OOIR: Observatory of International Research

Papers

(The TQCC of International Journal of Pharmaceutics-X is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Tailored ASD destabilization - Balancing shelf life stability and dissolution performance with hydroxypropyl cellulose	76
Exploring high-throughput synchrotron X-Ray powder diffraction for the structural analysis of pharmaceuticals	35
Oral etoposide and zosuquidar bioavailability in rats: Effect of co-administration and in vitro-in vivo correlation of P-glycoprotein inhibition	24
Rationalized landscape on protein-based cancer nanomedicine: Recent progress and challenges	21
Exploiting recent trends for the synthesis and surface functionalization of mesoporous silica nanoparticles towards biomedical applications	20
Enabling formulations of aprepitant: in vitro and in vivo comparison of nanocrystalline, amorphous and deep eutectic solvent based formulations	19
Phloretin-nanospanlastics for targeting the Akt/PI3K signaling pathways in dimethylhydrazine-induced colon cancer in mice	18
Autoencoder-based inverse design and surrogate-based optimization of an integrated wet granulation manufacturing process	14
Erratum regarding missing Conflict of Interest statements in previously published articles	14
Everolimus-encapsulation in Pluronic P123 self-assembled micelles as drug delivery systems for drug-coated balloons	14
Formulating a heat- and shear-labile drug in an amorphous solid dispersion: Balancing drug degradation and crystallinity	13
Enhancing oocyte in vitro maturation and quality by melatonin/bilirubin cationic nanoparticles: A promising strategy for assisted reproduction techniques	12
Continuous direct compression: Development of an empirical predictive model and challenges regarding PAT implementation	12
Polydopamine-activated celastrol carbon dots for synergistic chemotherapy-photothermal therapy of tumors	12
Polycaprolactone – Vitamin E TPGS micelles for delivery of paclitaxel: In vitro and in vivo evaluation	11
Impact of process stress on protein stability in highly-loaded solid protein/PEG formulations from small-scale melt extrusion	11
Development, characterization, and in vitro evaluation of poly(ethylene oxide)-block-poly(ε-caprolactone)-α-tocopheryl succinate micelles as a novel nanocarrier for rapamycin delivery	10
Editorial Board	10
Corrigendum to “Quantitative comparison of the protein corona of nanoparticles with different matrices” [Int J Pharm X 2022 Oct 21;4: 100136]	10
Formulation development of itraconazole PEGylated nano-lipid carriers for pulmonary aspergillosis using hot-melt extrusion technology	10
MgZnFe-layered double hydroxides as a dual-function platform for enhancing subunit vaccine efficacy in tumor immunotherapy	10
Predicting pharmaceutical inkjet printing outcomes using machine learning	10
At-line porosity sensing for non-destructive disintegration testing in immediate release tablets	10
RETRACTED: Corrigendum to “Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed solid oral dosage forms” [International Journal of Pharmaceutics:X Volume	10
Spanlastic-laden nanogel as a plausible platform for dermal delivery of bimatoprost with superior cutaneous deposition and hair regrowth efficiency in androgenic alopecia	10

Preparation of chitosan-coated hollow tin dioxide nanoparticles and their application in improving the oral bioavailability of febuxostat	9
A model-based optimization strategy to achieve fast and robust freeze-drying cycles	8
A network of regulatory innovations to improve FDA quality assessments of human drug applications	8
Formulation of multicomponent inclusion complex of cyclodextrin-amino acid with Chrysin: Physicochemical characterization, cell viability and apoptosis assessment in human primary glioblastoma cell li	8
Formulation, in silico, in vitro characterization, cytotoxicity and cellular uptake of cyclodextrin complexes and ion pairing/salt formation with functional excipients (azelaic acid, tartaric acid, an	8
Stability of Dexamethasone during Hot-Melt Extrusion of Filaments based on Eudragit® RS, Ethyl Cellulose and Polyethylene Oxide	8
Box Behnken optimization of cubosomes for enhancing the anticancer activity of metformin: Design, characterization, and in-vitro cell proliferation assay on MDA-MB-231 breast and LOVO colon cancer cel	8
A new engineering process of biodegradable polymeric solid implants for ultra-long-acting drug delivery	8
A tabletability change classification system in supporting the tablet formulation design via the roll compaction and dry granulation process	8
Preservative-free electrospun nanofibrous inserts for sustained delivery of ceftazidime; design, characterization and pharmacokinetic investigation in rabbit's eye	8
Repurposing celecoxib for colorectal cancer targeting via pH-triggered ultra-elastic nanovesicles: Pronounced efficacy through up-regulation of Wnt/β-catenin pathway in DMH-induced tumorigenesis	7
Synergistic effect of doxorubicin lauroyl hydrazone derivative delivered by α-tocopherol succinate micelles for the treatment of glioblastoma	7
Fucoidan/Polyvinylpyrrolidone/Hesperitin nanoparticle complex for corneal injury treatment: Synthesis, characterization, and therapeutic efficacy	7
HSPiP and QbD oriented optimized stearylamine-elastic liposomes for topical delivery of ketoconazole to treat deep seated fungal infections: In vitro and ex vivo evaluations	7
Nanoparticles design considerations to co-deliver nucleic acids and anti-cancer drugs for chemoresistance reversal	7
The shelf life of ASDs: 2. Predicting the shelf life at storage conditions	7
Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: In vitro and in vivo studies	7
Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and tr	7
Multifunctional poloxamer-based thermo-responsive hydrogel loaded with human lactoferricin niosomes: In vitro study on anti-bacterial activity, accelerate wound healing, and anti-inflammation	7
The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little	6
RETRACTED: Development of thermosensitive hydrogel of Amphotericin-B and Lactoferrin combination-loaded PLGA-PEG-PEI nanoparticles for potential eradication of ocular fungal infections: In-vitro, ex-v	6
Editorial board	6
Atorvastatin-loaded emulsomes foam as a topical antifungal formulation	6
Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings	6
Towards a better understanding of thermally treated polycarbophil matrix tablets for controlled release	6
Curcumin and EGCG combined formulation in nanostructured lipid carriers for anti-aging applications	6
Multifunctional Bi2S3-Au nanoclusters for fluorescence/infrared thermal imaging guided photothermal therapy	6
Development and optimization of vildagliptin solid lipid nanoparticles loaded ocuserts for controlled ocular delivery: A promising approach towards treating diabetic retinopathy	5
RP-HPLC-CAD method for the rapid analysis of lipids used in lipid nanoparticles derived from dual centrifugation	5
Co-assembled Glycyrrhiza nanoparticles embedded supramolecular protein hydrogels to enhance licochalcone A release for acute inflammation management	5
Oxidation of polysorbates – An underestimated degradation pathway?	5
β-Cyclodextrin metal-organic framework as a green carrier to improve the dissolution, bioavailability, and liver protective effect of luteolin	5
Process intensification of pharmaceutical powder blending at commercial throughputs by utilizing semi-continuous mini-blending	5
The impact of solvent selection on the characteristics of niosome nanoparticles prepared by microfluidic mixing	5
Ocular mucoadhesive and biodegradable spanlastics loaded cationic spongy insert for enhancing and sustaining the anti-inflammatory effect of prednisolone Na phosphate; Preparation, I-optimal optimizat	5
Reactive oxygen species responsive double-locked liposome collaborative photodynamic therapy for reducing electrical conduction recurrence after radiofrequency catheter ablation	5
Nanoscale metal-organic frameworks for the delivery of nucleic acids to cancer cells	5
The Dynamic Intestinal Absorption Model (Diamod®), an in vitro tool to study the interconnected kinetics of gastrointestinal solubility, supersaturation, precipitation, and intestinal permeation proce	5
How bulk fluid renewal can affect in vitro drug release from PLGA implants: Importance of the experimental set-up	5
Spanlastic-laden in situ gel as a promising approach for ocular delivery of Levofloxacin: In-vitro characterization, microbiological assessment, corneal permeability and in-vivo study	4
Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma	4
Modelling intramuscular drug fate in vitro with tissue-relevant biomimetic hydrogels	4
Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel	4
Editorial board	4
Characterisation of niosome nanoparticles prepared by microfluidic mixing for drug delivery	4
Neutrophils-mediated accelerated blood clearance phenomenon in beagles and rats based on the cross-injection of non-PEGylated and PEGylated nanoemulsions	4
M1 macrophage-membrane-cloaked paclitaxel/β-elemene nanoparticles targeting cervical cancer for enhanced therapy	4
The use of heat to deliver fentanyl via pulmonary drug delivery	4
In vitro synergistic activity of cisplatin and EGFR-targeted nanomedicine of anti-Bcl-xL siRNA in a non-small lung cancer cell line model	4
Tablet formulation development focusing on the functional behaviour of water uptake and swelling	4

Transfer of a rational formulation and process development approach for 2D inks for pharmaceutical 2D and 3D printing	4
Functional candesartan loaded lipid nanoparticles for the control of diabetes-associated stroke: In vitro and in vivo studies	4
Designing fisetin nanocrystals for enhanced in cellulo anti-angiogenic and anticancer efficacy	4
WITHDRAWN: The effect of particle size on the sublimation behavior of butylhydroxytoluene as antioxidant in tablets during storage and coating	4
Characterization and quantification of the interaction between the NFL-TBS.40‐63 peptide and lipid nanocapsules	4
The combined effect of permeation enhancement and proteolysis inhibition on the systemic exposure of orally administrated peptides: Salcaprozate sodium, soybean trypsin inhibitor, and teriparatide stu	4