OOIR: Observatory of International Research

Papers

(The TQCC of CRISPR Journal is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
CRISPR-Cas Gene Perturbation and Editing in Human Induced Pluripotent Stem Cells	470
Exploring the Cytoplasmic Retention of CRISPR-Cas9 in Eukaryotic Cells: The Role of Nuclear Localization Signals and Ribosomal Interactions	49
Hairpin Internal Nuclear Localization Signals in CRISPR-Cas9 Enhance Editing in Primary Human Lymphocytes	48
Adaptation by Type V-A and V-B CRISPR-Cas Systems Demonstrates Conserved Protospacer Selection Mechanisms Between Diverse CRISPR-Cas Types	43
Gene Editing Corrects In Vitro a G > A GLB1 Transition from a GM1 Gangliosidosis Patient	37
Increasing Genome Editing Efficiency of Cas9 Nucleases by the Simultaneous Use of Transcriptional Activators and Histone Acetyltransferase Activator	37
CRISPR Comparison Toolkit: Rapid Identification, Visualization, and Analysis of CRISPR Array Diversity	36
Will Advances in Genetic Medicine Lessen the Need for Germline Modifications?	36
Inference of CRISPR Edits from Sanger Trace Data	36
Editing Properties of Base Editors with SpCas9-NG in Discarded Human Tripronuclear Zygotes	31
A Taxonomic and Phylogenetic Classification of Diverse Base Editors	29
Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering	29
Acknowledgment of Reviewers 2022	29
Curing “GFP-itis” in Bacteria with Base Editors: Development of a Genome Editing Science Program Implemented with High School Biology Students	28
Generation of a Commercial-Scale Founder Population of Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs Using CRISPR-Cas	26
Gene Editing and Rett Syndrome: Does It Make the Cut?	26
Opposing Human Genetic Engineering	25
Advances in Cas12a-Based Amplification-Free Nucleic Acid Detection	25
Increasing the Targeting Scope of CRISPR Base Editing System Beyond NGG	23
Implementing CRISPR-Cas9 Yeast Practicals into Biology Curricula	20
Early Detection of Wildlife Disease Pathogens Using CRISPR-Cas System Methods	20
Comprehensive Analysis of CRISPR-Cas9 Editing Outcomes in Yeast Xanthophyllomyces dendrorhous	19
CRISPR Crops and Sustainable Agriculture	19
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors	17
The Roles and Responsibilities of Scientific Journals in Research Governance: Editorial Policymaking at Nature and Springer Nature (1995–2023)	17

Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing	17
CRISPR à la carte	16
Widespread Impact of Natural Genetic Variations in CRISPR-Cas9 Outcomes	15
CRISPR Rewrites the Future of Medicine	15
Evolutionary Biology and Gene Editing of Cat Allergen, Fel d 1	15
A Story of Perseverance: An Interview with Matthew Porteus	15
Automated Good Manufacturing Practice-Compatible CRISPR-Cas9 Editing of Hematopoietic Stem and Progenitor Cells for Clinical Treatment of β-Hemoglobinopathies	14
Combined Theoretical, Bioinformatic, and Biochemical Analyses of RNA Editing by Adenine Base Editors	14
Evolution of Type IV CRISPR-Cas Systems: Insights from CRISPR Loci in Integrative Conjugative Elements of Acidithiobacillia	14
dCas9 Tells Tales: Probing Gene Function and Transcription Regulation in Cancer	13
Gene Editing in the Chagas Disease Vector Rhodnius prolixus by Cas9-Mediated ReMOT Control	13
Specific High-Sensitivity Enzymatic Reporter UnLOCKing-Mediated Detection of Oncogenic BCR::ABL1 and EGFR Rearrangements	13
Engineered Antiviral Sensor Targets Infected Mosquitoes	13
Institutional Bioethics: From Critical Interdisciplinarity to Cosmopolitanism	12
CRISPR Momentum in the Clinic and the Field	12
Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects	12
Engineering CjCas9 for Efficient Base Editing and Prime Editing	12
Application of CRISPR-Cas9 Editing for Virus Engineering and the Development of Recombinant Viral Vaccines	11
Fanzors: Mysterious TnpB-Like Bacterial Transposon-Related RNA-Guided DNA Nucleases of Eukaryotes	11
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors	11
Enhancements of the CRISPR-Cas System in the Silkworm Bombyx mori	11
A PCR-Induced Mutagenesis-Restriction Fragment Length Polymorphism Method for the Detection of CRISPR-Induced Indels	10
Affordable Pricing of CRISPR Treatments is a Pressing Ethical Imperative	10
Spotlight on Genetic Design in a Spotted Wing Crop Killer	10
A Multiplexed Cas13-Based Assay with Point-of-Care Attributes for Simultaneous COVID-19 Diagnosis and Variant Surveillance	10
A Protein-Cutting CRISPR Complex Caught in Action	9
Rapid and Technically Simple Detection of SARS-CoV-2 Variants Using CRISPR Cas12 and Cas13	9
Bacterial Retrons Enable Precise Gene Editing in Human Cells	9
CRISPR-Cas9-Mediated Correction of TSC2 Pathogenic Variants in iPSCs from Patients with Tuberous Sclerosis Complex Type 2	9
It's a Knockout for Cat Allergies?	9
Warrior Spirit: An Interview with Victoria Gray, Sickle Cell Pioneer	9
Introducing Faith-Based Claims to Ethical Discourse on Scientific Matters	9
Cas12a-Capture: A Novel, Low-Cost, and Scalable Method for Targeted Sequencing	9
The CRISPR Revolution in the Drug Discovery Workflow: An Industry Perspective	9
Acknowledgment of Reviewers 2023	9
Genome Editing Headwinds: Can CRISPR Stay on Target?	8
Five Years of Progress in CRISPR Clinical Trials (2019–2024)	8
Genome Editing Therapy for the Blood: Ex Vivo Success and In Vivo Prospects	8
Rapid Variant Pathogenicity Analysis by CRISPR Activation of CRB1 Gene Expression in Patient-Derived Fibroblasts	8
CRISPR-Cas9 Gene Editing Protects from the A53T-SNCA Overexpression-Induced Pathology of Parkinson's Disease In Vivo	8
Navigating Viral Space with CRISPR Technologies	8
Reduction of Pre-Existing Adaptive Immune Responses Against SaCas9 in Humans Using Epitope Mapping and Identification	7
Special Issue: Manipulating the Microbiome with CRISPR	7
Characterization of Research Support of Genome Editing Technologies and Transition to Clinical Trials	7
Trichostatin A for Efficient CRISPR-Cas9 Gene Editing of Human Pluripotent Stem Cells	7
Moving Therapeutic Genome Editing into Global Clinical Trials and Medicine	7
Bio-Orthogonal Chemistry Conjugation Strategy Facilitates Investigation of N-methyladenosine and Thiouridine Guide RNA Modifications on CRISPR Activity	7
The New Old Colonialism	7
Base Editing of Somatic Cells Using CRISPR–Cas9 in Drosophila	7
Correction to: APOBEC Reporter Systems for Evaluating diNucleotide Editing Levels by Rieffer et al. The CRISPR Journal, 2023;6(5):430–446; DOI: 10.1089/crispr.2023.0027	7

Diverse Class 2 CRISPR Effectors as Active Nucleases with Expanded Targeting Capabilities