OOIR: Observatory of International Research

Papers

(The TQCC of CRISPR Journal is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
CRISPR-Cas Gene Perturbation and Editing in Human Induced Pluripotent Stem Cells	481
Exploring the Cytoplasmic Retention of CRISPR-Cas9 in Eukaryotic Cells: The Role of Nuclear Localization Signals and Ribosomal Interactions	50
Hairpin Internal Nuclear Localization Signals in CRISPR-Cas9 Enhance Editing in Primary Human Lymphocytes	48
Adaptation by Type V-A and V-B CRISPR-Cas Systems Demonstrates Conserved Protospacer Selection Mechanisms Between Diverse CRISPR-Cas Types	44
Gene Editing Corrects In Vitro a G > A GLB1 Transition from a GM1 Gangliosidosis Patient	40
Increasing Genome Editing Efficiency of Cas9 Nucleases by the Simultaneous Use of Transcriptional Activators and Histone Acetyltransferase Activator	40
CRISPR Comparison Toolkit: Rapid Identification, Visualization, and Analysis of CRISPR Array Diversity	37
Will Advances in Genetic Medicine Lessen the Need for Germline Modifications?	36
Inference of CRISPR Edits from Sanger Trace Data	33
Editing Properties of Base Editors with SpCas9-NG in Discarded Human Tripronuclear Zygotes	31
A Taxonomic and Phylogenetic Classification of Diverse Base Editors	30
Acknowledgment of Reviewers 2022	30
Curing “GFP-itis” in Bacteria with Base Editors: Development of a Genome Editing Science Program Implemented with High School Biology Students	28
Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering	27
Advances in Cas12a-Based Amplification-Free Nucleic Acid Detection	27
Opposing Human Genetic Engineering	26
Gene Editing and Rett Syndrome: Does It Make the Cut?	24
Generation of a Commercial-Scale Founder Population of Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs Using CRISPR-Cas	22
Early Detection of Wildlife Disease Pathogens Using CRISPR-Cas System Methods	21
Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing	20
Implementing CRISPR-Cas9 Yeast Practicals into Biology Curricula	20
Increasing the Targeting Scope of CRISPR Base Editing System Beyond NGG	20
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors	17
CRISPR Crops and Sustainable Agriculture	17
Comprehensive Analysis of CRISPR-Cas9 Editing Outcomes in Yeast Xanthophyllomyces dendrorhous	17

The Roles and Responsibilities of Scientific Journals in Research Governance: Editorial Policymaking at Nature and Springer Nature (1995–2023)	16
CRISPR Rewrites the Future of Medicine	15
CRISPR à la carte	15
A Story of Perseverance: An Interview with Matthew Porteus	15
Evolutionary Biology and Gene Editing of Cat Allergen, Fel d 1	14
Widespread Impact of Natural Genetic Variations in CRISPR-Cas9 Outcomes	14
Gene Editing in the Chagas Disease Vector Rhodnius prolixus by Cas9-Mediated ReMOT Control	13
Engineered Antiviral Sensor Targets Infected Mosquitoes	13
Evolution of Type IV CRISPR-Cas Systems: Insights from CRISPR Loci in Integrative Conjugative Elements of Acidithiobacillia	12
Combined Theoretical, Bioinformatic, and Biochemical Analyses of RNA Editing by Adenine Base Editors	12
dCas9 Tells Tales: Probing Gene Function and Transcription Regulation in Cancer	12
Institutional Bioethics: From Critical Interdisciplinarity to Cosmopolitanism	12
Automated Good Manufacturing Practice-Compatible CRISPR-Cas9 Editing of Hematopoietic Stem and Progenitor Cells for Clinical Treatment of β-Hemoglobinopathies	12
Engineering CjCas9 for Efficient Base Editing and Prime Editing	11
CRISPR Momentum in the Clinic and the Field	11
Specific High-Sensitivity Enzymatic Reporter UnLOCKing-Mediated Detection of Oncogenic BCR::ABL1 and EGFR Rearrangements	11
Fanzors: Mysterious TnpB-Like Bacterial Transposon-Related RNA-Guided DNA Nucleases of Eukaryotes	11
Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects	11
A PCR-Induced Mutagenesis-Restriction Fragment Length Polymorphism Method for the Detection of CRISPR-Induced Indels	10
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors	10
Enhancements of the CRISPR-Cas System in the Silkworm Bombyx mori	10
Affordable Pricing of CRISPR Treatments is a Pressing Ethical Imperative	10
A Protein-Cutting CRISPR Complex Caught in Action	9
A Multiplexed Cas13-Based Assay with Point-of-Care Attributes for Simultaneous COVID-19 Diagnosis and Variant Surveillance	9
The CRISPR Revolution in the Drug Discovery Workflow: An Industry Perspective	9
Bacterial Retrons Enable Precise Gene Editing in Human Cells	9
Rapid and Technically Simple Detection of SARS-CoV-2 Variants Using CRISPR Cas12 and Cas13	9
It's a Knockout for Cat Allergies?	9
Warrior Spirit: An Interview with Victoria Gray, Sickle Cell Pioneer	9
Introducing Faith-Based Claims to Ethical Discourse on Scientific Matters	8
Acknowledgment of Reviewers 2023	8
Cas12a-Capture: A Novel, Low-Cost, and Scalable Method for Targeted Sequencing	8
Spotlight on Genetic Design in a Spotted Wing Crop Killer	8
CRISPR-Cas9-Mediated Correction of TSC2 Pathogenic Variants in iPSCs from Patients with Tuberous Sclerosis Complex Type 2	8
Navigating Viral Space with CRISPR Technologies	7
Five Years of Progress in CRISPR Clinical Trials (2019–2024)	7
Reduction of Pre-Existing Adaptive Immune Responses Against SaCas9 in Humans Using Epitope Mapping and Identification	7
Base Editing of Somatic Cells Using CRISPR–Cas9 in Drosophila	7
Rapid Variant Pathogenicity Analysis by CRISPR Activation of CRB1 Gene Expression in Patient-Derived Fibroblasts	7
Genome Editing Headwinds: Can CRISPR Stay on Target?	7
The New Old Colonialism	7
CRISPR-Cas9 Gene Editing Protects from the A53T-SNCA Overexpression-Induced Pathology of Parkinson's Disease In Vivo	7
Genome Editing Therapy for the Blood: Ex Vivo Success and In Vivo Prospects	7
Trichostatin A for Efficient CRISPR-Cas9 Gene Editing of Human Pluripotent Stem Cells	7
Moving Therapeutic Genome Editing into Global Clinical Trials and Medicine	7