JOR Spine

Article	Citations
Slow twitch paraspinal muscle dysregulation in adolescent idiopathic scoliosis exhibiting HIF‐2α misexpression	80
Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration	71
PHLPP1 deficiency protects against age‐related intervertebral disc degeneration	70
An in vitro 3D annulus fibrosus cell culture model with type I collagen: An examination of cell–matrix interactions	59
MRI‐based measurement of in vivo disc mechanics in a young population due to flexion, extension, and diurnal loading	53
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Using the cobweb classification system as a digital location system for the neurologic compression in cervical degenerative disease	36
Finite element modeling to predict the influence of anatomic variation and implant placement on performance of biological intervertebral disc implants	34
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High throughput computational evaluation of how scaffold architecture, material selection, and loading modality influence the cellular micromechanical environment in tissue engineering strategies	29
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Experimental confirmation and bioinformatics reveal biomarkers of immune system infiltration and hypertrophy ligamentum flavum	21
Cryopreserving the intact intervertebral disc without compromising viability	21
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Hyperosmolar expansion medium improves nucleus pulposus cell phenotype	18
Cervical facet capsular ligament mechanics: Estimations based on subject‐specific anatomy and kinematics	18
Biomechanical evaluation of a novel biomimetic artificial intervertebral disc in canine cervical cadaveric spines	17
A fully automatic MRI‐guided decision support system for lumbar disc herniation using machine learning	15
Influence of macrophage polarization in herniated nucleus pulposus tissue on clinical efficacy after lumbar discectomy	15
Analysis of the value of potential biomarker S100‐A8 protein in the diagnosis and pathogenesis of spinal tuberculosis	14
The efficacy and safety of oral antibiotic treatment in patients with chronic low back pain and Modic changes: A systematic review and meta‐analysis	13
The effect of local steroid application on bony fusion in a rat posterolateral spinal arthrodesis model	12
In vitro coupled motions of the whole human thoracic and lumbar spine with rib cage	12

Panax notoginseng saponins attenuate intervertebral disc degeneration by reducing the end plate porosity in lumbar spinal instability mice	12
Comparison of four in vitro test methods to assess nucleus pulposus replacement device expulsion risk	11
Pericellular heparan sulfate proteoglycans: Role in regulating the biosynthetic response of nucleus pulposus cells to osmotic loading	11
Identifying critical modules and biomarkers of intervertebral disc degeneration by using weighted gene co‐expression network	11
The effects of extracellular matrix‐degrading enzymes polymorphisms on intervertebral disc degeneration	11
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Clinical efficacy and biomechanical analysis of a novel hollow pedicle screw combined with kyphoplasty for the treatment of Kümmell disease	10
Bone morphogenetic proteins, DNA methylation, and gut microbiota interaction in lumbar disc degeneration: A multi‐omics Mendelian randomization study	10
Percutaneous lumbar annular puncture: A rat model to study intervertebral disc degeneration and pain‐related behavior	10
Scoliosis instrumentation alters primary and coupled motions of the spine: An in vitro study using entire thoracolumbar spine and rib cage specimens	10
Wharton's Jelly mesenchymal stromal cell‐derived extracellular vesicles promote nucleus pulposus cell anabolism in an in vitro 3D alginate‐bead culture model	9
Single‐cell RNA Seq reveals cellular landscape‐specific characteristics and potential etiologies for adolescent idiopathic scoliosis	9
Axial hypersensitivity is associated with aberrant nerve sprouting in a novel model of disc degeneration in female Sprague Dawley rats	9
The degenerative impact of hyperglycemia on the structure and mechanics of developing murine intervertebral discs	9
Structure‐function relationships of the human vertebral endplate	9
The Significance of MAPK Signaling Pathway in the Diagnosis and Subtype Classification of Intervertebral Disc Degeneration	8
The non‐causative role of abnormal serum uric acid in intervertebral disc degeneration: A Mendelian randomization study	8
An exploration of knowledge‐organizing technologies to advance transdisciplinary back pain research	7
Intervertebral disc degeneration and how it leads to low back pain	7
Enhancing Clinical Insights: New Radiographic Grading for Lumbar Facet Joint Degeneration, A Reliability Study	7
Tracing the disc: The novel qualitative morphometric MRI based disc degeneration classification system	7
E74‐like ETS transcription factor 3 expression and regulation in human intervertebral disc	7
Paraspinal muscle pathophysiology associated with low back pain and spine degenerative disorders	7
Gene Expression Changes Precede Elevated Mechanical Sensitivity in the Mouse Intervertebral Disc Injury Model	7
The influence of ligament biomechanics on proximal junctional kyphosis and failure in patients with adult spinal deformity	6
Comparative analysis of paraspinal muscle imbalance between idiopathic scoliosis and congenital scoliosis from the transcriptome aspect	6
Kinematics, kinetics, and new insights from a contemporary analysis of the first experiments to produce cervical facet dislocations in the laboratory	6
Development of normalized quantitative measures of lumbar disc degeneration	6
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Dynamics of N6‐methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc	6
TRPV4 differentially controls inflammatory cytokine networks during static and dynamic compression of the intervertebral disc	6
TRPV4 mediates cell damage induced by hyperphysiological compression and regulates COX2/PGE2 in intervertebral discs	6
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy	6
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Preclinical to clinical translation for intervertebral disc repair: Effects of species‐specific scale, metabolism, and matrix synthesis rates on cell‐based regeneration	5
L‐type Voltage‐Gated calcium channels partly mediate Mechanotransduction in the intervertebral disc	5
Can axial loading restore in vivo disc geometry, opening pressure, and T2 relaxation time?	5
Paraspinal muscles in individuals undergoing surgery for lumbar spine pathology lack a myogenic response to an acute bout of resistance exercise	5
The role of the complement system in disc degeneration and Modic changes	4
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A major achievement and a very good news in this first half of 2021!	4
Evaluating the causal effect of atherosclerosis on the risk of intervertebral disc degeneration	4
SSR1andCKAP4as potential biomarkers for intervertebral disc degeneration based on integrated bioinformatics analysis	4
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Using embedded alginate microparticles to tune the properties of in situ forming poly(N‐isopropylacrylamide)‐graft‐chondroitin sulfate bioadhesive hydrogels for replacement and repair of the nu	4
Rat tail models for the assessment of injectable nucleus pulposus regeneration strategies	4
Evaluation of the efficacy of modal analysis in predicting the pullout strength of fixation bone screws	4
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Injectable decellularized nucleus pulposus tissue exhibits neuroinhibitory properties	4
Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner	4

The influence of intervertebral disc overloading on nociceptor calcium flickering	3
Transcriptional profiling of intervertebral disc in a post‐traumatic early degeneration organ culture model	3
In silico modeling the potential clinical effect of growth factor treatment on the metabolism of human nucleus pulposus cells	3
N‐acetylcysteine attenuates oxidative stress‐mediated cell viability loss induced by dimethyl sulfoxide in cryopreservation of human nucleus pulposus cells: A potential solution for mass produc	3
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Effect of cigarette smoke exposure and cessation on regional diffusion properties in rat intervertebral discs	3
M1 macrophage‐derived oncostatin M induces osteogenic differentiation of ligamentum flavum cells through the JAK2/STAT3 pathway	3
An in vivo model of ligamentum flavum hypertrophy from early‐stage inflammation to fibrosis	3
Correlation between motor behavior and age‐related intervertebral disc degeneration in cynomolgus monkeys	3
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The Relationship Between ADAMTS‐4 and ADAMTS‐5 Enzyme Levels in Patients With Degenerative Disc Disease: A Prospective Biochemical Study	3
Collagen integrity of the annulus fibrosus in degenerative disc disease individuals quantified with collagen hybridizing peptide	3
Developmental morphogens direct human induced pluripotent stem cells toward an annulus fibrosus‐like cell phenotype	3
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Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc	3
Repetitive strikes loading organ culture model to investigate the biological and biomechanical responses of the intervertebral disc	3
Combining adhesive and nonadhesive injectable hydrogels for intervertebral disc repair in an ovine discectomy model	3
Hydrogen sulfide regulates autophagy in nucleus pulposus cells under hypoxia	3
Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health	3
Patient‐specific apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs	3
Fibrotic and inflammatory characteristics of epidural fat adjacent to the ossification area in patients with ossification of the ligament flavum	3
Paraspinal muscle morphology and composition in adolescent idiopathic scoliosis: A histological analysis	3
Development of a mouse model of chronic ventral spinal cord compression: Neurobehavioral, radiological, and pathological changes	3
Exploring the therapeutic potential of puerarin on intervertebral disc degeneration by regulating apoptosis of nucleus pulposus cells	3
Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization	3
Is There a Positive or Negative Correlation Between Cervical Vertebral Bone Quality and Intervertebral Disc Degeneration by Pfirrmann Grading	2
Contemporary clinical perspectives on chronic low back pain: The biology, mechanics, etc. underpinning clinical and radiological evaluation	2
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Evaluation of lumbar spinal fusion utilizing recombinant human platelet derived growth factor‐B chain homodimer (rhPDGF‐BB) combined with a bovine collagen/β‐tricalcium phosphate (β‐TC	2
A Novel Dynamic Growth Rod Inducing Spinal Growth Modulation for the Correction of Spinal Deformities	2
Intervertebral Disc Degeneration Mediates the Causal Effect of Genetically Predicted Diffuse Idiopathic Skeletal Hyperostosis on Spinal Stenosis: Evidence From a Mendelian Randomization Study	2
Exploring the Causal Relationship Between the Plasma Levels of MMP1 (Matrix Metalloproteinase‐1), MMP3, MMP7, MMP10, and MMP12 and Intervertebral	2
Variations in ECM Topography, Fiber Alignment, Mechanical Stiffness, and Cellular Composition Between Ventral and Dorsal Ligamentum Flavum Layers: Insights Into Hypertrophy Pathogenesis	2
Links among MRI features in paraspinal muscles, inflammatory processes, and related back pain in patients with lumbar disc herniation	2
Automatic Lenke classification of adolescent idiopathic scoliosis with deep learning	2
Unilateral Lumbo‐Pelvic Fixation for Denis Type I Unilateral Sacral Fracture: A Finite Element Analysis	2
Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants	2
Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL‐4 and IL‐10 in Intervertebral Disc Pathophysiology	2
Transient Receptor Potential Vanilloid 4 Knockdown Decreases Extracellular Matrix Synthesis via Autophagy Suppression in the Rat Intervertebral Disc	2
Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research	1
Evaluation of instrumentation and pedicle screw design for posterior lumbar fixation: A pre‐clinical in vivo/ex vivo ovine model	1
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Three‐dimensional ultrasonography could be a potential non‐ionizing tool to evaluate vertebral rotation of subjects with adolescent idiopathic scoliosis	1
Influence of patient‐specific factors when comparing multifidus fat infiltration between chronic low back pain patients and asymptomatic controls	1
2022: A landmark year for JOR Spine	1
Consolidating and re‐evaluating the human disc nutrient microenvironment	1
Transcriptomic profiling reveals key early response genes during GDF6‐mediated differentiation of human adipose‐derived stem cells to nucleus pulposus cells	1
Socioeconomic status, mental health, and nutrition are the principal traits for low back pain phenotyping: Data from the osteoarthritis initiative	1
Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration	1
Constitutive and conditional gene knockout mice for the study of intervertebral disc degeneration: Current status, decision considerations, and future possibilities	1
Integrated DNA methylation analysis reveals a potential role for PTPRN2 in Marfan syndrome scoliosis	1
A successful PSRS special issue and Spine across the globe	1
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Improving how orthopedic journals report research outcomes based on sex and gender	1
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Sacral anatomical parameters varies in different Roussouly sagittal shapes as well as their relations to lumbopelvic parameters	1
Protective effects of curcumin against spinal cord injury	1
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The genetic causal association between arthritis and low back pain	1
The proteomic landscape of extracellular vesicles derived from human intervertebral disc cells	1
JOR Spine: Reaping the harvest of a community effort	1
Epidemiology of Modic changes in dogs: Prevalence, possible risk factors, and association with spinal phenotypes	1
Advancing spinal research beyond COVID‐19	1
A perspective on the ORS Spine Section initiative to develop a multi‐species JOR Spine histopathology series	1
Advancing basic and preclinical spine research: Highlights from the ORS PSRS 6th International Spine Research Symposium	1
Comparative proteome analysis of the ligamentum flavum of patients with lumbar spinal canal stenosis	1
Characterization and modulation of the pro‐inflammatory effects of immune cells in the canine intervertebral disk	1
The potential effect of romosozumab on perioperative management for instrumentation surgery	1
Distinct clinical characteristics of adolescent idiopathic scoliosis with asymmetrical ESR1 expression in paraspinal muscle progenitor cells	1
MRI‐based degeneration grades for lumbar facet joints do not correlate with cartilage mechanics	0
Bioinformatics‐based discovery of intervertebral disc degeneration biomarkers and immune‐inflammatory infiltrates	0
Development of a standardized histopathology scoring system for intervertebral disc degeneration in rat models: An initiative of the ORS spine section	0
A pilot study: Nano‐hydroxyapatite‐PEG/PLA containing low dose rhBMP2 stimulates proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stem cells	0
The effect of fatty infiltration, revision surgery, and sex on lumbar multifidus passive mechanical properties	0
Three‐dimensional fiber patterning in the annulus fibrosus can be derived from vertebral endplate topography	0
FAM172A supervises ER (endoplasmic reticulum) stress‐triggered autophagy in the epidural fibrosis process	0
Deep learning‐based detection and classification of lumbar disc herniation on magnetic resonance images	0
Novel 3D printed lattice structure titanium cages evaluated in an ovine model of interbody fusion	0
Correction to “Development and validation of deep learning models for identifying the brand of pedicle screws on plain spine radiographs”	0

A comprehensive tool box for large animal studies of intervertebral disc degeneration	0
Melatonin attenuates degenerative disc degression by downregulating DLX5 via the TGF/Smad2/3 pathway in nucleus pulposus cells	0
Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue	0
Species variation in the cartilaginous endplate of the lumbar intervertebral disc	0
Phase 1 evaluation of an elastomeric nucleus pulposus device as an option to augment disc at microdiscectomy: Experimental results from biomechanical and biocompatibility testing and first in human	0
Homing of vertebral‐delivered mesenchymal stromal cells for degenerative intervertebral discs repair – an in vivo proof‐of‐concept study	0
Osteoconductivity and neurotoxicity of silver‐containing hydroxyapatite coating cage for spinal interbody fusion in rats	0
@JORSPine	0
Phosphorylated heat shock protein 27 improves the bone formation ability of osteoblasts and bone marrow stem cells from patients with adolescent idiopathic scoliosis	0
Comparison and optimization of sheep in vivo intervertebral disc injury model	0
Biomarkers for intervertebral disc and associated back pain: From diagnosis to disease prognosis and personalized treatment	0
DeVa (Decay Variance): A Novel Score Calculated via Postprocessing the Changes in Signal Intensity of an Intervertebral Disc in a T2* Multi‐Echo Magnetic Resonance Image Can Quan	0
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Harmonization and standardization of nucleus pulposus cell extraction and culture methods	0
Biomolecular therapies for chronic discogenic low back pain: A narrative review	0
In vivo fluid transport in human intervertebral discs varies by spinal level and disc region	0
Gut Microbiome and Metabolome Changes in Chronic Low Back Pain Patients With Vertebral Bone Marrow Lesions	0
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Preclinical in vivo animal models of intervertebral disc degeneration. Part 1: A systematic review	0
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Sex differences in the biomechanical and biochemical responses of caudal rat intervertebral discs to injury	0
Nucleus pulposus structure and function assessed in shear using magnetic resonance elastography, quantitative MRI, and rheometry	0
Optimal intermittent administration interval of parathyroid hormone 1‐34 for bone morphogenetic protein‐induced bone formation in a rat spinal fusion model	0
DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling	0
Associations between femoral 3D curvature and sagittal imbalance of spine	0
Analysis of Nicotine Toxicity and Mechanisms of Senescence in Nucleus Pulposus Cells Using Network Toxicology and Molecular Docking Technique	0
A comprehensive review of cell transplantation and platelet‐rich plasma therapy for the treatment of disc degeneration‐related back and neck pain: A systematic evidence‐based analysis	0
Analysis of cell‐free circulating DNA fragment size and level in patients with lumbar canal stenosis	0
Assessment of Vertebral Bone Marrow Perfusion, Fat/Water Content, and Trabecular Bone Changes Using Multimodal MRI and Micro‐CT in a Rat Model of Chronic Kidney Disease	0
Another milestone, accomplished!	0
Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model—An ORS spine section initiative	0
Annulus Fibrosus Repair via Interpenetration of a Non‐Woven Scaffold Supports Tissue Integration and Prevents Re‐Herniation	0
Impact of autophagy inhibition on intervertebral disc cells and extracellular matrix	0
Inactivation of Tnf‐α/Tnfr signaling attenuates progression of intervertebral disc degeneration in mice	0
The association between low virulence organisms in different locations and intervertebral disc structural failure: A meta‐analysis and systematic review	0
Another year over, and a new one is up for highest impact!	0
The research landscape of immunology research in spinal cord injury from 2012 to 2022	0
An in vitro comparison of three nucleus pulposus removal techniques for partial intervertebral disc replacement: An ultra‐high resolution MRI study	0
Comparative histopathological analysis of age‐associated intervertebral disc degeneration in CD‐1 and C57BL/6 mice: Anatomical and sex‐based differences	0
Galectin‐3 and RAGE differentially control advanced glycation endproduct‐induced collagen damage in murine intervertebral disc organ culture	0
Facet joint degeneration—An initial procedure of the cervical spine degeneration	0
Investigation of in vivo three‐dimensional changes of the spinal canal after corrective surgeries of the idiopathic scoliosis	0
Flexible support material maintains disc height and supports the formation of hydrated tissue engineered intervertebral discs in vivo	0
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In vitro and ex vivo screening of microRNA combinations with enhanced cell penetrating peptides to stimulate intervertebral disc regeneration	0
Static study and numerical simulation of the influence of cement distribution in the upper and lower adjacent vertebrae on sandwich vertebrae in osteoporotic patients: Finite element analysis	0
Low‐Frequency Cyclic Stretch Upregulates the Expression of Nuclear Factor Erythroid 2‐Related Factor 2 in Human Nucleus Pulposus Cells to Inhibit the Resistin‐Induced Interleukin‐20 Expression	0
The Cross‐Sectional Areas and Anterior–Posterior Balance of the Cervical Paraspinal Muscles in Dropped Head Syndrome and Cervical Spondylotic Myelopathy: A Propensity Score‐Matched Analysis	0
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Mechanism of Intervertebral Disc Degeneration via the β‐Catenin/CCL2 Pathway in Sox9 Conditional Knockout Mice	0
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Range of Motion and Neutral Zone of All Human Spinal Motion Segments: A Data Collection of 30 Years of In Vitro Experiments Performed Under Standardized Testing Conditions	0
Range of international surgical strategies for adolescent idiopathic scoliosis: Evaluation of a multi‐center survey	0
Building on our momentum	0
An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therape	0
Intervertebral disc microbiome in Modic changes: Lack of result replication underscores the need for a consensus in low‐biomass microbiome analysis	0
Investigating the causal links between inflammatory cytokines and scoliosis through bidirectional Mendelian randomization analysis	0
Density and mechanical properties of vertebral trabecular bone—A review	0
An additively manufactured model for preclinical testing of cervical devices	0
Phosphatidylcholine Ameliorates Palmitic Acid‐Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration	0
Targeted screening of inflammatory mediators in spontaneous degenerative disc disease in dogs reveals an upregulation of the tumor necrosis superfamily	0
pH: A major player in degenerative intervertebral disks	0
Posterior Ligamentum Complex Preservation Alleviate ASD‐Related Biomechanical Deterioration in Lumbar Interbody Fusion Models: A Finite Element Analysis	0
An in‐depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration	0
Modic type 2 changes are fibroinflammatory changes with complement system involvement adjacent to degenerated vertebral endplates	0
Pharmacokinetics of PP353, a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first‐in‐human, Phase 1b, ope	0
Pain behavior and phenotype in a modified anterior lumbar disc puncture mouse model	0
Advances in basic and preclinical spine research: Highlights from the Chinese Spine Research Community	0
Multiplex epigenome editing of ion channel expression in nociceptive neurons abolished degenerative IVD‐conditioned media‐induced mechanical sensitivity	0
Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation	0
Welcome to Volume 5!	0
Effects of circulating inflammatory proteins on spinal degenerative diseases: Evidence from genetic correlations and Mendelian randomization study	0
Biomedical applications of silk and its role for intervertebral disc repair	0
Development of a standardized histopathology scoring system for intervertebral disc degeneration and regeneration in rabbit models‐An initiative of the ORSspine section	0
Why clinical trials in disc regeneration strive to achieve completion: Insights from publication status and funding sources	0
Two‐ and three‐dimensional in vitro nucleus pulposus cultures: An in silico analysis of local nutrient microenvironments	0
Analysis of intervertebral disc CCR6 and IL‐6 gene levels with short‐term postoperative low back pain after spinal fusion in lumbar degenerative disease	0
Automatic grading of intervertebral disc degeneration in lumbar dog spines	0
Nonviral overexpression of Scleraxis or Mohawk drives reprogramming of degenerate human annulus fibrosus cells from a diseased to a healthy phenotype	0
A missense GDF5 variant causes brachydactyly type A1 and multiple‐synostoses syndrome 2	0
Transcriptome Data Combined With Mendelian Randomization Analysis Identifies Key Genes Associated With Mitochondria and Programmed Cell Death in Intervertebral Disc Degeneration	0
Automatic detection and voxel‐wise mapping of lumbar spine Modic changes with deep learning	0
Ruxolitinib Delays Nucleus Pulposus Cell Senescence in Rat Intervertebral Discs	0
Mechanical crosstalk between the intervertebral disc, facet joints, and vertebral endplate following acute disc injury in a rabbit model	0
Application and Validation of Semiautomatic Quantification of Immunohistochemically Stained Sections for Low Cellular Tissue Such as Intervertebral Disc Using QuPath	0
Exploring causal correlations between inflammatory cytokines and intervertebral disc degeneration: A Mendelian randomization	0
Effect of contrast media on the enzyme activity of condoliase: In vitro assessment	0
Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research	0
Histological analysis of nucleus pulposus tissue from patients with lumbar disc herniation after condoliase administration	0
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Single‐level cervical disc arthroplasty in the spine with reversible kyphosis: A finite element study	0
Silibinin promotes healing in spinal cord injury through anti‐ferroptotic mechanisms	0
Ovine model of congenital chest wall and spine deformity: From birth to 3 months follow‐up	0