OOIR: Observatory of International Research

Papers

(The TQCC of Cancer Communications is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses	653
	601
Issue Information	441
Loss of SMARCB1 evokes targetable epigenetic vulnerabilities in epithelioid sarcoma	386
Ex vivo STAT3 phosphorylation in circulating immune cells: a novel biomarker for early cancer diagnosis and response to anti‐PD‐1 therapy	323
Issue Information	229
Tumor derived cell‐free nucleic acid upregulates programmed death‐ligand 1 expression in neutrophil via intracellular Toll‐like receptor signaling	200
SYNCRIP promotes cell cycle progression and lung tumorigenesis by modulating AURKB translation	194
Issue Information	184
Worldwide trends in esophageal cancer survival, by sub‐site, morphology, and sex: an analysis of 696,974 adults diagnosed in 60 countries during 2000‐2014 (CONCORD‐3)	178
Cover Image, Volume 41, Issue 12	165
A novel strategy for treating oncogene‐mutated tumors by targeting tumor microenvironment and synergistically enhancing anti‐PD‐1 immunotherapy	160
Issue Information	140
Issue Information	139
Cover Image, Volume 42, Issue 6	125
Cover Image, Volume 43, Issue 6	123
Fascin lysine 471 acetylation cooperates with serine 39 phosphorylation to inhibit actin‐bundling activity and tumor metastasis in esophageal squamous cell carcinoma	123
Issue Information	113
	112
Single‐cell transcriptomics and epigenomics point to CD58‐CD2 interaction in controlling primary melanoma growth and immunity	111
Bioequivalence of alternative pembrolizumab dosing regimens: current practice and future perspectives	110
Circulating tumor cells share RNA modules with early embryo trophectoderm and with metastatic cancer	106
Anti‐tumor drug supervision in China from 2010 to 2024: the evolution and prospect of drug review standards	92
Cover Image, Volume 43, Issue 11	90
	85

The efficacy and possible mechanisms of immune checkpoint inhibitors in treating non‐small cell lung cancer patients with epidermal growth factor receptor mutation	84
	82
Issue Information	81
Vitamin D₃ for reducing mortality from cancer and other outcomes before, during and beyond the COVID‐19 pandemic: A plea for harvesting low‐hanging fruit	80
Two distinct stem cell‐like subtypes of hepatocellular carcinoma with clinical significance and their therapeutic potentials	75
Long‐term survival outcomes and immune checkpoint inhibitor retreatment in patients with advanced cervical cancer treated with camrelizumab plus apatinib in the phase II CLAP study	74
Spatial relationship of tertiary lymphoid structures and tumor‐associated neutrophils in bladder cancer and prognostic potential for anti‐PD‐L1 immunotherapy	74
Metabolic regulation in the immune response to cancer	73
A serum microRNA signature for enhanced selection of people for lung cancer screening	69
	67
Interleukin‐10 gives exhausted chimeric antigen receptor (CAR) T cells a second breath	65
Kindlin‐1 drives early steps of breast cancer metastasis	63
Loss of CDKN1B induces an age‐related clonal hematopoietic disorder via Notch2 activity dysregulation	61
	61
Cover Image, Volume 42, Issue 8	60
	59
Age‐specific effectiveness of primary human papillomavirus screening versus cytology in a cervical cancer screening program: a nationwide cross‐sectional study	59
Issue Information	58
AP4 induces JNK1 and a miR‐22‐3p/FOSL1 feed‐forward loop to activate AP‐1 and promote colorectal cancer metastasis	57
Updated overall survival and circulating tumor DNA analysis of ensartinib for crizotinib‐refractory ALK‐positive NSCLC from a phase II study	52
Targeting ferroptosis resistance resensitizes metastatic HR⁺HER2⁻ breast cancer cells to palbociclib‐hormone therapy	52
Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1	52
Disclosing the true impact of screening endoscopy in colorectal cancer prevention	50
Revealing the secret behind Epstein‐Barr virus‐specific tumor immune contexture	50
Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy	48
	48
Cell models with inducible oncogenic translocations allow to evaluate the potential of drugs to favor secondary translocations	45
A single measurement of fecal hemoglobin concentration outperforms polygenic risk score in colorectal cancer risk assessment	39
Integrated circulating tumor DNA and T cell repertoire predict radiotherapeutic response and outcome in non‐small cell lung cancer patients with brain metastasis	39
Issue Information	39
Nine‐fold variation of risk of advanced colorectal neoplasms according to smoking and polygenic risk score: Results from a cross‐sectional study in a large screening colonoscopy cohort	37
	37
Issue Information	35
Targeting the LMP1‐ALIX axis in EBV⁺ nasopharyngeal carcinoma inhibits immunosuppressive small extracellular vesicle secretion and boosts anti‐tumor immunity	35
Unveiling quality of clinical trial in China: from concern to confirmation	34
Survival trends of patients with non‐metastatic gastric adenocarcinoma in the US and European countries: the impact of decreasing resection rates	34
Defining and tracing subtypes of patient‐derived xenograft models in pancreatic ductal adenocarcinoma	33
Dietary intake of advanced glycation endproducts (AGEs) and cancer risk across more than 20 anatomical sites: A multinational cohort study	33
Leptin‐mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer	33
Combined local therapy and CAR‐GPC3 T‐cell therapy in advanced hepatocellular carcinoma: a proof‐of‐concept treatment strategy	33
The scaffold protein menin is essential for activating the MYC locus and MYC‐mediated androgen receptor transcription in androgen receptor‐dependent prostate cancer cells	33
Childhood overweight and risk of obesity‐related adult cancer in men	32
Advanced precision modeling reveals divergent responses of hepatocellular carcinoma to combinatorial immunotherapy	32
Impact of prior chemotherapy with two different fluoropyrimidines on the efficacy of capecitabine plus irinotecan or FOLFIRI with or without bevacizumab in metastatic colorectal cancer: a post hoc ana	31
	28
Detection of pancreatic cancer by indocyanine green‐assisted fluorescence imaging in the first and second near‐infrared windows	27
Immune mediated support of metastasis: Implication for bone invasion	27
Converting “cold” to “hot”: epigenetics strategies to improve immune therapy effect by regulating tumor‐associated immune suppressive cells	27
Whole‐genome CRISPR‐Cas9 knockout screens identify SHOC2 as a genetic dependency in NRAS‐mutant melanoma	26
Gene amplification‐driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A‐YTHDF2‐dependent in lung adenocarcinoma	26

Activation of Piezo1 contributes to matrix stiffness‐induced angiogenesis in hepatocellular carcinoma	25
Improving antitumor immunity using antiangiogenic agents: Mechanistic insights, current progress, and clinical challenges	25
Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first‐line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, r	25
The regulatory roles and clinical significance of glycolysis in tumor	25
Enhancing sensitivity of triple‐negative breast cancer to DNA‐damaging therapy through chemical inhibition of the m6A methyltransferase METTL3	25
Beyond success: unveiling the hidden potential of radiotherapy and immunotherapy in solid tumors	25
Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer	24
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism	24
Criteria and regulatory considerations for the conditional approval of innovative antitumor drugs in China: from the perspective of clinical reviewers	23
Trends in cancer mortality in China from 2004 to 2018: A nationwide longitudinal study	23
Lipid metabolism in pancreatic cancer: emerging roles and potential targets	23
Survival impact of early MRI progression after stereotactic radiotherapy for brain metastases	22
The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of colorectal cancer, 2024 update	22
Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives	22
Radiotherapy‐resistant prostate cancer cells escape immune checkpoint blockade through the senescence‐related ataxia telangiectasia and Rad3‐related protein	22
Current status and perspectives of esophageal cancer: a comprehensive review	22
Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti‐PD‐1 therapy in hepatocellular carcinoma	21
Cancer‐associated fibroblast‐derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib	21
Issue Information	20
Real‐world outcomes of niraparib treatment in patients with ovarian cancer: a multicenter non‐interventional study in China	20
Single‐cell transcriptomics provides insights into the origin and immune microenvironment of cervical precancerous lesions	20
Issue Information	20
Crosstalk between IL‐15Rα⁺tumor‐associated macrophages and breast cancer cells reduces CD8⁺T cell recruitment	20
A nanotherapeutic strategy to target drug‐tolerant cells and overcome EGFR tyrosine kinase inhibitor resistance in lung cancer	19
Phospholipase iPLA2β acts as a guardian against ferroptosis	19
Issue Information	19
Reciprocal tumor‐platelet interaction through the EPHB1‐EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma	19
The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential	19
The interplay between natural killer cells and pancreatic stellate cells in pancreatic ductal adenocarcinoma	18
Neoadjuvant HER2 inhibition induces ESR1 DNA methylation alterations resulting in clinically relevant ER expression changes in breast cancers	18
Issue Information	17
Development and validation of an artificial intelligence model for predicting post‐transplant hepatocellular cancer recurrence	17
Social‐epigenetic mediators for racial disparities in pulmonary impairment among childhood cancer survivors	17
	17
Cover Image, Volume 42, Issue 4	16
Non‐recovery of renal function was correlated with increased mortality in the cancer cohort with septic shock	16
Research trends of cancer metabolism: analysis from a Chinese perspective	16
Intra‐heterogeneity in transcription and chemoresistant property of leukemia‐initiating cells in murine Setd2^−/− acute myeloid leukemia	15
Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy	15
Cover Image, Volume 42, Issue 5	15
Matrisomal genes in squamous cell carcinoma of head and neck influence tumor cell motility and response to cetuximab treatment	15
Targeted intracellular delivery of molecular cargo to hypoxic human breast cancer stem cells	15
Retreatment in locally recurrent nasopharyngeal carcinoma: Current status and perspectives	14
Impact of pre‐existing cardiometabolic diseases on metastatic cancer stage at diagnosis: a prospective multinational cohort study	14
A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82	14
The repertoire of germline variants in patients with early‐onset rectal cancer	14
Perivascular localized cells commit erythropoiesis in PDGF‐B‐expressing solid tumors	13
	13
Partial hepatectomy versus interventional treatment in patients with hepatitis B virus‐related hepatocellular carcinoma and clinically significant portal hypertension: a randomized comparative clinica	13
	13
Pivotal roles of tumor‐draining lymph nodes in the abscopal effects from combined immunotherapy and radiotherapy	13
	13
p38γ and p38δ as biomarkers in the interplay of colon cancer and inflammatory bowel diseases	12
Issue Information	12
Establishment of an orthotopic perirenal space xenograft mouse model of retroperitoneal sarcoma	12
Cover Image, Volume 44, Issue 6	12
Candidate therapeutic agents in a newly established triple wild‐type mucosal melanoma cell line	12
Nasopharyngeal carcinoma treatment paradigm after HK0501 – a potential way forward	12
Efficacy and safety of KN026 and docetaxel for HER2‐positive breast cancer: a phase II clinical trial	12
	12
Issue Information	12
Efficacy and safety of first‐line sintilimab plus anlotinib versus chemotherapy for metastatic non‐small cell lung cancer: a phase II, open‐label, randomized controlled trial	11
Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2‐negative breast cancer	11
RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment	11
Parkin deficiency promotes colorectal tumorigenesis and progression through RIPK3‐dependent necroptotic inflammation	11
MFN2 suppresses clear cell renal cell carcinoma progression by modulating mitochondria‐dependent dephosphorylation of EGFR	11
	11
Neoadjuvant chemotherapy plus anlotinib in the treatment of resectable head and neck squamous cell carcinoma: A pilot phase II trial	11
MAGE‐C3 promotes cancer metastasis by inducing epithelial‐mesenchymal transition and immunosuppression in esophageal squamous cell carcinoma	11