Circulation-Genomic and Precision Medicine

Article	Citations
MYH7 p.Glu903Gln Is a Pathogenic Variant Associated With Hypertrophic Cardiomyopathy	154
Multiomic Profiling in Black and White Populations Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Adults	106
Evaluating the Cardiometabolic Efficacy and Safety of Lipoprotein Lipase Pathway Targets in Combination With Approved Lipid-Lowering Targets: A Drug Target Mendelian Randomization Study	90
Compound Heterozygous Truncating Variants in the BAG5 Gene As a Cause of Early-Onset Dilated Cardiomyopathy	72
Retraction of: Systematic Evaluation of KCNQ1 variant using ACMG/AMP Guidelines and Risk Stratification in Long QT Syndrome Type 1	67
Pregnancy Outcomes in Females With Dilated Cardiomyopathy–Associated Rare Genetic Variants	55
Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes	50
Pharmacogenomics of the Efficacy and Safety of Colchicine in COLCOT	40
Clinical Characteristics of SCN5A p.R965C Carriers: A Common Founder Variant Predisposing to Brugada Syndrome in Thailand	33
Genome-Wide De Novo Variants in Congenital Heart Disease Are Not Associated With Maternal Diabetes or Obesity	31
How Normal Is Low-Normal Left Ventricular Ejection Fraction in Familial Dilated Cardiomyopathy?	30
Polygenic Risk and Coronary Artery Disease Severity	27
Reproductive Carrier Screening: Identifying Families at Risk for Familial Hypercholesterolemia in the United States	27
Mulibrey Nanism and the Real Time Use of Genome and Biobank Engines to Inform Clinical Care in an Ultrarare Disease	23
Hidden Risk: Arrhythmogenic Genes in the General Population	23
Genetically Predicted Pulse Pressure and Risk of Abdominal Aortic Aneurysm: A Mendelian Randomization Analysis	23
Rare Genetic Variants Associated With Sudden Cardiac Arrest in the Young: A Prospective, Population-Based Study	22
Cardioinformatics Advancements in Healthcare and Biotechnology	22
Editorial Board	21
Correction to: Coassin et al, Genome-Wide Characterization of a Highly Penetrant Form of Hyperlipoprotein(a)emia Associated With Genetically Elevated Cardiovascular Risk	21
Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course	20
Prognostic Implications Between hsCRP and CYP2C19 Genotype in Patients From East Asia: Insights From the PTRG-DES Consortium	20
Lipoprotein(a) Atherosclerotic Cardiovascular Disease Risk Score Development and Prediction in Primary Prevention From Real-World Data	20
Recent Advances on the Genetics of Spontaneous Coronary Artery Dissection	20
CHDgene: A Curated Database for Congenital Heart Disease Genes	19

Molecular Management of Multifocal Atrial Tachycardia in Noonan’s Syndrome With MEK1/2 Inhibitor Trametinib	19
Rapidly Progressive Peripheral Artery Disease: Importance of Oligogenic Inheritance and Functional Validation	18
Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy	18
Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults	18
Admixture Mapping of Chronic Kidney Disease and Risk Factors in Hispanic/Latino Individuals From Central America Country of Origin	18
Novel SCN5A Variant Shows Multiple Phenotypic Expression in the Same Family	18
Development of a Patient-Specific p.D85N-Potassium Voltage-Gated Channel Subfamily E Member 1–Induced Pluripotent Stem Cell–Derived Cardiomyocyte Model for Drug-Induced Long QT Syndrome	18
Life-Time Covariation of Major Cardiovascular Diseases	18
Plasma Proteomic Profile Predicts Survival in Heart Failure With Reduced Ejection Fraction	18
Variant Location Is a Novel Risk Factor for Individuals With Arrhythmogenic Cardiomyopathy Due to a Desmoplakin ( DSP ) Truncating Variant	18
Polygenic Scoring for Detection of Ascending Thoracic Aortic Dilation	17
Phenotypic Spectrum of Subclinical Sarcomere-Related Hypertrophic Cardiomyopathy and Transition to Overt Disease	17
Validation of a Polygenic Score for Beta-Blocker Survival Benefit in Patients With Heart Failure Using the United Kingdom Biobank	17
Heritability of Atrial Fibrillation Among Swedish Adoptees	16
Enhancing the Prediction Power of Polygenic Risk Scores in Genetically Diverse Coronary Heart Disease	16
Long-Term Prevalence of Systolic Dysfunction in MYBPC3 Versus MYH7-Related Hypertrophic Cardiomyopathy	15
Dilated Cardiomyopathy With Concomitant Salt-Losing Renal Tubulopathy Caused by Heterozygous RRAGD Gene Variant	15
System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan	15
Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Choleste	15
Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization	15
Suppression and Replacement Gene Therapy for KCNH2 -Mediated Arrhythmias	14
Clinical Implications of SCN10A Loss-of-Function Variants in 169 610 Exomes Representing the General Population	14
Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias	14
DNA Damage Response and Repair Genes and Anthracycline-Induced Cardiomyopathy in Childhood Cancer Survivors: A Report From the Children’s Oncology Group and the Childhood Cancer Survivor Study	14
Transcription Factors Leave Their Mark on the Heart	14
Current State and Future of Polygenic Risk Scores in Cardiometabolic Disease: A Scoping Review	13
Single-Cell Dissection of the Immune Response After Acute Myocardial Infarction	13
Long-term Effects of Mavacamten on Patients Based on Hypertrophic Cardiomyopathy Pathogenic Genetic Variant Status: Insights from VALOR-HCM Trial	13
Investigation of Copy Number Variation in South African Patients With Congenital Heart Defects	13
Integrating Clinical Phenotype With Multiomics Analyses of Human Cardiac Tissue Unveils Divergent Metabolic Remodeling in Genotype-Positive and Genotype-Negative Patients With Hypertrophic Cardiomyopa	13
Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease Among Low-Income Black and White Americans	12
Is There a Role for Genetic Testing in Patients With Myocarditis?	12
Role of TBX20 Truncating Variants in Dilated Cardiomyopathy and Left Ventricular Noncompaction	12
Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses	11
Long-Read Sequence Confirmed a Large Deletion Including MYH6 and MYH7 in an Infant of Atrial Septal Defect and Atrial Arrhythmias	11
Homozygous SPEG Mutation Is Associated With Isolated Dilated Cardiomyopathy	11
Genetic Effect on Body Mass Index and Cardiovascular Disease Across Generations	11
Novel Insights Into DMD-Associated Dilated Cardiomyopathy	11
DiscoVari : A Web-Based Precision Medicine Tool for Predicting Variant Pathogenicity in Cardiomyopathy- and Channelopathy-Associated Genes	10
Sex-Specific Survival Bias and Interaction Modeling in Coronary Artery Disease Risk Prediction	10
Genetic European Ancestry and Incident Diabetes in Black Individuals: Insights From the SPRINT Trial	10
Multi-Trait Genetic Analysis Reveals Clinically Interpretable Hypertension Subtypes	10
Common SYNE2 Genetic Variant Associated With Atrial Fibrillation Lowers Expression of Nesprin-2α1 With Downstream Effects on Nuclear and Electrophysiological Traits	10
Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research	10
Association of Plasma Branched-Chain Amino Acid With Biomarkers of Inflammation and Lipid Metabolism in Women	10
Clinical Outcomes and Genetic Analyses of Restrictive Cardiomyopathy in Children	10
Circulating Blood Plasma Profiling Reveals Proteomic Signature and a Causal Role for SVEP1 in Sudden Cardiac Death	10
Polygenic Risk in Families With Dilated Cardiomyopathy	10
Genetically Predicted Lipid Traits, Diabetes Liability, and Carotid Intima-Media Thickness in African Ancestry Individuals: A Mendelian Randomization Study	9
Causal Relationship Between Average Alcohol Consumption and Risk of Atrial Fibrillation: A Mendelian Randomization Study	9

PRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study	9
Splicing Functional Assays Into the Genetic Testing Pipeline	9
Cardiomyopathy Genes and Idiopathic VF: A Known Unknown?	9
Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors	9
Low-Cost High-Throughput Genotyping for Diagnosing Familial Hypercholesterolemia	9
Ultra-Rapid Nanopore Whole Genome Genetic Diagnosis of Dilated Cardiomyopathy in an Adolescent With Cardiogenic Shock	9
Communal Coping as a Strategy to Enhance Family Engagement in Dilated Cardiomyopathy	9
Calmodulinopathy Associated Long QT Syndrome, Hypertrophic Cardiomyopathy With Excessive Trabeculation in a 14-Year-Old Girl Presenting With Ventricular Fibrillation	9
Incremental Value of a Metabolic Risk Score for Heart Failure Mortality: A Population-Based Study	9
The Genetic Basis of Primary Cardiomyopathies in Childhood: Implications for Clinical Genetic Testing	9
Coronary Artery Disease Polygenic Risk Score Identifies Patients at Higher Risk for Recurrent Cardiovascular Events in the CANTOS Trial	9
Early Childhood-Onset Hypertrophic Cardiomyopathy in a Family With an In-Frame MYH7 Deletion	9
Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, K Ca 1.1, in Sinus Node Function and Arrhythmia Risk	8
High-Risk Nonclassical Long-QT Syndrome Genotypes: Spectrum of Genetic and Phenotypic Features	8
Potential Diagnostic Role for a Combined Postmortem DNA and RNA Sequencing for Brugada Syndrome	8
Regional Variation in Cardiovascular Genes Enables a Tractable Genome Editing Strategy	8
Provocation Testing and Therapeutic Response in a Newly Described Channelopathy: RyR2 Calcium Release Deficiency Syndrome	8
New Genetic Variant in the MYH7 Gene Associated With Hypoplastic Right Heart Syndrome and Hypertrophic Cardiomyopathy in the Same Family	8
Rare Variant in MRC2 Associated With Familial Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome	8
Genetic Basis of Left Ventricular Noncompaction	8
Clinical Conditions and Their Impact on Utility of Genetic Scores for Prediction of Acute Coronary Syndrome	8
Development and Implementation of an Integrated Preclinical Atherosclerosis Database	8
Familial Hypercholesterolemia in the Electronic Medical Records and Genomics Network: Prevalence, Penetrance, Cardiovascular Risk, and Outcomes After Return of Results	8
Risks of Ventricular Arrhythmia and Heart Failure in Carriers of RBM20 Variants	8
Multisite Validation of a Functional Assay to Adjudicate SCN5A Brugada Syndrome–Associated Variants	8
DMD-Associated Dilated Cardiomyopathy: Genotypes, Phenotypes, and Phenocopies	8
Artificial Intelligence to Enhance Precision Medicine in Cardio-Oncology: A Scientific Statement From the American Heart Association	7
Estimating the Posttest Probability of Long QT Syndrome Diagnosis for Rare KCNH2 Variants	7
Impact of Genetic Testing for Cardiomyopathy on Emotional Well-Being and Family Dynamics: A Study of Parents and Adolescents	7
Alcohol Exposure Among Patients With Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study	7
Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy	7
Pathogenicity Assignment of Variants in Genes Associated With Cardiac Channelopathies Evolve Toward Diagnostic Uncertainty	7
Mechanisms of RBM20 Cardiomyopathy: Insights From Model Systems	7
Effect of Disclosing a Polygenic Risk Score for Coronary Heart Disease on Adverse Cardiovascular Events	7
Use of Advanced Echocardiographic Modalities to Discriminate Preclinical Hypertrophic Cardiomyopathy Mutation Carriers From Non-Carriers	7
Clinical Genetic Risk Variants Inform a Functional Protein Interaction Network for Tetralogy of Fallot	7
Prediction of Major Adverse Cardiovascular Events in Patients With Hypertrophic Cardiomyopathy Using Proteomics Profiling	7
Fibromuscular Dysplasia and Abdominal Aortic Aneurysms Are Dimorphic Sex-Specific Diseases With Shared Complex Genetic Architecture	7
Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments	6
Cost-Effectiveness of Polygenic Risk Scores to Guide Statin Therapy for Cardiovascular Disease Prevention	6
Crossing the Threshold of Therapeutic Hope for Patients With PKP2 Arrhythmogenic Cardiomyopathy	6
Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Rand	6
Patient-Scientist Perspective on Developing Genetic Therapies for Marfan Syndrome	6
Clinical Guideline for Preimplantation Genetic Testing in Inherited Cardiac Diseases	6
Prevalence and Clinical Consequences of Multiple Pathogenic Variants in Dilated Cardiomyopathy	6
Genome-Wide Association and Inheritance-Based Analyses Implicate Unconventional Myosin Genes in Hypoplastic Left Heart Syndrome	6
Genotype-Phenotype Taxonomy of Hypertrophic Cardiomyopathy	6
Susceptibility Locus for Pregnancy-Associated Spontaneous Coronary Artery Dissection	6
Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes	6
Interpretation of Incidental Genetic Findings Localizing to Genes Associated With Cardiac Channelopathies and Cardiomyopathies	5
Iterative Reanalysis of Hypertrophic Cardiomyopathy Exome Data Reveals Causative Pathogenic Mitochondrial DNA Variants	5
Genotype-Phenotype Correlation of SCN5A Genotype in Patients With Brugada Syndrome and Arrhythmic Events: Insights From the SABRUS in 392 Probands	5
The Need for Inclusive Genomic Research	5
Contiguous Gene Deletion of Chromosome 15q25.2q25.3 in Biallelic ALPK3 -Related Cardiomyopathy: Novel Insights Into Phenotypic Presentation and Variant Spectrum	5
Patient and Clinician Perceptions of Precision Cardiology Care: Findings From the HeartCare Study	5
Genetic Contribution to End-Stage Cardiomyopathy Requiring Heart Transplantation	5
Prevalence and Outcomes of p.Val142Ile TTR Amyloidosis Cardiomyopathy: A Systematic Review	5
Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association With Arrhythmogenic Right Ventricular Cardiomyopathy: A UK Biobank Analysis	5
PLEKHM2 Loss-of-Function Is Associated With Dilated Cardiomyopathy	5
Intrinsic Atrial Myopathy Precedes Left Ventricular Dysfunction and Predicts Atrial Fibrillation in Lamin A/C Cardiomyopathy	5
AAV-Mediated Delivery of Plakophilin-2a Arrests Progression of Arrhythmogenic Right Ventricular Cardiomyopathy in Murine Hearts: Preclinical Evidence Supporting Gene Therapy in Humans	5
Editors and Editorial Board	5
Acacetin, a Potent Transient Outward Current Blocker, May Be a Novel Therapeutic for KCND3 -Encoded Kv4.3 Gain-of-Function-Associated J-Wave Syndromes	5
Pathway-Specific Polygenic Risk Scores Identify Obstructive Sleep Apnea–Related Pathways Differentially Moderating Genetic Susceptibility to Coronary Artery Disease	5
Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization: A Mendelian Randomization Study in the UK Biobank	5
Presence of the V122I Variant of Hereditary Transthyretin-Mediated Amyloidosis Among Self-Reported White Individuals in a Sponsored Genetic Testing Program	5
Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis	5
Childhood Hypertrophic Cardiomyopathy Caused by Beta-Myosin Heavy Chain Variants Is Associated With a More Obstructive but Less Arrhythmogenic Phenotype Than Myosin-Binding Protein C Disease	5
Familial Hypercholesterolemia Identification by Machine Learning Using Lipid Profile Data Performs as Well as Clinical Diagnostic Criteria	5
Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy	5
Genetic Determinants of the Interventricular Septum Are Linked to Ventricular Septal Defects and Hypertrophic Cardiomyopathy	4
Arrhythmogenic Right Ventricular Cardiomyopathy Prevalence and Arrhythmic Outcomes in At-Risk Family Members: A Systematic Review and Meta-Analysis	4
Data Interoperability for Ambulatory Monitoring of Cardiovascular Disease: A Scientific Statement From the American Heart Association	4
Polygenic Prediction of Recurrent Events After Early-Onset Myocardial Infarction	4
Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing	4
Mono and Biallelic Variants in TRIM63 Are Frequently Associated With a Unique Form of Hypertrophic Cardiomyopathy	4
Prediction of Positive Genetic Testing for Arrhythmogenic Left Ventricular Cardiomyopathy	4
Genetic Basis of Childhood Cardiomyopathy	4
Interpreting Incidentally Identified Variants in Genes Associated With Heritable Cardiovascular Disease: A Scientific Statement From the American Heart Association	4
Prevalence of Pathogenic Variants in Dilated Cardiomyopathy–Associated Genes in Patients Evaluated for Cardiac Sarcoidosis	4

Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems	4
Using Omics to Identify Novel Therapeutic Targets in Heart Failure	4
Clinical Impact of Secondary Risk Factors in TTN -Mediated Dilated Cardiomyopathy	4
Understanding the Complex Genetics of Spontaneous Coronary Artery Dissection: A Guide for Clinicians	4
Random Survival Forest Machine Learning for the Prediction of Cardiovascular Events Among Patients With a Measured Lipoprotein(a) Level: A Model Development Study	4
Prognostic Value of a Polygenic Risk Score for Coronary Heart Disease in Individuals Aged 70 Years and Older	3
Familial Associations of Complete Atrioventricular Block: A National Family Study in Sweden	3
Evidence-Based Assessment of Congenital Heart Disease Genes to Enable Returning Results in a Genomic Study	3
Cadherin 2-Related Arrhythmogenic Cardiomyopathy	3
Value of Genetic Testing for Lipoprotein(a) Variants	3
Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in ANGPTL3	3
Correction to: High-Resolution Regulatory Maps Connect Vascular Risk Variants to Disease-Related Pathways	3
Impact of Hormonal Therapies for Treatment of Hormone-Dependent Cancers (Breast and Prostate) on the Cardiovascular System: Effects and Modifications: A Scientific Statement From the American Heart As	3
Prediction of Genotype Positivity in Patients With Hypertrophic Cardiomyopathy Using Machine Learning	3
Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms	3
Transcriptome Sequencing of Patients With Hypertrophic Cardiomyopathy Reveals Novel Splice-Altering Variants in MYBPC3	3
Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults	3
Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular Events	3
Cardiovascular Disease Pathogenicity Predictor (CVD-PP): A Tissue-Specific In Silico Tool for Discriminating Pathogenicity of Variants of Unknown Significance in Cardiovascular Disease Genes	3
Combined RNA Splicing and Patch-Clamp Analysis Reveal Pathogenicity of Splice-Altering Variants in KCNH2 -Related LQTS	3
Implementation of Rapid Genome Sequencing for Critically Ill Infants With Complex Congenital Heart Disease	3
Proactive Variant Effect Mapping Aids Diagnosis in Pediatric Cardiac Arrest	3
Risk of Congenital Heart Defects in Offspring of Affected Mothers and Fathers	3
Association of Genome-Wide Polygenic Risk Score for Body Mass Index With Cardiometabolic Health From Childhood Through Midlife	3
Many Journeys Originating at the Same Source to Arrive at Solutions to the Common Problem of High Lipoprotein(a)	3
Resource of Gene Expression Data From a Multiethnic Population Cohort of Induced Pluripotent Stem Cell–Derived Cardiomyocytes	3