Life Science Alliance

Article	Citations
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells	554
A FIJI macro for quantifying pattern in extracellular matrix	79
Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer	78
USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation	71
Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids	70
Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages	64
1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells	63
A serum proteome signature to predict mortality in severe COVID-19 patients	62
Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression	51
SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamsters	48
Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution	43
An extended DNA-free intranuclear compartment organizes centrosome microtubules in malaria parasites	41
High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo	39
GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program	38
MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes	37
An atlas of human proximal epididymis reveals cell-specific functions and distinct roles for CFTR	37
Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family	34
ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway	33
Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosis	33
FIREWORKS: a bottom-up approach to integrative coessentiality network analysis	32
Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation	32
LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade	29
Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria	29
CellMixS: quantifying and visualizing batch effects in single-cell RNA-seq data	28
The DREAM complex represses growth in response to DNA damage in Arabidopsis	27

Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing	27
MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling	27
Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes	26
Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity	26
Lipid-associated PML structures assemble nuclear lipid droplets containing CCTα and Lipin1	26
PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands	25
Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer	25
Prognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19	25
Leishmania-infected macrophages release extracellular vesicles that can promote lesion development	25
Mapping the micro-proteome of the nuclear lamina and lamina-associated domains	25
The bacterial quorum sensing signal DSF hijacks Arabidopsis thaliana sterol biosynthesis to suppress plant innate immunity	25
Comparative profiling of stress granule clearance reveals differential contributions of the ubiquitin system	25
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19	24
multicrispr: gRNA design for prime editing and parallel targeting of thousands of targets	24
Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology	24
mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients	24
STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers	23
EBV renders B cells susceptible to HIV-1 in humanized mice	23
Polycomb mutant partially suppresses DNA hypomethylation–associated phenotypes in Arabidopsis	23
Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells	23
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma	23
Fungal mycelia and bacterial thiamine establish a mutualistic growth mechanism	23
Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progression	23
Structure of human Dispatched-1 provides insights into Hedgehog ligand biogenesis	23
Cancer-associated cells release citrate to support tumour metastatic progression	21
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy	21
An evolutionary approach to systematic discovery of novel deubiquitinases, applied to Legionella	21
SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escape	21
CryoEM structure ofDrosophilaflight muscle thick filaments at 7 Å resolution	20
Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1	20
Exploiting somatic piRNAs in Bemisia tabaci enables novel gene silencing through RNA feeding	20
NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation	20
Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors	20
Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ42toxicity	20
HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails	20
TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection	20
Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatus	19
Multiplexed chemogenetics in astrocytes and motoneurons restore blood–spinal cord barrier in ALS	19
STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer	19
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting	19
The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies	19
Notch1 signaling determines the plasticity and function of fibroblasts in diabetic wounds	18
Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe	18
Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells	18
RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels	18
Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo	18
Attenuation of cGAS/STING activity during mitosis	18
Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration	18
Human BRCA pathogenic variants were originated during recent human history	18
DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis	18

Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activity	18
Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data	18
Role of opioid signaling in kidney damage during the development of salt-induced hypertension	18
Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation	18
Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase	18
Serine palmitoyltransferase assembles at ER–mitochondria contact sites	17
Chromosome length and gene density contribute to micronuclear membrane stability	17
The different activities of RNA G-quadruplex structures are controlled by flanking sequences	17
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia	17
ScRNA-seq expression ofIFI27andAPOC2identifies four alveolar macrophage superclusters in healthy BALF	17
Dendritic cell entry to lymphatic capillaries is orchestrated by CD44 and the hyaluronan glycocalyx	17
Single-cell RNA sequencing of mouse islets exposed to proinflammatory cytokines	17
RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes	16
Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase	16
Glucocorticoid signaling induces transcriptional memory and universally reversible chromatin changes	16
TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy	16
The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells	16
Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress	16
Electron cryo-tomography structure of axonemal doublet microtubule from Tetrahymena thermophila	16
Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2	16
Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations	16
Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques	16
Islet Gene View—a tool to facilitate islet research	16
Profiles of telomeric repeats in Insecta reveal diverse forms of telomeric motifs in Hymenopterans	16
The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells	15
Incomplete antiviral treatment may induce longer durations of viral shedding during SARS-CoV-2 infection	15
Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling	15
In vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancer	15
Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19	15
Pancreatic cancer triggers diabetes through TGF-β–mediated selective depletion of islet β-cells	15
Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories	15
Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH	15
Reduced RNA turnover as a driver of cellular senescence	15
Thymosin α1 protects from CTLA-4 intestinal immunopathology	15
Meflin-positive cancer-associated fibroblasts enhance tumor response to immune checkpoint blockade	15
Regulation of axonal morphogenesis by the mitochondrial protein Efhd1	15
Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies	15
Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway	15
Nonsense-mediated mRNA decay uses complementary mechanisms to suppress mRNA and protein accumulation	15
Interplay between MPIase, YidC, and PMF during Sec-independent insertion of membrane proteins	15
Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network	14
Engineered RNA biosensors enable ultrasensitive SARS-CoV-2 detection in a simple color and luminescence assay	14
Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infection	14
Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19	14
Insulin signaling mediates neurodegeneration in glioma	14
Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells	14
Scratch-induced partial skin wounds re-epithelialize by sheets of independently migrating keratinocytes	14
Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitor	14
Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids	14
Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup	14
Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer	14
Long noncoding RNA HOTAIR interacts with Y-Box Protein-1 (YBX1) to regulate cell proliferation	14
Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F	14
Elevated glucose increases genomic instability by inhibiting nucleotide excision repair	14
Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors	13
The actin regulator profilin 1 is functionally associated with the mammalian centrosome	13
Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice	13
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers	13
Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells	13
IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection	13
Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila	13
Adipose tissue–specific ablation of Ces1d causes metabolic dysregulation in mice	13
Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model	13
Fast but not furious: a streamlined selection method for genome-edited cells	13
CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7	13
CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP	13
Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1	13
Mitochondrial spongiotic brain disease: astrocytic stress and harmful rapamycin and ketosis effect	13
Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis	12
Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells	12
Identification of human gene research articles with wrongly identified nucleotide sequences	12
Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2	12
BRD2 regulation of sigma-2 receptor upon cholesterol deprivation	12
SCFCdc4ubiquitin ligase regulates synaptonemal complex formation during meiosis	12
Multifaceted regulation of hepatic lipid metabolism by YY1	12
Specific N-cadherin–dependent pathways drive human breast cancer dormancy in bone marrow	12
The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets	12
Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis	11
Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF	11
Cell-free expression of the outer membrane protein OprF of Pseudomonas aeruginosa for vaccine purposes	11

The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular health	11
Up-regulation of ubiquitin–proteasome activity upon loss of NatA-dependent N-terminal acetylation	11
Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction	11
Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse	11
A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells	11
Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission	11
Cell-autonomousToxoplasmakilling program requires Irgm2 but not its microbe vacuolar localization	11
Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response	11
MicroRNA regulation of murine trophoblast stem cell self-renewal and differentiation	11
Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity	11
Bis-choline tetrathiomolybdate prevents copper-induced blood–brain barrier damage	11
Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells	11
Heparan sulfate proteoglycans mediate prion-like α-synuclein toxicity in Parkinson’s in vivo models	11
A novel role of DNA polymerase λ in translesion synthesis in conjunction with DNA polymerase ζ	11
Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly	11
Phylogenetic profiling resolves early emergence of PRC2 and illuminates its functional core	10
Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy	10
Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer	10
The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration	10
PGE2accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking	10
miR-486 is essential for muscle function and suppresses a dystrophic transcriptome	10
MMD-associated RNF213 SNPs encode dominant-negative alleles that globally impair ubiquitylation	10
A novel canis lupus familiaris reference genome improves variant resolution for use in breed-specific GWAS	10
Tricalbin proteins regulate plasma membrane phospholipid homeostasis	10
Origin and segregation of the human germline	10
Unbiased yeast screens identify cellular pathways affected in Niemann–Pick disease type C	10
BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes	10
The m6A(m)-independent role of FTO in regulating WNT signaling pathways	10
Incipient sympatric speciation in wild barley caused by geological-edaphic divergence	10
A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses	10
NovelDNM1Lvariants impair mitochondrial dynamics through divergent mechanisms	10
Gradual compaction of the central spindle decreases its dynamicity in PRC1 and EB1 gene-edited cells	10
SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart	10
Peptide-based quorum sensing systems in Paenibacillus polymyxa	10
Structure and conformational dynamics of Clostridioides difficile toxin A	10
The HDL particle composition determines its antitumor activity in pancreatic cancer	10
TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition	10
Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin	10
Exosomes/microvesicles target SARS-CoV-2 via innate and RNA-induced immunity with PIWI-piRNA system	10
Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites	10
ATAD2 controls chromatin-bound HIRA turnover	9
Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in rats	9
β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy	9
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures	9
Short-term IL-15 priming leaves a long-lasting signalling imprint in mouse NK cells independently of a metabolic switch	9
Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling	9
Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis	9
Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia	9
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality	9
TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis	9
UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma	9
AGO1 regulates pericentromeric regions in mouse embryonic stem cells	9
Phylo-geo-network and haplogroup analysis of 611 novel coronavirus (SARS-CoV-2) genomes from India	9
TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration	9
Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19	9
Growth-rate-dependent and nutrient-specific gene expression resource allocation in fission yeast	9
Leishmania survives by exporting miR-146a from infected to resident cells to subjugate inflammation	9
The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites	9
Translatome profiling in fatal familial insomnia implicates TOR signaling in somatostatin neurons	9
Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells	9
Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions	9
ERK-Smurf1-RhoA signaling is critical for TGFβ-drived EMT and tumor metastasis	9
Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4	9
Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs	8
Expression regulation of genes is linked to their CpG density distributions around transcription start sites	8
Urinary prostaglandin E2 as a biomarker for recurrent UTI in postmenopausal women	8
LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity	8
Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors	8
Expression of immunoglobulin constant domain genes in neurons of the mouse central nervous system	8
Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy	8
SustainedHelicobacter pyloriinfection accelerates gastric dysplasia in a mouse model	8
Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast	8
Semaphorin 6D–expressing mesenchymal cells regulate IL-10 production by ILC2s in the lung	8
Stepwise transmigration of T- and B cells through a perivascular channel in high endothelial venules	8
CDCP1 promotes compensatory renal growth by integrating Src and Met signaling	8
Biochemical and functional characterization of a meiosis-specific Pch2/ORC AAA+ assembly	8
Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formation	8
HIV-1 infection enhances innate function and TLR7 expression in female plasmacytoid dendritic cells	8
Structure-based design and characterization of Parkin-activating mutations	8
Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme	8
Quantitative profiling of adaptation to cyclin E overproduction	8
ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1	8
MET∆14 promotes a ligand-dependent, AKT-driven invasive growth	8
Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signaling in melanoma phenotype switching	8
Set4 regulates stress response genes and coordinates histone deacetylases within yeast subtelomeres	8
A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8	8
Macrophages-induced IL-18–mediated eosinophilia promotes characteristics of pancreatic malignancy	8
Existence of log-phase Escherichia coli persisters and lasting memory of a starvation pulse	8
A time-resolved interaction analysis of Bem1 reconstructs the flow of Cdc42 during polar growth	8
DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF	8
Myc controls NK cell development, IL-15-driven expansion, and translational machinery	7
Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response	7
KIF13B-mediated VEGFR2 trafficking is essential for vascular leakage and metastasis in vivo	7
De novo discovery of traits co-occurring with chronic obstructive pulmonary disease	7
Proteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cells	7