OOIR: Observatory of International Research

Papers

(The TQCC of Cancer Communications is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Global patterns of breast cancer incidence and mortality: A population‐based cancer registry data analysis from 2000 to 2020	411
Cancer incidence, mortality, and burden in China: a time‐trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020	370
The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2021	325
LncRNA‐mediated posttranslational modifications and reprogramming of energy metabolism in cancer	277
Cancer burden of major cancers in China: A need for sustainable actions	260
A nomogram for predicting overall survival in patients with low‐grade endometrial stromal sarcoma: A population‐based analysis	202
Ferroptosis in cancer and cancer immunotherapy	200
EMT‐associated microRNAs and their roles in cancer stemness and drug resistance	161
Non‐small cell lung cancer in China	147
Boron neutron capture therapy: Current status and future perspectives	144
The Chinese Society of Clinical Oncology (CSCO) clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma	132
Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review	115
Single‐cell RNA sequencing in breast cancer: Understanding tumor heterogeneity and paving roads to individualized therapy	111
The FTO/miR‐181b‐3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer	108
The role of the HIF‐1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer	106
Advancing to the era of cancer immunotherapy	91
A global assessment of recent trends in gastrointestinal cancer and lifestyle‐associated risk factors	90
New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer	89
Tumor‐associated macrophages in liver cancer: From mechanisms to therapy	85
Breast cancer: an up‐to‐date review and future perspectives	80
Artificial intelligence for assisting cancer diagnosis and treatment in the era of precision medicine	79
Efficacy and safety of a novel anti‐HER2 therapeutic antibody RC48 in patients with HER2‐overexpressing, locally advanced or metastatic gastric or gastroesophageal junction cancer: a single‐arm phase	78
Aberrant translation regulated by METTL1/WDR4‐mediated tRNA N7‐methylguanosine modification drives head and neck squamous cell carcinoma progression	73
Neoadjuvant immunotherapy for non–small cell lung cancer: State of the art	71
Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma	68

Phase II clinical trial using camrelizumab combined with apatinib and chemotherapy as the first‐line treatment of advanced esophageal squamous cell carcinoma	67
Cancer‐associated fibroblasts in breast cancer: Challenges and opportunities	65
The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential	61
New insights into molecules and pathways of cancer metabolism and therapeutic implications	59
Tumor organoids: synergistic applications, current challenges, and future prospects in cancer therapy	53
Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives	52
Multifunctional inorganic nanomaterials for cancer photoimmunotherapy	51
Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells	49
Cytokine‐ and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy	49
Clinical characteristics and survival of 5283 esophageal cancer patients: A multicenter study from eighteen hospitals across six regions in China	46
HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5‐WDR5‐dependent transcriptional program	46
N‐acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4‐acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA	46
The Fibrillin‐1/VEGFR2/STAT2 signaling axis promotes chemoresistance via modulating glycolysis and angiogenesis in ovarian cancer organoids and cells	45
Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa‐miR‐6887‐3p	44
The theory of tumor ecosystem	43
Improving antitumor immunity using antiangiogenic agents: Mechanistic insights, current progress, and clinical challenges	41
Trends in cancer mortality in China from 2004 to 2018: A nationwide longitudinal study	40
S100A8 promotes epithelial‐mesenchymal transition and metastasis under TGF‐β/USF2 axis in colorectal cancer	40
Clinical utility of Epstein‐Barr virus DNA and other liquid biopsy markers in nasopharyngeal carcinoma	40
An update on the molecular biology of glioblastoma, with clinical implications and progress in its treatment	39
Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1	38
Molecular subtyping of hepatocellular carcinoma: A step toward precision medicine	36
Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities	35
Combined treatment of non‐small cell lung cancer using radiotherapy and immunotherapy: challenges and updates	35
Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1‐mediated MAPK signaling	34
Tumor microenvironment signaling and therapeutics in cancer progression	33
KRAS‐G12D mutation drives immune suppression and the primary resistance of anti‐PD‐1/PD‐L1 immunotherapy in non‐small cell lung cancer	32
Tumor heterogeneity and the potential role of liquid biopsy in bladder cancer	32
Cancer situation in China: what does the China cancer map indicate from the first national death survey to the latest cancer registration?	31
Correlation between the genetic variants of base excision repair (BER) pathway genes and neuroblastoma susceptibility in eastern Chinese children	31
Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma	31
The mortality of lung cancer attributable to smoking among adults in China and the United States during 1990–2017	30
Anti‐PD‐L1/TGF‐βR fusion protein (SHR‐1701) overcomes disrupted lymphocyte recovery‐induced resistance to PD‐1/PD‐L1 inhibitors in lung cancer	30
Programmed death ligand‐1 regulates angiogenesis and metastasis by participating in the c‐JUN/VEGFR2 signaling axis in ovarian cancer	30
Elevated neutrophil extracellular traps by HBV‐mediated S100A9‐TLR4/RAGE‐ROS cascade facilitate the growth and metastasis of hepatocellular carcinoma	30
Activation of Piezo1 contributes to matrix stiffness‐induced angiogenesis in hepatocellular carcinoma	30
Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma	29
A phase I study of toripalimab, an anti‐PD‐1 antibody, in patients with refractory malignant solid tumors	29
Atezolizumab plus bevacizumab versus sorafenib as first‐line treatment for unresectable hepatocellular carcinoma: a cost‐effectiveness analysis	28
Clinical outcomes of coronavirus disease 2019 (COVID‐19) in cancer patients with prior exposure to immune checkpoint inhibitors	27
The EGFR‐P38 MAPK axis up‐regulates PD‐L1 through miR‐675‐5p and down‐regulates HLA‐ABC via hexokinase‐2 in hepatocellular carcinoma cells	27
A newly discovered role of metabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis	26
Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T‐cell acute lymphoblastic leukemia	25
T‐cell receptor repertoire analysis for the diagnosis and treatment of solid tumor: A methodology and clinical applications	25
Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis	25
N⁶‐methyladenosine Steers RNA Metabolism and Regulation in Cancer	24
Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first‐line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, r	24
Predictions of mortality related to four major cancers in China, 2020 to 2030	24
The five major autoimmune diseases increase the risk of cancer: epidemiological data from a large‐scale cohort study in China	24
Analysis of the Global Burden of Disease study highlights the trends in death and disability‐adjusted life years of leukemia from 1990 to 2017	24

PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism	24
Gene amplification‐driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A‐YTHDF2‐dependent in lung adenocarcinoma	23
Cancer‐associated fibroblast‐derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib	23
Estrogen receptor‐low breast cancer: Biology chaos and treatment paradox	23
CRISPR/Cas9 screening identifies a kinetochore‐microtubule dependent mechanism for Aurora‐A inhibitor resistance in breast cancer	23
Lipid metabolism in pancreatic cancer: emerging roles and potential targets	23
Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine/β₂‐AR/MACC1 axis	22
KDELR2 promotes breast cancer proliferation via HDAC3‐mediated cell cycle progression	22
Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor	22
Is post‐transplant chemotherapy feasible in liver transplantation for colorectal cancer liver metastases?	21
Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis	21
Resistance to antibody‐drug conjugates in breast cancer: mechanisms and solutions	21
METTL5 stabilizes c‐Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression	21
Harness the functions of gut microbiome in tumorigenesis for cancer treatment	20
Spatial metabolomics for evaluating response to neoadjuvant therapy in non‐small cell lung cancer patients	20
Exhaled breath diagnostics of lung and gastric cancers in China using nanosensors	20
Phosphatidylserine released from apoptotic cells in tumor induces M2‐like macrophage polarization through the PSR‐STAT3‐JMJD3 axis	19
Metabolic regulation in the immune response to cancer	19
The efficacy and possible mechanisms of immune checkpoint inhibitors in treating non‐small cell lung cancer patients with epidermal growth factor receptor mutation	18
YB1 regulates miR‐205/200b‐ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma	18
RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment	18
Crosstalk between IL‐15Rα⁺tumor‐associated macrophages and breast cancer cells reduces CD8⁺T cell recruitment	17
Meiotic nuclear divisions 1 (MND1) fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma	17
Emerging radiotherapy technologies and trends in nasopharyngeal cancer	17
Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4	17
LncRNA LINC00525 suppresses p21 expression via mRNA decay and triplex‐mediated changes in chromatin structure in lung adenocarcinoma	17
m⁶A‐mediated regulation of PBX1‐GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels	17
Retreatment in locally recurrent nasopharyngeal carcinoma: Current status and perspectives	17
Expert opinions on immunotherapy for patients with colorectal cancer	17
ZNF582 hypermethylation promotes metastasis of nasopharyngeal carcinoma by regulating the transcription of adhesion molecules Nectin‐3 and NRXN3	17
Sintilimab versus docetaxel as second‐line treatment in advanced or metastatic squamous non‐small‐cell lung cancer: an open‐label, randomized controlled phase 3 trial (ORIENT‐3)	16
A non‐metabolic function of hexokinase 2 in small cell lung cancer: promotes cancer cell stemness by increasing USP11‐mediated CD133 stability	16
Antibody variable region engineering for improving cancer immunotherapy	16
Clinical spectrum and prognostic value of TP53 mutations in circulating tumor DNA from breast cancer patients in China	16
Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis‐associated cancer	16
Infection complications in febrile chimeric antigen receptor (CAR)‐T recipients during the peri‐CAR‐T cell treatment period examined using metagenomic next‐generation sequencing (mNGS)	16
Safety, tolerability, and pharmacokinetics of BAT8001 in patients with HER2‐positive breast cancer: An open‐label, dose‐escalation, phase I study	15
Ovarian cancer‐excreted exosomal miR‐199a‐5p suppresses tumor metastasis by targeting hypoxia‐inducible factor‐2α in hypoxia microenvironment	15
Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges	15
Epi‐immunotherapy for cancers: rationales of epi‐drugs in combination with immunotherapy and advances in clinical trials	15
Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer	15
Tescalcin is an unfavorable prognosis factor that regulats cell proliferation and survival in hepatocellular carcinoma patients	15
P300/CBP‐associated factor (PCAF)‐mediated acetylation of Fascin at lysine 471 inhibits its actin‐bundling activity and tumor metastasis in esophageal cancer	15
Favorable response to immunotherapy in a pancreatic neuroendocrine tumor with temozolomide‐induced high tumor mutational burden	15
Nuclear Aurora kinase A triggers programmed death‐ligand 1‐mediated immune suppression by activating MYC transcription in triple‐negative breast cancer	14
CD70‐targeting CAR‐T cells have potential activity against CD19‐negative B‐cell Lymphoma	14
Snail acetylation by autophagy‐derived acetyl‐coenzyme A promotes invasion and metastasis of KRAS‐LKB1 co‐mutated lung cancer cells	14
The role of myeloid‐derived suppressor cells in gastrointestinal cancer	14
Activity and bioavailability of tepotinib for leptomeningeal metastasis of NSCLC with MET exon 14 skipping mutation	13
Outcomes in refractory diffuse large B‐cell lymphoma: results from a multicenter real‐world study in China	13
XELOX doublet regimen versus EOX triplet regimen as first‐line treatment for advanced gastric cancer: An open‐labeled, multicenter, randomized, prospective phase III trial (EXELOX)	13
BRD2 induces drug resistance through activation of the RasGRP1/Ras/ERK signaling pathway in adult T‐cell lymphoblastic lymphoma	13
The diagnosis, classification, and treatment of sarcoma in this era of artificial intelligence and immunotherapy	13
Abscopal effect of stereotactic radiotherapy combined with anti‐PD‐1/PD‐L1 immunotherapy: Mechanisms, clinical efficacy, and issues	13
Pivotal roles of tumor‐draining lymph nodes in the abscopal effects from combined immunotherapy and radiotherapy	13
MAGE‐C3 promotes cancer metastasis by inducing epithelial‐mesenchymal transition and immunosuppression in esophageal squamous cell carcinoma	13
Bevacizumab biosimilar LY01008 compared with bevacizumab (Avastin) as first‐line treatment for Chinese patients with unresectable, metastatic, or recurrent non‐squamous non–small‐cell lung cancer: A m	13
Liquid biopsy for esophageal cancer: Is detection of circulating cell‐free DNA as a biomarker feasible?	12
A new mouse esophageal cancer cell line (mEC25)‐derived pre‐clinical syngeneic tumor model for immunotherapy	12
Dicer‐independent snRNA/snoRNA‐derived nuclear RNA 3 regulates tumor‐associated macrophage function by epigenetically repressing inducible nitric oxide synthase transcription	12
Macrophage inhibitory cytokine‐1 induced by a high‐fat diet promotes prostate cancer progression by stimulating tumor‐promoting cytokine production from tumor stromal cells	12