OOIR: Observatory of International Research

Papers

(The TQCC of Cancer Communications is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
	493
Issue Information	459
Issue Information	285
Kindlin‐1 drives early steps of breast cancer metastasis	273
Correction to “Improving antitumor immunity using antiangiogenic agents: Mechanistic insights, current progress, and clinical challenges”	215
Combined local therapy and CAR‐GPC3 T‐cell therapy in advanced hepatocellular carcinoma: a proof‐of‐concept treatment strategy	199
The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of colorectal cancer, 2024 update	188
Current status and perspectives of esophageal cancer: a comprehensive review	185
Long‐term survival outcomes and immune checkpoint inhibitor retreatment in patients with advanced cervical cancer treated with camrelizumab plus apatinib in the phase II CLAP study	176
Defining and tracing subtypes of patient‐derived xenograft models in pancreatic ductal adenocarcinoma	159
Loss of CDKN1B induces an age‐related clonal hematopoietic disorder via Notch2 activity dysregulation	156
Fascin lysine 471 acetylation cooperates with serine 39 phosphorylation to inhibit actin‐bundling activity and tumor metastasis in esophageal squamous cell carcinoma	147
Issue Information	144
	143
Single‐cell transcriptomics and epigenomics point to CD58‐CD2 interaction in controlling primary melanoma growth and immunity	126
Nine‐fold variation of risk of advanced colorectal neoplasms according to smoking and polygenic risk score: Results from a cross‐sectional study in a large screening colonoscopy cohort	124
	121
Age‐specific effectiveness of primary human papillomavirus screening versus cytology in a cervical cancer screening program: a nationwide cross‐sectional study	115
Issue Information	114
Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives	114
Research trends of cancer metabolism: analysis from a Chinese perspective	111
Nasopharyngeal carcinoma treatment paradigm after HK0501 – a potential way forward	107
Single‐cell transcriptomics provides insights into the origin and immune microenvironment of cervical precancerous lesions	101
	100
Impact of pre‐existing cardiometabolic diseases on metastatic cancer stage at diagnosis: a prospective multinational cohort study	98

Validation of different personalized risk models of chemotherapy‐induced nausea and vomiting: results of a randomized, double‐blind, phase III trial of fosaprepitant for cancer patients treated with h	92
	89
Comparative single‐cell analysis of esophageal cancer subtypes reveals tumor microenvironment distinctions explaining varied immunotherapy responses	86
Neoadjuvant chemoradiotherapy with capecitabine and irinotecan guided by UGT1A1 status in patients with locally advanced rectal cancer: 5‐year update of the CinClare trial	85
Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2‐negative breast cancer	78
EXPRESSION OF CONCERN: Discovery of a Novel Viroid‐Like Circular RNA in Colorectal Cancer	77
A nanotherapeutic strategy to target drug‐tolerant cells and overcome EGFR tyrosine kinase inhibitor resistance in lung cancer	76
Development and validation of an artificial intelligence model for predicting post‐transplant hepatocellular cancer recurrence	70
Partial hepatectomy versus interventional treatment in patients with hepatitis B virus‐related hepatocellular carcinoma and clinically significant portal hypertension: a randomized comparative clinica	69
Residual circulating tumor DNA after adjuvant chemotherapy effectively predicts recurrence of stage II‐III gastric cancer	67
Efficacy and safety of first‐line sintilimab plus anlotinib versus chemotherapy for metastatic non‐small cell lung cancer: a phase II, open‐label, randomized controlled trial	62
HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5‐WDR5‐dependent transcriptional program	59
Oral transforming growth factor‐beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti‐tumor immunity	54
Multifunctional inorganic nanomaterials for cancer photoimmunotherapy	54
p38γ and p38δ as biomarkers in the interplay of colon cancer and inflammatory bowel diseases	53
N⁶‐methyladenosine‐regulated exosome biogenesis orchestrates an immunosuppressive pre‐metastatic niche in gastric cancer peritoneal metastasis	53
Issue Information	51
Cover Image, Volume 45, Issue 6	50
	50
Association of previously irradiated stable brain metastases with outcomes of atezolizumab‐treated non‐small cell lung cancer: A pooled analysis of individual patient data from three randomized trials	50
Cover Image, Volume 42, Issue 1	48
	48
Acquired RD3 loss regulates immune surveillance in high‐risk and therapy defying progressive neuroblastoma	47
Incidence of and survival with bone and soft tissue sarcoma: A nation‐wide study over four decades	46
Impact of small molecule‐mediated inhibition of ammonia detoxification on lung malignancies and liver metabolism	44
Intercellular communications and metabolic reprogramming as new predictive markers for immunotherapy responses in gastric cancer	44
Comprehensive DSRCT multi‐omics analyses unveil CACNA2D2 as a diagnostic hallmark and super‐enhancer‐driven EWSR1::WT1 signature gene	43
First‐line serplulimab plus chemotherapy in extensive‐stage small‐cell lung cancer: Updated results and biomarker analysis from the ASTRUM‐005 randomized clinical trial	43
FOXO1 or not FOXO1: that is the question	42
Targeting IL‐17A to manage immunotherapy‐induced toxicity in melanoma	41
Harnessing chimeric antigen receptor macrophages against solid tumors	40
Antitumoral effects of cannabis in Notch1‐mutated T‐cell acute lymphoblastic leukemia	40
Association between antipsychotic agents and risk of lung cancer: a nested case‐control study	39
Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2‐mediated increase of SOAT2 RNA methylation	39
A strong internal promoter drives massive expression of YEATS‐domain devoid MLLT3 transcripts in HSC and most lethal AML	38
A multimodal integrative approach to model transcriptional addiction of thyroid cancer on RUNX2	37
Ubiquitination in cancer: mechanisms and therapeutic opportunities	36
Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis	35
Correction to: **ZNF582 hypermethylation promotes metastasis of nasopharyngeal carcinoma by regulating the transcription of adhesion molecules Nectin‐3 and NRXN3**	34
Issue Information	34
Low household income and income volatility increase risk of lung cancer: A nationwide retrospective cohort study	34
Long‐term outcomes of intraoperative radiotherapy for early‐stage breast cancer in China: a multicenter real‐world study	33
Correction to “Circulating tumor cells share RNA modules with early embryo trophectoderm and with metastatic cancer”	32
m⁶A‐modified EHD1 controls PD‐L1 endosomal trafficking to modulate immune evasion and immunotherapy responses in lung adenocarcinoma	31
Transcriptomic analyses of localized prostate cancers of East Asian and North American men reveal race‐specific luminal‐basal and microenvironmental differences	31
Enhanced selection of people for lung cancer screening using AHRR (cg05575921) or F2RL3 (cg03636183) methylation as biological markers of smoking exposure	31
An HGF‐dependent positive feedback loop between bladder cancer cells and fibroblasts mediates lymphangiogenesis and lymphatic metastasis	31
Development of antibody‐drug conjugates in cancer: Overview and prospects	30
Breast cancer: an up‐to‐date review and future perspectives	30
JUPITER‐02 trial: advancing survival for recurrent metastatic nasopharyngeal carcinoma and next steps	29

Genomic information of children with malignant brain tumors for the prediction of length of hospitalization	29
Gene expression profiling improves prognostication by nomogram in patients with soft‐tissue sarcomas	27
4‐1BB transcriptomic expression patterns across malignancies: Implications for clinical trials of 4‐1BB agonists	27
Long‐term antibiotic use and risk of hepatocellular carcinoma later in life: a nationwide cohort study of 9.8 million participants	27
Inhibition of mTOR attenuates the initiation and progression of BRCA1‐associated mammary tumors	26
N‐acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4‐acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA	26
Spatial metabolomics for evaluating response to neoadjuvant therapy in non‐small cell lung cancer patients	25
Breaking barriers: the cGAS‐STING pathway as a novel frontier in cancer immunotherapy	25
Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract	25
circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer	25
Neuroinflammation drives apathy in cancer cachexia	25
Issue Information	24
Single‐cell and bulk transcriptomics identifies a tumor‐specific CD36⁺ cancer‐associated fibroblast subpopulation in colorectal cancer	24
Knowing nodal Rouviére: the power of human intelligence in toxicity reduction	24
	24
Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy	24
DNA methylation signature predicts cancer response to demethylation agents from profiling diverse cancer cell lines	24
Issue Information	24
Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms	23
Combination of photodynamic therapy and stimulator of interferon genes (STING) agonist inhibits colorectal tumor growth and recurrence	23
Cover Image, Volume 44, Issue 4	23
Sunitinib in metastatic renal cell carcinoma: clinical outcomes across risk groups in a Turkish Oncology Group Kidney Cancer Consortium	23
Breaking barriers: Smart vaccine platforms for cancer immunomodulation	23
The E3 ubiquitin ligase HUWE1 acts through the N‐Myc‐DLL1‐NOTCH1 signaling axis to suppress glioblastoma progression	23
Enhancement of CAR‐T cell activity against cholangiocarcinoma by simultaneous knockdown of six inhibitory membrane proteins	22
Galectin 3‐binding protein (LGALS3BP) depletion attenuates hepatic fibrosis by reducing transforming growth factor‐β1 (TGF‐β1) availability and inhibits hepatocarcinogenesis	22
Pancreatic cancer survival trends in the US from 2001 to 2014: a CONCORD‐3 study	22
Tumor microenvironment signaling and therapeutics in cancer progression	22
Issue Information	20
Advanced precision modeling reveals divergent responses of hepatocellular carcinoma to combinatorial immunotherapy	20
Ex vivo STAT3 phosphorylation in circulating immune cells: a novel biomarker for early cancer diagnosis and response to anti‐PD‐1 therapy	20
	20
Cover Image, Volume 43, Issue 6	20
A single measurement of fecal hemoglobin concentration outperforms polygenic risk score in colorectal cancer risk assessment	20
Enhancing sensitivity of triple‐negative breast cancer to DNA‐damaging therapy through chemical inhibition of the m6A methyltransferase METTL3	19
Single‐cell‐eQTL mapping in circulating immune cells reveals genetic regulation of response‐associated networks in lung cancer immunotherapy	19
Targeting ferroptosis resistance resensitizes metastatic HR⁺HER2⁻ breast cancer cells to palbociclib‐hormone therapy	19
The regulatory roles and clinical significance of glycolysis in tumor	19
Leptin‐mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer	18
Beyond success: unveiling the hidden potential of radiotherapy and immunotherapy in solid tumors	18
	18
RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment	17
Proteomic identification of new diagnostic biomarkers of early‐stage cutaneous mycosis fungoides	17
Targeting N4‐acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2‐mediated HMGB2 mRNA translation	17
The SARS‐CoV‐2 spike protein induces lung cancer migration and invasion in a TLR2‐dependent manner	17
Evolution of tumor microenvironment in colorectal liver metastases under treatment stress	17
Issue Information	17
Perivascular localized cells commit erythropoiesis in PDGF‐B‐expressing solid tumors	17
Concurrent chemoradiotherapyof different radiation doses and different irradiation fields for locally advanced thoracic esophageal squamous cell carcinoma: A randomized, multicenter, phase III clinica	16
Safety and immunogenicity of a third dose of mRNA‐1273 vaccine among cancer patients	16
Lysosomal TMEM9‐LAMTOR4‐controlled mTOR signaling integrity is required for mammary tumorigenesis	16
Single‐cell atlas reveals a distinct immune profile fostered by T cell‐B cell crosstalk in triple negative breast cancer	16
Real‐world outcomes of niraparib treatment in patients with ovarian cancer: a multicenter non‐interventional study in China	16
Infection complications in febrile chimeric antigen receptor (CAR)‐T recipients during the peri‐CAR‐T cell treatment period examined using metagenomic next‐generation sequencing (mNGS)	16
Diagnostic value of genetic mutation analysis and mutation profiling of cell‐free DNA in intraocular fluid for vitreoretinal lymphoma	15
Tumor‐derived insulin‐like growth factor‐binding protein‐1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors	15
	15
Issue Information	15
Discovery of a novel viroid‐like circular RNA in colorectal cancer	15
Ferroptosis in cancer and cancer immunotherapy	15
Combination of anti‐PD‐L1 antibody with peptide MEL‐dKLA targeting M2 tumor‐associated macrophages suppresses breast cancer metastasis	14
NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma	14
RNA m¹A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target	14
Unraveling the routes to distant metastases in colorectal cancer: Tumor deposits and lymph node metastases as the gateway	14
Transient and DNA‐free in vivo CRISPR/Cas9 genome editing for flexible modeling of endometrial carcinogenesis	14