OOIR: Observatory of International Research

Papers

(The median citation count of CRISPR Journal is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
CRISPR-Cas Gene Perturbation and Editing in Human Induced Pluripotent Stem Cells	481
Exploring the Cytoplasmic Retention of CRISPR-Cas9 in Eukaryotic Cells: The Role of Nuclear Localization Signals and Ribosomal Interactions	50
Hairpin Internal Nuclear Localization Signals in CRISPR-Cas9 Enhance Editing in Primary Human Lymphocytes	48
Adaptation by Type V-A and V-B CRISPR-Cas Systems Demonstrates Conserved Protospacer Selection Mechanisms Between Diverse CRISPR-Cas Types	44
Gene Editing Corrects In Vitro a G > A GLB1 Transition from a GM1 Gangliosidosis Patient	40
Increasing Genome Editing Efficiency of Cas9 Nucleases by the Simultaneous Use of Transcriptional Activators and Histone Acetyltransferase Activator	40
CRISPR Comparison Toolkit: Rapid Identification, Visualization, and Analysis of CRISPR Array Diversity	37
Will Advances in Genetic Medicine Lessen the Need for Germline Modifications?	36
Inference of CRISPR Edits from Sanger Trace Data	33
Editing Properties of Base Editors with SpCas9-NG in Discarded Human Tripronuclear Zygotes	31
A Taxonomic and Phylogenetic Classification of Diverse Base Editors	30
Acknowledgment of Reviewers 2022	30
Curing “GFP-itis” in Bacteria with Base Editors: Development of a Genome Editing Science Program Implemented with High School Biology Students	28
Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering	27
Advances in Cas12a-Based Amplification-Free Nucleic Acid Detection	27
Opposing Human Genetic Engineering	26
Gene Editing and Rett Syndrome: Does It Make the Cut?	24
Generation of a Commercial-Scale Founder Population of Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs Using CRISPR-Cas	22
Early Detection of Wildlife Disease Pathogens Using CRISPR-Cas System Methods	21
Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing	20
Implementing CRISPR-Cas9 Yeast Practicals into Biology Curricula	20
Increasing the Targeting Scope of CRISPR Base Editing System Beyond NGG	20
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors	17
CRISPR Crops and Sustainable Agriculture	17
Comprehensive Analysis of CRISPR-Cas9 Editing Outcomes in Yeast Xanthophyllomyces dendrorhous	17

The Roles and Responsibilities of Scientific Journals in Research Governance: Editorial Policymaking at Nature and Springer Nature (1995–2023)	16
CRISPR Rewrites the Future of Medicine	15
CRISPR à la carte	15
A Story of Perseverance: An Interview with Matthew Porteus	15
Evolutionary Biology and Gene Editing of Cat Allergen, Fel d 1	14
Widespread Impact of Natural Genetic Variations in CRISPR-Cas9 Outcomes	14
Gene Editing in the Chagas Disease Vector Rhodnius prolixus by Cas9-Mediated ReMOT Control	13
Engineered Antiviral Sensor Targets Infected Mosquitoes	13
Evolution of Type IV CRISPR-Cas Systems: Insights from CRISPR Loci in Integrative Conjugative Elements of Acidithiobacillia	12
Combined Theoretical, Bioinformatic, and Biochemical Analyses of RNA Editing by Adenine Base Editors	12
dCas9 Tells Tales: Probing Gene Function and Transcription Regulation in Cancer	12
Institutional Bioethics: From Critical Interdisciplinarity to Cosmopolitanism	12
Automated Good Manufacturing Practice-Compatible CRISPR-Cas9 Editing of Hematopoietic Stem and Progenitor Cells for Clinical Treatment of β-Hemoglobinopathies	12
Engineering CjCas9 for Efficient Base Editing and Prime Editing	11
CRISPR Momentum in the Clinic and the Field	11
Specific High-Sensitivity Enzymatic Reporter UnLOCKing-Mediated Detection of Oncogenic BCR::ABL1 and EGFR Rearrangements	11
Fanzors: Mysterious TnpB-Like Bacterial Transposon-Related RNA-Guided DNA Nucleases of Eukaryotes	11
Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects	11
A PCR-Induced Mutagenesis-Restriction Fragment Length Polymorphism Method for the Detection of CRISPR-Induced Indels	10
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors	10
Enhancements of the CRISPR-Cas System in the Silkworm Bombyx mori	10
Affordable Pricing of CRISPR Treatments is a Pressing Ethical Imperative	10
A Protein-Cutting CRISPR Complex Caught in Action	9
A Multiplexed Cas13-Based Assay with Point-of-Care Attributes for Simultaneous COVID-19 Diagnosis and Variant Surveillance	9
The CRISPR Revolution in the Drug Discovery Workflow: An Industry Perspective	9
Bacterial Retrons Enable Precise Gene Editing in Human Cells	9
Rapid and Technically Simple Detection of SARS-CoV-2 Variants Using CRISPR Cas12 and Cas13	9
It's a Knockout for Cat Allergies?	9
Warrior Spirit: An Interview with Victoria Gray, Sickle Cell Pioneer	9
Introducing Faith-Based Claims to Ethical Discourse on Scientific Matters	8
Acknowledgment of Reviewers 2023	8
Cas12a-Capture: A Novel, Low-Cost, and Scalable Method for Targeted Sequencing	8
Spotlight on Genetic Design in a Spotted Wing Crop Killer	8
CRISPR-Cas9-Mediated Correction of TSC2 Pathogenic Variants in iPSCs from Patients with Tuberous Sclerosis Complex Type 2	8
Navigating Viral Space with CRISPR Technologies	7
Five Years of Progress in CRISPR Clinical Trials (2019–2024)	7
Reduction of Pre-Existing Adaptive Immune Responses Against SaCas9 in Humans Using Epitope Mapping and Identification	7
Base Editing of Somatic Cells Using CRISPR–Cas9 in Drosophila	7
Rapid Variant Pathogenicity Analysis by CRISPR Activation of CRB1 Gene Expression in Patient-Derived Fibroblasts	7
Genome Editing Headwinds: Can CRISPR Stay on Target?	7
The New Old Colonialism	7
CRISPR-Cas9 Gene Editing Protects from the A53T-SNCA Overexpression-Induced Pathology of Parkinson's Disease In Vivo	7
Genome Editing Therapy for the Blood: Ex Vivo Success and In Vivo Prospects	7
Trichostatin A for Efficient CRISPR-Cas9 Gene Editing of Human Pluripotent Stem Cells	7
Moving Therapeutic Genome Editing into Global Clinical Trials and Medicine	7
Correction to: Give Cas a Chance: An Actionable Path to a Platform for CRISPR Cures, by Fyodor D. Urnov [DOI: 10.1089/crispr.2024.0082]	6
Clonally Selected Lines After CRISPR-Cas Editing Are Not Isogenic	6
Characterization of Research Support of Genome Editing Technologies and Transition to Clinical Trials	6
Extreme Genome Editing	6
CRISPR-Cas9 Long-Read Sequencing for Mapping Transgenes in the Mouse Genome	6

Special Issue: CRISPR Trials	6
Special Issue: Manipulating the Microbiome with CRISPR	6
Bio-Orthogonal Chemistry Conjugation Strategy Facilitates Investigation of N-methyladenosine and Thiouridine Guide RNA Modifications on CRISPR Activity	6
Novel off-Targeting Events Identified after Genome Wide Analysis of CRISPR-Cas Edited Pigs	6
PASTE: The Way Forward for Large DNA Insertions	6
Correction to: APOBEC Reporter Systems for Evaluating diNucleotide Editing Levels by Rieffer et al. The CRISPR Journal, 2023;6(5):430–446; DOI: 10.1089/crispr.2023.0027	6
Diverse Class 2 CRISPR Effectors as Active Nucleases with Expanded Targeting Capabilities	6
An Efficient and Cost-Effective Novel Strategy for Identifying CRISPR-Cas-Mediated Mutants in Plant Offspring	5
CRISPR-Cas12a Genome Editing at the Whole-Plant Level Using Two Compatible RNA Virus Vectors	5
A Reset for Bioethics: A Statement from the Global Observatory for Genome Editing	5
CRISPR-Cas9-Mediated Targeting of Multidrug Resistance Genes in Methicillin-Resistant Staphylococcus aureus	5
Recalibrating Health Governance, Equity, and Reproductive Rights in India: A Case Study from the Global South	5
Celebrating a Decade of CRISPR-Fueled Genome Editing	5
Electroporation-Mediated Delivery of Cas9 Ribonucleoproteins Results in High Levels of Gene Editing in Primary Hepatocytes	5
Viral Delivery of Compact CRISPR-Cas12f for Gene Editing Applications	4
Efficient and Economical Targeted Insertion in Plant Genomes via Protoplast Regeneration	4
Science with Society at Science Gallery Bengaluru	4
APOBEC Reporter Systems for Evaluating diNucleotide Editing Levels	4
High-Throughput Imaging of CRISPR- and Recombinant Adeno-Associated Virus–Induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells	4
Green Fluorescent Protein Tagged Polycistronic Reporter System Reveals Functional Editing Characteristics of CRISPR-Cas	4
Correction to: Genotyping MUltiplexed-Sequencing of CRISPR-Localized Editing (GMUSCLE): An Experimental and Computational Approach for Analyzing CRISPR-Edited Cells by Zhang et al. The CRISP	4
Discovery and Characterization of Novel Type V Cas12f Nucleases with Diverse Protospacer Adjacent Motif Preferences	4
Reprogramming of Human B Cells from Secreting IgG to IgM by Genome Editing	4
Optimization of Genomewide CRISPR Screens Using AsCas12a and Multi-Guide Arrays	4
Introducing Perspectives from the Global Observatory for Genome Editing	4
Genetic Manipulation of a CAST of Characters in a Microbial Community	4
Novel and Engineered Type II CRISPR Systems from Uncultivated Microbes with Broad Genome Editing Capability	4
Modified Cas9-Guided Oxford Nanopore Technology Sequencing Uncovers Single and Multiple Transgene Insertion Sites in a Zebrafish Melanoma Model	4
Facing Systemic Uncertainty, Can the CRISPR Community Stay the Course?	4
Genome Editing in Apicomplexan Parasites: Current Status, Challenges, and Future Possibilities	3
CRISPRi-Mediated Treatment of Dominant Rhodopsin-Associated Retinitis Pigmentosa	3
Genomic and Transcriptomic Analyses of Prime Editing Guide RNA–Independent Off-Target Effects by Prime Editors	3
CRISPR-Cas9 Genome Editing Uncovers the Mode of Action of Methoprene in the Yellow Fever Mosquito, Aedes aegypti	3
Enhanced Myogenesis by Silencing Myostatin with Nonviral Delivery of a dCas9 Ribonucleoprotein Complex	3
Response to Cook et al. re: Novel Off-Targeting Events Identified After Genome Wide Analysis of CRISPR-Cas Edited Pig	3
Toward a Global Deliberative System for Genome Editing	3
Modulating CRISPR-Cas Genome Editing Using Guide-Complementary DNA Oligonucleotides	3
Developing Bottom-Up Induced Pluripotent Stem Cell Derived Solid Tumor Models Using Precision Genome Editing Technologies	3
Predicting Mutations Generated by Cas9, Base Editing, and Prime Editing in Mammalian Cells	3
As CRISPR Technologies Ripen, What Should We Prioritize?	3
AI and SynBio Meet CRISPR Heralding a New Genome Editing Era	3
Acknowledgment of Reviewers 2021	3
CRISPR's Path to the Clinic	2
Model System to Analyze RNA-Mediated DNA Repair in Mammalian Cells	2
CRISPR and the Plant Pathologists' Holy Grail	2
Establishment of a CRISPR-Cas9-Mediated Genome Editing System in Flax	2
Biotechnologies in the World: On Global Asymmetries and the Need for Cosmopolitanism	2
Advances in Gene Therapy for Sickle Cell Disease: From Preclinical Innovations to Clinical Implementation and Access Challenges	2
JACKIE: Fast Enumeration of Genome-Wide Single- and Multicopy CRISPR Target Sites and Their Off-Target Numbers	2
Highly Efficient One-Step Tagging of Endogenous Genes in Primary Cells Using CRISPR-Cas Ribonucleoproteins	2
Functional Characterization of Type III-A CRISPR-Cas in a Clinical Human Methicillin-R Staphylococcus aureus Strain	2
Rosalind Franklin Society Proudly Announces the 2023 Award Recipient for The CRISPR Journal	2
A Mutation-Agnostic Hematopoietic Stem Cell Gene Therapy for Metachromatic Leukodystrophy	2
Optimizing Genome Editing in Mollusks (Crassostrea gigas) in Vitro Validation of sgRNA and Identifying Key Factors Influencing Efficiency	2
Periodontal Disease Pathogens, Pathogenesis, and Therapeutics: The CRISPR-Cas Effect	2
The Promises and Pitfalls of CRISPR-Mediated Base Editing in Stem Cells	2
Special Issue on CRISPR Diagnostics	2
Monitoring the Land and Sea: Enhancing Efficiency Through CRISPR-Cas Driven Depletion and Enrichment of Environmental DNA	2
Search for Origins of Anti-CRISPR Proteins by Structure Comparison	2
Efficient Generation of SOCS2 Knock-Out Sheep by Electroporation of CRISPR-Cas9 Ribonucleoprotein Complex with Dual-sgRNAs	2
Enrichment of Allelic Editing Outcomes by Prime Editing in Induced Pluripotent Stem Cells	2
Compact Cje3Cas9 for Efficient In Vivo Genome Editing and Adenine Base Editing	2
CRISPR Empowers Tree Bioengineering for a Sustainable Future	2
Identification of a Guide RNA Targeting an Ultraconserved Element for Evaluation of Cas9 Genome Editors Across Mammalian Species	2
Correction to: Generation of a Commercial-Scale Founder Population of Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs Using CRISPR-Cas by Burger et al. The CRISPR Journal,	2
Special Issue: Manipulating the Microbiome with CRISPR	2