iScience

Article	Citations
Distance-weighted Sinkhorn loss for Alzheimer’s disease classification	272
CRISPRe: An innate transcriptional enhancer for endogenous genes in CRISPR-Cas immunity	264
Risk of cerebrovascular disease after cancer diagnosis in the United States	249
MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma	241
Decline in stability of forest productivity in the tropics as determined by canopy water content	221
Antimicrobial peptide LL37 and regulatory T cell associated with late-onset sepsis in very preterm infants	164
Retraction Notice to: Modulation of TNFa Activity by the microRNA Let-7 Coordinates Zebrafish Heart Regeneration	140
WITHDRAWN: Fibromodulin alleviates matrix stiffness-induced degeneration of the nucleus pulposus by regulating cytoskeleton and autophagy	137
Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency	136
Dose-dependent association between physical activity and mental health, and mitigation effects on risk behaviors	128
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells	126
Changing the spin disorder of two-dimensional magnetic Cr2TiC2Tx to long-range order through noble metal adhesion	125
Ion adsorption promotes Frank-van der Merwe growth of 2D transition metal tellurides	116
Visual deprivation induces a stronger dive response in a harbor porpoise	113
Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials	112
Sound effects on body perception vary with the social support network of individuals	109
Activity modulation of the Escherichia coli F1FO ATP synthase by a designed antimicrobial peptide via cardiolipin sequestering	109
Iterative multiscale and multi-physics computations for operando catalyst nanostructure elucidation and kinetic modeling	105
Semen promotes oocyte development in Sebastes schlegelii elucidating ovarian development dynamics in live-bearing fish	105
Development of a loop-mediated isothermal amplification (LAMP)-based electrochemical test for rapid detection of SARS-CoV-2	105
Microhabitat-specific diurnal metabolomic responses of the intertidal limpet Cellana toreuma to winter low temperature	104
Inflammation conditional genome editing mediated by the CRISPR-Cas9 system	98
Some dogs can find the payoff-dominant outcome in the Assurance game	97
Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism	96
Thermal conductivity across transition metal dichalcogenide bilayers	96

Chemical inhibition of phosphatidylcholine biogenesis reveals its role in mitochondrial division	95
Classification of polyphenol oxidases shows ancient gene duplication leading to two distinct enzyme types	95
How do preschoolers and adults ascribe authority?	94
Lymphocyte subset-based non-invasive biomarker predicts immunochemotherapy efficacy in EGFR-TKI-pretreated EGFR-mutated NSCLC	92
Adaptive individualized gene pair signatures distinguishing melanoma and predicting response to immune checkpoint blockade	91
The trogocytosis of neutrophils on initial transplanted tumor in mice	90
Seasonal shifts in pan-Arctic Ocean downward radiation and key drivers	90
Bitter taste receptor T2R14-Gαi coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis	89
The transcription factor IRF4 regulates the homeostasis and function of intestinal ILC3s	88
Sediment provenance of Late Carboniferous-Early Triassic in the Puyang area, Eastern North China Craton	86
Metabolic stratification of human breast tumors reveal subtypes of clinical and therapeutic relevance	86
Unsupervised attribute reduction based on variable precision weighted neighborhood dependency	85
Transforming the CRISPR/dCas9-based gene regulation technique into a forward screening tool in Plasmodium falciparum	85
Inflammation modulates intercellular adhesion and mechanotransduction in human epidermis via ROCK2	84
Oleuropein activates autophagy to circumvent anti-plasmodial defense	82
The roles of lncMALAT1 in coronary artery disease regulation and therapeutic perspective: A systematic review	82
A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles	82
Endolysosomal dysfunction impairs proteostasis and induces neurodegeneration in vivo	81
Enhancing mRNA translation efficiency with discriminative and generative artificial intelligence by optimizing 5′ UTR sequences	81
Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice	80
Release of extracellular DNA by Pseudomonas sp. as a major determinant for biofilm switching and an early indicator for cell population control	79
Exploring the substrate stereoselectivity and catalytic mechanism of nonribosomal peptide macrocyclization in surugamides biosynthesis	78
Gradient phase and amplitude errors in atomic magnetic gradiometers for biomagnetic imaging systems	78
Processing visual ambiguity in fractal patterns: Pareidolia as a sign of creativity	78
Reverse subsidy dilemma caused by the transformation from individual heating to central heating	78
The role of chirality and plastic crystallinity in the optical and mechanical properties of chlorosomes	78
Thermal acclimation uncovers a simple genetic basis of adaptation to high temperature in a cosmopolitan pest	78
Smiling underwater: Exploring playful signals and rapid mimicry in bottlenose dolphins	77
Nuclear talin-1 provides a bridge between cell adhesion and gene expression	76
The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses	75
Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19	75
Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease	74
Cellular resistance to an oncolytic virus is driven by chronic activation of innate immunity	73
The attitudinal space framework: Embracing the multidimensionality of attitudinal diversity	73
Perovskite-based photodetector for real-time and quantitative monitoring of sports motion	73
T cells with increased responsiveness cause obesity in mice without diet intervention	73
Replication fork blocking deficiency leads to a reduction of rDNA copy number in budding yeast	73
Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles	72
A mathematical model of neuroimmune interactions in epileptogenesis for discovering treatment strategies	72
The mitochondrial stress signaling tunes immunity from a view of systemic tumor microenvironment and ecosystem	71
Impact of myocardial reperfusion on human plasma lipidome	71
Interdisciplinarity at the nexus of biomedical science training: The R3 Center for Innovation in Science Education	70
Different mechanisms driving increasing abundance of microbial phosphorus cycling gene groups along an elevational gradient	70
The implication of integrative multiple RNA modification-based subtypes in gastric cancer immunotherapy and prognosis	69
Enhancing corrosion resistance of biodegradable magnesium with dicalcium phosphate dihydrate and Chlorella sp. biomass	69
Amitriptyline revitalizes ICB response via dually inhibiting Kyn/Indole and 5-HT pathways of tryptophan metabolism in ovarian cancer	69
Stenotrophomonas maltophilia provokes NEU1-mediated release of a flagellin-binding decoy receptor that protects against lethal infection	68
Electro-, thermo-, and photocatalysis of versatile nanocomposites toward tandem process	68
Longitudinal cohort study highlights cancer-preventive benefits of lipid-lowering drugs	68
A pilot study on a patient with refractory headache: Personalized deep brain stimulation through stereoelectroencephalography	67

Uncovering the impact and mechanisms of air pollution on eye and ear health in China	67
Differences in biomarker levels and proteomic survival prediction across two COVID-19 cohorts with distinct treatments	67
Touching with the eyes: Oculomotor self-touch induces illusory body ownership	67
Protein-constrained models pinpoints the role of underground metabolism in robustness of metabolic phenotypes	67
β-hydroxybutyrate recapitulates the beneficial effects of ketogenic metabolic therapy in polycystic kidney disease	67
Advancements in coupled processes numerical models: Upscaling aperture fields using spatial continuity	67
Cell surface heparan sulfate is an attachment receptor for grass carp reovirus	66
Abundant repressor binding sites in human enhancers are associated with the fine-tuning of gene regulation	65
Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity	65
Cellular plasticity and immune microenvironment of malignant pleural effusion are associated with EGFR-TKI resistance in non–small-cell lung carcinoma	64
Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids	64
Extended X-ray absorption fine structure spectroscopy measurements and ab initio molecular dynamics simulations reveal the hydration structure of the radium(II) ion	64
WIPF1 promotes gastric cancer progression by regulating PI3K/Akt signaling in a myocardin-dependent manner	63
Lifespan associations of resting-state brain functional networks with ADHD symptoms	63
IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells	63
Optically induced quantum transitions in direct probed mesoscopic NbSe2 for prototypical bolometers	63
Short-term auditory priming in freely-moving mice	62
Florigen and antiflorigen gene expression correlates with reproductive state in a marine angiosperm, Zostera marina	62
Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults	62
Cooperative RNA degradation stabilizes intermediate epithelial-mesenchymal states and supports a phenotypic continuum	61
Multi-omic profiling of pathogen-stimulated primary immune cells	61
Longitudinal monitoring of individual infection progression in Drosophila melanogaster	61
Sample multiplexing for retinal single-cell RNA sequencing	61
Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA mimicry and histone chaperone efficiency	60
Predictable sequential structure augments auditory sensitivity at threshold	60
Genome editing is induced in a binary manner in single human cells	60
Low intensity transcranial ultrasound stimulation induces hemodynamic responses through neurovascular coupling	59
Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation	59
Schwann cells contribute to demyelinating diabetic neuropathy and nerve terminal structures in white adipose tissue	59
Low levels of CIITA and high levels of SOCS1 predict COVID-19 disease severity in children and adults	59
Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration	59
Diverse bacteriophages for biocontrol of ESBL- and AmpC-β-lactamase-producing E. coli	59
Functional genomic analysis of Candida albicans protein kinases reveals modulators of morphogenesis in diverse environments	59
MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity	58
Tumor cell malignancy: A complex trait built through reciprocal interactions between tumors and tissue-body system	58
Crosstalk between 6-methyladenine and 4-methylcytosine in Geobacter sulfurreducens exposed to extremely low-frequency electromagnetic field	57
Broadband circularly polarized magneto-electric dipole antenna for millimeter-wave communication	56
An SI-traceable reference material for virus-like particles	56
Integrated edge information and pathway topology for drug-disease associations	56
Mapping structural variations in Haemaphysalis longicornis and Rhipicephalus microplus reveals vector-pathogen adaptation	56
Prognostic significance of inflammation in patients with coronary artery disease at low residual inflammatory risk	56
Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants	55
PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective	55
Standardized two-step testing of antibody activity in COVID-19 convalescent plasma	55
The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress	55
Sex differences in left-ventricular strain in a murine model of coxsackievirus B3 myocarditis	55
Overexpression and knockdown of cotton GhdadD gene reveals its drought and salt stress tolerance role	54
Detecting tandem repeat variants in coding regions using code-adVNTR	54
Heterostructured CoO/MoB MBene composites for high performance lithium-ion batteries anode	54
Comparative tissue proteomics reveals unique action mechanisms of vaccine adjuvants	53
Matter-wave gap solitons and vortices in three-dimensional parity-time-symmetric optical lattices	53
Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence	52
Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis	52
Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction	52
Trash-to-fuel: Converting municipal waste into transportation fuels by pyrolysis	51
Oxytocin promotes social proximity and decreases vigilance in groups of African lions	50
Network characterization linc1393 in the maintenance of pluripotency provides the principles for lncRNA targets prediction	50
HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice	50
Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters	50
Clathrin-mediated endocytosis cooperates with bulk endocytosis to generate vesicles	50
Predicting stroke and myocardial infarction risk in Takayasu arteritis with automated machine learning models	50
Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein	49
Chronic disease incidence explained by stepwise models and co-occurrence among them	49
Tickle contagion in the rat somatosensory cortex	49
The branched receptor-binding complex of Ackermannviridae phages promotes adaptive host recognition	49
Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design	49
Extracellular vesicles: Antiviral functions and applications in therapeutics and vaccines	49
Merits of dietary patterns for China’s future food security satisfying socioeconomic development and climate change adaptation	49
Derived myeloid lineage induced pluripotent stem as a platform to study human C-C chemokine receptor type 5Δ32 homozygotes	49
Genomic analyses reveal three phylogenetic species and their evolutionary histories in the big-headed turtle	49
Targeting Claudin18.2 for cancer theranostics: From molecular imaging to precision therapy	49
Antithrombogenic polysaccharide coatings to improve hemocompatibility, protein-repellence, and endothelial cell response	49
Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia	49
Lasso peptides sviceucin and siamycin I exhibit anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant pathogens	48
Early TRAIL-engagement elicits potent multimodal targeting of melanoma by CD34+ progenitor cell-derived NK cells	48
Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma	48
Electrochemical ammonium-cation-assisted pyridylation of inert N-heterocycles via dual-proton-coupled electron transfer	48
Applications of single-cell technologies in drug discovery for tumor treatment	48
Immune microenvironment and fibroblast subpopulation in diabetic wound healing	48
LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p/CDKN1C axis	48

Temperature and livestock grazing trigger transcriptome responses in bumblebees along an elevational gradient	48
Sverdrup-Henson crater: A candidate location for the first lunar South Pole settlement	48
A two-component cocktail of engineered DIII nanoparticles elicits broadly neutralizing antibody responses against dengue virus in mice	48
Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)	48
Identification of mitochondria-related gene biomarkers associated with immune infiltration in acute myocardial infarction	48
Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time	47
Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes	47
Acute dietary methionine restriction triggers cell cycle arrest and reversible growth defects in the neocortex	47
DLL3 regulates Notch signaling in small cell lung cancer	47
Cell-based sialoglycan arrays for directly comparing influenza A virus receptor requirements for binding and infection	47
Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty	47
Preparation of WSi@SiOx/Ti3C2 from photovoltaic silicon waste as high-performance anode materials for lithium-ion batteries	47
Impact of ATF6 deletion on the embryonic brain development	47
Prefrontal cortex encodes value pop-out in visual search	47
Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease	46
Traffic noise inhibits inhibitory control in wild-caught songbirds	46
YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia	46
Genomic evidence of symbiotic adaptations in fungus-associated bacteria	46
Nuclear transfer improves the developmental potential of embryos derived from cytoplasmic deficient oocytes	46
Design and validation of depth camera-based static posture assessment system	46
Lactate-driven type I collagen deposition facilitates cancer stem cell-like phenotype of head and neck squamous cell carcinoma	46
Microglia-containing cerebral organoids derived from induced pluripotent stem cells for the study of neurological diseases	46
MOCSS: Multi-omics data clustering and cancer subtyping via shared and specific representation learning	46
Inspired by struggle: A personal journey to global precision brain health	46
Cytomegalovirus-specific neutralizing antibodies effectively prevent uncontrolled infection after allogeneic hematopoietic stem cell transplantation	45
Robustness of machine learning predictions for Fe-Co-Ni alloys prepared by various synthesis methods	45
Perturbation of EPHA2 and EFNA1 trans binding amplifies inflammatory response in airway epithelial cells	45
A regulatory linkage between scytonemin production and hormogonia differentiation in Nostoc punctiforme	45
Predicting phage-host interaction via hyperbolic Poincaré graph embedding and large-scale protein language technique	45
SENP2-based N-terminal truncation of α-synuclein in Lewy pathology propagation	45
Zinc finger protein 593 promotes breast cancer development by ensuring DNA damage repair and cell-cycle progression	45
Native T1 mapping-based radiomics diagnosis of kidney function and renal fibrosis in chronic kidney disease	45
Panera: An innovative framework for surmounting uncertainty in microbial community modeling using pan-genera metabolic models	45
An AI-driven workflow for the accelerated optimization of cell-free protein synthesis	45
Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment	44
Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome	44
Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19	44
Multifunctional injectable GelMA hydrogel incorporating Icariin-loaded Mesoporous silica nanoparticles to promote osseointegration	44
Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models	44
Type I interferon regulation by USP18 is a key vulnerability in cancer	44
Chidamide: Exploration of maintenance therapy for patients with DLBCL with HBV infection	44
Large-scale and cost-efficient agrivoltaics system by spectral separation	44
Targeted bacteriophage T4 nanoparticles reverse HIV-1 latency in human T cell line models	44
TMS-EEG and resting-state EEG applied to altered states of consciousness: oscillations, complexity, and phenomenology	44
Exploring the roles of intestinal flora in enhanced recovery after surgery	44
Neuron-glia interaction at the receptor level affects olfactory perception in adult Drosophila	44
MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae	44
Developmental analysis of visually evoked defensive behavior identifies age and sex-specific responses and underlying synaptic and glia changes	44
Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling	44
Montmorillonite and amino acid composites for heavy metal ion adsorption	44
An NLP-based technique to extract meaningful features from drug SMILES	43
Audition controls the flow of visual time during multisensory perception	43
High-throughput screening identifies broad-spectrum Coronavirus entry inhibitors	43
Microbial diversity in mountain-dwelling amphibians: The combined effects of host and climatic factors	43
Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models	43
Combinatorial drug screening on 3D Ewing sarcoma spheroids using droplet-based microfluidics	43
Unveiling the role of inorganic nanoparticles in Earth’s biochemical evolution through electron transfer dynamics	43
Systemic cyst(e)inase administration induces ferroptosis and synergizes with temozolomide in glioblastoma	43
DDX56 promotes EMT and cancer stemness via MELK-FOXM1 axis in hepatocellular carcinoma	43
Do not compromise: Nurse honeybees practice strict protein-lipid regulation	43
Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response	43
DeepASmRNA: Reference-free prediction of alternative splicing events with a scalable and interpretable deep learning model	43
RAD21 deficiency drives corneal to scleral differentiation fate switching via upregulating WNT9B	43
RNA editing in host lncRNAs as potential modulator in SARS-CoV-2 variants-host immune response dynamics	43
Terahertz waves regulate the mechanical unfolding of tau pre-mRNA hairpins	43
Spatiotemporal patterns and drivers of ecosystem service interactions in karst regions: Insights for environmental protection and sustainability	42
Variational adaptive Gaussian approximation filter for nonlinear systems with generalized unknown disturbances	42
Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus	42
Social rank-dependent effects of testosterone on huddling strategies in mice	42
IRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2/FPN1 signaling axis depended on NFKB2	42
Proteoforms expand the world of microproteins and short open reading frame-encoded peptides	42
Nanozyme-based wearable biosensors for application in healthcare	42
Exploring drought-responsive crucial genes in Sorghum	42
Sex peptide regulates female receptivity through serotoninergic neurons in Drosophila	42
Histatin 1-modified SIS hydrogels enhance the sealing of peri-implant mucosa to prevent peri-implantitis	41
Atherosclerotic plaque vulnerability quantification system for clinical and biological interpretability	41
Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses	41
Does shoe cushioning space affect patellofemoral pain risk? A study based on the integrated finite element model	41
Architecture inspired structure engineering toward carbon nanotube hybrid for microwave absorption promotion	41
ENTPD8 overexpression enhances anti-PD-L1 therapy in hepatocellular carcinoma via miR-214-5p inhibition	41
A fast method to distinguish between fermentative and respiratory metabolisms in single yeast cells	41
Evolution of zygomycete secretomes and the origins of terrestrial fungal ecologies	41
The cutaneous response to a mosquito bite is influenced by the diurnal rhythm	41
Sevoflurane-induced gut microbiota dysbiosis drives adolescent neurobehavioral deficits in neonatal rats: Protective role of eicosapentaenoic acid	41
Microbiome depletion prior to repeat mild TBI differentially alters social deficits and prefrontal cortex plasticity in adolescent and adult rats	41
Unrevealed effect of silver species on hydrocarbon pool in ethylene conversion on ZSM-5 by 2D COS FT-IR and 2D COS UV-vis operando spectroscopies	41
Condensation of water vapor from humid air inside vertical channels formed by flat plates	41
Evolutionary analyses of the animal glycosyltransferase family 54 reveals two β1,4-N-acetylglucosaminyltransferase families	41
Investigating the impacts of future oil prices on the achievement of 1.5°C climate goal	41
Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling	41
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway	41
Identification of optimal conditions for human placental explant culture and extracellular vesicle release	40
The Prc and CtpA proteases modulate cell-surface signaling activity and virulence in Pseudomonas aeruginosa	40
Serum proteome profiling reveals heparanase as a candidate biomarker for chronic thromboembolic pulmonary hypertension	40
Bta-miR-30f promotes adipogenesis and unsaturated fatty acid accumulation by targeting RAD23B in buffalo intramuscular preadipocytes	40