Bone

Papers
(The TQCC of Bone is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)
ArticleCitations
Editorial Board / Barcode101
Editorial Board / Barcode86
Age-associated changes in microRNAs affect the differentiation potential of human mesenchymal stem cells: Novel role of miR-29b-1-5p expression85
Sustained hypophosphatemia after denosumab in a patient on hemodialysis81
Reorganization of the osteocyte lacuno-canalicular network characteristics in tumor sites of an immunocompetent murine model of osteotropic cancers80
Editorial Board / Barcode70
The association between fracture and short-term adverse health outcomes among children with cerebral palsy65
Resting heart rate, self-reported physical activity in middle age, and long-term risk of hip fracture. A NOREPOS cohort study of 367,386 men and women58
Sexual differences in bone porosity, osteocyte density, and extracellular matrix organization due to osteoblastic-specific Bmp2 deficiency in mice57
Impact of bisphosphonates and comorbidities on initial hip fracture prognosis57
The impact of acute fracture on interpretation of bone turnover marker measurements for patients starting anti-resorptive therapies57
Transmembrane protein 53 craniotubular dysplasia (OMIM # 619727): The skeletal disease and consequent blindness of this new disorder55
The risk of fractures after entering long-term care facilities55
Natural history and genetic spectrum of the Turkish metaphyseal dysplasia cohort, including rare types caused by biallelic COL10A1, COL2A1, and LBR variants53
OSTM1 pleiotropic roles from osteopetrosis to neurodegeneration47
Assessment of glycosaminoglycan content in bone using Raman spectroscopy47
Influence of growth plate morphology on bone trabecular groups, a framework computational approach46
Calcium isotope composition in serum and urine for the assessment of bone mineral balance (BMB) – The Osteolabs post-market follow-up study45
Rapid histological imaging of bone without microtome sectioning using nonlinear microscopy44
Decline in clinical severity of Paget's disease of bone: Comparison between a contemporary cohort and a historical cohort44
High cardiorespiratory disease burden following a fracture among adults with intellectual disabilities42
microRNA-324 mediates bone homeostasis and the regulation of osteoblast and osteoclast differentiation and activity42
A machine learning-based scoring system and ten factors associated with hip fracture occurrence in the elderly40
Differential Effects of Neurectomy and Botox-induced Muscle Paralysis on Bone Phenotype and Titanium Implant Osseointegration39
Osteoclast rich osteopetrosis due to defects in the TCIRG1 gene38
Hypophosphatemia after intravenous iron therapy: Comprehensive review of clinical findings and recommendations for management37
Causative or associative: A critical review of the role of advanced glycation end-products in bone fragility36
Upacicalcet, a positive allosteric modulator of the calcium-sensing receptor, prevents vascular calcification and bone disorder in a rat adenine-induced secondary hyperparathyroidism model36
Moderate tibial loading and treadmill running, but not overloading, protect adult murine bone from destruction by metastasized breast cancer35
Mineralised bone properties in a child with recessive osteogenesis imperfecta type XIV and in a conditional Tmem38b knockout murine model (Runx2-Cre; Tmem38b)34
Letter to the editor: “Exposure to low humidex increases the risk of hip fracture admissions in a subtropical coastal Chinese city”33
Multiple vertebral fractures after antiosteoporotic medications discontinuation: A comparative study to evaluate the potential rebound effect of denosumab33
AFFnet - a deep convolutional neural network for the detection of atypical femur fractures from anteriorposterior radiographs32
Chloroquine increases osteoclast activity in vitro but does not improve the osteopetrotic bone phenotype of ADO2 mice32
Novel resin tissue array system reduces sample preparation time, labour and reagent costs in bone tissue histology32
OMIBONE: Omics-driven computer model of bone regeneration for personalized treatment32
The association of vitamin D with bone microarchitecture, muscle strength, and mobility performance in older women in long-term care31
The risk of osteoporosis is not increased after cholecystectomy. A nationwide cohort study31
Tertiary hyperparathyroidism in two paediatric patients with X-linked hypophosphatemia during Burosumab treatment31
The effect of pharmacological cessation and restoration of menstrual cycle on bone metabolism in premenopausal women with endometriosis31
Genetically engineered zebrafish as models of skeletal development and regeneration30
A transcriptome-wide association study to detect novel genes for volumetric bone mineral density29
Corrigendum to “PTCH1 regulates anchorage-independent growth and bone metastasis of non-small cell lung cancer cells” [Bone. 2021 Mar;144:115829]29
Human osteoclasts in vitro are dose dependently both inhibited and stimulated by cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC)28
Ankle flexor torque, size and density are differential determinants of distal tibia trabecular plate-rod morphometry and bone strength: The Ankle Quality Study28
Genotype–phenotype analysis, and assessment of the importance of the zinc-binding site in PHEX in Japanese patients with X-linked hypophosphatemic rickets using 3D structure modeling28
Osteopetrosis: The patient point of view and medical challenges28
Fractures in type 2 diabetes confer excess mortality: The Dubbo osteoporosis epidemiology study27
Adaptive enhancement of apatite crystal orientation and Young's modulus under elevated load in rat ulnar cortical bone27
PTH pre-treatment prior to tibial mechanical loading improves their synergistic anabolic effects in mice26
Manipulating load-induced fluid flow in vivo to promote bone adaptation26
Evidence for the cardiovascular effects of osteoporosis treatments in randomized trials of post-menopausal women: A systematic review and Bayesian network meta-analysis26
Combination of metformin and exercise alleviates osteoarthritis in ovariectomized mice fed a high-fat diet25
Targeted postnatal knockout of Sclerostin using a bone-targeted adeno-associated viral vector increases bone anabolism and decreases canalicular density25
Age-related changes in the midpalatal suture: Comparison between CBCT staging and bone micromorphology25
Causal roles of circulating adiponectin in osteoporosis and cancers25
Prevalence of bone complications in young patients with sickle cell disease presenting low bone mineral density25
Deletion of IL-17ra in osteoclast precursors increases bone mass by decreasing osteoclast precursor abundance24
An investigation of composition, morphology, mechanical properties, and microdamage accumulation of human type 2 diabetic bone24
Estimated bone mineral density and white matter hyperintensities: A bidirectional Mendelian randomization study24
Acarbose diminishes postprandial suppression of bone resorption in patients with type 2 diabetes23
The Wnt pathway: An important control mechanism in bone's response to mechanical loading23
CD4+ T-cell activation of bone marrow causes bone fragility and insulin resistance in type 2 diabetes23
Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects in primary cultures of osteoblasts and osteoclasts23
PRMT1-mediated arginine methylation promotes postnatal calvaria bone formation through BMP-Smad signaling22
Lif-deficiency promote systemic Iron metabolism disorders and increases the susceptibility of osteoblasts to ferroptosis22
Side-to-side differences in hip bone mineral density in patients with unilateral hip osteoarthritis22
Bone mineral density, vitamin D and osseous metabolism indices in neurofibromatosis type 1: A systematic review and meta-analysis22
Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts22
Bone matrix quality in paired iliac bone biopsies from postmenopausal women treated for 12 months with strontium ranelate or alendronate22
Spatiotemporal distribution of thrombospondin-4 and -5 in cartilage during endochondral bone formation and repair22
GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice21
Comparison of off-the-shelf β-tricalcium phosphate implants with novel resorbable 3D printed implants in mandible ramus of pigs21
Rat perichondrium transplanted to articular cartilage defects forms articular-like, hyaline cartilage21
Rhizoma Drynariae-derived EV-like particles alleviate osteoporosis by promoting osteogenic differentiation in BMSCs through the activation of the hsa_circ_0001275/miR-422a pathway21
Assessing bone maturity: Compositional and mechanical properties of rib cortical bone at different ages21
Letter to the editor21
Phlpp1 alters the murine chondrocyte phospho-proteome during endochondral bone formation21
Are balance and lower extremity muscle strength correlated with fracture risk independent of bone mineral density in postmenopausal women?: A cross-sectional study21
HR-pQCT measurements of changes in periarticular bone density and microarchitecture one year after acute knee injury and after reconstructive surgery21
Regulation and mechanistic insights into tensile strain in mesenchymal stem cell osteogenic differentiation21
Brd4 is required for chondrocyte differentiation and endochondral ossification21
The interruption of romosozumab treatment during COVID lockdown among US post-menopausal women enrolled in Medicare21
FBXO11 regulates bone development21
The multifaced role of HtrA1 in the development of joint and skeletal disorders20
A new ex vivo model of the bone tissue response to the hyperglycemic environment – The embryonic chicken femur organotypic culture in high glucose conditions20
Bone structure and composition in a hyperglycemic, obese, and leptin receptor-deficient rat: Microscale characterization of femur and calvarium20
Risk of fracture in women with glucocorticoid requiring diseases is independent from glucocorticoid use: An analysis on a nation-wide database20
Computational model of endochondral ossification: Simulating growth of a long bone20
Unraveling the transcriptome profile of pulsed electromagnetic field stimulation in bone regeneration using a bioreactor-based investigation platform20
Bone microarchitecture of the distal fibula assessed by HR-pQCT20
Bone characteristics of autosomal dominant hypophosphatemic rickets patients20
Orchiectomy sensitizes cortical bone in male mice to the harmful effects of kynurenine20
Multidirectional basketball activities load different regions of the tibia: A subject-specific muscle-driven finite element study20
Glucose-stimulated PGC-1α couples with CBP and Runx2 to mediate intervertebral disc degeneration through transactivation of ADAMTS4/5 in diet-induced obesity mice20
Editorial overview: Scaffolds and applications for bone regeneration/tissue engineering19
Global burden of injury due to low bone mineral density in adults aged 55 years and older, 1990 to 2021: A population-based study19
Combination treatment with growth hormone and zoledronic acid in a mouse model of Osteogenesis imperfecta19
A map of glycation and glycoxidation sites in collagen I of human cortical bone: Effects of sex and type 2 diabetes19
Editorial Board19
Sex-specific effects of a Mediterranean diet on lower limb bone strength in Polish children19
Potassium bicarbonate, not sodium bicarbonate, maintains acidosis-mediated bone dissolution19
Parental fracture history is associated with offspring early-life fracture risk: The Geelong Osteoporosis Study19
Bone density and body composition in small for gestational age children with adequate catch up growth: A preliminary retrospective case control study19
Bone quality analysis of the mandible in alcoholic liver cirrhosis: Anatomical, microstructural, and microhardness evaluation19
Post-traumatic osteoarthritic-mediated changes in condylar shape do not covary with changes in the internal microstructure of the bone19
Periorbital inflammation associated with craniofacial fibrous dysplasia: Report of three cases and review of the literature19
Associations of pregnancy phthalate concentrations and their mixture with early adolescent bone mineral content and density: The Health Outcomes and Measures of the Environment (HOME) study18
Sclerostin antibody improves phosphate metabolism hormones, bone formation rates, and bone mass in adult Hyp mice18
Automated, calibration-free quantification of cortical bone porosity and geometry in postmenopausal osteoporosis from ultrashort echo time MRI and deep learning18
Extracellular pH is a critical regulator of osteoclast fusion, size and activation18
Mettl3 regulates hypertrophic differentiation of chondrocytes through modulating Dmp1 mRNA via Ythdf1-mediated m6A modification18
3D osteocyte lacunar morphometry of human bone biopsies with high resolution microCT: From monoclonal gammopathy to newly diagnosed multiple myeloma18
Fracture patterns and associated risk factors in pediatric and early adulthood type 1 diabetes: Findings from a nationwide retrospective cohort study18
Combined effect of lower muscle quality and quantity on incident falls and fall-related fractures in community-dwelling older adults: A 3-year follow-up study18
Daily administration of parathyroid hormone slows the progression of basic multicellular units in the cortical bone of the rabbit distal tibia18
Characteristics of bisphosphonate and non-bisphosphonate related atypical femoral fracture in a South East Asian population – Secondary analysis18
Clinical value of RANKL, OPG, IL-6 and sclerostin as biomarkers for fibrous dysplasia/McCune-Albright syndrome18
Mechanically-regulated bone repair18
Chondrocyte hypertrophy in the growth plate promotes stress anisotropy affecting long bone development through chondrocyte column formation18
The association between blood pressure variability and hip or vertebral fracture risk: A population-based study18
The efficacy and safety of burosumab in two patients with cutaneous skeletal hypophosphatemia syndrome18
Associations between osteoporosis and drug exposure: A post-marketing study of the World Health Organization pharmacovigilance database (VigiBase®)18
Response to “Utilising DXA for body composition research studies”17
Predictors of lumbar spine trabecular bone score in women with postsurgical hypoparathyroidism17
Response to “Concerns regarding the use of 3D-DXA”17
The effects of endurance trainability phenotype, sex, and interval running training on bone collagen synthesis in adult rats17
Mineral tessellation in mouse enthesis fibrocartilage, Achilles tendon, and Hyp calcifying enthesopathy: A shared 3D mineralization pattern17
Zinc and vitamin D deficiency and supplementation in hypophosphatasia patients – A retrospective study17
MicroRNA-26b regulates BMSC osteogenic differentiation of TMJ subchondral bone through β-catenin in osteoarthritis17
Optineurin regulates osteoblast function in an age-dependent fashion in a mouse model of Paget's disease of bone17
Letter regarding – Denosumab use in bone fibrous dysplasia refractory to bisphosphonate: A retrospective multicentric study17
Bone marrow adiposity in pediatric Crohn's disease17
Retraction notice to “A human chondrogenic cell line retains multi-potency that differentiates into osteoblasts and adipocytes” [Bone 34(4) (2018) 648–655]17
Editorial Board / Barcode17
Effect of physical activity and BMI SDS on bone metabolism in children and adolescents17
P21 deficiency exhibits delayed endochondral ossification during fracture healing17
Intramembranous bone regeneration in diversity outbred mice is heritable17
The bone strain index predicts fragility fractures. The OFELY study16
Statistical shape modelling of the first carpometacarpal joint: A cross-sectional analysis of an osteoarthritis initiative cohort16
Berberine ameliorates nonalcoholic fatty liver disease-induced bone loss by inhibiting ferroptosis16
Osteoimmunology in periodontitis; a paradigm for Th17/IL-17 inflammatory bone loss16
RANKL inhibition halts lesion progression and promotes bone remineralization in mice with fibrous dysplasia16
Professional cyclists have lower levels of bone markers than amateurs. Is there a risk of osteoporosis in cyclist?16
Mechanotransduction pathways regulating YAP nuclear translocation under Yoda1 and vibration in osteocytes16
MI192 induced epigenetic reprogramming enhances the therapeutic efficacy of human bone marrows stromal cells for bone regeneration16
Editorial Board16
Association of insulin resistance with bone mineral density in a nationwide health check-up population in China16
Meeting Report from 2nd ICCBH-ERN BOND Spinal Complications in Children and Adults with Achondroplasia Workshop, Dublin, Ireland, 2nd July 202216
A comparison of bone microarchitectural and transcriptomic changes in murine long bones in response to hindlimb unloading and aging16
Bone microarchitectural alterations associated with spinal cord injury: Relation to sex hormones, metabolic factors, and loading16
Urinary phthalate metabolites associated with bone mineral density in adults: Data from the NHANES 2011–201816
Development of a manufacturer-independent convolutional neural network for the automated identification of vertebral compression fractures in vertebral fracture assessment images using active learning15
Blood cadmium is associated with increased fracture risk in never-smokers - results from a case-control study using data from the Malmö Diet and Cancer cohort15
Tumor induced osteomalacia: A single center experience on 17 patients15
Static histomorphometry parameters can identify bone turnover status in children and adults with chronic kidney disease15
Exposure to famine in every stage of life and the risk of osteoporosis and fractures later in life: A cross-sectional study15
Editorial Board15
Beyond BMD: Clinical implications of vertebral biomechanical decline under ADT15
Creatine supplementation for older adults: Focus on sarcopenia, osteoporosis, frailty and Cachexia15
Impact of heavy alcohol consumption on cortical bone mechanical properties in male rhesus macaques15
Aerobic exercise training-induced bone and vascular adaptations in mice lacking adiponectin15
Corrigendum to “Deep learning of lumbar spine X-ray for osteopenia and osteoporosis screening: A multicenter retrospective cohort study” [Bone 140, November 2020, 115561]15
Stress fracture of bone under physiological multiaxial cyclic loading: Activity-based predictive models15
Circulating lumican as a potential biomarker for osteosarcopenia in older adults15
Serum bicarbonate concentration is associated with bone density in adults with type 2 diabetes mellitus: African American-Diabetes Heart Study15
Evaluating the role of biological age in osteoporosis risk among middle-aged and older adults: A nationwide perspective15
How to identify children with cerebral palsy at risk of low bone mineral density15
Automated micro-CT morphometry of femoral biopsies from hip arthroplasties: adaptive local thresholding, volume of interest wrapping and removal of debris15
Swim training induces distinct osseous gene expression patterns in anosteocytic and osteocytic teleost fish15
Microarchitectural analysis of the metacarpophalangeal joint using HR-pQCT in patients with rheumatoid arthritis: A comparison with healthy controls15
Current advancements in bio-ink technology for cartilage and bone tissue engineering15
Early zoledronate treatment inhibits subchondral bone microstructural changes in skeletally-mature, ACL-transected canine knees15
X-linked hypophosphatemia caused by a deep intronic variant in PHEX identified by PCR-based RNA analysis of urine-derived cells14
PDGF-BB prevents destructive repair and promotes reparative osteogenesis of steroid-associated osteonecrosis of the femoral head in rabbits14
The detection of Gper1 as an important gene promoting jawbone regeneration in the context of estrogen deficiency14
Editorial Board14
A multi-stack registration technique to improve measurement accuracy and precision across longitudinal HR-pQCT scans14
Atorvastatin reduces zoledronic acid-induced osteonecrosis of the jaws of rats14
Chondrocyte Tsc1 controls cranial base bone development by restraining the premature differentiation of synchondroses14
RANKL biology14
Marrow adipogenic lineage precursors (MALPs) facilitate bone marrow recovery after chemotherapy14
Tibial-fibular geometry and density variations associated with elevated bone strain and sex disparities in young active adults14
Impact of high fat and low lean mass phenotype on bone mineral content: A cross-sectional study of Chinese adolescent population14
Fam83h mutation causes mandible underdevelopment via CK1α-mediated Wnt/β-catenin signaling in male C57/BL6J mice14
MACF1 promotes osteoblastic cell migration by regulating MAP1B through the GSK3beta/TCF7 pathway14
Investigating the link between gut microbiome and bone mineral density: The role of genetic factors14
Monitoring Skull Base Abnormalities in Children with Osteogenesis Imperfecta – Review of Current Practice and a Suggested Clinical Pathway14
Using the specificity and overload principles to prevent sarcopenia, falls and fractures with exercise14
Real-world safety and effectiveness of romosozumab following daily or weekly administration of teriparatide in primary and secondary osteoporosis13
Combining systemic and local osteoporosis treatments: A longitudinal in vivo microCT study in ovariectomized rats13
Expression of concern: “Differential effect of treadmill exercise on three cancellous bone sites in the young growing rat” [Bone Volume 24, Issue 3 (1999) 163-169]13
Identification of focal lesion characteristics in MRI which indicate presence of corresponding osteolytic lesion in CT in patients with multiple myeloma13
Protein kinase D3 conditional knockout impairs osteoclast formation and increases trabecular bone volume in male mice13
Bone marrow adipose tissue composition following high-caloric feeding and fasting13
“Which skeletal imaging modality is best for assessing bone health in children and young adults compared to DXA? A systematic review and meta-analysis”13
Small animal DXA instrument comparison and validation13
Limb lengthening in individuals with achondroplasia: Analysis of an international survey13
Secular trends in the incidence of fracture hospitalization between 2000 and 2015 among the middle-aged and elderly persons in Taiwan: A nationwide register-based cohort study13
Editorial Board / Barcode13
Human nonunion tissues display differential gene expression in comparison to physiological fracture callus13
Impairment in activities of daily living and cognitive decline mediate the association between depressive symptoms and incident hip fractures in Chinese older adults13
Is decreased psoas volume a risk factor for hip fracture? A comparative study of patients with and without hip fractures using the exact matching technique13
Ergothioneine alleviates osteoporosis via the ROS-MAPK signaling Axis13
Pulsed ultrasound and moderate exercise accelerate bone healing in an experimental tibial fracture model: biochemical, radiological and biomechanical evidence13
Editorial Board13
Craniofacial and dental phenotype of two girls with osteogenesis imperfecta due to mutations in CRTAP13
PTX3-assembled pericellular hyaluronan matrix enhances endochondral ossification during fracture healing and heterotopic ossification13
Trabecular bone score (TBS) in Cushing's disease: TBS gain after hypercortisolism normalization13
Dispensing anti-osteoporotic drugs changed during the COVID-19 pandemic13
A review of the skeletal effects of exposure to high altitude and potential mechanisms for hypobaric hypoxia-induced bone loss13
Interaction of high lipogenic states with titanium on osteogenesis13
In children under two years of age, does the bone health index value differ between those with and without osteogenesis imperfecta?13
Integration of osteoclastogenesis through addition of PBMCs in human osteochondral explants cultured ex vivo12
Health-related quality of life and fatigue in adult rare bone disease patients: A cross-sectional study from Austria12
Meeting the challenges and clinical requirements for dental regeneration; the New Zealand experience12
Associations of sleep behaviors and genetic risk with risk of incident osteoporosis: A prospective cohort study of 293,164 participants12
The sacroiliac joint: An original and highly sensitive tool to highlight altered bone phenotype in murine models of skeletal disorders12
Bone intrinsic material and compositional properties in postmenopausal women diagnosed with long-term Type-1 diabetes12
The cytoskeleton and connected elements in bone cell mechano-transduction12
Bone-targeted bortezomib increases bone formation within Calvarial trans-sutural distraction osteogenesis12
Alendronate prolongs the reversal-resorption phase in human cortical bone remodeling12
Biologic and pathologic aspects of osteocytes in the setting of medication-related osteonecrosis of the jaw (MRONJ)12
Increased fracture risk in Parkinson's disease – An exploration of mechanisms and consequences for fracture prediction with FRAX12
Editorial Board / Barcode12
Editorial Board / Barcode12
Association between physical activity, sedentary behavior patterns with bone health among Chinese older women12
Depletion of macrophages deteriorates bisphosphonate-related osteonecrosis of the jaw-like lesions in mice12
miR181a/b-1 controls osteocyte metabolism and mechanical properties independently of bone morphology12
Combination treatment with ibandronate and eldecalcitol prevents osteoporotic bone loss and deterioration of bone quality characterized by nano-arrangement of the collagen/apatite in an ovariectomized12
Bone microstructure evaluated by TBS and HR-pQCT in Chinese adults with X-linked hypophosphatemia12
Editorial Board / Barcode12
Bone parameters in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder: A comparative cross-sectional study12
AI-based opportunistic quantitative image analysis of lung cancer screening CTs to reduce disparities in osteoporosis screening12
The association of waist circumference with bone mineral density and risk of osteoporosis in US adult: National health and nutrition examination survey12
Large-scale quantification of human osteocyte lacunar morphological biomarkers as assessed by ultra-high-resolution desktop micro-computed tomography11
Alterations of a serum marker of collagen X in growing children with osteogenesis imperfecta11
Editorial Board / Barcode11
A microCT imaging protocol for reproducible and efficient quantitative morphometric analysis (QMA) of joint structures of the in situ mouse tibio-femoral joint11
Functional defects in cementoblasts with disrupted bone sialoprotein functional domains, in vitro11
Osteocalcin improves glucose tolerance, insulin sensitivity and secretion in older male mice11
Crosstalk between axon guidance signaling and bone remodeling11
Impact of COVID-19 public health restrictions on fall-related hip fracture hospitalizations: An interrupted time series analysis11
Editorial Board11
Super-resolution of clinical CT: Revealing microarchitecture in whole bone clinical CT image data11
Bilirubin increases viability and decreases osteoclast apoptosis contributing to osteoporosis in advanced liver diseases11
Trabecular, but not cortical, bone tissue protein synthesis rates are lower in the femoral head when compared to the proximal femur following an intracapsular hip fracture11
Editorial Board11
In vivo corrosion on retrieved hip endoprostheses and in vitro effects of corrosion products on bone mineralization11
The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes – A longitudinal nationwide population-based study11
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