OOIR: Observatory of International Research

Papers

(The median citation count of International Journal of Pharmaceutics-X is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Tailored ASD destabilization - Balancing shelf life stability and dissolution performance with hydroxypropyl cellulose	70
Exploring high-throughput synchrotron X-Ray powder diffraction for the structural analysis of pharmaceuticals	34
Oral etoposide and zosuquidar bioavailability in rats: Effect of co-administration and in vitro-in vivo correlation of P-glycoprotein inhibition	24
Rationalized landscape on protein-based cancer nanomedicine: Recent progress and challenges	19
Phloretin-nanospanlastics for targeting the Akt/PI3K signaling pathways in dimethylhydrazine-induced colon cancer in mice	19
Transferrin conjugated pH/NIR-responsive black phosphorus nanoplatform: A novel multimodal approach for breast cancer theranostics	18
Enabling formulations of aprepitant: in vitro and in vivo comparison of nanocrystalline, amorphous and deep eutectic solvent based formulations	16
Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications	14
Autoencoder-based inverse design and surrogate-based optimization of an integrated wet granulation manufacturing process	14
Erratum regarding missing Conflict of Interest statements in previously published articles	13
Formulating a heat- and shear-labile drug in an amorphous solid dispersion: Balancing drug degradation and crystallinity	12
Everolimus-encapsulation in Pluronic P123 self-assembled micelles as drug delivery systems for drug-coated balloons	12
Continuous direct compression: Development of an empirical predictive model and challenges regarding PAT implementation	11
Construction and applications of exosome-microneedle integrated systems	11
Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors	11
Development, characterization, and in vitro evaluation of poly(ethylene oxide)-block-poly(ε-caprolactone)-α-tocopheryl succinate micelles as a novel nanocarrier for rapamycin delivery	10
At-line porosity sensing for non-destructive disintegration testing in immediate release tablets	10
Polycaprolactone – Vitamin E TPGS micelles for delivery of paclitaxel: In vitro and in vivo evaluation	10
Enhancing oocyte in vitro maturation and quality by melatonin/bilirubin cationic nanoparticles: A promising strategy for assisted reproduction techniques	10
Impact of process stress on protein stability in highly-loaded solid protein/PEG formulations from small-scale melt extrusion	10
Corrigendum to “Quantitative comparison of the protein corona of nanoparticles with different matrices” [Int J Pharm X 2022 Oct 21;4: 100136]	9
Formulation development of itraconazole PEGylated nano-lipid carriers for pulmonary aspergillosis using hot-melt extrusion technology	9
Editorial Board	9
Corrigendum to “Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed solid oral dosage forms” [International Journal of Pharmaceutics:X Volume 6 (2023) 10	9
Spanlastic-laden nanogel as a plausible platform for dermal delivery of bimatoprost with superior cutaneous deposition and hair regrowth efficiency in androgenic alopecia	8

A network of regulatory innovations to improve FDA quality assessments of human drug applications	8
Preparation of chitosan-coated hollow tin dioxide nanoparticles and their application in improving the oral bioavailability of febuxostat	8
A tabletability change classification system in supporting the tablet formulation design via the roll compaction and dry granulation process	8
Predicting pharmaceutical inkjet printing outcomes using machine learning	8
Stability of Dexamethasone during Hot-Melt Extrusion of Filaments based on Eudragit® RS, Ethyl Cellulose and Polyethylene Oxide	8
Formulation of multicomponent inclusion complex of cyclodextrin-amino acid with Chrysin: Physicochemical characterization, cell viability and apoptosis assessment in human primary glioblastoma cell li	7
Formulation, in silico, in vitro characterization, cytotoxicity and cellular uptake of cyclodextrin complexes and ion pairing/salt formation with functional excipients (azelaic acid, tartaric acid, an	7
Multifunctional poloxamer-based thermo-responsive hydrogel loaded with human lactoferricin niosomes: In vitro study on anti-bacterial activity, accelerate wound healing, and anti-inflammation	7
Glucose-functionalized redox-responsive dihydroartemisinin prodrug nanosystem for targeted malaria therapy	7
Fucoidan/Polyvinylpyrrolidone/Hesperitin nanoparticle complex for corneal injury treatment: Synthesis, characterization, and therapeutic efficacy	7
A new engineering process of biodegradable polymeric solid implants for ultra-long-acting drug delivery	7
A model-based optimization strategy to achieve fast and robust freeze-drying cycles	7
Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and tr	7
Preservative-free electrospun nanofibrous inserts for sustained delivery of ceftazidime; design, characterization and pharmacokinetic investigation in rabbit's eye	7
Box Behnken optimization of cubosomes for enhancing the anticancer activity of metformin: Design, characterization, and in-vitro cell proliferation assay on MDA-MB-231 breast and LOVO colon cancer cel	7
Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: In vitro and in vivo studies	7
Synergistic effect of doxorubicin lauroyl hydrazone derivative delivered by α-tocopherol succinate micelles for the treatment of glioblastoma	7
Multifunctional Bi2S3-Au nanoclusters for fluorescence/infrared thermal imaging guided photothermal therapy	6
HSPiP and QbD oriented optimized stearylamine-elastic liposomes for topical delivery of ketoconazole to treat deep seated fungal infections: In vitro and ex vivo evaluations	6
Repurposing celecoxib for colorectal cancer targeting via pH-triggered ultra-elastic nanovesicles: Pronounced efficacy through up-regulation of Wnt/β-catenin pathway in DMH-induced tumorigenesis	6
Editorial board	6
The shelf life of ASDs: 2. Predicting the shelf life at storage conditions	6
The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little	6
Towards a better understanding of thermally treated polycarbophil matrix tablets for controlled release	6
Nanoparticles design considerations to co-deliver nucleic acids and anti-cancer drugs for chemoresistance reversal	6
RP-HPLC-CAD method for the rapid analysis of lipids used in lipid nanoparticles derived from dual centrifugation	5
Development and optimization of vildagliptin solid lipid nanoparticles loaded ocuserts for controlled ocular delivery: A promising approach towards treating diabetic retinopathy	5
Oxidation of polysorbates – An underestimated degradation pathway?	5
RETRACTED: Development of thermosensitive hydrogel of Amphotericin-B and Lactoferrin combination-loaded PLGA-PEG-PEI nanoparticles for potential eradication of ocular fungal infections: In-vitro, ex-v	5
Ocular mucoadhesive and biodegradable spanlastics loaded cationic spongy insert for enhancing and sustaining the anti-inflammatory effect of prednisolone Na phosphate; Preparation, I-optimal optimizat	5
Co-assembled Glycyrrhiza nanoparticles embedded supramolecular protein hydrogels to enhance licochalcone A release for acute inflammation management	5
β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin	5
Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings	5
Atorvastatin-loaded emulsomes foam as a topical antifungal formulation	5
Nanoscale metal-organic frameworks for the delivery of nucleic acids to cancer cells	5
Neutrophils-mediated accelerated blood clearance phenomenon in beagles and rats based on the cross-injection of non-PEGylated and PEGylated nanoemulsions	5
Curcumin and EGCG combined formulation in nanostructured lipid carriers for anti-aging applications	5
How bulk fluid renewal can affect in vitro drug release from PLGA implants: Importance of the experimental set-up	5
The impact of solvent selection on the characteristics of niosome nanoparticles prepared by microfluidic mixing	4
The use of heat to deliver fentanyl via pulmonary drug delivery	4
M1 macrophage-membrane-cloaked paclitaxel/β-elemene nanoparticles targeting cervical cancer for enhanced therapy	4
Transfer of a rational formulation and process development approach for 2D inks for pharmaceutical 2D and 3D printing	4
WITHDRAWN: The effect of particle size on the sublimation behavior of butylhydroxytoluene as antioxidant in tablets during storage and coating	4
Reactive oxygen species responsive double-locked liposome collaborative photodynamic therapy for reducing electrical conduction recurrence after radiofrequency catheter ablation	4
Functional candesartan loaded lipid nanoparticles for the control of diabetes-associated stroke: In vitro and in vivo studies	4
Designing fisetin nanocrystals for enhanced in cellulo anti-angiogenic and anticancer efficacy	4
Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel	4
The Dynamic Intestinal Absorption Model (Diamod®), an in vitro tool to study the interconnected kinetics of gastrointestinal solubility, supersaturation, precipitation, and intestinal permeation proce	4
Process intensification of pharmaceutical powder blending at commercial throughputs by utilizing semi-continuous mini-blending	4
Spanlastic-laden in situ gel as a promising approach for ocular delivery of Levofloxacin: In-vitro characterization, microbiological assessment, corneal permeability and in-vivo study	4

Modelling intramuscular drug fate in vitro with tissue-relevant biomimetic hydrogels	4
Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma	4
EVA implants for controlled drug delivery to the inner ear	3
Pectin nanoparticles loaded with nitric oxide donor drug: A potential approach for tissue regeneration	3
Mechanistic insights of desmopressin loaded elastic liposomes for transdermal delivery: HSPiP predictive parameters and instrumental based evidences	3
Releasing fast and slow: Non-destructive prediction of density and drug release from SLS 3D printed tablets using NIR spectroscopy	3
Integrating pressure sensor control into semi-solid extrusion 3D printing to optimize medicine manufacturing	3
End-to-end approach for the characterization and control of product-related impurities in T cell bispecific antibody preparations	3
Tablet formulation development focusing on the functional behaviour of water uptake and swelling	3
Characterization and quantification of the interaction between the NFL-TBS.40‐63 peptide and lipid nanocapsules	3
Characterisation of niosome nanoparticles prepared by microfluidic mixing for drug delivery	3
Experimental determination of the velocity distribution in USP Apparatus 1 (basket apparatus) using Particle Image Velocimetry (PIV)	3
Effect of wound dressing porosity and exudate viscosity on the exudate absorption: In vitro and in silico tests with 3D printed hydrogels	3
The effect of excipient particle size on the reduction of compactibility after roller compaction	3
Oral delivery of Kaempferia parviflora's methoxyflavones via nanostructured lipid carriers: Its effect on obesity and dyslipidemia treatment”	3
Off-the-shelf medication transformed: Custom-dosed metoprolol tartrate tablets via semisolid extrusion additive manufacturing and the perception of this technique in a hospital context	3
Stimuli-sensitive biomimetic nanoparticles for the inhibition of breast cancer recurrence and pulmonary metastasis	3
Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying	3
The combined effect of permeation enhancement and proteolysis inhibition on the systemic exposure of orally administrated peptides: Salcaprozate sodium, soybean trypsin inhibitor, and teriparatide stu	3
In vitro synergistic activity of cisplatin and EGFR-targeted nanomedicine of anti-Bcl-xL siRNA in a non-small lung cancer cell line model	3
A drug repurposing approach of Atorvastatin calcium for its antiproliferative activity for effective treatment of breast cancer: In vitro and in vivo assessment	3
Quantitative comparison of the protein corona of nanoparticles with different matrices	3
Trastuzumab-functionalized SK-BR-3 cell membrane-wrapped mesoporous silica nanoparticles loaded with pyrotinib for the targeted therapy of HER-2-positive breast cancer	3
Non-invasive caffeinated-nanovesicles as adipocytes-targeted therapy for cellulite and localized fats	3
From design to 3D printing: A proof-of-concept study for multiple unit particle systems (MUPS) printed by dual extrusion fused filament fabrication	3
Feasibility of In-line monitoring of critical coating quality attributes via OCT: Thickness, variability, film homogeneity and roughness	3
Biological activity of gold nanoparticles combined with the NFL-TBS.40-63 peptide, or with other cell penetrating peptides, on rat glioblastoma cells	3
Feed factor profile prediction model for two-component mixed powder in the twin-screw feeder	3
A case study on decentralized manufacturing of 3D printed medicines	3
Editorial board	3
In vitro and in vivo assessment of hydroxypropyl cellulose as functional additive for enabling formulations containing itraconazole	3
Prodigiosin hydrogel to promote healing of trauma-infected multidrug-resistant Staphylococcus aureus mice wounds	3
Chicken embryo model for in vivo acute toxicological and antitumor efficacy evaluation of lipid nanocarrier containing doxorubicin	3
Editorial Board	2
In vivo pharmacokinetic study of remdesivir dry powder for inhalation in hamsters	2
Cod liver oil nano-structured lipid carriers (Cod-NLCs) as a promising platform for nose to brain delivery: Preparation, in vitro optimization, ex vivo cytotoxicity & in vivo biodistribution utili	2
Systematic investigation of the impact of screw elements in continuous wet granulation	2
Enhancing the anticancer potential of metformin: fabrication of efficient nanospanlastics, in vitro cytotoxic studies on HEP-2 cells and reactome enhanced pathway analysis	2
The effect of lung emptying before the inhalation of aerosol drugs on drug deposition in the respiratory system	2
Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies	2
Digitalization in pharmaceutical industry: What to focus on under the digital implementation process?	2
Preparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs	2
Phase homogeneity in ternary amorphous solid dispersions and its impact on solubility, dissolution and supersaturation – Influence of processing and hydroxypropyl cellulose grade	2
Additive manufacturing technologies with emphasis on stereolithography 3D printing in pharmaceutical and medical applications: A review	2
Drug crystal growth in ternary amorphous solid dispersions: Effect of surfactants and polymeric matrix-carriers	2
The use of X-ray microtomography to investigate the microstructure of pharmaceutical tablets: Potentials and comparison to common physical methods	2
Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel	2
Complexities related to the amorphous content of lactose carriers	2
Preparation of atorvastatin calcium-loaded liposomes using thin-film hydration and coaxial micromixing methods: A comparative study	2
Fine excipient materials in carrier-based dry powder inhalation formulations: The interplay of particle size and concentration effects	2
Biopharmaceutical profiling of anti-infective sanggenons from Morus alba root bark for inhalation administration	2
Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying – A QbD approach	2
X-ray imaging: A potential enabler of automated particulate detection and cake-structure analysis in lyophilized products?	2
Resveratrol liposomes reverse sorafenib resistance in renal cell carcinoma models by modulating PI3K-AKT-mTOR and VHL-HIF signaling pathways	2
Accelerating 3D printing of pharmaceutical products using machine learning	2
Colon targeting in rats, dogs and IBD patients with species-independent film coatings	2
An aptamer-conjugated mesoporous polydopamine formulation for synergistic targeted and photothermal therapy of hepatocellular carcinoma	2
To infinity and beyond: Strategies for fabricating medicines in outer space	2
Effect of treatment with original or biosimilar adalimumab on SARS-CoV2 vaccination antibody titers	2
Advances in the delivery of anticancer drugs by nanoparticles and chitosan-based nanoparticles	2
Dual-targeting inhibition of TNFR1 for alleviating rheumatoid arthritis by a novel composite nucleic acid nanodrug	2
Nanoparticles from Gantrez-based conjugates for the oral delivery of camptothecin	2
Neutrophil-Mimetic oleanolic acid-loaded Liposomes targeted to alleviate oxidative stress for renal ischemia-reperfusion injury treatment	2
Kinetics of elastic recovery in roll compaction	2
An in vitro human mammary epithelial cell permeability assay to assess drug secretion into breast milk	2
Comparing the transfection efficiency of cationic monomer ratios in vinylimidazole and aminoethyl methacrylate copolymers	2
Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter	2
Exploring the potential of antifungal-loaded proniosomes to consolidate corneal permeation in fungal keratitis: A comprehensive investigation from laboratory characterization to microbiological evalua	2
Impact of mucus modulation by N-acetylcysteine on nanoparticle toxicity	2
3D printed infliximab suppositories for rectal biologic delivery	2