iScience

Article	Citations
CRISPRe: An innate transcriptional enhancer for endogenous genes in CRISPR-Cas immunity	341
Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency	333
Release of extracellular DNA by Pseudomonas sp. as a major determinant for biofilm switching and an early indicator for cell population control	313
The implication of integrative multiple RNA modification-based subtypes in gastric cancer immunotherapy and prognosis	195
Enhancing corrosion resistance of biodegradable magnesium with dicalcium phosphate dihydrate and Chlorella sp. biomass	167
The attitudinal space framework: Embracing the multidimensionality of attitudinal diversity	156
Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice	146
A mathematical model of neuroimmune interactions in epileptogenesis for discovering treatment strategies	135
Network characterization linc1393 in the maintenance of pluripotency provides the principles for lncRNA targets prediction	127
Advancements in coupled processes numerical models: Upscaling aperture fields using spatial continuity	127
Antimicrobial peptide LL37 and regulatory T cell associated with late-onset sepsis in very preterm infants	112
Longitudinal cohort study highlights cancer-preventive benefits of lipid-lowering drugs	110
Chronic disease incidence explained by stepwise models and co-occurrence among them	109
Changing the spin disorder of two-dimensional magnetic Cr2TiC2Tx to long-range order through noble metal adhesion	109
Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models	109
Ion adsorption promotes Frank-van der Merwe growth of 2D transition metal tellurides	107
Visual deprivation induces a stronger dive response in a harbor porpoise	102
Metabolic stratification of human breast tumors reveal subtypes of clinical and therapeutic relevance	102
Large-scale and cost-efficient agrivoltaics system by spectral separation	101
Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults	100
Sex peptide regulates female receptivity through serotoninergic neurons in Drosophila	100
Crosstalk between 6-methyladenine and 4-methylcytosine in Geobacter sulfurreducens exposed to extremely low-frequency electromagnetic field	99
An SI-traceable reference material for virus-like particles	98
Sex differences in left-ventricular strain in a murine model of coxsackievirus B3 myocarditis	95
Genomic analyses reveal three phylogenetic species and their evolutionary histories in the big-headed turtle	94

Comparative tissue proteomics reveals unique action mechanisms of vaccine adjuvants	94
Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein	93
Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty	92
A regulatory linkage between scytonemin production and hormogonia differentiation in Nostoc punctiforme	92
Uncovering the impact and mechanisms of air pollution on eye and ear health in China	90
Stenotrophomonas maltophilia provokes NEU1-mediated release of a flagellin-binding decoy receptor that protects against lethal infection	90
Protein-constrained models pinpoints the role of underground metabolism in robustness of metabolic phenotypes	89
IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells	89
Extended X-ray absorption fine structure spectroscopy measurements and ab initio molecular dynamics simulations reveal the hydration structure of the radium(II) ion	89
Optically induced quantum transitions in direct probed mesoscopic NbSe2 for prototypical bolometers	88
Microwave Ablation Synergizes with Lipopolysaccharide to Drive Abscopal Tumor Regression Associated with Ferroptosis in Hepatocellular Carcinoma	87
Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia	87
Overexpression and knockdown of cotton GhdadD gene reveals its drought and salt stress tolerance role	87
Unrevealed effect of silver species on hydrocarbon pool in ethylene conversion on ZSM-5 by 2D COS FT-IR and 2D COS UV-vis operando spectroscopies	86
The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress	86
Sevoflurane-induced gut microbiota dysbiosis drives adolescent neurobehavioral deficits in neonatal rats: Protective role of eicosapentaenoic acid	85
Smiling underwater: Exploring playful signals and rapid mimicry in bottlenose dolphins	85
The cutaneous response to a mosquito bite is influenced by the diurnal rhythm	85
Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses	85
Evolutionary analyses of the animal glycosyltransferase family 54 reveals two β1,4-N-acetylglucosaminyltransferase families	85
Unsupervised attribute reduction based on variable precision weighted neighborhood dependency	82
Merits of dietary patterns for China’s future food security satisfying socioeconomic development and climate change adaptation	80
Do not compromise: Nurse honeybees practice strict protein-lipid regulation	80
Detecting tandem repeat variants in coding regions using code-adVNTR	78
TMS-EEG and resting-state EEG applied to altered states of consciousness: oscillations, complexity, and phenomenology	78
Development of a loop-mediated isothermal amplification (LAMP)-based electrochemical test for rapid detection of SARS-CoV-2	77
Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis	76
Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA mimicry and histone chaperone efficiency	76
Predicting stroke and myocardial infarction risk in Takayasu arteritis with automated machine learning models	75
Investigating the impacts of future oil prices on the achievement of 1.5°C climate goal	75
Evidence of self-care tooling and phylogenetic modeling reveal parrot tool use is not rare	74
Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling	74
Exploring drought-responsive crucial genes in Sorghum	74
Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response	74
Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models	74
Chemical inhibition of phosphatidylcholine biogenesis reveals its role in mitochondrial division	73
Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19	72
Integrated edge information and pathway topology for drug-disease associations	72
Different mechanisms driving increasing abundance of microbial phosphorus cycling gene groups along an elevational gradient	72
Native T1 mapping-based radiomics diagnosis of kidney function and renal fibrosis in chronic kidney disease	71
Perturbation of EPHA2 and EFNA1 trans binding amplifies inflammatory response in airway epithelial cells	71
Spatiotemporal patterns and drivers of ecosystem service interactions in karst regions: Insights for environmental protection and sustainability	71
Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19	71
The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses	70
Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity	70
Classification of polyphenol oxidases shows ancient gene duplication leading to two distinct enzyme types	69
Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes	69
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway	68
IGFBP2 derived from PO-MSCs promote epithelial barrier destruction by activating FAK signaling in nasal polyps	67
Terahertz waves regulate the mechanical unfolding of tau pre-mRNA hairpins	67

Ecological firewalls for synthetic biology	67
Inflammation conditional genome editing mediated by the CRISPR-Cas9 system	66
MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae	66
Retraction Notice to: Modulation of TNFa Activity by the microRNA Let-7 Coordinates Zebrafish Heart Regeneration	66
WITHDRAWN: Fibromodulin alleviates matrix stiffness-induced degeneration of the nucleus pulposus by regulating cytoskeleton and autophagy	66
Exploring the substrate stereoselectivity and catalytic mechanism of nonribosomal peptide macrocyclization in surugamides biosynthesis	65
Tickle contagion in the rat somatosensory cortex	64
Idealized analysis of relative values of bidirectional versus unidirectional electric vehicle charging in deeply decarbonized electricity systems	64
YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia	64
Touching with the eyes: Oculomotor self-touch induces illusory body ownership	64
Mitochondrial translation is the primary determinant of secondary mitochondrial complex I deficiencies	63
Impact of ATF6 deletion on the embryonic brain development	63
A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles	63
Interdisciplinarity at the nexus of biomedical science training: The R3 Center for Innovation in Science Education	63
β-hydroxybutyrate recapitulates the beneficial effects of ketogenic metabolic therapy in polycystic kidney disease	62
Combinatorial drug screening on 3D Ewing sarcoma spheroids using droplet-based microfluidics	62
The trogocytosis of neutrophils on initial transplanted tumor in mice	62
Design and validation of depth camera-based static posture assessment system	61
Serum proteome profiling reveals heparanase as a candidate biomarker for chronic thromboembolic pulmonary hypertension	61
How do preschoolers and adults ascribe authority?	61
Lymphocyte subset-based non-invasive biomarker predicts immunochemotherapy efficacy in EGFR-TKI-pretreated EGFR-mutated NSCLC	61
Cellular plasticity and immune microenvironment of malignant pleural effusion are associated with EGFR-TKI resistance in non–small-cell lung carcinoma	61
Microhabitat-specific diurnal metabolomic responses of the intertidal limpet Cellana toreuma to winter low temperature	61
Systemic cyst(e)inase administration induces ferroptosis and synergizes with temozolomide in glioblastoma	60
Adsorption and desorption behavior of Zn2+ in a flow-through electrosorption reactor	60
Some dogs can find the payoff-dominant outcome in the Assurance game	60
Adaptive individualized gene pair signatures distinguishing melanoma and predicting response to immune checkpoint blockade	60
Montmorillonite and amino acid composites for heavy metal ion adsorption	59
Chidamide: Exploration of maintenance therapy for patients with DLBCL with HBV infection	59
Variational adaptive Gaussian approximation filter for nonlinear systems with generalized unknown disturbances	59
Nuclear talin-1 provides a bridge between cell adhesion and gene expression	58
Social rank-dependent effects of testosterone on huddling strategies in mice	58
Acute dietary methionine restriction triggers cell cycle arrest and reversible growth defects in the neocortex	58
Transforming the CRISPR/dCas9-based gene regulation technique into a forward screening tool in Plasmodium falciparum	57
Audition controls the flow of visual time during multisensory perception	57
Machine learning unveils immune-related signature in multicenter glioma studies	56
Identification of mitochondria-related gene biomarkers associated with immune infiltration in acute myocardial infarction	56
Atherosclerotic plaque vulnerability quantification system for clinical and biological interpretability	56
A fast method to distinguish between fermentative and respiratory metabolisms in single yeast cells	56
Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence	56
An NLP-based technique to extract meaningful features from drug SMILES	56
Tumor cell malignancy: A complex trait built through reciprocal interactions between tumors and tissue-body system	55
Semen promotes oocyte development in Sebastes schlegelii elucidating ovarian development dynamics in live-bearing fish	55
Low intensity transcranial ultrasound stimulation induces hemodynamic responses through neurovascular coupling	55
Short-term auditory priming in freely-moving mice	55
Prognostic significance of inflammation in patients with coronary artery disease at low residual inflammatory risk	55
Zinc finger protein 593 promotes breast cancer development by ensuring DNA damage repair and cell-cycle progression	55
Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction	54
Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design	54
Preparation of WSi@SiOx/Ti3C2 from photovoltaic silicon waste as high-performance anode materials for lithium-ion batteries	54
Identification of optimal conditions for human placental explant culture and extracellular vesicle release	54
Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma	54
Vimentin is an important ACE2 co-receptor for SARS-CoV-2 in epithelial cells	54
Florigen and antiflorigen gene expression correlates with reproductive state in a marine angiosperm, Zostera marina	54
Risk of cerebrovascular disease after cancer diagnosis in the United States	53
Decline in stability of forest productivity in the tropics as determined by canopy water content	53
Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism	53
The Prc and CtpA proteases modulate cell-surface signaling activity and virulence in Pseudomonas aeruginosa	53
Early TRAIL-engagement elicits potent multimodal targeting of melanoma by CD34+ progenitor cell-derived NK cells	53
Gradient phase and amplitude errors in atomic magnetic gradiometers for biomagnetic imaging systems	52
Endolysosomal dysfunction impairs proteostasis and induces neurodegeneration in vivo	52
Broadband circularly polarized magneto-electric dipole antenna for millimeter-wave communication	52
Targeting Claudin18.2 for cancer theranostics: From molecular imaging to precision therapy	52
Extracellular vesicles: Antiviral functions and applications in therapeutics and vaccines	52
Inspired by struggle: A personal journey to global precision brain health	51
Replication fork blocking deficiency leads to a reduction of rDNA copy number in budding yeast	51
Enhancing mRNA translation efficiency with discriminative and generative artificial intelligence by optimizing 5′ UTR sequences	51
Histatin 1-modified SIS hydrogels enhance the sealing of peri-implant mucosa to prevent peri-implantitis	51
ENTPD8 overexpression enhances anti-PD-L1 therapy in hepatocellular carcinoma via miR-214-5p inhibition	51
Insights into the hydrogen generation and catalytic mechanism on Co-based nanocomposites derived from pyrolysis of organic metal precursor	51
Thermal conductivity across transition metal dichalcogenide bilayers	51
CD168+ macrophages promote hepatocellular carcinoma tumor stemness and progression through TOP2A/β-catenin/YAP1 axis	51
SENP2-based N-terminal truncation of α-synuclein in Lewy pathology propagation	50
Panera: An innovative framework for surmounting uncertainty in microbial community modeling using pan-genera metabolic models	50
Unveiling the role of inorganic nanoparticles in Earth’s biochemical evolution through electron transfer dynamics	50
Neuron-glia interaction at the receptor level affects olfactory perception in adult Drosophila	50
Sample multiplexing for retinal single-cell RNA sequencing	50
Reverse subsidy dilemma caused by the transformation from individual heating to central heating	50
Cooperative RNA degradation stabilizes intermediate epithelial-mesenchymal states and supports a phenotypic continuum	50
Microbiome depletion prior to repeat mild TBI differentially alters social deficits and prefrontal cortex plasticity in adolescent and adult rats	49

Seasonal shifts in pan-Arctic Ocean downward radiation and key drivers	49
Robustness of machine learning predictions for Fe-Co-Ni alloys prepared by various synthesis methods	49
Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration	49
Activity-based protein profiling of human and plasmodium serine hydrolases and interrogation of potential antimalarial targets	49
A pilot study on a patient with refractory headache: Personalized deep brain stimulation through stereoelectroencephalography	49
Dynamics of base pairs with low stability in RNA by solid-state nuclear magnetic resonance exchange spectroscopy	49
Predicting phage-host interaction via hyperbolic Poincaré graph embedding and large-scale protein language technique	49
Lactate-driven type I collagen deposition facilitates cancer stem cell-like phenotype of head and neck squamous cell carcinoma	49
The branched receptor-binding complex of Ackermannviridae phages promotes adaptive host recognition	49
DeepASmRNA: Reference-free prediction of alternative splicing events with a scalable and interpretable deep learning model	49
Genomic evidence of symbiotic adaptations in fungus-associated bacteria	49
Genome editing is induced in a binary manner in single human cells	49
Predictable sequential structure augments auditory sensitivity at threshold	49
Distance-weighted Sinkhorn loss for Alzheimer’s disease classification	48
LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p/CDKN1C axis	48
A two-component cocktail of engineered DIII nanoparticles elicits broadly neutralizing antibody responses against dengue virus in mice	48
Temperature and livestock grazing trigger transcriptome responses in bumblebees along an elevational gradient	48
Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids	48
MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity	48
T cells with increased responsiveness cause obesity in mice without diet intervention	48
Dose-dependent association between physical activity and mental health, and mitigation effects on risk behaviors	48
Architecture inspired structure engineering toward carbon nanotube hybrid for microwave absorption promotion	47
Evolution of zygomycete secretomes and the origins of terrestrial fungal ecologies	47
Inflammation modulates intercellular adhesion and mechanotransduction in human epidermis via ROCK2	47
Oleuropein activates autophagy to circumvent anti-plasmodial defense	47
Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)	47
Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation	47
Derived myeloid lineage induced pluripotent stem as a platform to study human C-C chemokine receptor type 5Δ32 homozygotes	47
TRIM47 promotes head and neck squamous cell carcinoma malignant progression by degrading XAF1 through ubiquitination	47
Differences in biomarker levels and proteomic survival prediction across two COVID-19 cohorts with distinct treatments	46
Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials	46
Perovskite-based photodetector for real-time and quantitative monitoring of sports motion	46
Longitudinal monitoring of individual infection progression in Drosophila melanogaster	46
Abundant repressor binding sites in human enhancers are associated with the fine-tuning of gene regulation	46
Prefrontal cortex encodes value pop-out in visual search	46
Amitriptyline revitalizes ICB response via dually inhibiting Kyn/Indole and 5-HT pathways of tryptophan metabolism in ovarian cancer	46
Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease	46
Leisure-time physical activity modulates associations of sarcopenia and functional disability with mortality in older adults	45
Multi-omic profiling of pathogen-stimulated primary immune cells	45
DDX56 promotes EMT and cancer stemness via MELK-FOXM1 axis in hepatocellular carcinoma	45
Nanozyme-based wearable biosensors for application in healthcare	45
Diverse bacteriophages for biocontrol of ESBL- and AmpC-β-lactamase-producing E. coli	45
Processing visual ambiguity in fractal patterns: Pareidolia as a sign of creativity	45
Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters	45
Neuromuscular Junction Innervation and Motor Function Are Preserved by Restoring Muscarinic Signaling in Perisynaptic Glia in ALS	45
Temporal dynamics of the soil bacterial community following Bacillus invasion	45
RNA editing in host lncRNAs as potential modulator in SARS-CoV-2 variants-host immune response dynamics	45
DUSP6 deletion protects mice and reduces disease severity in autoimmune arthritis	44
Multifunctional injectable GelMA hydrogel incorporating Icariin-loaded Mesoporous silica nanoparticles to promote osseointegration	44
Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment	44
High-throughput screening identifies broad-spectrum Coronavirus entry inhibitors	44
Targeted bacteriophage T4 nanoparticles reverse HIV-1 latency in human T cell line models	44
DLL3 regulates Notch signaling in small cell lung cancer	44
RAD21 deficiency drives corneal to scleral differentiation fate switching via upregulating WNT9B	44
Red blood cell flickering activity locally controlled by holographic optical tweezers	44
Developmental analysis of visually evoked defensive behavior identifies age and sex-specific responses and underlying synaptic and glia changes	44
IRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2/FPN1 signaling axis depended on NFKB2	44
Does shoe cushioning space affect patellofemoral pain risk? A study based on the integrated finite element model	43
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells	43
Electrochemical ammonium-cation-assisted pyridylation of inert N-heterocycles via dual-proton-coupled electron transfer	43
Slow wave canonical activity deviation concept: Toward a slow wave-based EEG-fMRI reference map for health-associated network function	43
Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time	43
Heterostructured CoO/MoB MBene composites for high performance lithium-ion batteries anode	43
Nuclear transfer improves the developmental potential of embryos derived from cytoplasmic deficient oocytes	43
Microglia-containing cerebral organoids derived from induced pluripotent stem cells for the study of neurological diseases	43
Type I interferon regulation by USP18 is a key vulnerability in cancer	43
Electro-, thermo-, and photocatalysis of versatile nanocomposites toward tandem process	43
Immune microenvironment and fibroblast subpopulation in diabetic wound healing	43
A model decomposition method for the real-time non-line-of-sight imaging	43
Reinforcement learning for dynamic speed control in connected and autonomous vehicles: A review of applications and challenges	42
Dynamic tracking of breastfeeding and weaning in carbon isotopes of tooth enamel	42
Unscrambling the history of African indicine cattle genomes	42
Cell-based sialoglycan arrays for directly comparing influenza A virus receptor requirements for binding and infection	42
Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen	42
Bisphenol A and breast cancer: Can mechanistic plausibility be reconciled with epidemiological inconsistency?	42
A platelet-rich plasma-loaded chitosan-based hydrogel for promoting type 2 diabetes wound healing	42
The rise of chiral carbon nanomaterials: From chirality-governed mechanisms to future environmental applications	42
pH-responsive Folate-PEG modified ZIF-8 Nanoparticles deliver fisetin to Aquaporin-3 for cervical cancer therapy	42
Suggested experimental design and computational modeling to infer single-cell lipid dynamics from a single destructive measurement	42
Kinetics of resilience with onset and remission of pediatric functional gastrointestinal disorders: A longitudinal study	42
Toward accurate prediction of pediatric epidemic disease patient volume in the Chaoshan region: A deep learning framework	42
The mitochondrial stress signaling tunes immunity from a view of systemic tumor microenvironment and ecosystem	41
Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease	41
The transcription factor IRF4 regulates the homeostasis and function of intestinal ILC3s	41
scUmaper: an automated framework for doublet removal and cell-type annotation in single-cell transcriptomics	41
An AI-driven workflow for the accelerated optimization of cell-free protein synthesis	41
Neural decision dynamics underlying reinforcement learning and working memory	41
Differentiation of mesenchymal stem/stromal cells into CD45+ macrophage-like cells: expanding insights into MSC plasticity	40
Evolutionarily entrenched odorant receptors for (E)-β-farnesene signaling in Aphidinae aphids	40
Fluoroscopic control of a magnetorobotic capsule for precision gastrointestinal sampling and delivery	40
Lifespan associations of resting-state brain functional networks with ADHD symptoms	40
Projected cardiovascular mortality attributable to extreme temperatures under climate scenarios in Taiyuan, China	40
Augmentation of self-motion perception with synthetic auditory cues	40
Environmental and health risks of perovskite solar modules: Case for better test standards and risk mitigation solutions	40
Obesity mediates the association of outdoor artificial light at night with type 2 diabetes mellitus	40