OOIR: Observatory of International Research

Papers

(The median citation count of Bio-Design and Manufacturing is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Enhancing angiogenesis and osseointegration through a double gyroid Ti6Al4V scaffold with triply periodic minimal surface	213
Research and clinical applications of selective laser melting tantalum bone plates	99
Deep phenotyping of testosterone-prompted fibrosis in arrhythmogenic right ventricular cardiomyopathy using iPSC-derived engineered cardiac spheroids	81
A crosstalk-free dual-mode sweat sensing system for naked-eye sweat loss quantification via changes in structural reflectance	81
Electrospun fiber membrane with asymmetric NO release for the differential regulation of cell growth	61
Generation of ring-shaped human iPSC-derived functional heart microtissues in a Möbius strip configuration	50
3D printing of osteocytic Dll4 integrated with PCL for cell fate determination towards osteoblasts in vitro	47
Physics problems in bio or bioinspired additive manufacturing	46
Novel assisted cough system based on simulating cough airflow dynamics	45
Biomanufacturing: from biomedicine to biomedicine	44
A 3D in vitro co-culture model for evaluating biomaterial-mediated modulation of foreign-body responses	44
Novel heart valve leaflet designs with stiff polymeric materials and biomimetic kinematics	42
Temporal and spatial regulation of biomimetic vascularization in 3D-printed skeletal muscles	42
Additive manufactured osseointegrated screws with hierarchical design	40
Customized scaffolds for large bone defects using 3D-printed modular blocks from 2D-medical images	39
Alginate/gelatin/boron-doped hydroxyapatite-coated Ti implants: in vitro and in vivo evaluation of osseointegration	35
Performance of novel 3D printing tools in removing coronary-artery calcification tissue	35
Industry news: the additive manufacturing of nerve conduits for the treatment of peripheral nerve injury	32
Microcurvature landscapes induce neural stem cell polarity and enhance neural differentiation	29
Development of a multifunctional uniaxial bioreactor with real-time monitoring of culture conditions and tissue health	29
Design, fabrication, and structural safety validation of 3D-printable biporous bone augments	29
Accelerated fracture healing by osteogenic Ti45Nb implants through the PI3K–Akt signaling pathway	29
Recent advances in stretchable triboelectric nanogenerators for use in wearable bioelectronic devices	28
Trilayer anisotropic structure versus randomly oriented structure in heart valve leaflet tissue engineering	27
A novel wavy non-uniform ligament chiral stent with J-shaped stress–strain behavior to mimic the native trachea	27

Soft, body conformable electronics for thermoregulation enabled by kirigami	27
Balancing the customization and standardization: exploration and layout surrounding the regulation of the growing field of 3D-printed medical devices in China	25
3D printing of patient-specific 316L–stainless–steel medical implants using fused filament fabrication technology: two veterinary case studies	24
Numerical simulation and printability analysis of fused deposition modeling with dual-temperature control	24
Biofabrication and biomanufacturing in Ireland and the UK	23
Electrospinning/3D printing-integrated porous scaffold guides oral tissue regeneration in beagles	23
Ag-doped CNT/HAP nanohybrids in a PLLA bone scaffold show significant antibacterial activity	23
Reduced graphene oxide-mediated electron-hole separation using titanium dioxide increases the photocatalytic antibacterial activity of bone scaffolds	23
Microfluidic thermotaxic selection of highly motile sperm and in vitro fertilization	22
3D-printed tissue repair patch combining mechanical support and magnetism for controlled skeletal muscle regeneration	22
3D spiral channels combined with flexible micro-sieve for high-throughput rare tumor cell enrichment and assay from clinical pleural effusion samples	22
Facile suspension culture protocol of the liver biliary organoids	22
140 k vs 40 k! Does this journal need short papers?	22
3D printing of patient-specific implants for osteochondral defects: workflow for an MRI-guided zonal design	21
Emerging wearable flexible sensors for sweat analysis	21
Kinematics of mandibular advancement devices (MADs): Why do some MADs move the lower jaw backward during mouth opening?	20
In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds	20
Development of a portable reflectance confocal microscope and its application in the noninvasive in vivo evaluation of mesenchymal stem cell-promoted cutaneous wound healing	19
Biofabrication of size-controlled liver microtissues incorporated with ECM-derived microparticles to prolong hepatocyte function	19
Injectable bioactive polymethyl methacrylate–hydrogel hybrid bone cement loaded with BMP-2 to improve osteogenesis for percutaneous vertebroplasty and kyphoplasty	19
Novel pneumatically assisted atomization device for living cell delivery: application of sprayed mesenchymal stem cells for skin regeneration	19
Evaluation of large language models for the classification of medical device software	18
Light-based 3D printing of stimulus-responsive hydrogels for miniature devices: recent progress and perspective	18
Design and realization of lung organoid cultures for COVID-19 applications	18
Nacre-inspired MXene-based film for highly sensitive piezoresistive sensing over a broad sensing range	18
Enhanced axonal regeneration and functional recovery of the injured sciatic nerve in a rat model by lithium-loaded electrospun nanofibrous scaffolds	17
Dissolvable temporary barrier: a novel paradigm for flexible hydrogel patterning in organ-on-a-chip models	17
Hydroxy-α-sanshool-loaded adipose-targeted mesoporous silica nanoparticles induce white adipose browning and reduce obesity by activating TRPV1	17
Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species	17
The use of machine learning to predict the effects of cryoprotective agents on the GelMA-based bioinks used in extrusion cryobioprinting	16
4D printing of core–shell hydrogel capsules for smart controlled drug release	16
3D bioprinting of complex biological structures with tunable elastic modulus and porosity using freeform reversible embedding of suspended hydrogels	16
Laser-induced jigsaw-like graphene structure inspired by Oxalis corniculata Linn. leaf	15
The emerging technology of biohybrid micro-robots: a review	15
4D printing of PLA/PCL shape memory composites with controllable sequential deformation	15
A 3D-printed microfluidic gradient concentration chip for rapid antibiotic-susceptibility testing	14
Simultaneous multimaterial multimethod bioprinting	14
Development of conductive hydrogels: from design mechanisms to frontier applications	14
Porous hydrogel arrays for hepatoma cell spheroid formation and drug resistance investigation	14
Biomanufacturing in Japan: frontier research from 2018 to 2023	14
From oral formulations to drug-eluting implants: using 3D and 4D printing to develop drug delivery systems and personalized medicine	13
Recent advances and innovations in the design and fabrication of wearable flexible biosensors and human health monitoring systems based on conjugated polymers	13
3D bioprinting of in vitro porous hepatoma models: establishment, evaluation, and anticancer drug testing	13
Three-dimensional printing for heart diseases: clinical application review	13
Application of lung microphysiological systems to COVID-19 modeling and drug discovery: a review	12
Assembly of 3D-printed Ti scaffold and free vascularized fibula using a customized Ti plate for the reconstruction of mandibular defects	12
Fabrication of bioinspired edible liquid marble with phase transition and tunable water barrier property	12
Future directions for research on tissue-engineered trachea	11
Junction matters in hydraulic circuit bio-design of microfluidics	11
What’s next toward the bio-design and manufacturing field?	11

Customizable design of multiple-biomolecule delivery platform for enhanced osteogenic responses via ‘tailored assembly system’	11
Three-dimensional kagome structures in a PCL/HA-based hydrogel scaffold to lead slow BMP-2 release for effective bone regeneration	11
Ionic liquid-based transparent membrane-coupled human lung epithelium-on-a-chip demonstrating PM0.5 pollution effect under breathing mechanostress	10
Introducing 3D-potting: a novel production process for artificial membrane lungs with superior blood flow design	10
Implantable probe with integrated reference electrode for in situ neural signal and calcium ion monitoring	10
3D-printed, bi-layer, biomimetic artificial periosteum for boosting bone regeneration	10
Highly sensitive ratiometric fluorescent fiber matrices for oxygen sensing with micrometer spatial resolution	10
Wearable multilead ECG sensing systems using on-skin stretchable and breathable dry adhesives	9
3D printing of personalized polylactic acid scaffold laden with GelMA/autologous auricle cartilage to promote ear reconstruction	9
Rapid fabrication of modular 3D paper-based microfluidic chips using projection-based 3D printing	9
3D bioprinting of a dermal scaffold for full-thickness skin tissue regeneration	9
Cellular interplay to 3D in vitro microphysiological disease model: cell patterning microbiota–gut–brain axis	9
Benidipine-loaded nanoflower-like magnesium silicate improves bone regeneration	9
A novel integrated microfluidic chip for on-demand electrostatic droplet charging and sorting	9
Bio-manufacturing innovation lights up the future	9
Gelatin-based hydrogel functionalized with taurine moieties for in vivo skin tissue regeneration	8
Organoids: a novel modality in disease modeling	8
Spheroid construction strategies and application in 3D bioprinting	8
Functionalized alginate-based bioinks for microscale electrohydrodynamic bioprinting of living tissue constructs with improved cellular spreading and alignment	7
Enhanced wear resistance, antibacterial performance, and biocompatibility using nanotubes containing nano-Ag and bioceramics in vitro	7
Droplet-based bioprinting enables the fabrication of cell–hydrogel–microfibre composite tissue precursors	7
Innovation leading development: a glimpse into three-dimensional bioprinting in Israel	7
Evaluation of different crosslinking methods in altering the properties of extrusion-printed chitosan-based multi-material hydrogel composites	7
Jetting-based bioprinting: process, dispense physics, and applications	7
Electrochemical biosensors for point-of-care testing	7
A framework for the sustainability implications of 3D bioprinting through nature-inspired materials and structures	6
High-efficiency 3D cell spheroid formation via the inertial focusing effect in rotating droplets	6
Deep brain implantable microelectrode arrays for detection and functional localization of the subthalamic nucleus in rats with Parkinson’s disease	6
Designs and methodologies to recreate in vitro human gut microbiota models	6
Pharmaceutical digital transformation in China: digital quality assurance takes the driver’s seat	6
Biomaterials and emerging technologies for tissue engineering and in vitro models	6
Emerging trends and prospects of electroconductive bioinks for cell-laden and functional 3D bioprinting	6
Novel structural designs of 3D-printed osteogenic graft for rapid angiogenesis	6