Circulation-Genomic and Precision Medicine

Article	Citations
Editorial Board	81
Compound Heterozygous Truncating Variants in the BAG5 Gene As a Cause of Early-Onset Dilated Cardiomyopathy	78
Polygenic Scoring for Detection of Ascending Thoracic Aortic Dilation	61
Investigation of Copy Number Variation in South African Patients With Congenital Heart Defects	56
Clinical Implications of SCN10A Loss-of-Function Variants in 169 610 Exomes Representing the General Population	45
Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Choleste	40
Mechanistic Pathways Underlying Genetic Predisposition to Atrial Fibrillation Are Associated With Different Cardiac Phenotypes and Cardioembolic Stroke Risk	38
Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization	37
Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy	36
DMD-Associated Dilated Cardiomyopathy: Genotypes, Phenotypes, and Phenocopies	29
Genotype-Phenotype Taxonomy of Hypertrophic Cardiomyopathy	29
Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors	28
Pathogenicity Assignment of Variants in Genes Associated With Cardiac Channelopathies Evolve Toward Diagnostic Uncertainty	27
Role of TBX20 Truncating Variants in Dilated Cardiomyopathy and Left Ventricular Noncompaction	26
Low-Cost High-Throughput Genotyping for Diagnosing Familial Hypercholesterolemia	25
Mechanisms of RBM20 Cardiomyopathy: Insights From Model Systems	24
Multisite Validation of a Functional Assay to Adjudicate SCN5A Brugada Syndrome–Associated Variants	24
Calmodulinopathy Associated Long QT Syndrome, Hypertrophic Cardiomyopathy With Excessive Trabeculation in a 14-Year-Old Girl Presenting With Ventricular Fibrillation	24
Association of Plasma Branched-Chain Amino Acid With Biomarkers of Inflammation and Lipid Metabolism in Women	23
Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes: Mendelian Rand	23
Coronary Artery Disease Polygenic Risk Score Identifies Patients at Higher Risk for Recurrent Cardiovascular Events in the CANTOS Trial	22
Resource of Gene Expression Data From a Multiethnic Population Cohort of Induced Pluripotent Stem Cell–Derived Cardiomyocytes	22
Childhood Hypertrophic Cardiomyopathy Caused by Beta-Myosin Heavy Chain Variants Is Associated With a More Obstructive but Less Arrhythmogenic Phenotype Than Myosin-Binding Protein C Disease	22
PRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study	22
Editors and Editorial Board	22

Pathway-Specific Polygenic Risk Scores Identify Obstructive Sleep Apnea–Related Pathways Differentially Moderating Genetic Susceptibility to Coronary Artery Disease	21
Familial Hypercholesterolemia Identification by Machine Learning Using Lipid Profile Data Performs as Well as Clinical Diagnostic Criteria	21
Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes	21
Using Omics to Identify Novel Therapeutic Targets in Heart Failure	20
Genetic Determinants of the Interventricular Septum Are Linked to Ventricular Septal Defects and Hypertrophic Cardiomyopathy	20
Proactive Variant Effect Mapping Aids Diagnosis in Pediatric Cardiac Arrest	20
DNA Methylation-Based Biomarkers of Protein Levels and Cardiovascular Disease Risk: Opportunities and Challenges for Precision Cardiology	19
Exome Sequencing Highlights a Potential Role for Concealed Cardiomyopathies in Youthful Sudden Cardiac Death	19
Machine Learning to Understand Genetic and Clinical Factors Associated With the Pulse Waveform Dicrotic Notch	19
Novel Multiplexed Plasma Biomarker Panel Has Diagnostic and Prognostic Potential in Children With Hypertrophic Cardiomyopathy	18
Causative Variants for Inherited Cardiac Conditions in a Southeast Asian Population Cohort	18
End Stage Mitochondrial Cardiomyopathy and Heart Transplantation Due to Biallelic Pathogenic C1QBP Variants	18
Risk for Heart Failure and Atrial Fibrillation Across the Lifespan for Carriers of the Amyloidogenic p.V142I TTR Variant	18
Prevalence of Genetic Diagnoses in a Cohort With Valvar Pulmonary Stenosis	18
Genome-Wide Analysis of Left Ventricular Maximum Wall Thickness in the UK Biobank Cohort Reveals a Shared Genetic Background With Hypertrophic Cardiomyopathy	18
Phenotypic Characterization of Timothy Syndrome Caused by the CACNA1C p.Gly402Ser Variant	17
Prevalence of Pathogenic Variants in Cardiomyopathy-Associated Genes in Myocarditis	17
In Memoriam: Prof. Dr. Jeanette Erdmann (1965–2023)	17
Clinical Utility of Protein Language Models in Resolution of Variants of Uncertain Significance in KCNQ1, KCNH2 , and SCN5A Compared With	16
Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases	16
Invasive Assessment of Coronary Artery Disease in Clonal Hematopoiesis of Indeterminate Potential	16
Phenotype of ASDs Associated With 4p16 Risk Locus and Novel Genome-Wide Associations of ASD Patients in the Finnish Population	16
Impact of GLA Variant Classification on the Estimated Prevalence of Fabry Disease: A Systematic Review and Meta-Analysis of Screening Studies	16
Prevalence and Phenotypic Burden of Monogenic Arrhythmias Using Integration of Electronic Health Records With Genetics	15
Yield of Genetic Testing for Long-QT Syndrome in Elderly Patients With Torsades de Pointes	15
Clinical Outcome in KLHL24 Cardiomyopathy	15
Differential Deep RNA Sequencing for Diagnostic Detection of Microbial Infections in Inflammatory Cardiomyopathy	14
Genetic Testing for Heritable Cardiovascular Diseases in Pediatric Patients: A Scientific Statement From the American Heart Association	14
Pharmacogenomic Study of Statin-Associated Muscle Symptoms in the ODYSSEY OUTCOMES Trial	14
Correction to: Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction	14
Monomorphic and Polymorphic Ventricular Arrhythmias in Heterozygous Calsequestrin-2 Mutation Carriers	14
Pregnancy Outcomes in Females With Dilated Cardiomyopathy–Associated Rare Genetic Variants	13
Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy	13
Current State and Future of Polygenic Risk Scores in Cardiometabolic Disease: A Scoping Review	13
Correction to: Development and Validation of Polygenic Risk Scores for Blood Pressure Traits in Continental African Populations	13
Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes	13
Development and Implementation of an Integrated Preclinical Atherosclerosis Database	12
Splicing Functional Assays Into the Genetic Testing Pipeline	12
Acacetin, a Potent Transient Outward Current Blocker, May Be a Novel Therapeutic for KCND3 -Encoded Kv4.3 Gain-of-Function-Associated J-Wave Syndromes	12
Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis	12
DiscoVari : A Web-Based Precision Medicine Tool for Predicting Variant Pathogenicity in Cardiomyopathy- and Channelopathy-Associated Genes	12
Provocation Testing and Therapeutic Response in a Newly Described Channelopathy: RyR2 Calcium Release Deficiency Syndrome	12
Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems	12
Causal Relationship Between Average Alcohol Consumption and Risk of Atrial Fibrillation: A Mendelian Randomization Study	12
Artificial Intelligence to Enhance Precision Medicine in Cardio-Oncology: A Scientific Statement From the American Heart Association	12
Lung Single-Cell Transcriptomics Reveal Diverging Pathobiology and Opportunities for Precision Targeting in Scleroderma-Associated Versus Idiopathic Pulmonary Arterial Hypertension	12
Prevalence of Pathogenic Variants in Dilated Cardiomyopathy–Associated Genes in Patients Evaluated for Cardiac Sarcoidosis	11
Evaluating the Cardiovascular Impact of Genetically Proxied PCSK9 and HMGCR Inhibition in East Asian and European Populations: A Drug-Target Mendelian Randomization Study	11
Correction to: High-Resolution Regulatory Maps Connect Vascular Risk Variants to Disease-Related Pathways	11
Association of Genome-Wide Polygenic Risk Score for Body Mass Index With Cardiometabolic Health From Childhood Through Midlife	11

Genome-Wide Association Study for Idiopathic Ventricular Tachyarrhythmias Identifies Key Role of CCR7 and PKN2 in Calcium Homeostasis and	11
Machine Learning-Based Plasma Protein Risk Score Improves Atrial Fibrillation Prediction Over Clinical and Genomic Models	11
Role of Genetic Testing for Cardiomyopathies in Pediatric Patients With Left Ventricular Dysfunction Secondary to Chemotherapy	11
Long Noncoding RNA TRIBAL Links the 8q24.13 Locus to Hepatic Lipid Metabolism and Coronary Artery Disease	11
Titin Allelic Expression and Protein Processing Pathways in Early-Stage Dilated Cardiomyopathy Patients With Truncating Titin Variants	10
Functional Assays Reclassify Suspected Splice-Altering Variants of Uncertain Significance in Mendelian Channelopathies	10
Association of Predicted Damaging De Novo Variants on Ventricular Function in Individuals With Congenital Heart Disease	10
Analysis of TTN Truncating Variants in >74 000 Cases Reveals New Clinically Relevant Gene Regions	10
Correction to: Interpreting Incidentally Identified Variants in Genes Associated With Heritable Cardiovascular Disease: A Scientific Statement From the American Heart Association	10
Enhancing the Detection and Care of Heterozygous Familial Hypercholesterolemia in Primary Care: Cost-Effectiveness and Return on Investment	10
Rationale, Design, and the Baseline Characteristics of the RHDGen (The Genetics of Rheumatic Heart Disease) Network Study†	10
On Penetrance Estimation in Family, Clinical, and Population Cohorts	10
Natural History, Phenotype Spectrum, and Clinical Outcomes of Desmin ( DES )-Associated Cardiomyopathy	10
Recreational and Occupational Physical Activity and Risk of Adverse Events in Truncating MYBPC3 Founder Variant Carriers	10
Harnessing the Potential of Genetics to Understand the Impact of Sleep Apnea on Cardiovascular Risk	10
Familial Aggregation Studies: A Valuable Tool in the Genetic Toolbox	10
Value of Genetic Testing for Lipoprotein(a) Variants	10
Diagnostic MicroRNA Signatures to Support Classification of Pulmonary Hypertension	10
Importance of Clinical, Laboratory, and Genetic Risk Factors for Incident CAD	10
Prevalence and Disease Expression of Pathogenic and Likely Pathogenic Variants Associated With Inherited Cardiomyopathies in the General Population	10
Rare Genetic Variants Associated With Sudden Cardiac Arrest in the Young: A Prospective, Population-Based Study	9
Sex Differences in the Association of Multiethnic Genome-Wide Blood Pressure Polygenic Risk Score With Population-Level Systolic Blood Pressure Trajectories	9
Reproductive Carrier Screening: Identifying Families at Risk for Familial Hypercholesterolemia in the United States	9
Evaluating the Cardiometabolic Efficacy and Safety of Lipoprotein Lipase Pathway Targets in Combination With Approved Lipid-Lowering Targets: A Drug Target Mendelian Randomization Study	9
Exercise Intolerance and Low Cardiac Filling Pressures in a Woman With a Novel eNOS Mutation	9
Genetically Predicted Pulse Pressure and Risk of Abdominal Aortic Aneurysm: A Mendelian Randomization Analysis	9
Efficacy and Safety of ARRY-371797 in LMNA -Related Dilated Cardiomyopathy: A Phase 2 Study	9
Associations Between Genetic Variation in the Targets of Low-Density Lipoprotein–Lowering Drugs and Rheumatoid Arthritis	9
Enhancing the Prediction Power of Polygenic Risk Scores in Genetically Diverse Coronary Heart Disease	8
Molecular Management of Multifocal Atrial Tachycardia in Noonan’s Syndrome With MEK1/2 Inhibitor Trametinib	8
Long-Term Effects of Mavacamten on Patients Based on Hypertrophic Cardiomyopathy Pathogenic Genetic Variant Status: Insights From VALOR-HCM Trial	8
Clinical Guideline for Preimplantation Genetic Testing in Inherited Cardiac Diseases	8
Admixture Mapping of Chronic Kidney Disease and Risk Factors in Hispanic/Latino Individuals From Central America Country of Origin	8
MYH7 p.Glu903Gln Is a Pathogenic Variant Associated With Hypertrophic Cardiomyopathy	8
Genetic Basis of Left Ventricular Noncompaction	8
Implementing Precision Medicine for Dilated Cardiomyopathy: Insights From the DCM Consortium	7
Combined RNA Splicing and Patch-Clamp Analysis Reveal Pathogenicity of Splice-Altering Variants in KCNH2 -Related LQTS	7
Prevalence and Outcomes of p.Val142Ile TTR Amyloidosis Cardiomyopathy: A Systematic Review	7
The Genetic Basis of Primary Cardiomyopathies in Childhood: Implications for Clinical Genetic Testing	7
Polygenic Risk in Families With Dilated Cardiomyopathy	7
Human Genetics Informing Drug Development in Cardiovascular Disease: Interleukin-6 Signaling as a Case Study	7
Prognostic Value of a Polygenic Risk Score for Coronary Heart Disease in Individuals Aged 70 Years and Older	7
Patient-Scientist Perspective on Developing Genetic Therapies for Marfan Syndrome	7
Mono and Biallelic Variants in TRIM63 Are Frequently Associated With a Unique Form of Hypertrophic Cardiomyopathy	7
Susceptibility Locus for Pregnancy-Associated Spontaneous Coronary Artery Dissection	7
Data Interoperability for Ambulatory Monitoring of Cardiovascular Disease: A Scientific Statement From the American Heart Association	6
Screening of ABCG5 and ABCG8 Genes for Sitosterolemia in a Familial Hypercholesterolemia Cascade Screening Program	6
Cross-Sectional Gene-Smoking Interaction Analysis in Relation to Subclinical Atherosclerosis-Results From the IMPROVE Study	6
Targeted Proteomics Reveals Functional Targets for Early Diabetes Susceptibility in Young Adults	6
Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure	6
CELSR1 Risk Alleles in Familial Bicuspid Aortic Valve and Hypoplastic Left Heart Syndrome	6
COL3A1 Missense Variant in a Patient Presenting With Hemoptysis	6
Clinical Validity of Autosomal Dominant ALPK3 Loss-of-Function Variants as a Cause of Hypertrophic Cardiomyopathy	6
Clinical Impact of Copy Number Variation on the Genetic Diagnosis of Syndromic Aortopathies	6
Combining Polygenic and Proteomic Risk Scores With Clinical Risk Factors to Improve Performance for Diagnosing Absence of Coronary Artery Disease in Patients With de novo Chest Pain	6
Contribution of Noncanonical Splice Variants to TTN Truncating Variant Cardiomyopathy	6
Noncanonical Splice-Altering Variants: Hidden Culprits of Congenital Heart Disease	6
Circulating Branched-Chain Amino Acids, Incident Cardiovascular Disease, and Mortality in the African American Study of Kidney Disease and Hypertension	6
Common Polymorphism That Protects From Cardiovascular Disease Increases Fibronectin Processing and Secretion	6
Family Screening in Patients With Dilated and Arrhythmogenic Cardiomyopathy: The Road Toward Gene-Specific Recommendations	6
Whole Genome Analysis of Venous Thromboembolism: the Trans-Omics for Precision Medicine Program	6
Genome-Wide Association Meta-Analysis Supports Genes Involved in Valve and Cardiac Development to Associate With Mitral Valve Prolapse	6
NEXN Gene in Cardiomyopathies and Sudden Cardiac Deaths: Prevalence, Phenotypic Expression, and Prognosis	6
Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry	5
Molecular Phenogroups in Heart Failure: Large-Scale Proteomics in a Population-Based Cohort	5
Incremental Value of a Metabolic Risk Score for Heart Failure Mortality: A Population-Based Study	5
Genetic Effect on Body Mass Index and Cardiovascular Disease Across Generations	5
Rapidly Progressive Peripheral Artery Disease: Importance of Oligogenic Inheritance and Functional Validation	5
Heritability of Atrial Fibrillation Among Swedish Adoptees	5
Estimating the Posttest Probability of Long QT Syndrome Diagnosis for Rare KCNH2 Variants	5
New Genetic Variant in the MYH7 Gene Associated With Hypoplastic Right Heart Syndrome and Hypertrophic Cardiomyopathy in the Same Family	5
Dilated Cardiomyopathy With Concomitant Salt-Losing Renal Tubulopathy Caused by Heterozygous RRAGD Gene Variant	5
Long-Term Prevalence of Systolic Dysfunction in MYBPC3 Versus MYH7-Related Hypertrophic Cardiomyopathy	5
Risks of Ventricular Arrhythmia and Heart Failure in Carriers of RBM20 Variants	5
High-Risk Nonclassical Long-QT Syndrome Genotypes: Spectrum of Genetic and Phenotypic Features	5
Long-Read Sequence Confirmed a Large Deletion Including MYH6 and MYH7 in an Infant of Atrial Septal Defect and Atrial Arrhythmias	5
Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research	4
Single-Cell Dissection of the Immune Response After Acute Myocardial Infarction	4
Cardiovascular Disease Pathogenicity Predictor (CVD-PP): A Tissue-Specific In Silico Tool for Discriminating Pathogenicity of Variants of Unknown Significance in Cardiovascular Disease Genes	4
Contiguous Gene Deletion of Chromosome 15q25.2q25.3 in Biallelic ALPK3 -Related Cardiomyopathy: Novel Insights Into Phenotypic Presentation and Variant Spectrum	4

Novel Insights Into DMD-Associated Dilated Cardiomyopathy	4
Familial Hypercholesterolemia in the Electronic Medical Records and Genomics Network: Prevalence, Penetrance, Cardiovascular Risk, and Outcomes After Return of Results	4
Correction of the Murine Model of Congenital Heart Disease Associated With the Nkx2-5 Mutation Using Prime Editing	4
Crossing the Threshold of Therapeutic Hope for Patients With PKP2 Arrhythmogenic Cardiomyopathy	4
Prediction of Major Adverse Cardiovascular Events in Patients With Hypertrophic Cardiomyopathy Using Proteomics Profiling	4
Potential Diagnostic Role for a Combined Postmortem DNA and RNA Sequencing for Brugada Syndrome	4
Clinical Conditions and Their Impact on Utility of Genetic Scores for Prediction of Acute Coronary Syndrome	4
Prediction of Positive Genetic Testing for Arrhythmogenic Left Ventricular Cardiomyopathy	4
Risk of Congenital Heart Defects in Offspring of Affected Mothers and Fathers	4
Network Preservation Analysis Reveals Dysregulated Metabolic Pathways in Human Vascular Smooth Muscle Cell Phenotypic Switching	3
Circulating Metabolite Profiles and Risk of Coronary Heart Disease Among Racially and Geographically Diverse Populations	3
Anthropometric Traits and Risk of Mitral Valve Prolapse: A Mendelian Randomization Study	3
Implementation of Rapid Genome Sequencing for Critically Ill Infants With Complex Congenital Heart Disease	3
Patient Perceptions of Emerging Gene Therapies for Arrhythmogenic Right Ventricular Cardiomyopathy	3
Patient and Clinician Perceptions of Precision Cardiology Care: Findings From the HeartCare Study	3
Genetic Testing in Sudden Cardiac Arrest: the History and Physical Exam Remain Central in the Genomics Era	3
Burden of Cardiomyopathic Genetic Variation in Lethal Pediatric Myocarditis	3
Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms	3
The Need for Inclusive Genomic Research	3
Familial Associations of Complete Atrioventricular Block: A National Family Study in Sweden	3
Role of Calmodulin in Cardiac Disease: Insights on Genotype and Phenotype	3
Race, Ancestry, and Disease Outcomes in Black Individuals: a Clarification	3
Hypertrophic Cardiomyopathy Secondary to RAF1 Cysteine-Rich Domain Variants	3
Truncating Variants in OBSCN Gene Associated With Disease-Onset and Outcomes of Hypertrophic Cardiomyopathy	3
Dysmorphology-Based Prediction Model for Genetic Disorders in Infants With Congenital Heart Disease	3
Intrinsic Atrial Myopathy Precedes Left Ventricular Dysfunction and Predicts Atrial Fibrillation in Lamin A/C Cardiomyopathy	3
Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing	3
Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing	3
Type 2 Diabetes Modifies the Association of CAD Genomic Risk Variants With Subclinical Atherosclerosis	3
Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular Events	3
Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population	3