JOR Spine

Article	Citations
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Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration	69
Comparison of four in vitro test methods to assess nucleus pulposus replacement device expulsion risk	53
Tracing the disc: The novel qualitative morphometric MRI based disc degeneration classification system	44
Bone morphogenetic proteins, DNA methylation, and gut microbiota interaction in lumbar disc degeneration: A multi‐omics Mendelian randomization study	39
Clinical efficacy and biomechanical analysis of a novel hollow pedicle screw combined with kyphoplasty for the treatment of Kümmell disease	34
The effects of extracellular matrix‐degrading enzymes polymorphisms on intervertebral disc degeneration	33
The efficacy and safety of oral antibiotic treatment in patients with chronic low back pain and Modic changes: A systematic review and meta‐analysis	31
Injection Volume Is a Better Predictor of Stiffness Restoration Than Injection Force in an In Vitro Study of Nucleus Augmentation of the Intervertebral Disc	28
Feasibility of Physical Exam and Performance‐Based Tests in Individuals With Chronic Low Back Pain: A Descriptive Study	26
M1 macrophage‐derived oncostatin M induces osteogenic differentiation of ligamentum flavum cells through the JAK2/STAT3 pathway	23
Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants	22
Exploring the therapeutic potential of puerarin on intervertebral disc degeneration by regulating apoptosis of nucleus pulposus cells	20
Issue Information	20
Paraspinal muscles in individuals undergoing surgery for lumbar spine pathology lack a myogenic response to an acute bout of resistance exercise	18
Repetitive strikes loading organ culture model to investigate the biological and biomechanical responses of the intervertebral disc	17
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy	16
Can axial loading restore in vivo disc geometry, opening pressure, and T2 relaxation time?	15
Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization	15
TNFα Receptor 1 and Not Receptor 2 Affect Annulus Fibrosus and Nucleus Pulposus Response to Cytokine Challenge in a Rat Model	15
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Evaluation of instrumentation and pedicle screw design for posterior lumbar fixation: A pre‐clinical in vivo/ex vivo ovine model	14
Deep learning‐based detection and classification of lumbar disc herniation on magnetic resonance images	14

Effect of cigarette smoke exposure and cessation on regional diffusion properties in rat intervertebral discs	14
Analysis of Nicotine Toxicity and Mechanisms of Senescence in Nucleus Pulposus Cells Using Network Toxicology and Molecular Docking Technique	14
The proteomic landscape of extracellular vesicles derived from human intervertebral disc cells	13
Constitutive and conditional gene knockout mice for the study of intervertebral disc degeneration: Current status, decision considerations, and future possibilities	13
Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation	13
Three‐dimensional ultrasonography could be a potential non‐ionizing tool to evaluate vertebral rotation of subjects with adolescent idiopathic scoliosis	13
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Issue Information	12
Nonviral overexpression of Scleraxis or Mohawk drives reprogramming of degenerate human annulus fibrosus cells from a diseased to a healthy phenotype	12
Clinical implications of linking microstructure, spatial biochemical, spatial biomechanical, and radiological features in ligamentum flavum degeneration	11
Ovine model of congenital chest wall and spine deformity: From birth to 3 months follow‐up	11
Static study and numerical simulation of the influence of cement distribution in the upper and lower adjacent vertebrae on sandwich vertebrae in osteoporotic patients: Finite element analysis	11
Correction to “Development and validation of deep learning models for identifying the brand of pedicle screws on plain spine radiographs”	10
How to improve the mechanical safety of a novel spinal implant while saving costs and time	10
Single‐Cell Analysis Integrated With Machine Learning Elucidates the Mechanisms of Nucleus Pulposus Cells Apoptosis in Intervertebral Disc Degeneration and Therapeutic Interventions	10
Issue Information	10
Deep learning‐based structure segmentation and intramuscular fat annotation on lumbar magnetic resonance imaging	10
Biomedical applications of silk and its role for intervertebral disc repair	10
Dynamic loading leads to increased metabolic activity and spatial redistribution of viable cell density in nucleus pulposus tissue	9
Molecular Subtypes and Immune Microenvironment Characterization of the Annulus Fibrosus in Intervertebral Disc Degeneration: Insights From Translation Factor‐Related Gene Analysis	9
Macrophage Changes and High‐Throughput Sequencing in Aging Mouse Intervertebral Disks	9
Why clinical trials in disc regeneration strive to achieve completion: Insights from publication status and funding sources	9
The Cross‐Sectional Areas and Anterior–Posterior Balance of the Cervical Paraspinal Muscles in Dropped Head Syndrome and Cervical Spondylotic Myelopathy: A Propensity Score‐Matched Analysis	9
Characterizing the host response to rhPDGF‐BB in a rat spinal arthrodesis model	8
Associations between femoral 3D curvature and sagittal imbalance of spine	8
MRI‐based degeneration grades for lumbar facet joints do not correlate with cartilage mechanics	8
The effect of fatty infiltration, revision surgery, and sex on lumbar multifidus passive mechanical properties	8
Preclinical in vivo animal models of intervertebral disc degeneration. Part 1: A systematic review	8
Range of Motion and Neutral Zone of All Human Spinal Motion Segments: A Data Collection of 30 Years of In Vitro Experiments Performed Under Standardized Testing Conditions	7
FAM172A supervises ER (endoplasmic reticulum) stress‐triggered autophagy in the epidural fibrosis process	7
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Physiological and Anthropometric Factors Associated With Spine Loading Estimates From Imaging‐Based Subject‐Specific Musculoskeletal Models	7
Diurnal Asymmetric Loading Modulates Cell Phenotype in Intervertebral Disc	7
Phase 1 evaluation of an elastomeric nucleus pulposus device as an option to augment disc at microdiscectomy: Experimental results from biomechanical and biocompatibility testing and first in human	7
Finite element modeling to predict the influence of anatomic variation and implant placement on performance of biological intervertebral disc implants	7
The non‐causative role of abnormal serum uric acid in intervertebral disc degeneration: A Mendelian randomization study	7
Ruxolitinib Delays Nucleus Pulposus Cell Senescence in Rat Intervertebral Discs	7
The Helical Compliance Vector: Utility for Quantifying Spinal Mechanics	7
Density and mechanical properties of vertebral trabecular bone—A review	7
Enhancing Clinical Insights: New Radiographic Grading for Lumbar Facet Joint Degeneration, A Reliability Study	7
Silibinin promotes healing in spinal cord injury through anti‐ferroptotic mechanisms	7
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Correlation between motor behavior and age‐related intervertebral disc degeneration in cynomolgus monkeys	6
Using the cobweb classification system as a digital location system for the neurologic compression in cervical degenerative disease	6
Identifying critical modules and biomarkers of intervertebral disc degeneration by using weighted gene co‐expression network	6
Patient‐specific apparent diffusion maps used to model nutrient availability in degenerated intervertebral discs	6
An in vivo model of ligamentum flavum hypertrophy from early‐stage inflammation to fibrosis	6
Analysis of the value of potential biomarker S100‐A8 protein in the diagnosis and pathogenesis of spinal tuberculosis	6
Axial hypersensitivity is associated with aberrant nerve sprouting in a novel model of disc degeneration in female Sprague Dawley rats	6
Paraspinal muscle pathophysiology associated with low back pain and spine degenerative disorders	6

Focal osteoporosis defect is associated with vertebral compression fracture prevalence in a bone mineral density‐independent manner	6
Single‐cell RNA Seq reveals cellular landscape‐specific characteristics and potential etiologies for adolescent idiopathic scoliosis	6
Biomechanical evaluation of a novel biomimetic artificial intervertebral disc in canine cervical cadaveric spines	6
Issue Information	5
Evidence for a Causal Association Between Human Cytomegalovirus Infection and Chronic Back Pain: A One‐Sample Mendelian Randomization Study	5
Evaluating the causal effect of atherosclerosis on the risk of intervertebral disc degeneration	5
Phosphatidylethanolamine Protects Nucleus Pulposus Cells From Oxidative Stress‐Induced Cellular Senescence and Extracellular Matrix Degradation by Promoting Autophagy	5
Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL‐4 and IL‐10 in Intervertebral Disc Pathophysiology	5
Exploring the Causal Relationship Between the Plasma Levels of MMP1 (Matrix Metalloproteinase‐1), MMP3, MMP7, MMP10, and MMP12 and Intervertebral	5
Transient Receptor Potential Vanilloid 4 Knockdown Decreases Extracellular Matrix Synthesis via Autophagy Suppression in the Rat Intervertebral Disc	5
Consolidating and re‐evaluating the human disc nutrient microenvironment	5
Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health	5
Is There a Positive or Negative Correlation Between Cervical Vertebral Bone Quality and Intervertebral Disc Degeneration by Pfirrmann Grading	5
Unilateral Lumbo‐Pelvic Fixation for Denis Type I Unilateral Sacral Fracture: A Finite Element Analysis	5
Comparative proteome analysis of the ligamentum flavum of patients with lumbar spinal canal stenosis	5
Characterization and modulation of the pro‐inflammatory effects of immune cells in the canine intervertebral disk	4
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Another milestone, accomplished!	4
Threats and opportunities of using ChatGPT in scientific writing—The risk of getting spineless	4
Epidemiology of Modic changes in dogs: Prevalence, possible risk factors, and association with spinal phenotypes	4
Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration	4
Understanding the etiopathogenesis of lumbar intervertebral disc herniation: From clinical evidence to basic scientific research	4
Facet deflection and strain are dependent on axial compression and distraction in C5–C7 spinal segments under constrained flexion	4
The involvement of immune system in intervertebral disc herniation and degeneration	4
An in‐depth analysis of the immunomodulatory mechanisms of intervertebral disc degeneration	4
Pain behavior and phenotype in a modified anterior lumbar disc puncture mouse model	4
Socioeconomic status, mental health, and nutrition are the principal traits for low back pain phenotyping: Data from the osteoarthritis initiative	4
Mechanical crosstalk between the intervertebral disc, facet joints, and vertebral endplate following acute disc injury in a rabbit model	4
Intradiscal administration of autologous platelet‐rich plasma in patients with Modic type 1 associated low back pain: A prospective pilot study	4
A successful PSRS special issue and Spine across the globe	4
Phosphorylated heat shock protein 27 improves the bone formation ability of osteoblasts and bone marrow stem cells from patients with adolescent idiopathic scoliosis	3
Pharmacokinetics of PP353, a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first‐in‐human, Phase 1b, ope	3
Spatial and Diurnal Variations in Sodium Content Within Intervertebral Disc Tissue	3
pH: A major player in degenerative intervertebral disks	3
Bioinformatics‐based discovery of intervertebral disc degeneration biomarkers and immune‐inflammatory infiltrates	3
Demographic and Biomedical Characteristics of an Observational Cohort With Chronic Low Back Pain: A Descriptive Analysis	3
Non‐enzymatic glycation reduces glucose transport in the human cartilage endplate independently of matrix porosity or proteoglycan content	3
Inactivation of Tnf‐α/Tnfr signaling attenuates progression of intervertebral disc degeneration in mice	3
Neural network segmentation of disc volume from magnetic resonance images and the effect of degeneration and spinal level	3
Welcome to Volume 5!	3
Biomolecular therapies for chronic discogenic low back pain: A narrative review	3
Transcriptome Data Combined With Mendelian Randomization Analysis Identifies Key Genes Associated With Mitochondria and Programmed Cell Death in Intervertebral Disc Degeneration	3
Automatic grading of intervertebral disc degeneration in lumbar dog spines	3
DeVa (Decay Variance): A Novel Score Calculated via Postprocessing the Changes in Signal Intensity of an Intervertebral Disc in a T2* Multi‐Echo Magnetic Resonance Image Can Quan	3
Novel 3D printed lattice structure titanium cages evaluated in an ovine model of interbody fusion	3
A missense GDF5 variant causes brachydactyly type A1 and multiple‐synostoses syndrome 2	3
Flexible support material maintains disc height and supports the formation of hydrated tissue engineered intervertebral discs in vivo	3
Wharton's Jelly mesenchymal stromal cell‐derived extracellular vesicles promote nucleus pulposus cell anabolism in an in vitro 3D alginate‐bead culture model	2
Intervertebral Disc Degeneration Mediates the Causal Effect of Genetically Predicted Diffuse Idiopathic Skeletal Hyperostosis on Spinal Stenosis: Evidence From a Mendelian Randomization Study	2
Paraspinal muscle morphology and composition in adolescent idiopathic scoliosis: A histological analysis	2
Panax notoginseng saponins attenuate intervertebral disc degeneration by reducing the end plate porosity in lumbar spinal instability mice	2
E74‐like ETS transcription factor 3 expression and regulation in human intervertebral disc	2
Harmonization and standardization of nucleus pulposus cell extraction and culture methods	2
An additively manufactured model for preclinical testing of cervical devices	2
Structure‐function relationships of the human vertebral endplate	2
Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain	2
Variations in ECM Topography, Fiber Alignment, Mechanical Stiffness, and Cellular Composition Between Ventral and Dorsal Ligamentum Flavum Layers: Insights Into Hypertrophy Pathogenesis	2
The influence of ligament biomechanics on proximal junctional kyphosis and failure in patients with adult spinal deformity	2
Developmental morphogens direct human induced pluripotent stem cells toward an annulus fibrosus‐like cell phenotype	2
Slow twitch paraspinal muscle dysregulation in adolescent idiopathic scoliosis exhibiting HIF‐2α misexpression	2
Application and Validation of Semiautomatic Quantification of Immunohistochemically Stained Sections for Low Cellular Tissue Such as Intervertebral Disc Using QuPath	2
The degenerative impact of hyperglycemia on the structure and mechanics of developing murine intervertebral discs	2
Short‐Term Dynamic Unloading of Bovine Tail Discs in Culture Partially Mitigates Induced Degeneration After One‐Strike Trigger	2
Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc	2
Development of a mouse model of chronic ventral spinal cord compression: Neurobehavioral, radiological, and pathological changes	2
Collagen integrity of the annulus fibrosus in degenerative disc disease individuals quantified with collagen hybridizing peptide	2
An exploration of knowledge‐organizing technologies to advance transdisciplinary back pain research	2
Mechanistic Interactions Driving Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration: A Multi‐Axial Perspective of Mechanical, Immune, and Metabolic Pathways	2
In Vivo Measurements Reveal Increased Nucleus Pulposus Lactate and Oxygen Concentrations in a Goat Model of Intervertebral Disc Degeneration	2
Animal Models of Disc Degeneration Using Puncture Injury: A 20 Year Perspective	2
A novel spine tester TO GO	1
The effect of local steroid application on bony fusion in a rat posterolateral spinal arthrodesis model	1
Mechanism of Intervertebral Disc Degeneration via the β‐Catenin/CCL2 Pathway in Sox9 Conditional Knockout Mice	1
Development and validation of deep learning models for identifying the brand of pedicle screws on plain spine radiographs	1
An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therape	1
In vivo fluid transport in human intervertebral discs varies by spinal level and disc region	1
Diverse and multifunctional roles for perlecan (HSPG2) in repair of the intervertebral disc	1
Issue Information	1
Revealing the novel metabolism‐related genes in the ossification of the ligamentum flavum based on whole transcriptomic data	1
Improving how orthopedic journals report research outcomes based on sex and gender	1

Intradiscal injection for the management of low back pain	1
Transcriptomic profiling reveals key early response genes during GDF6‐mediated differentiation of human adipose‐derived stem cells to nucleus pulposus cells	1
Issue Information	1
Advancing spinal research beyond COVID‐19	1
Targeting nucleus pulposus cell death in the treatment of intervertebral disc degeneration	1
Investigation into theanti‐inflammatoryproperties of metformin in intervertebral disc cells	1
Issue Information	1
DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling	1
Another year over, and a new one is up for highest impact!	1
Wharton's Jelly Mesenchymal Stromal Cell‐Derived Extracellular Vesicles Attenuate Intervertebral Disc Degeneration Under Inflammatory Stress in an In Vitro 3D Culture System	1
Relationship Between Lumbar Multifidus Morphometry and Pain/Disability in Individuals With Chronic Nonspecific Low Back Pain After Considering Demographics, Fear‐Avoidance Beliefs, Insomnia, and Spina	1
Automated magnetic resonance imaging‐based grading of the lumbar intervertebral disc and facet joints	1
Efficacy of using autologous cells with graft substitutes for spinal fusion surgery: A systematic review and meta‐analysis of clinical outcomes and imaging features	1
The potential effect of romosozumab on perioperative management for instrumentation surgery	1
Causal Relationship Between Gut Microbiota, Blood Metabolites, and Intervertebral Disc Degeneration: A Two‐Step, Two‐Sample Bidirectional Mendelian Randomization Study	1
A pilot study: Nano‐hydroxyapatite‐PEG/PLA containing low dose rhBMP2 stimulates proliferation and osteogenic differentiation of human bone marrow derived mesenchymal stem cells	1
Assessment of Vertebral Bone Marrow Perfusion, Fat/Water Content, and Trabecular Bone Changes Using Multimodal MRI and Micro‐CT in a Rat Model of Chronic Kidney Disease	1
Sacral anatomical parameters varies in different Roussouly sagittal shapes as well as their relations to lumbopelvic parameters	1
Ultrafine‐Grained Materials With Antibacterial Properties: A Novel Approach to Reducing Spinal Implant‐Associated Infections	1
Annulus Fibrosus Repair via Interpenetration of a Non‐Woven Scaffold Supports Tissue Integration and Prevents Re‐Herniation	1
Proteomic analysis of serum in a population‐based cohort did not reveal a biomarker for Modic changes	1
Influence of macrophage polarization in herniated nucleus pulposus tissue on clinical efficacy after lumbar discectomy	1
Range of international surgical strategies for adolescent idiopathic scoliosis: Evaluation of a multi‐center survey	1
Targeted screening of inflammatory mediators in spontaneous degenerative disc disease in dogs reveals an upregulation of the tumor necrosis superfamily	1
Correction to ‘Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization’	1
Effects of circulating inflammatory proteins on spinal degenerative diseases: Evidence from genetic correlations and Mendelian randomization study	1
Issue Information	1
Development and Validation of a Machine Learning‐Based Online Prognostic Model for Cervical Spondylosis Patients After Anterior Cervical Discectomy and Fusion: A Multicenter Study	1
A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain	1
Complex In Vivo Motion of the Bovine Tail Provides Unique Insights Into Intervertebral Disc Adaptation	1
The association between low virulence organisms in different locations and intervertebral disc structural failure: A meta‐analysis and systematic review	1
Advancing basic and preclinical spine research: Highlights from the ORS PSRS 6th International Spine Research Symposium	1
The influence of intervertebral disc overloading on nociceptor calcium flickering	1
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