iScience

Article	Citations
CD168+ macrophages promote hepatocellular carcinoma tumor stemness and progression through TOP2A/β-catenin/YAP1 axis	401
Nuclear transfer improves the developmental potential of embryos derived from cytoplasmic deficient oocytes	215
The implication of integrative multiple RNA modification-based subtypes in gastric cancer immunotherapy and prognosis	209
Matter-wave gap solitons and vortices in three-dimensional parity-time-symmetric optical lattices	189
IGFBP2 derived from PO-MSCs promote epithelial barrier destruction by activating FAK signaling in nasal polyps	180
Functional genomic analysis of Candida albicans protein kinases reveals modulators of morphogenesis in diverse environments	164
Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism	149
Risk of cerebrovascular disease after cancer diagnosis in the United States	137
Visual deprivation induces a stronger dive response in a harbor porpoise	125
MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae	125
MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma	123
MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity	120
The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress	111
The Prc and CtpA proteases modulate cell-surface signaling activity and virulence in Pseudomonas aeruginosa	110
Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin-mediated six-transmembrane epithelial antigen of prostate 4 degradation	108
Antimicrobial peptide LL37 and regulatory T cell associated with late-onset sepsis in very preterm infants	106
Longitudinal cohort study highlights cancer-preventive benefits of lipid-lowering drugs	105
Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults	105
Lifespan associations of resting-state brain functional networks with ADHD symptoms	104
Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response	104
Activity-based protein profiling of human and plasmodium serine hydrolases and interrogation of potential antimalarial targets	103
Overexpression and knockdown of cotton GhdadD gene reveals its drought and salt stress tolerance role	102
Transforming the CRISPR/dCas9-based gene regulation technique into a forward screening tool in Plasmodium falciparum	101
Red blood cell flickering activity locally controlled by holographic optical tweezers	101
Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction	96

A host lipase prevents lipopolysaccharide-induced foam cell formation	94
Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design	91
Audition controls the flow of visual time during multisensory perception	90
DDX56 promotes EMT and cancer stemness via MELK-FOXM1 axis in hepatocellular carcinoma	87
Cooperative RNA degradation stabilizes intermediate epithelial-mesenchymal states and supports a phenotypic continuum	87
Ecological firewalls for synthetic biology	86
Cytomegalovirus-specific neutralizing antibodies effectively prevent uncontrolled infection after allogeneic hematopoietic stem cell transplantation	86
WITHDRAWN: Fibromodulin alleviates matrix stiffness-induced degeneration of the nucleus pulposus by regulating cytoskeleton and autophagy	86
Retraction Notice to: Modulation of TNFa Activity by the microRNA Let-7 Coordinates Zebrafish Heart Regeneration	84
Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency	84
Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome	83
Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis	83
A regulatory linkage between scytonemin production and hormogonia differentiation in Nostoc punctiforme	83
Different mechanisms driving increasing abundance of microbial phosphorus cycling gene groups along an elevational gradient	82
Development of a loop-mediated isothermal amplification (LAMP)-based electrochemical test for rapid detection of SARS-CoV-2	80
Identification of optimal conditions for human placental explant culture and extracellular vesicle release	80
Electro-, thermo-, and photocatalysis of versatile nanocomposites toward tandem process	80
Ion adsorption promotes Frank-van der Merwe growth of 2D transition metal tellurides	79
Touching with the eyes: Oculomotor self-touch induces illusory body ownership	79
Serum proteome profiling reveals heparanase as a candidate biomarker for chronic thromboembolic pulmonary hypertension	78
A pilot study on a patient with refractory headache: Personalized deep brain stimulation through stereoelectroencephalography	77
DLL3 regulates Notch signaling in small cell lung cancer	77
Exploring the roles of intestinal flora in enhanced recovery after surgery	76
Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19	76
Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters	76
IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells	75
Neofunctionalization of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes	75
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway	75
A fast method to distinguish between fermentative and respiratory metabolisms in single yeast cells	75
Insights into the hydrogen generation and catalytic mechanism on Co-based nanocomposites derived from pyrolysis of organic metal precursor	74
Perovskite-based photodetector for real-time and quantitative monitoring of sports motion	73
Tickle contagion in the rat somatosensory cortex	72
Attenuated humoral responses in HIV after SARS-CoV-2 vaccination linked to B cell defects and altered immune profiles	71
Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus	70
Short-term auditory priming in freely-moving mice	68
Sex peptide regulates female receptivity through serotoninergic neurons in Drosophila	68
Biophysical characterization of the recording of unmyelinated and myelinated fiber activity with peripheral interfaces	68
Mitochondrial translation is the primary determinant of secondary mitochondrial complex I deficiencies	68
NKG2D-CAR-targeted iPSC-derived MSCs efficiently target solid tumors expressing NKG2D ligand	67
Microhabitat-specific diurnal metabolomic responses of the intertidal limpet Cellana toreuma to winter low temperature	67
Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma	67
Nanozyme-based wearable biosensors for application in healthcare	66
Activity modulation of the Escherichia coli F1FO ATP synthase by a designed antimicrobial peptide via cardiolipin sequestering	66
Smiling underwater: Exploring playful signals and rapid mimicry in bottlenose dolphins	65
WIPF1 promotes gastric cancer progression by regulating PI3K/Akt signaling in a myocardin-dependent manner	64
Machine learning unveils immune-related signature in multicenter glioma studies	64
The branched receptor-binding complex of Ackermannviridae phages promotes adaptive host recognition	64
Large-scale and cost-efficient agrivoltaics system by spectral separation	64
Longitudinal monitoring of individual infection progression in Drosophila melanogaster	63
Targeting ITK signaling for T cell-mediated diseases	63

RNA editing in host lncRNAs as potential modulator in SARS-CoV-2 variants-host immune response dynamics	63
Integrative analysis of multimodal patient data identifies personalized predictors of tuberculosis treatment prognosis	62
Lasso peptides sviceucin and siamycin I exhibit anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant pathogens	62
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells	62
Combinatorial drug screening on 3D Ewing sarcoma spheroids using droplet-based microfluidics	62
Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models	62
Bacterial surface properties influence the activity of the TAT-RasGAP317-326 antimicrobial peptide	62
Coexistence of large mammals and humans is possible in Europe's anthropogenic landscapes	62
Cell surface heparan sulfate is an attachment receptor for grass carp reovirus	62
Differences in biomarker levels and proteomic survival prediction across two COVID-19 cohorts with distinct treatments	61
Protein-constrained models pinpoints the role of underground metabolism in robustness of metabolic phenotypes	61
Release of extracellular DNA by Pseudomonas sp. as a major determinant for biofilm switching and an early indicator for cell population control	61
Predictable sequential structure augments auditory sensitivity at threshold	61
A two-component cocktail of engineered DIII nanoparticles elicits broadly neutralizing antibody responses against dengue virus in mice	60
Predicting stroke and myocardial infarction risk in Takayasu arteritis with automated machine learning models	60
Impact of ATF6 deletion on the embryonic brain development	60
Sex differences in left-ventricular strain in a murine model of coxsackievirus B3 myocarditis	60
Interdisciplinarity at the nexus of biomedical science training: The R3 Center for Innovation in Science Education	59
Cell-based sialoglycan arrays for directly comparing influenza A virus receptor requirements for binding and infection	59
Acute dietary methionine restriction triggers cell cycle arrest and reversible growth defects in the neocortex	59
Predicting phage-host interaction via hyperbolic Poincaré graph embedding and large-scale protein language technique	59
Eco-evolutionary feedbacks under artificial light at night	59
Understanding menstrual blood-derived stromal/stem cells: Definition and properties. Are we rushing into their therapeutic applications?	58
Data-driven models and digital twins for sustainable combustion technologies	58
Schwann cells contribute to demyelinating diabetic neuropathy and nerve terminal structures in white adipose tissue	58
Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity	57
Unveiling the role of inorganic nanoparticles in Earth’s biochemical evolution through electron transfer dynamics	57
Native T1 mapping-based radiomics diagnosis of kidney function and renal fibrosis in chronic kidney disease	56
TRIM47 promotes head and neck squamous cell carcinoma malignant progression by degrading XAF1 through ubiquitination	56
Bidirectional electroactive microbial biofilms and the role of biogenic sulfur in charge storage and release	56
Robustness of machine learning predictions for Fe-Co-Ni alloys prepared by various synthesis methods	56
Abundant repressor binding sites in human enhancers are associated with the fine-tuning of gene regulation	56
Vimentin is an important ACE2 co-receptor for SARS-CoV-2 in epithelial cells	56
Early TRAIL-engagement elicits potent multimodal targeting of melanoma by CD34+ progenitor cell-derived NK cells	55
Environmental and health risks of perovskite solar modules: Case for better test standards and risk mitigation solutions	55
Inflammation modulates intercellular adhesion and mechanotransduction in human epidermis via ROCK2	55
Pressure dependent thermoreflectance spectroscopy induced by interband transitions in metallic nano-film	55
Detecting tandem repeat variants in coding regions using code-adVNTR	55
Decline in stability of forest productivity in the tropics as determined by canopy water content	55
Derived myeloid lineage induced pluripotent stem as a platform to study human C-C chemokine receptor type 5Δ32 homozygotes	54
DeepASmRNA: Reference-free prediction of alternative splicing events with a scalable and interpretable deep learning model	54
RAD21 deficiency drives corneal to scleral differentiation fate switching via upregulating WNT9B	54
CRISPRe: An innate transcriptional enhancer for endogenous genes in CRISPR-Cas immunity	54
Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time	53
HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice	53
DUSP6 deletion protects mice and reduces disease severity in autoimmune arthritis	53
Prognostic significance of inflammation in patients with coronary artery disease at low residual inflammatory risk	53
Long non-coding RNA MIAT is involved in the regulation of pyroptosis in diabetic cardiomyopathy via targeting miR-214-3p	53
Crosstalk between 6-methyladenine and 4-methylcytosine in Geobacter sulfurreducens exposed to extremely low-frequency electromagnetic field	52
Social rank-dependent effects of testosterone on huddling strategies in mice	52
Enhancing corrosion resistance of biodegradable magnesium with dicalcium phosphate dihydrate and Chlorella sp. biomass	52
Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants	52
Uncovering the impact and mechanisms of air pollution on eye and ear health in China	52
Multi-omic profiling of pathogen-stimulated primary immune cells	51
SENP2-based N-terminal truncation of α-synuclein in Lewy pathology propagation	51
Chronic disease incidence explained by stepwise models and co-occurrence among them	51
Regulation of interstitial fluid flow in adventitia along vasculature by heartbeat and respiration	50
Low intensity transcranial ultrasound stimulation induces hemodynamic responses through neurovascular coupling	50
Tendon-inspired anti-freezing tough gels	50
Panera: An innovative framework for surmounting uncertainty in microbial community modeling using pan-genera metabolic models	50
Microglia-containing cerebral organoids derived from induced pluripotent stem cells for the study of neurological diseases	50
The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses	50
Diminished representation of vitamin-B12-producing bacteria in constipated elders with frailty	49
Nuclear talin-1 provides a bridge between cell adhesion and gene expression	49
Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis	49
Optically induced quantum transitions in direct probed mesoscopic NbSe2 for prototypical bolometers	49
Stenotrophomonas maltophilia provokes NEU1-mediated release of a flagellin-binding decoy receptor that protects against lethal infection	49
The trogocytosis of neutrophils on initial transplanted tumor in mice	48
Genome editing is induced in a binary manner in single human cells	48
A resource of high-quality and versatile nanobodies for drug delivery	48
Standardized two-step testing of antibody activity in COVID-19 convalescent plasma	48
Reverse subsidy dilemma caused by the transformation from individual heating to central heating	48
Sample multiplexing for retinal single-cell RNA sequencing	48
Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein	48
ENTPD8 overexpression enhances anti-PD-L1 therapy in hepatocellular carcinoma via miR-214-5p inhibition	48
Impact of myocardial reperfusion on human plasma lipidome	48
Advancements in coupled processes numerical models: Upscaling aperture fields using spatial continuity	48
PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective	48
Perturbation of EPHA2 and EFNA1 trans binding amplifies inflammatory response in airway epithelial cells	47
Classification of polyphenol oxidases shows ancient gene duplication leading to two distinct enzyme types	47

Multilingual multi-aspect explainability analyses on machine reading comprehension models	47
Terahertz waves regulate the mechanical unfolding of tau pre-mRNA hairpins	47
An SI-traceable reference material for virus-like particles	47
Applications of single-cell technologies in drug discovery for tumor treatment	47
Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence	47
Comparative tissue proteomics reveals unique action mechanisms of vaccine adjuvants	46
Hydroxyapatite catalyzed hydrothermal liquefaction transforms food waste from an environmental liability to renewable fuel	46
Genomic analyses reveal three phylogenetic species and their evolutionary histories in the big-headed turtle	46
Dynamics of base pairs with low stability in RNA by solid-state nuclear magnetic resonance exchange spectroscopy	46
The attitudinal space framework: Embracing the multidimensionality of attitudinal diversity	46
Idealized analysis of relative values of bidirectional versus unidirectional electric vehicle charging in deeply decarbonized electricity systems	45
Quantitative analysis of asynchronous transcription-translation and transcription processivity in Bacillus subtilis under various growth conditions	45
Exploring drought-responsive crucial genes in Sorghum	45
Bacterial lipopolysaccharides can initiate regeneration of the Xenopus tadpole tail	45
Cellular plasticity and immune microenvironment of malignant pleural effusion are associated with EGFR-TKI resistance in non–small-cell lung carcinoma	45
Network characterization linc1393 in the maintenance of pluripotency provides the principles for lncRNA targets prediction	45
Neuronal-enriched small extracellular vesicles trigger a PD-L1-mediated broad suppression of T cells in Parkinson’s disease	44
Lactate-driven type I collagen deposition facilitates cancer stem cell-like phenotype of head and neck squamous cell carcinoma	44
Extended X-ray absorption fine structure spectroscopy measurements and ab initio molecular dynamics simulations reveal the hydration structure of the radium(II) ion	44
Prefrontal cortex encodes value pop-out in visual search	44
Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials	44
Microbial diversity in mountain-dwelling amphibians: The combined effects of host and climatic factors	44
Integrated edge information and pathway topology for drug-disease associations	44
Adsorption and desorption behavior of Zn2+ in a flow-through electrosorption reactor	44
Design and validation of depth camera-based static posture assessment system	44
A limitation map of performance for porous electrodes in lithium-ion batteries	44
Cellular resistance to an oncolytic virus is driven by chronic activation of innate immunity	44
Origin, heterogeneity, and interconversion of noncanonical bistable switches from the positive feedback loops under dual signaling	44
Mapping structural variations in Haemaphysalis longicornis and Rhipicephalus microplus reveals vector-pathogen adaptation	44
Antithrombogenic polysaccharide coatings to improve hemocompatibility, protein-repellence, and endothelial cell response	43
T cells with increased responsiveness cause obesity in mice without diet intervention	43
Diverse bacteriophages for biocontrol of ESBL- and AmpC-β-lactamase-producing E. coli	43
Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice	43
Iterative multiscale and multi-physics computations for operando catalyst nanostructure elucidation and kinetic modeling	43
Low levels of CIITA and high levels of SOCS1 predict COVID-19 disease severity in children and adults	43
Trash-to-fuel: Converting municipal waste into transportation fuels by pyrolysis	43
Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling	43
Atherosclerotic plaque vulnerability quantification system for clinical and biological interpretability	43
The role of chirality and plastic crystallinity in the optical and mechanical properties of chlorosomes	43
Sediment provenance of Late Carboniferous-Early Triassic in the Puyang area, Eastern North China Craton	42
β-hydroxybutyrate recapitulates the beneficial effects of ketogenic metabolic therapy in polycystic kidney disease	42
Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life	42
Evolution of zygomycete secretomes and the origins of terrestrial fungal ecologies	42
Histatin 1-modified SIS hydrogels enhance the sealing of peri-implant mucosa to prevent peri-implantitis	42
Some dogs can find the payoff-dominant outcome in the Assurance game	42
Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis	42
Amitriptyline revitalizes ICB response via dually inhibiting Kyn/Indole and 5-HT pathways of tryptophan metabolism in ovarian cancer	42
Zinc finger protein 593 promotes breast cancer development by ensuring DNA damage repair and cell-cycle progression	42
Unsupervised attribute reduction based on variable precision weighted neighborhood dependency	42
Oxytocin promotes social proximity and decreases vigilance in groups of African lions	42
Processing visual ambiguity in fractal patterns: Pareidolia as a sign of creativity	41
Proteoforms expand the world of microproteins and short open reading frame-encoded peptides	41
Clathrin-mediated endocytosis cooperates with bulk endocytosis to generate vesicles	41
Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA mimicry and histone chaperone efficiency	41
Thermal conductivity across transition metal dichalcogenide bilayers	41
Preparation of WSi@SiOx/Ti3C2 from photovoltaic silicon waste as high-performance anode materials for lithium-ion batteries	41
Exploring the substrate stereoselectivity and catalytic mechanism of nonribosomal peptide macrocyclization in surugamides biosynthesis	41
Identification of mitochondria-related gene biomarkers associated with immune infiltration in acute myocardial infarction	41
A mathematical model of neuroimmune interactions in epileptogenesis for discovering treatment strategies	41
Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function	41
Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia	41
The mitochondrial stress signaling tunes immunity from a view of systemic tumor microenvironment and ecosystem	41
Neuron-glia interaction at the receptor level affects olfactory perception in adult Drosophila	41
Florigen and antiflorigen gene expression correlates with reproductive state in a marine angiosperm, Zostera marina	41
Genomic evidence of symbiotic adaptations in fungus-associated bacteria	40
A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles	40
How many markers are needed to robustly determine a cell's type?	40
Heterostructured CoO/MoB MBene composites for high performance lithium-ion batteries anode	40
Genome-wide mRNA profiling in urinary extracellular vesicles reveals stress gene signature for diabetic kidney disease	40
Temporal dynamics of the soil bacterial community following Bacillus invasion	40
Evidence of self-care tooling and phylogenetic modeling reveal parrot tool use is not rare	40
Tumor cell malignancy: A complex trait built through reciprocal interactions between tumors and tissue-body system	40
Inflammation conditional genome editing mediated by the CRISPR-Cas9 system	39
The transcription factor IRF4 regulates the homeostasis and function of intestinal ILC3s	39
Do not compromise: Nurse honeybees practice strict protein-lipid regulation	39
Architecture inspired structure engineering toward carbon nanotube hybrid for microwave absorption promotion	39
Inspired by struggle: A personal journey to global precision brain health	39
The roles of lncMALAT1 in coronary artery disease regulation and therapeutic perspective: A systematic review	39
Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment	39
Oleuropein activates autophagy to circumvent anti-plasmodial defense	39
TMS-EEG and resting-state EEG applied to altered states of consciousness: oscillations, complexity, and phenomenology	39
High-throughput screening identifies broad-spectrum Coronavirus entry inhibitors	39
Condensation of water vapor from humid air inside vertical channels formed by flat plates	39
LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p/CDKN1C axis	39
Type I interferon regulation by USP18 is a key vulnerability in cancer	38
YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia	38
Distance-weighted Sinkhorn loss for Alzheimer’s disease classification	38
Replication fork blocking deficiency leads to a reduction of rDNA copy number in budding yeast	38
Bitter taste receptor T2R14-Gαi coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis	38
Semen promotes oocyte development in Sebastes schlegelii elucidating ovarian development dynamics in live-bearing fish	38
RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma	38
Temperature and livestock grazing trigger transcriptome responses in bumblebees along an elevational gradient	37
Chemical inhibition of phosphatidylcholine biogenesis reveals its role in mitochondrial division	37
Merits of dietary patterns for China’s future food security satisfying socioeconomic development and climate change adaptation	37
Traffic noise inhibits inhibitory control in wild-caught songbirds	37