Circulation-Genomic and Precision Medicine

Article	Citations
Editorial Board	69
Relationships of Circulating Plasma Metabolites With the QT Interval in a Large Population Cohort	63
Cardiac Troponin C E135A Variant Impairs Myofilament Response to PKA Phosphorylation and Is Associated With Autosomal Dominant Dilated Cardiomyopathy With Diastolic Dysfunction	60
Compound Heterozygous Truncating Variants in the BAG5 Gene As a Cause of Early-Onset Dilated Cardiomyopathy	39
Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy	38
Diagnostic Yield of Exome Sequencing in Patients With Congenital Heart Disease From Southern Africa	38
Investigation of Copy Number Variation in South African Patients With Congenital Heart Defects	37
Polygenic Scoring for Detection of Ascending Thoracic Aortic Dilation	35
Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization	33
Metabolomic and Proteomic Signatures of Cardiorespiratory Fitness for Predicting All-Cause Mortality and Non-Communicable Disease Risk: A Prospective Study in the UK Biobank	31
Mechanistic Pathways Underlying Genetic Predisposition to Atrial Fibrillation Are Associated With Different Cardiac Phenotypes and Cardioembolic Stroke Risk	31
Plasma Protein Profile Associated With a Family History of Early-Onset Coronary Heart Disease	30
Calmodulinopathy Associated Long QT Syndrome, Hypertrophic Cardiomyopathy With Excessive Trabeculation in a 14-Year-Old Girl Presenting With Ventricular Fibrillation	30
PRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study	30
Role of TBX20 Truncating Variants in Dilated Cardiomyopathy and Left Ventricular Noncompaction	30
Low-Cost High-Throughput Genotyping for Diagnosing Familial Hypercholesterolemia	29
Multisite Validation of a Functional Assay to Adjudicate SCN5A Brugada Syndrome–Associated Variants	29
Polygenic Prediction of Nongoal Response to Statin Therapy	28
Mechanisms of RBM20 Cardiomyopathy: Insights From Model Systems	28
Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors	28
DMD-Associated Dilated Cardiomyopathy: Genotypes, Phenotypes, and Phenocopies	28
Proactive Variant Effect Mapping Aids Diagnosis in Pediatric Cardiac Arrest	27
Genotype-Phenotype Taxonomy of Hypertrophic Cardiomyopathy	27
Hereditary Hemorrhagic Telangiectasia Prevalence Estimates Calculated From GnomAD Allele Frequencies of Predicted Pathogenic Variants in ENG and	26
Editors and Editorial Board	26

Childhood Hypertrophic Cardiomyopathy Caused by Beta-Myosin Heavy Chain Variants Is Associated With a More Obstructive but Less Arrhythmogenic Phenotype Than Myosin-Binding Protein C Disease	26
Resource of Gene Expression Data From a Multiethnic Population Cohort of Induced Pluripotent Stem Cell–Derived Cardiomyocytes	25
Genetic Determinants of the Interventricular Septum Are Linked to Ventricular Septal Defects and Hypertrophic Cardiomyopathy	25
Associations of the ICAM1 p.K56M HFpEF Risk Variant With Pericardial Adiposity and the Inflammatory Proteome	24
Pathway-Specific Polygenic Risk Scores Identify Obstructive Sleep Apnea–Related Pathways Differentially Moderating Genetic Susceptibility to Coronary Artery Disease	23
Using Omics to Identify Novel Therapeutic Targets in Heart Failure	21
Familial Hypercholesterolemia Identification by Machine Learning Using Lipid Profile Data Performs as Well as Clinical Diagnostic Criteria	21
DNA Methylation-Based Biomarkers of Protein Levels and Cardiovascular Disease Risk: Opportunities and Challenges for Precision Cardiology	21
Genome-Wide Analysis of Left Ventricular Maximum Wall Thickness in the UK Biobank Cohort Reveals a Shared Genetic Background With Hypertrophic Cardiomyopathy	20
Prevalence of Genetic Diagnoses in a Cohort With Valvar Pulmonary Stenosis	20
Risk for Heart Failure and Atrial Fibrillation Across the Lifespan for Carriers of the Amyloidogenic p.V142I TTR Variant	20
Newfoundland Mutation TMEM43 -p.S358L Causes Impaired Cardiac Energy Metabolism and Mitochondrial Function Through Altered Protein Interaction	20
Phenotype of ASDs Associated With 4p16 Risk Locus and Novel Genome-Wide Associations of ASD Patients in the Finnish Population	19
Novel Multiplexed Plasma Biomarker Panel Has Diagnostic and Prognostic Potential in Children With Hypertrophic Cardiomyopathy	19
In Memoriam: Prof. Dr. Jeanette Erdmann (1965–2023)	19
Performance of Polygenic Risk Scores for Atherosclerotic Cardiovascular Disease in the All of Us Program	19
Machine Learning to Understand Genetic and Clinical Factors Associated With the Pulse Waveform Dicrotic Notch	19
Cardiomyopathy-Associated Mutations in a Hotspot Region at the C-Terminal Part of Desmin Coil-2 Domain Impair the Intermediate Filament Assembly	18
Influence of Genotype on Cardiac Phenotype in Pediatric Hypertrophic Cardiomyopathy	18
Impact of GLA Variant Classification on the Estimated Prevalence of Fabry Disease: A Systematic Review and Meta-Analysis of Screening Studies	17
Phenotypic Characterization of Timothy Syndrome Caused by the CACNA1C p.Gly402Ser Variant	17
Rare Variants in HTRA1, SGTB, and RBM12 Confer Risk of Atherosclerotic Cardiovascular Disease Independent of Traditional Cardiovascular Risk Factors	17
Yield of Genetic Testing for Long-QT Syndrome in Elderly Patients With Torsades de Pointes	17
Structural Evaluation of RYR2 -CPVT Missense Variants and Continuous Bayesian Estimates of Their Penetrance	16
Clinical Outcome in KLHL24 Cardiomyopathy	16
Differential Deep RNA Sequencing for Diagnostic Detection of Microbial Infections in Inflammatory Cardiomyopathy	16
Prevalence and Phenotypic Burden of Monogenic Arrhythmias Using Integration of Electronic Health Records With Genetics	15
Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases	15
Gamut of Patients Referred to Cardiology for Question of Clonal Hematopoiesis	14
Biobank-Scale Plasma Proteomics Identifies Novel Biomarkers in Hypertrophic Cardiomyopathy	14
Current State and Future of Polygenic Risk Scores in Cardiometabolic Disease: A Scoping Review	14
Invasive Assessment of Coronary Artery Disease in Clonal Hematopoiesis of Indeterminate Potential	14
Targeting PPAR-γ Reduces Fibrosis and Arrhythmogenic Remodeling in DSG2-Linked Arrhythmogenic Cardiomyopathy	14
Population Genomic Screening and Improved Lipid Management in Patients With Familial Hypercholesterolemia	14
Correction to: Development and Validation of Polygenic Risk Scores for Blood Pressure Traits in Continental African Populations	14
Tumor Whole-Genome Sequencing for Prediction of Venous Thromboembolism in Patients With Metastasized Solid Cancer	14
Clinical Utility of Protein Language Models in Resolution of Variants of Uncertain Significance in KCNQ1, KCNH2 , and SCN5A Compared With	14
Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes	14
Development and Implementation of an Integrated Preclinical Atherosclerosis Database	13
DiscoVari : A Web-Based Precision Medicine Tool for Predicting Variant Pathogenicity in Cardiomyopathy- and Channelopathy-Associated Genes	13
Artificial Intelligence to Enhance Precision Medicine in Cardio-Oncology: A Scientific Statement From the American Heart Association	13
Causal Relationship Between Average Alcohol Consumption and Risk of Atrial Fibrillation: A Mendelian Randomization Study	13
Splicing Functional Assays Into the Genetic Testing Pipeline	13
Large-Scale Proteomics-Based Risk Score for the Prediction of Incident Cardio-Kidney-Metabolic Disease Risk	13
Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy	13
Twenty-Five–Year Follow-Up of the MDDC1 Family: A LMNA Gene Variant Associated With Dilated Cardiomyopathy With Variable Skeletal Muscle Involvement	12
Acacetin, a Potent Transient Outward Current Blocker, May Be a Novel Therapeutic for KCND3 -Encoded Kv4.3 Gain-of-Function-Associated J-Wave Syndromes	12
Machine Learning-Based Plasma Protein Risk Score Improves Atrial Fibrillation Prediction Over Clinical and Genomic Models	12
Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis	12
Lung Single-Cell Transcriptomics Reveal Diverging Pathobiology and Opportunities for Precision Targeting in Scleroderma-Associated Versus Idiopathic Pulmonary Arterial Hypertension	12

Association of Genome-Wide Polygenic Risk Score for Body Mass Index With Cardiometabolic Health From Childhood Through Midlife	12
Long Noncoding RNA TRIBAL Links the 8q24.13 Locus to Hepatic Lipid Metabolism and Coronary Artery Disease	11
Prevalence of Pathogenic Variants in Dilated Cardiomyopathy–Associated Genes in Patients Evaluated for Cardiac Sarcoidosis	11
Evaluating the Cardiovascular Impact of Genetically Proxied PCSK9 and HMGCR Inhibition in East Asian and European Populations: A Drug-Target Mendelian Randomization Study	11
Role of Genetic Testing for Cardiomyopathies in Pediatric Patients With Left Ventricular Dysfunction Secondary to Chemotherapy	11
Digging Deeper Into Cardiovascular Plasma Proteomics: Opportunities and Limitations of Current Platforms	11
Analysis of TTN Truncating Variants in >74 000 Cases Reveals New Clinically Relevant Gene Regions	11
Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems	11
Multipopulation Genome-Wide Association Study Identifies Novel Loci for Bicuspid Aortic Valve and Reveals Shared Genetic Architecture With Aortopathies	11
Genome-Wide Association Study for Idiopathic Ventricular Tachyarrhythmias Identifies Key Role of CCR7 and PKN2 in Calcium Homeostasis and	11
Association of Predicted Damaging De Novo Variants on Ventricular Function in Individuals With Congenital Heart Disease	10
Precision Medicine and the FDA Modernization Act 2.0: Catalyzing Innovation in Cardiovascular Therapy	10
On Penetrance Estimation in Family, Clinical, and Population Cohorts	10
Rationale, Design, and the Baseline Characteristics of the RHDGen (The Genetics of Rheumatic Heart Disease) Network Study†	10
Titin Allelic Expression and Protein Processing Pathways in Early-Stage Dilated Cardiomyopathy Patients With Truncating Titin Variants	10
Familial Aggregation Studies: A Valuable Tool in the Genetic Toolbox	10
Diagnostic MicroRNA Signatures to Support Classification of Pulmonary Hypertension	9
Harnessing the Potential of Genetics to Understand the Impact of Sleep Apnea on Cardiovascular Risk	9
Genetic Architecture of N-Terminal Pro-B-Type Natriuretic Peptide in a Multiancestry Study Population	9
Prevalence and Disease Expression of Pathogenic and Likely Pathogenic Variants Associated With Inherited Cardiomyopathies in the General Population	9
Natural History, Phenotype Spectrum, and Clinical Outcomes of Desmin ( DES )-Associated Cardiomyopathy	9
Functional Assays Reclassify Suspected Splice-Altering Variants of Uncertain Significance in Mendelian Channelopathies	9
Importance of Clinical, Laboratory, and Genetic Risk Factors for Incident CAD	8
Enhancing the Detection and Care of Heterozygous Familial Hypercholesterolemia in Primary Care: Cost-Effectiveness and Return on Investment	8
Sex Differences in the Association of Multiethnic Genome-Wide Blood Pressure Polygenic Risk Score With Population-Level Systolic Blood Pressure Trajectories	8
Unlocking the Regulatory Genome: Interpreting the Clinical Impact of Noncoding Variants in Genetic Cardiomyopathies	8
Associations Between Genetic Variation in the Targets of Low-Density Lipoprotein–Lowering Drugs and Rheumatoid Arthritis	8
Exercise Intolerance and Low Cardiac Filling Pressures in a Woman With a Novel eNOS Mutation	8
Recreational and Occupational Physical Activity and Risk of Adverse Events in Truncating MYBPC3 Founder Variant Carriers	8
Correction to: Interpreting Incidentally Identified Variants in Genes Associated With Heritable Cardiovascular Disease: A Scientific Statement From the American Heart Association	8
Efficacy and Safety of ARRY-371797 in LMNA -Related Dilated Cardiomyopathy: A Phase 2 Study	7
Reproductive Carrier Screening: Identifying Families at Risk for Familial Hypercholesterolemia in the United States	7
Rare Genetic Variants Associated With Sudden Cardiac Arrest in the Young: A Prospective, Population-Based Study	7
Genetic Testing in Congenital Heart Disease: From Microarray to Genome Sequencing	7
FGF12 Alleviates Cardiac Hypertrophy by Inhibiting Phosphorylation of CaM/CaMKII/CREB1 Axis	7
Enhancing the Prediction Power of Polygenic Risk Scores in Genetically Diverse Coronary Heart Disease	7
Clinical Guideline for Preimplantation Genetic Testing in Inherited Cardiac Diseases	6
The Genetic Basis of Primary Cardiomyopathies in Childhood: Implications for Clinical Genetic Testing	6
Evaluating the Cardiometabolic Efficacy and Safety of Lipoprotein Lipase Pathway Targets in Combination With Approved Lipid-Lowering Targets: A Drug Target Mendelian Randomization Study	6
Patient-Scientist Perspective on Developing Genetic Therapies for Marfan Syndrome	6
Polygenic Risk in Families With Dilated Cardiomyopathy	6
Implementing Precision Medicine for Dilated Cardiomyopathy: Insights From the DCM Consortium	6
Long-Term Effects of Mavacamten on Patients Based on Hypertrophic Cardiomyopathy Pathogenic Genetic Variant Status: Insights From VALOR-HCM Trial	6
Clinical Validity of Autosomal Dominant ALPK3 Loss-of-Function Variants as a Cause of Hypertrophic Cardiomyopathy	6
Long-Term Efficacy and Safety of GLP-1R Agonist and SGLT2 Inhibitor Therapy in the General Population: A Mendelian Randomization Study	6
Admixture Mapping of Chronic Kidney Disease and Risk Factors in Hispanic/Latino Individuals From Central America Country of Origin	6
Yield of Postmortem Genetic Testing in Sudden Arrhythmic Death Syndrome: A Systematic Review and Meta-Analysis	6
Combined RNA Splicing and Patch-Clamp Analysis Reveal Pathogenicity of Splice-Altering Variants in KCNH2 -Related LQTS	5
Circulating Branched-Chain Amino Acids, Incident Cardiovascular Disease, and Mortality in the African American Study of Kidney Disease and Hypertension	5
Human Genetics Informing Drug Development in Cardiovascular Disease: Interleukin-6 Signaling as a Case Study	5
Angiographic Burden of Coronary Atherosclerosis Partially Mediates the Association Between ASCVD Risk Factors and Outcomes	5
Mono and Biallelic Variants in TRIM63 Are Frequently Associated With a Unique Form of Hypertrophic Cardiomyopathy	5
Data Interoperability for Ambulatory Monitoring of Cardiovascular Disease: A Scientific Statement From the American Heart Association	5
Noncanonical Splice-Altering Variants: Hidden Culprits of Congenital Heart Disease	5
ROBO2 Variants Associated With Atrial Septal Defect Define a Novel Regulatory Element	5
Variant Site-Specific Natural History of Titin-Induced Cardiomyopathy: An International Multicenter Registry	5
MEK Inhibition Improves Clinical Outcome in Premature Infants With Multisystemic RASA1 Disease	5
Evaluation of the Diagnostic Yield of Exome-Based Panels for Congenital Heart Defects in Different Clinical Settings	5
NEXN Gene in Cardiomyopathies and Sudden Cardiac Deaths: Prevalence, Phenotypic Expression, and Prognosis	5
Phenome-Wide Mendelian Randomization Identifying Circulating Proteins for Cardiovascular Traits in Populations of African Ancestry	4
Combining Polygenic and Proteomic Risk Scores With Clinical Risk Factors to Improve Performance for Diagnosing Absence of Coronary Artery Disease in Patients With de novo Chest Pain	4
Family Screening in Patients With Dilated and Arrhythmogenic Cardiomyopathy: The Road Toward Gene-Specific Recommendations	4
Exome Sequencing Enhances Screening for Familial Hypercholesterolemia Within a Multi-Site Healthcare System	4
Novel Truncating Variant c.1222DupC in RBM20 Causes Cardiomyopathy Consistent With Haploinsufficiency	4
Potential Diagnostic Role for a Combined Postmortem DNA and RNA Sequencing for Brugada Syndrome	4
Incremental Value of a Metabolic Risk Score for Heart Failure Mortality: A Population-Based Study	4
Drug Target Mendelian Randomization: Distinguishing Between Causal Mechanisms and Biomarkers of Those Mechanisms	4
Rapidly Progressive Peripheral Artery Disease: Importance of Oligogenic Inheritance and Functional Validation	4
Heritability of Atrial Fibrillation Among Swedish Adoptees	4
Targeted Proteomics Reveals Functional Targets for Early Diabetes Susceptibility in Young Adults	4
Molecular Phenogroups in Heart Failure: Large-Scale Proteomics in a Population-Based Cohort	4
Assessing Genetic Testing in Adult Congenital Heart Disease: Current State and Patient Perspectives	4
Calmodulinopathies: The Need for a Registry	4
New Genetic Variant in the MYH7 Gene Associated With Hypoplastic Right Heart Syndrome and Hypertrophic Cardiomyopathy in the Same Family	4
Novel Insights Into DMD-Associated Dilated Cardiomyopathy	4
Genetic Effect on Body Mass Index and Cardiovascular Disease Across Generations	4
Detecting and Mitigating Bias for Inclusive and Trustworthy Clinical Research: A Scientific Statement From the American Heart Association	4
Cross-Sectional Gene-Smoking Interaction Analysis in Relation to Subclinical Atherosclerosis-Results From the IMPROVE Study	4
Whole Genome Analysis of Venous Thromboembolism: the Trans-Omics for Precision Medicine Program	4
Dilated Cardiomyopathy With Concomitant Salt-Losing Renal Tubulopathy Caused by Heterozygous RRAGD Gene Variant	4

Friend of GATA2 Variant Ser657Gly Is Associated With Coronary Microvascular Disease	4
Familial Hypercholesterolemia in the Electronic Medical Records and Genomics Network: Prevalence, Penetrance, Cardiovascular Risk, and Outcomes After Return of Results	4
Long-Term Prevalence of Systolic Dysfunction in MYBPC3 Versus MYH7-Related Hypertrophic Cardiomyopathy	4
Network Preservation Analysis Reveals Dysregulated Metabolic Pathways in Human Vascular Smooth Muscle Cell Phenotypic Switching	3
Risks of Ventricular Arrhythmia and Heart Failure in Carriers of RBM20 Variants	3
Prediction of Positive Genetic Testing for Arrhythmogenic Left Ventricular Cardiomyopathy	3
Crossing the Threshold of Therapeutic Hope for Patients With PKP2 Arrhythmogenic Cardiomyopathy	3
Implementation of Rapid Genome Sequencing for Critically Ill Infants With Complex Congenital Heart Disease	3
Prediction of Major Adverse Cardiovascular Events in Patients With Hypertrophic Cardiomyopathy Using Proteomics Profiling	3
Machine Learning Reveals the Contribution of Rare Genetic Variants and Enhances Risk Prediction for Coronary Artery Disease in the Japanese Population	3
Functional and Molecular Characterization of Novel GDF2 (BMP9 ) and BMP10 Variants From the French PAH and	3
Risk of Congenital Heart Defects in Offspring of Affected Mothers and Fathers	3
Genome-Wide Association Study of Chronic Venous Insufficiency and Lymphedema in the Million Veteran Program	3
Cardiovascular Disease Pathogenicity Predictor (CVD-PP): A Tissue-Specific In Silico Tool for Discriminating Pathogenicity of Variants of Unknown Significance in Cardiovascular Disease Genes	3
Intrinsic Atrial Myopathy Precedes Left Ventricular Dysfunction and Predicts Atrial Fibrillation in Lamin A/C Cardiomyopathy	3
Single-Cell Dissection of the Immune Response After Acute Myocardial Infarction	3
Contiguous Gene Deletion of Chromosome 15q25.2q25.3 in Biallelic ALPK3 -Related Cardiomyopathy: Novel Insights Into Phenotypic Presentation and Variant Spectrum	3
PPARγ Antagonism: Expanding the Therapeutic Armamentarium in Arrhythmogenic Cardiomyopathy	3
Patient and Clinician Perceptions of Precision Cardiology Care: Findings From the HeartCare Study	3
Anthropometric Traits and Risk of Mitral Valve Prolapse: A Mendelian Randomization Study	3
Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular Events	3
Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research	3
Correction of the Murine Model of Congenital Heart Disease Associated With the Nkx2-5 Mutation Using Prime Editing	3
Hypertrophic Cardiomyopathy Secondary to RAF1 Cysteine-Rich Domain Variants	3
High-Risk Nonclassical Long-QT Syndrome Genotypes: Spectrum of Genetic and Phenotypic Features	3
Familial Associations of Complete Atrioventricular Block: A National Family Study in Sweden	3
Metabolic Task Analysis Reveals Distinct Metabotypes in End-Stage Dilated Cardiomyopathy	3
Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing	3