Life Science Alliance

Article	Citations
Novel determinants of NOTCH1 trafficking and signaling in breast epithelial cells	126
Enhancer mutations modulate the severity of chemotherapy-induced myelosuppression	95
DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF	79
Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19	57
Loss of cell–cell adhesion triggers cell migration through Rac1-dependent ROS generation	55
Single-cell RNA sequencing of mouse islets exposed to proinflammatory cytokines	52
Sustained induction of autophagy enhances survival during prolonged starvation in newt cells	49
Cryo-EM structures reveal the H+/citrate symport mechanism ofDrosophilaINDY	49
FGF7 as an essential mediator for the onset of ankylosing enthesitis related to psoriatic dermatitis	41
Knockout of PA200 improves proteasomal degradation and myelination in a proteotoxic neuropathy	34
Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing	34
Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes	34
Revisiting degron motifs in human AURKA required for its targeting by APC/CFZR1	32
Yolk-deprivedCaenorhabditis eleganssecure brood size at the expense of competitive fitness	31
TRIM25 targets p300 for degradation	31
Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity	31
Transcription factor EB (TFEB) activity increases resistance of TNBC stem cells to metabolic stress	31
Automated staging of zebrafish embryos with deep learning	30
Activation of XBP1 but not ATF6α rescues heart failure induced by persistent ER stress in medaka fish	30
MacrophageSult2b1promotes pathological neovascularization in age-related macular degeneration	30
Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cells	29
Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo	28
The CHARGE syndrome-associated protein FAM172A controls AGO2 nuclear import	28
Structural evidence for elastic tethers connecting separating chromosomes in crane-fly spermatocytes	28
B-cell targeting with anti-CD38 daratumumab: implications for differentiation and memory responses	27

Causal links of α-thalassemia indices and cardiometabolic traits and diabetes: MR study	27
PRMT5 triggers glucocorticoid-induced cell migration in triple-negative breast cancer	27
Structural insights into CED-3 activation	26
Gene-regulation modules in nonalcoholic fatty liver disease revealed by single-nucleus ATAC-seq	26
Tumor necrosis factor mediates USE1-independent FAT10ylation under inflammatory conditions	26
Distant sequence regions of JBP1 contribute to J-DNA binding	26
Passive diffusion accounts for the majority of intracellular nanovesicle transport	25
Toward an understanding of glucose metabolism in radial glial biology and brain development	25
Performance and robustness analysis reveals phenotypic trade-offs in yeast	24
Chromatin priming elements direct tissue-specific gene activity before hematopoietic specification	24
Themis controls T cell activation, effector functions, and metabolism of peripheral CD8+T cells	23
Spt5 interacts genetically with Myc and is limiting for brain tumor growth inDrosophila	23
Mitochondrial phosphoproteomes are functionally specialized across tissues	22
Inhibition of protein arginine deiminase 4 prevents inflammation-mediated heart failure in arthritis	22
An immune-based tool platform for in vivo cell clearance	22
Single-cell time series analysis reveals the dynamics of HSPC response to inflammation	22
Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain	22
2′,3′ cyclic nucleotide 3′ phosphodiesterase 1 functional isoform antagonizes HIV-1 particle assembly	22
Regulation of proteostasis by sleep through autophagy inDrosophilamodels of Alzheimer’s disease	21
Biogenesis, inheritance, and 3D ultrastructure of the microsporidian mitosome	21
Full-length transcript alterations in human bronchial epithelial cells withU2AF1S34F mutations	21
The origin, evolution, and molecular diversity of the chemokine system	21
Correction: Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops	21
Common analysis of direct RNA sequencinG CUrrently leads to misidentification of m5C at GCU motifs	21
Catalytic mechanism of the zinc-dependent MutL endonuclease reaction	21
Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses	21
MAP4K4 regulates forces at cell–cell and cell–matrix adhesions to promote collective cell migration	21
Integrins regulate hERG1 dynamics by girdin-dependent Gαi3: signaling and modeling in cancer cells	21
Proteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cells	20
Distinct landscapes of deleterious variants in DNA damage repair system in ethnic human populations	20
Genetic reprogramming with stem cells regenerates glomerular epithelial podocytes in Alport syndrome	20
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting	20
Ccrk-Mak/Ick signaling is a ciliary transport regulator essential for retinal photoreceptor survival	20
Concatemer-assisted stoichiometry analysis: targeted mass spectrometry for protein quantification	19
The different activities of RNA G-quadruplex structures are controlled by flanking sequences	19
SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP	19
Metabolic adaptation pilots the differentiation of human hematopoietic cells	19
Single-housing–induced islet epigenomic changes are related to polymorphisms in diabetic KK mice	19
Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation	19
Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19	18
MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea	18
Rbfox1 is required for myofibril development and maintaining fiber type–specific isoform expression in Drosophila muscles	18
Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations	18
The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization	18
Nanoscale imaging of DNA-RNA identifies transcriptional plasticity at heterochromatin	17
Correction: Microglia are essential for tissue contraction in wound closure after brain injury in zebrafish larvae	17
Quantitative profiling of adaptation to cyclin E overproduction	17
Phosphorylation of RGS regulates MAP kinase localization and promotes completion of cytokinesis	17
Mitochondrial stress-induced GFRAL signaling controls diurnal food intake and anxiety-like behavior	17
Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques	17

Dose-dependent phosphorylation and activation of Hh pathway transcription factors	17
All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal	17
mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients	17
Genetic and compound screens uncover factors modulating cancer cell response to indisulam	16
ERK-Smurf1-RhoA signaling is critical for TGFβ-drived EMT and tumor metastasis	16
Single-domain antibody screening by isPLA-seq	16
Poly(ADP-ribosyl)ating pathway regulates development from stem cell niche to longevity control	16
Neuropeptide signalling shapes feeding and reproductive behaviours in male Caenorhabditis elegans	16
The HDL particle composition determines its antitumor activity in pancreatic cancer	16
Contribution of the Golgi apparatus in morphogenesis of a virus-induced cytopathic vacuolar system	15
Correction: Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome	15
In vivo probing of SECIS-dependent selenocysteine translation in Archaea	15
Cdh5-lineage–independent origin of dermal lymphatics shown by temporally restricted lineage tracing	15
An inducible amphipathic α-helix mediates subcellular targeting and membrane binding of RPE65	15
Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells	15
The m6A(m)-independent role of FTO in regulating WNT signaling pathways	15
Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication	15
Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model	15
Correction: CDKL3 promotes osteosarcoma progression by activating Akt/PKB	15
Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage	15
Nodal andchurchill1position the expression of a notch ligand duringXenopusgerm layer segregation	15
Mitochondrial impairment and intracellular reactive oxygen species alter primary cilia morphology	15
CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau	15
Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function	15
Comparative functional genomics identifies unique molecular features of EPSCs	15
Linking medicinal cannabis to autotaxin–lysophosphatidic acid signaling	15
Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H+-driven lysosomal pyridoxine exporter	14
Plasma proteome dynamics of COVID-19 severity learnt by a graph convolutional network of multi-scale topology	14
S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation	14
Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma	14
Retinitis pigmentosa–associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule cells	14
HR repair pathway plays a crucial role in maintaining neural stem cell fate under irradiation stress	14
Lipid saturation induces degradation of squalene epoxidase for sterol homeostasis and cell survival	14
FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function againstCandida albicans	14
Tracking connectivity maps in human stem cell–derived neuronal networks by holographic optogenetics	14
The ERK activator, BCI, inhibits ciliogenesis and causes defects in motor behavior, ciliary gating, and cytoskeletal rearrangement	14
H4K20me1 plays a dual role in transcriptional regulation of regeneration and axis patterning inHydra	14
Disruption of polyhomeotic polymerization decreases nucleosome occupancy and alters genome accessibility	14
New algorithms for accurate and efficient de novo genome assembly from long DNA sequencing reads	14
Simultaneous solving high-resolution structures of various enzymes from human kidney microsomes	14
De novo discovery of traits co-occurring with chronic obstructive pulmonary disease	14
Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathway	14
Insight into the mechanism of DNA synthesis by human terminal deoxynucleotidyltransferase	14
Timing of TORC1 inhibition dictates Pol III involvement inCaenorhabditis eleganslongevity	13
Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes inC9orf72ALS/FTD models	13
Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection	13
Molecular insights into high-altitude adaption and acclimatisation ofAporrectodea caliginosa	13
Systems genetics analysis of human body fat distribution genes identifies adipocyte processes	13
Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish	13
A multiomic characterization of the leukemia cell line REH using short- and long-read sequencing	13
Differential modulation of polycomb-associated histone marks by cBAF, pBAF, and gBAF complexes	13
DEFA1A3DNA gene-dosage regulates the kidney innate immune response during upper urinary tract infection	13
arfAantisense RNA regulates MscL excretory activity	13
Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor models	13
Ubiquitome profiling reveals a regulatory pattern of UPL3 with UBP12 on metabolic-leaf senescence	13
Brd4::Nutm1fusion gene initiates NUT carcinoma in vivo	13
Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy	13
The role ofLimch1alternative splicing in skeletal muscle function	13
Improving the computation efficiency of polygenic risk score modeling: faster in Julia	13
Generation of marmoset primordial germ cell–like cells under chemically defined conditions	13
FERM domain–containing proteins are active components of the cell nucleus	13
Human T-cell activation withToxoplasma gondiiantigens loaded in maltodextrin nanoparticles	12
Statistical guidelines for quality control of next-generation sequencing techniques	12
Epithelial-specific loss of Smad4 alleviates the fibrotic response in an acute colitis mouse model	12
Chaperone BiP controls ER stress sensor Ire1 through interactions with its oligomers	12
Calaxin is a key factor for calcium-dependent waveform control in zebrafish sperm	12
Depleting chemoresponsive mitochondrial fission mediator DRP1 does not mitigate sarcoma resistance	12
Morphological correlates of synaptic protein turnover in the mouse brain	12
Distribution of lipid droplets in hippocampal neurons and microglia: impact of diabetes and exercise	12
Functional annotation of noncoding mutations in cancer	12
Human BRCA pathogenic variants were originated during recent human history	12
Vascular dysfunction is at the onset of oxaliplatin-induced peripheral neuropathy symptoms in mice	12
The nucleolar phase of signal recognition particle assembly	12
Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progression	12
Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress	12
PNKP is required for maintaining the integrity of progenitor cell populations in adult mice	12
Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF	11
RedRibbon: A new rank–rank hypergeometric overlap for gene and transcript expression signatures	11
IMPA1 dependent regulation of phosphatidylinositol 4,5-bisphosphate and calcium signalling by lithium	11
Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity	11

Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19	11
Mass spectrometry–based proteomic exploration of diverse murine macrophage cellular models	11
High-resolution structure of a fish aquaporin reveals a novel extracellular fold	11
GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells	11
Incomplete activation ofAlyrefandGabpb1leads to preimplantation arrest in cloned mouse embryos	11
Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade	11
ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway	11
Myc controls NK cell development, IL-15-driven expansion, and translational machinery	11
ciBAR1 loss in mice causes laterality defects, pancreatic degeneration, and altered glucose tolerance	11
Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms	11
Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia	11
Antibodies targeting ADAM17 reverse neurite outgrowth inhibition by myelin-associated inhibitors	11
Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior	11
The C-terminal tail of CSNAP attenuates the CSN complex	11
Transcriptome analyses in infertile men reveal germ cell–specific expression and splicing patterns	11
Transducing compressive forces into cellular outputs in cancer and beyond	11
Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme	11
Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes	11
CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation	11
Actin-binding domain of Rng2 sparsely bound on F-actin strongly inhibits actin movement on myosin II	11
The DREAM complex represses growth in response to DNA damage in Arabidopsis	11
FAT10 and NUB1L cooperate to activate the 26S proteasome	11
The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis	11
Mechanical compressive forces increase PI3K output signaling in breast and pancreatic cancer cells	10
DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway	10
Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not Akt	10
Metabolic dysregulation contributes to the development of dysferlinopathy	10
Activity-based probe profiling of RNF12 E3 ubiquitin ligase function in Tonne-Kalscheuer syndrome	10
Mature B cells and mesenchymal stem cells control emergency myelopoiesis	10
HIV-1 infection enhances innate function and TLR7 expression in female plasmacytoid dendritic cells	10
Replication-associated inversions are the dominant form of bacterial chromosome structural variation	10
Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension	10
Whole genome sequencing of drug resistanceMycobacterium tuberculosisfrom extra-pulmonary sites	10
The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro	10
Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression	10
Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza	10
pyRBDome: a comprehensive computational platform for enhancing RNA-binding proteome data	10
Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy	10
DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer’s disease by enhancing microglial activity	10
Multidimensional conservation analysis decodes the expression of conserved long noncoding RNAs	10
α-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes	10
KIF13B-mediated VEGFR2 trafficking is essential for vascular leakage and metastasis in vivo	10
Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila	10
Rapid ER remodeling induced by a peptide–lipid complex in dying tumor cells	10
Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer	10
Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis	10
Tyrosine phosphorylation controlled poly(A) polymerase I activity regulates general stress response in bacteria	10
Epigenetic centromere identity is precisely maintained through DNA replication but is uniquely specified among human cells	10
Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions	10
Identification and characterization of a membrane receptor that binds to human STC1	10
Prostaglandin F2α regulates mitochondrial dynamics and mitophagy in the bovine corpus luteum	9
A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance	9
Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1	9
Meiotic DNA breaks activate a streamlined phospho-signaling response that largely avoids protein-level changes	9
Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest	9
An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing	9
A protocol for single nucleus RNA-seq from frozen skeletal muscle	9
Dual function of Rab1A in secretion and autophagy: hypervariable domain dependence	9
Time-resolved proteomic analyses of senescence highlight metabolic rewiring of mitochondria	9
CLN3 deficiency leads to neurological and metabolic perturbations during early development	9
Rolf Jessberger: cohesin, telomeres, & germ cells	9
SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress	9
Comparative analysis of bioinformatics tools to characterize SARS-CoV-2 subgenomic RNAs	9
Sleep–wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice	9
Gapless provides combined scaffolding, gap filling, and assembly correction with long reads	9
Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencing	9
Structure-based design and characterization of Parkin-activating mutations	9
Nutrient sensitive protein O-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis	9
Secondary findings in a large Pakistani cohort tested with whole genome sequencing	9
Disease- and sex-specific differences in patients with heart valve disease: a proteome study	9
The vacuole shapes the nucleus and the ribosomal DNA loop during mitotic delays	9
Microglia are essential for tissue contraction in wound closure after brain injury in zebrafish larvae	9
Generating fast-twitch myotubes in vitro with an optogenetic-based, quantitative contractility assay	9
Decline of DNA damage response along with myogenic differentiation	9
Missense variant interaction scanning reveals a critical role of the FERM domain for tumor suppressor protein NF2 conformation and function	9
Vitamin C protects retinal ganglion cells via SPP1 in glaucoma and after optic nerve damage	9
RA-induced prominence-specific response resulted in distinctive regulation of Wnt and osteogenesis	9
Modeling fibrotic alveolar transitional cells with pluripotent stem cell-derived alveolar organoids	9
Mutation-agnostic RNA interference with engineered replacement rescuesTmc1-related hearing loss	9
Small vault RNA1-2 modulates expression of cell membrane proteins through nascent RNA silencing	9
FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins	9
Subgenomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaption	9
Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma	9
IKBKB reduces huntingtin aggregation by phosphorylating serine 13 via a non-canonical IKK pathway	9
Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis	9
Spatial metabolomics for symbiotic marine invertebrates	9
Regulation of Liprin-α phase separation by CASK is disrupted by a mutation in its CaM kinase domain	9
Nef mediates neuroimmune response, myelin impairment, and neuronal injury in EcoHIV-infected mice	8
ER procollagen storage defect without coupled unfolded protein response drives precocious arthritis	8
LncRNA RUS shapes the gene expression program towards neurogenesis	8
Macrophages-induced IL-18–mediated eosinophilia promotes characteristics of pancreatic malignancy	8
2024 reviewer index	8
A critique of the hypothesis that CA repeats are primary targets of neuronal MeCP2	8
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease	8
MicroRNAs in tear fluids predict underlying molecular changes associated with Alzheimer’s disease	8