Circulation-Genomic and Precision Medicine

Article	Citations
Clinical Implications of SCN10A Loss-of-Function Variants in 169 610 Exomes Representing the General Population	86
Editorial Board	47
Mechanistic Pathways Underlying Genetic Predisposition to Atrial Fibrillation Are Associated With Different Cardiac Phenotypes and Cardioembolic Stroke Risk	38
Cardiac Troponin C E135A Variant Impairs Myofilament Response to PKA Phosphorylation and Is Associated With Autosomal Dominant Dilated Cardiomyopathy With Diastolic Dysfunction	37
Investigation of Copy Number Variation in South African Patients With Congenital Heart Defects	35
Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease Based on an Ancestrally Diverse Genome-Wide Association Study and Population-Specific Optimization	33
Polygenic Scoring for Detection of Ascending Thoracic Aortic Dilation	32
Compound Heterozygous Truncating Variants in the BAG5 Gene As a Cause of Early-Onset Dilated Cardiomyopathy	29
Calmodulinopathy Associated Long QT Syndrome, Hypertrophic Cardiomyopathy With Excessive Trabeculation in a 14-Year-Old Girl Presenting With Ventricular Fibrillation	27
Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy	27
Relationships of Circulating Plasma Metabolites With the QT Interval in a Large Population Cohort	27
Prediction of Coronary Artery Disease and Major Adverse Cardiovascular Events Using Clinical and Genetic Risk Scores for Cardiovascular Risk Factors	26
Low-Cost High-Throughput Genotyping for Diagnosing Familial Hypercholesterolemia	25
Role of TBX20 Truncating Variants in Dilated Cardiomyopathy and Left Ventricular Noncompaction	25
Coronary Artery Disease Polygenic Risk Score Identifies Patients at Higher Risk for Recurrent Cardiovascular Events in the CANTOS Trial	25
DMD-Associated Dilated Cardiomyopathy: Genotypes, Phenotypes, and Phenocopies	24
Multisite Validation of a Functional Assay to Adjudicate SCN5A Brugada Syndrome–Associated Variants	24
Pathogenicity Assignment of Variants in Genes Associated With Cardiac Channelopathies Evolve Toward Diagnostic Uncertainty	24
Mechanisms of RBM20 Cardiomyopathy: Insights From Model Systems	23
Genotype-Phenotype Taxonomy of Hypertrophic Cardiomyopathy	23
PRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study	22
Childhood Hypertrophic Cardiomyopathy Caused by Beta-Myosin Heavy Chain Variants Is Associated With a More Obstructive but Less Arrhythmogenic Phenotype Than Myosin-Binding Protein C Disease	21
Editors and Editorial Board	21
Using Omics to Identify Novel Therapeutic Targets in Heart Failure	21
Resource of Gene Expression Data From a Multiethnic Population Cohort of Induced Pluripotent Stem Cell–Derived Cardiomyocytes	21

Pathway-Specific Polygenic Risk Scores Identify Obstructive Sleep Apnea–Related Pathways Differentially Moderating Genetic Susceptibility to Coronary Artery Disease	20
Familial Hypercholesterolemia Identification by Machine Learning Using Lipid Profile Data Performs as Well as Clinical Diagnostic Criteria	20
DNA Methylation-Based Biomarkers of Protein Levels and Cardiovascular Disease Risk: Opportunities and Challenges for Precision Cardiology	19
Genetic Determinants of the Interventricular Septum Are Linked to Ventricular Septal Defects and Hypertrophic Cardiomyopathy	19
Hereditary Hemorrhagic Telangiectasia Prevalence Estimates Calculated From GnomAD Allele Frequencies of Predicted Pathogenic Variants in ENG and	19
Proactive Variant Effect Mapping Aids Diagnosis in Pediatric Cardiac Arrest	19
Causative Variants for Inherited Cardiac Conditions in a Southeast Asian Population Cohort	18
End Stage Mitochondrial Cardiomyopathy and Heart Transplantation Due to Biallelic Pathogenic C1QBP Variants	18
Risk for Heart Failure and Atrial Fibrillation Across the Lifespan for Carriers of the Amyloidogenic p.V142I TTR Variant	17
Machine Learning to Understand Genetic and Clinical Factors Associated With the Pulse Waveform Dicrotic Notch	17
Prevalence of Genetic Diagnoses in a Cohort With Valvar Pulmonary Stenosis	17
Phenotypic Characterization of Timothy Syndrome Caused by the CACNA1C p.Gly402Ser Variant	16
Impact of GLA Variant Classification on the Estimated Prevalence of Fabry Disease: A Systematic Review and Meta-Analysis of Screening Studies	16
Exome Sequencing Highlights a Potential Role for Concealed Cardiomyopathies in Youthful Sudden Cardiac Death	16
Genome-Wide Analysis of Left Ventricular Maximum Wall Thickness in the UK Biobank Cohort Reveals a Shared Genetic Background With Hypertrophic Cardiomyopathy	16
In Memoriam: Prof. Dr. Jeanette Erdmann (1965–2023)	16
Novel Multiplexed Plasma Biomarker Panel Has Diagnostic and Prognostic Potential in Children With Hypertrophic Cardiomyopathy	16
Phenotype of ASDs Associated With 4p16 Risk Locus and Novel Genome-Wide Associations of ASD Patients in the Finnish Population	16
Prevalence of Pathogenic Variants in Cardiomyopathy-Associated Genes in Myocarditis	15
Clinical Outcome in KLHL24 Cardiomyopathy	14
Yield of Genetic Testing for Long-QT Syndrome in Elderly Patients With Torsades de Pointes	14
Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases	14
Clinical Utility of Protein Language Models in Resolution of Variants of Uncertain Significance in KCNQ1, KCNH2 , and SCN5A Compared With	14
Monomorphic and Polymorphic Ventricular Arrhythmias in Heterozygous Calsequestrin-2 Mutation Carriers	14
Pharmacogenomic Study of Statin-Associated Muscle Symptoms in the ODYSSEY OUTCOMES Trial	14
Differential Deep RNA Sequencing for Diagnostic Detection of Microbial Infections in Inflammatory Cardiomyopathy	13
Invasive Assessment of Coronary Artery Disease in Clonal Hematopoiesis of Indeterminate Potential	13
Correction to: Development and Validation of Polygenic Risk Scores for Blood Pressure Traits in Continental African Populations	13
Prevalence and Phenotypic Burden of Monogenic Arrhythmias Using Integration of Electronic Health Records With Genetics	13
Pregnancy Outcomes in Females With Dilated Cardiomyopathy–Associated Rare Genetic Variants	13
Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes	12
Splicing Functional Assays Into the Genetic Testing Pipeline	12
Provocation Testing and Therapeutic Response in a Newly Described Channelopathy: RyR2 Calcium Release Deficiency Syndrome	12
Large-Scale Proteomics-Based Risk Score for the Prediction of Incident Cardio-Kidney-Metabolic Disease Risk	12
Current State and Future of Polygenic Risk Scores in Cardiometabolic Disease: A Scoping Review	12
Development and Implementation of an Integrated Preclinical Atherosclerosis Database	12
DiscoVari : A Web-Based Precision Medicine Tool for Predicting Variant Pathogenicity in Cardiomyopathy- and Channelopathy-Associated Genes	12
Lung Single-Cell Transcriptomics Reveal Diverging Pathobiology and Opportunities for Precision Targeting in Scleroderma-Associated Versus Idiopathic Pulmonary Arterial Hypertension	12
Causal Relationship Between Average Alcohol Consumption and Risk of Atrial Fibrillation: A Mendelian Randomization Study	12
Artificial Intelligence to Enhance Precision Medicine in Cardio-Oncology: A Scientific Statement From the American Heart Association	12
Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy	12
Association of Genome-Wide Polygenic Risk Score for Body Mass Index With Cardiometabolic Health From Childhood Through Midlife	12
Analysis of TTN Truncating Variants in >74 000 Cases Reveals New Clinically Relevant Gene Regions	11
Acacetin, a Potent Transient Outward Current Blocker, May Be a Novel Therapeutic for KCND3 -Encoded Kv4.3 Gain-of-Function-Associated J-Wave Syndromes	11
Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis	11
Machine Learning-Based Plasma Protein Risk Score Improves Atrial Fibrillation Prediction Over Clinical and Genomic Models	11
Evaluation of a Machine Learning-Guided Strategy for Elevated Lipoprotein(a) Screening in Health Systems	11
Prevalence of Pathogenic Variants in Dilated Cardiomyopathy–Associated Genes in Patients Evaluated for Cardiac Sarcoidosis	11
Long Noncoding RNA TRIBAL Links the 8q24.13 Locus to Hepatic Lipid Metabolism and Coronary Artery Disease	10
Evaluating the Cardiovascular Impact of Genetically Proxied PCSK9 and HMGCR Inhibition in East Asian and European Populations: A Drug-Target Mendelian Randomization Study	10

Value of Genetic Testing for Lipoprotein(a) Variants	10
Role of Genetic Testing for Cardiomyopathies in Pediatric Patients With Left Ventricular Dysfunction Secondary to Chemotherapy	10
Genome-Wide Association Study for Idiopathic Ventricular Tachyarrhythmias Identifies Key Role of CCR7 and PKN2 in Calcium Homeostasis and	10
Digging Deeper Into Cardiovascular Plasma Proteomics: Opportunities and Limitations of Current Platforms	10
Natural History, Phenotype Spectrum, and Clinical Outcomes of Desmin ( DES )-Associated Cardiomyopathy	9
Association of Predicted Damaging De Novo Variants on Ventricular Function in Individuals With Congenital Heart Disease	9
Titin Allelic Expression and Protein Processing Pathways in Early-Stage Dilated Cardiomyopathy Patients With Truncating Titin Variants	9
On Penetrance Estimation in Family, Clinical, and Population Cohorts	9
Familial Aggregation Studies: A Valuable Tool in the Genetic Toolbox	9
Rationale, Design, and the Baseline Characteristics of the RHDGen (The Genetics of Rheumatic Heart Disease) Network Study†	9
Diagnostic MicroRNA Signatures to Support Classification of Pulmonary Hypertension	8
Enhancing the Detection and Care of Heterozygous Familial Hypercholesterolemia in Primary Care: Cost-Effectiveness and Return on Investment	8
Recreational and Occupational Physical Activity and Risk of Adverse Events in Truncating MYBPC3 Founder Variant Carriers	8
Harnessing the Potential of Genetics to Understand the Impact of Sleep Apnea on Cardiovascular Risk	8
Prevalence and Disease Expression of Pathogenic and Likely Pathogenic Variants Associated With Inherited Cardiomyopathies in the General Population	8
Sex Differences in the Association of Multiethnic Genome-Wide Blood Pressure Polygenic Risk Score With Population-Level Systolic Blood Pressure Trajectories	8
Exercise Intolerance and Low Cardiac Filling Pressures in a Woman With a Novel eNOS Mutation	8
Functional Assays Reclassify Suspected Splice-Altering Variants of Uncertain Significance in Mendelian Channelopathies	8
Associations Between Genetic Variation in the Targets of Low-Density Lipoprotein–Lowering Drugs and Rheumatoid Arthritis	8
Importance of Clinical, Laboratory, and Genetic Risk Factors for Incident CAD	8
Genetically Predicted Pulse Pressure and Risk of Abdominal Aortic Aneurysm: A Mendelian Randomization Analysis	7
Enhancing the Prediction Power of Polygenic Risk Scores in Genetically Diverse Coronary Heart Disease	7
Rare Genetic Variants Associated With Sudden Cardiac Arrest in the Young: A Prospective, Population-Based Study	7
Evaluating the Cardiometabolic Efficacy and Safety of Lipoprotein Lipase Pathway Targets in Combination With Approved Lipid-Lowering Targets: A Drug Target Mendelian Randomization Study	7
Correction to: Interpreting Incidentally Identified Variants in Genes Associated With Heritable Cardiovascular Disease: A Scientific Statement From the American Heart Association	7
Reproductive Carrier Screening: Identifying Families at Risk for Familial Hypercholesterolemia in the United States	7
Long-Term Effects of Mavacamten on Patients Based on Hypertrophic Cardiomyopathy Pathogenic Genetic Variant Status: Insights From VALOR-HCM Trial	7
Efficacy and Safety of ARRY-371797 in LMNA -Related Dilated Cardiomyopathy: A Phase 2 Study	7
Clinical Guideline for Preimplantation Genetic Testing in Inherited Cardiac Diseases	6
Implementing Precision Medicine for Dilated Cardiomyopathy: Insights From the DCM Consortium	6
Combined RNA Splicing and Patch-Clamp Analysis Reveal Pathogenicity of Splice-Altering Variants in KCNH2 -Related LQTS	6
Prognostic Value of a Polygenic Risk Score for Coronary Heart Disease in Individuals Aged 70 Years and Older	6
Common Polymorphism That Protects From Cardiovascular Disease Increases Fibronectin Processing and Secretion	6
Human Genetics Informing Drug Development in Cardiovascular Disease: Interleukin-6 Signaling as a Case Study	6
Admixture Mapping of Chronic Kidney Disease and Risk Factors in Hispanic/Latino Individuals From Central America Country of Origin	6
Polygenic Risk in Families With Dilated Cardiomyopathy	6
Genetic Basis of Left Ventricular Noncompaction	6
Data Interoperability for Ambulatory Monitoring of Cardiovascular Disease: A Scientific Statement From the American Heart Association	6
NEXN Gene in Cardiomyopathies and Sudden Cardiac Deaths: Prevalence, Phenotypic Expression, and Prognosis	6
Family Screening in Patients With Dilated and Arrhythmogenic Cardiomyopathy: The Road Toward Gene-Specific Recommendations	6
The Genetic Basis of Primary Cardiomyopathies in Childhood: Implications for Clinical Genetic Testing	6
Patient-Scientist Perspective on Developing Genetic Therapies for Marfan Syndrome	6
Clinical Validity of Autosomal Dominant ALPK3 Loss-of-Function Variants as a Cause of Hypertrophic Cardiomyopathy	6
Mono and Biallelic Variants in TRIM63 Are Frequently Associated With a Unique Form of Hypertrophic Cardiomyopathy	6
CELSR1 Risk Alleles in Familial Bicuspid Aortic Valve and Hypoplastic Left Heart Syndrome	6
Noncanonical Splice-Altering Variants: Hidden Culprits of Congenital Heart Disease	6
Cross-Sectional Gene-Smoking Interaction Analysis in Relation to Subclinical Atherosclerosis-Results From the IMPROVE Study	5
Combining Polygenic and Proteomic Risk Scores With Clinical Risk Factors to Improve Performance for Diagnosing Absence of Coronary Artery Disease in Patients With de novo Chest Pain	5
Targeted Proteomics Reveals Functional Targets for Early Diabetes Susceptibility in Young Adults	5
Circulating Branched-Chain Amino Acids, Incident Cardiovascular Disease, and Mortality in the African American Study of Kidney Disease and Hypertension	5
Whole Genome Analysis of Venous Thromboembolism: the Trans-Omics for Precision Medicine Program	5
Rapidly Progressive Peripheral Artery Disease: Importance of Oligogenic Inheritance and Functional Validation	5
Screening of ABCG5 and ABCG8 Genes for Sitosterolemia in a Familial Hypercholesterolemia Cascade Screening Program	5
Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure	5
Long-Term Prevalence of Systolic Dysfunction in MYBPC3 Versus MYH7-Related Hypertrophic Cardiomyopathy	5
Incremental Value of a Metabolic Risk Score for Heart Failure Mortality: A Population-Based Study	4
Correction of the Murine Model of Congenital Heart Disease Associated With the Nkx2-5 Mutation Using Prime Editing	4
Heritability of Atrial Fibrillation Among Swedish Adoptees	4
Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research	4
Molecular Phenogroups in Heart Failure: Large-Scale Proteomics in a Population-Based Cohort	4
Novel Insights Into DMD-Associated Dilated Cardiomyopathy	4
High-Risk Nonclassical Long-QT Syndrome Genotypes: Spectrum of Genetic and Phenotypic Features	4
Familial Hypercholesterolemia in the Electronic Medical Records and Genomics Network: Prevalence, Penetrance, Cardiovascular Risk, and Outcomes After Return of Results	4
Dilated Cardiomyopathy With Concomitant Salt-Losing Renal Tubulopathy Caused by Heterozygous RRAGD Gene Variant	4
Potential Diagnostic Role for a Combined Postmortem DNA and RNA Sequencing for Brugada Syndrome	4
Genetic Effect on Body Mass Index and Cardiovascular Disease Across Generations	4
Prediction of Positive Genetic Testing for Arrhythmogenic Left Ventricular Cardiomyopathy	3
Patient and Clinician Perceptions of Precision Cardiology Care: Findings From the HeartCare Study	3
Prediction of Major Adverse Cardiovascular Events in Patients With Hypertrophic Cardiomyopathy Using Proteomics Profiling	3
Risks of Ventricular Arrhythmia and Heart Failure in Carriers of RBM20 Variants	3
The Need for Inclusive Genomic Research	3
Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing	3
Anthropometric Traits and Risk of Mitral Valve Prolapse: A Mendelian Randomization Study	3
Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular Events	3
Contiguous Gene Deletion of Chromosome 15q25.2q25.3 in Biallelic ALPK3 -Related Cardiomyopathy: Novel Insights Into Phenotypic Presentation and Variant Spectrum	3
New Genetic Variant in the MYH7 Gene Associated With Hypoplastic Right Heart Syndrome and Hypertrophic Cardiomyopathy in the Same Family	3
Single-Cell Dissection of the Immune Response After Acute Myocardial Infarction	3
Cardiovascular Disease Pathogenicity Predictor (CVD-PP): A Tissue-Specific In Silico Tool for Discriminating Pathogenicity of Variants of Unknown Significance in Cardiovascular Disease Genes	3
Risk of Congenital Heart Defects in Offspring of Affected Mothers and Fathers	3
Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms	3

Circulating Metabolite Profiles and Risk of Coronary Heart Disease Among Racially and Geographically Diverse Populations	3
Familial Associations of Complete Atrioventricular Block: A National Family Study in Sweden	3
Drug Target Mendelian Randomization: Distinguishing Between Causal Mechanisms and Biomarkers of Those Mechanisms	3
Crossing the Threshold of Therapeutic Hope for Patients With PKP2 Arrhythmogenic Cardiomyopathy	3
Intrinsic Atrial Myopathy Precedes Left Ventricular Dysfunction and Predicts Atrial Fibrillation in Lamin A/C Cardiomyopathy	3
Implementation of Rapid Genome Sequencing for Critically Ill Infants With Complex Congenital Heart Disease	3
Race, Ancestry, and Disease Outcomes in Black Individuals: a Clarification	3
Hypertrophic Cardiomyopathy Secondary to RAF1 Cysteine-Rich Domain Variants	3