight loss	102
A RalA between high-fat diet and mitochondrial shape	101
A systematic mutational framework for studying oxidative phosphorylation-related proteins	101
Querying stool for dietary information	100
Sweet signals for myelin: glucose sensing redirected to regeneration	100
Illuminating the ‘healthy obese’ phenotype	97
Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance	97
Proline fuels ILC3s to maintain gut health	97
Methionine and H2S alter cancer–immune dialogue	97
Mitochondrial RNA stimulates beige adipocyte development in young mice	96
Beyond Warburg: LDHA activates RAC for tumour growth	95
Gases define redox signalling: NO, H2S, O2 … and cyanide	95
Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia	95
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice	92
A century of the Warburg effect	91
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation	90
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut–liver axis	90
The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis	89
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research	88
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing’s syndrome	87
A researcher’s guide to preclinical mouse NASH models	87

Fuelling synapses via lipid metabolism	86
HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma	85
Neurometabolism in focus	84
An integrated single-cell islet atlas in health and disease	83
Lighting up targets of dual agonist therapies for diabetes and obesity	82
Cancer metabolite blunts immunity	82
Regulated insulin secretion from human and mouse islets exclusively composed of β-cells	81
Asters: rising stars in the cholesterol universe	81
A yeast vacuolar pH ‘heartbeat’ coordinates amino acid metabolism and the cell cycle	80
Feeding the hippocampus … with specific nutrients	80
Author Correction: Metabolic reconfiguration enables synthetic reductive metabolism in yeast	79
Insulin induces insulin receptor degradation in the liver through EphB4	79
Intracellular metabolic gradients dictate dependence on exogenous pyruvate	79
Itaconate boosts type I IFN response by disrupting cytoprotection	79
Sclerostin secreted from bone mediates cognitive decline in the brains of aged and Alzheimer’s disease mice	78
Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes	78
GLP-2 attenuates antipsychotics’ adverse metabolic effects	78
Human basal metabolic rate has declined over the past 30 years	77
Retraction Note: Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice	77
Angiocrine breakdown in metabolically stressed fat	76
Spatial protein gradients pattern liver metabolism	76
Humoral regulation of iron metabolism by extracellular vesicles drives antibacterial response	73
The genetics of obesity: aetiology, prevention and therapy	72
Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells	72
Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth	72
Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation	71
The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice	71
Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming	71
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function	71
Mapping the plasma metabolome to human health and disease in 274,241 adults	71
Principles and functions of metabolic compartmentalization	70
Glycerol is a new ally for heat production and bone health	70
Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis	69
Overcoming dietary dogmas	69
Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging	69
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease	68
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism	67
Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control	67
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc	66
Small intestinal protein sensing pathways regulate food intake and glucose homeostasis	66
TM6SF2 as new intestinal lipid player	66
MCT1 helps brown fat suck up succinate	65
A common framework for mouse hypothalamic cell atlases	64
Proteogenomic mapping sets stage for precision medicine	64
Career pathways, part 12	64
Bile acid binds heart failure and inflammation	63
Do not overlook the role of fructose in obesity	63
Iron at the intersection of macrophage–adipocyte interactions	62
Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis	62
AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids	62
Odour-imagery ability is linked to food craving, intake, and adiposity change in humans	61
Drowning in cysteine	60
Mitochondrial iNOS blocks itaconate production by interacting with IRG1	60
A food-sensitive olfactory circuit drives anticipatory satiety	60
NAD+ precursor supplementation in human ageing: clinical evidence and challenges	59
Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease	59
A catecholamine-independent pathway controlling adaptive adipocyte lipolysis	58
Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons	58
Cardiolipin preserves Treg metabolic fitness and immune homeostasis in the gut	58
Excess cysteine drives conjugate formation and impairs proliferation of NRF2-activated cancer cells	57
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells	57
ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP	57
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration	57
Systemic proteome adaptions to 7-day complete caloric restriction in humans	57
Mitochondrial function and phenotype are defined by bioenergetics	56
Career pathways, part 9	56
Author Correction: Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer	56
Publisher Correction: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function	56
GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice	55
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair	55
Metabolic regulation by tanycyte-derived extracellular vesicles through insulin precursor-mediated neuronal recognition and mTORC component delivery	55
Anaplerosis in action	55
Hypothalamic Grb10 enhances leptin signalling and promotes weight loss	54
Divergent roles for propionate and butyrate in colorectal cancer epigenetics	54
Liraglutide restores impaired associative learning in individuals with obesity	54
The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade	53
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity	52
NAD+ regeneration drives cancer cell proliferation	52
AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation	52
Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment	51

Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia	51
Longitudinal multimorbidity trajectories shape personalized glycaemic patterns	51
The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming	51
Metabolic Messengers: itaconate	50
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness	50
Revisiting the role of serine metabolism in hepatic lipogenesis	50
Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota	50
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism	50
Differential mechanisms affecting weight loss and weight loss maintenance	50
d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1	50
The hidden impact of in-source fragmentation in metabolic and chemical mass spectrometry data interpretation	49
A multi-omic trip through the human gut	49
Adipose glutaminolysis resurfaces in metabolic disease	49
Keeping ILCs in shape: PD-1 as a metabolic checkpoint	48
O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production	48
Reply to: revisiting the role of serine metabolism in hepatic lipogenesis	48
Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations	48
Career pathways, part 19	48
Vestibular nucleus mediation of motion sickness has implications for obesity control	48
Overlooked confounding in studies of metabolite salts	46
Mitochondrial NAD+ drives liver regeneration	46
A derivative of the ancient drug salicylate for obesity treatment	46
Signalling from adipose tissue to the brain is not just about leptin	46
Phenotypic profiling of solute carriers characterizes serine transport in cancer	46
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells	45
The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages	45
Activation of GPR81 by lactate drives tumour-induced cachexia	45
GAPDH redox redux—rewiring pentose phosphate flux	45
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance	44
NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis	44
Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome	44
Disrupting cholesterol homeostasis in T cells boosts antitumour responses	44
Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations	43
Obesity-induced inflammation: connecting the periphery to the brain	43
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome	42
SERPINA3C as a mediator of metabolic health in offspring	42
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production	42
The insulin signalling network	42
Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations	42
Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis	42
A local source of insulin protects the retina against starvation	42
Mitochondrial DNA editing with mitoARCUS	41
Early-life ketone body signalling promotes beige fat biogenesis through changes in histone acetylome and β-hydroxybutyrylome	41
A sex-specific brake on liver oestrogen signalling	41
Cold acclimation with shivering improves metabolic health in adults with overweight or obesity	41
Reawakening cAMP signalling in cancer cachexia	41
Weighing in on the incretin revolution	41
Metabolic Messengers: endocannabinoids	41
Mitochondrial and psychosocial stress-related regulation of FGF21 in humans	41
A brief guide to statistical analysis of grouped data in preclinical research	41
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss	41
Author Correction: Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance	41
Chaperone-mediated autophagy sustains muscle stem cell regenerative functions but declines with age	41
Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia	40
Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis	40
H2S as a metabolic saboteur	40
Subcellular quantitative imaging of metabolites at the organelle level	40
Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture	40
Considerations for designing and analysing inter-generational studies in rodents	40
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction	39
Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke	39
Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD	38
Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer	38
Itaconate trims the fat	37
Cancer tissue of origin constrains the growth and metabolism of metastases	37
Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol	37
A monolysocardiolipin–cytochrome c peroxidase causes defects in Barth syndrome	37
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus	37
Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency	37
Author Correction: ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response	37
Innate metabolic responses against viral infections	37
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix	37
Towards a Rosetta stone for metabolomics: recommendations to overcome inconsistent metabolite nomenclature	36
Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization	36
Epitranscriptomics in metabolic disease	36
Often forgotten but essential: long-chain acyl-CoAs in metabolic control	35
Serine synthesis promotes bone degradation	35
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics	35
Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer	35
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis	35
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health	35
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity	35
β-hydroxybutyrate inhibits Plasmodium falciparum development and confers protection against malaria in mice	35
Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21	35
Snake postprandial metabolite shows cross-species activation of hypothalamic neurons	35
NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection	35
Metabolic engineering for optimized CAR-T cell therapy	35
Triglycerides are an important fuel reserve for synapse function in the brain	35
Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase	35