Bone

Papers
(The TQCC of Bone is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
ArticleCitations
The risk of hip and non-vertebral fractures in type 1 and type 2 diabetes: A systematic review and meta-analysis update122
Bone regeneration is mediated by macrophage extracellular vesicles96
Molecular mechanisms of action of bisphosphonates and new insights into their effects outside the skeleton84
The role of gut microbiota in bone homeostasis80
Re-thinking the bone remodeling cycle mechanism and the origin of bone loss77
Deep learning of lumbar spine X-ray for osteopenia and osteoporosis screening: A multicenter retrospective cohort study70
The role of bone morphogenetic protein signaling in vascular calcification70
Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors67
The development, patterning and evolution of neural crest cell differentiation into cartilage and bone66
Epidemiology of bone metastases65
Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m6A modification60
The effect of exercise intensity on bone in postmenopausal women (part 2): A meta-analysis59
Epigenetic and transcriptional regulation of osteoclast differentiation51
Discovery of bone morphogenetic proteins – A historical perspective51
Raman and Fourier transform infrared imaging for characterization of bone material properties50
Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development49
Intracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction46
RANKL biology45
Irisin inhibits osteocyte apoptosis by activating the Erk signaling pathway in vitro and attenuates ALCT-induced osteoarthritis in mice45
Treatment of postmenopausal osteoporosis with bone-forming and antiresorptive treatments: Combined and sequential approaches45
A randomized pilot study using calcitriol in hospitalized COVID-19 patients44
Recent approaches towards bone tissue engineering44
Denosumab in postmenopausal women with osteoporosis and diabetes: Subgroup analysis of FREEDOM and FREEDOM extension43
Notch and the regulation of osteoclast differentiation and function43
The role of microRNAs in bone development43
Zoledronate43
PDGF-BB exhibited therapeutic effects on rat model of bisphosphonate-related osteonecrosis of the jaw by enhancing angiogenesis and osteogenesis42
Hypophosphatemia after intravenous iron therapy: Comprehensive review of clinical findings and recommendations for management41
Risk of major osteoporotic fracture after first, second and third fracture in Swedish women aged 50 years and older40
Growth plate skeletal stem cells and their transition from cartilage to bone39
The Wnt pathway: An important control mechanism in bone's response to mechanical loading38
Radiofrequency echographic multi spectrometry for the prediction of incident fragility fractures: A 5-year follow-up study37
Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use37
Circulating miRNAs in bone health and disease37
Bone morphogenic proteins in iron homeostasis36
BMP signalling in a mechanical context – Implications for bone biology36
Structural perspective of BMP ligands and signaling36
Crosstalk between skeletal and neural tissues is critical for skeletal health35
From genetics to epigenetics to unravel the etiology of adolescent idiopathic scoliosis35
Effects of prior osteoporosis treatment on early treatment response of romosozumab in patients with postmenopausal osteoporosis34
Novel therapeutic approaches for the treatment of achondroplasia32
Wnt modulation in bone healing32
Adjuvant therapies for MRONJ: A systematic review31
Bisphosphonates impair the onset of bone formation at remodeling sites31
Role of Prx1-expressing skeletal cells and Prx1-expression in fracture repair30
Energy metabolism: A newly emerging target of BMP signaling in bone homeostasis30
Bone mineral density and osteoporosis in relation to all-cause and cause-specific mortality in NHANES: A population-based cohort study30
The multifaced role of HtrA1 in the development of joint and skeletal disorders30
Clinical efficiency of epigenetic drugs therapy in bone malignancies30
Lifetime impact of achondroplasia: Current evidence and perspectives on the natural history30
Post-antibiotic gut dysbiosis-induced trabecular bone loss is dependent on lymphocytes30
Extracellular vesicles secreted from mouse muscle cells suppress osteoclast formation: Roles of mitochondrial energy metabolism29
Bariatric surgery and skeletal health: A narrative review and position statement for management by the European Calcified Tissue Society (ECTS)29
Risk factors for vertebral fractures and bone loss after denosumab discontinuation: A real-world observational study29
Targeting anti-cancer agents to bone using bisphosphonates29
Extracellular pyrophosphate: The body's “water softener”29
Bifidobacterium pseudocatenulatum CECT 7765 reverses the adverse effects of diet-induced obesity through the gut-bone axis29
Biological stenciling of mineralization in the skeleton: Local enzymatic removal of inhibitors in the extracellular matrix29
Scaffold-guided bone regeneration in large volume tibial segmental defects29
The origins and formation of bone-resorbing osteoclasts28
Osteoclast-mediated bone loss observed in a COVID-19 mouse model28
Radiofrequency Echographic Multi Spectrometry (REMS) for the diagnosis of osteoporosis in a European multicenter clinical context28
Multiscale finite element modeling of mechanical strains and fluid flow in osteocyte lacunocanalicular system28
Two adipocytokines, leptin and adiponectin, independently predict osteoporotic fracture risk at different bone sites in postmenopausal women28
Distinct immunopathology in the early stages between different antiresorptives-related osteonecrosis of the jaw-like lesions in mice28
History of alendronate28
Individuals with type 2 diabetes mellitus show dimorphic and heterogeneous patterns of loss in femoral bone quality28
The cardiovascular disease burden of non-traumatic fractures for adults with and without cerebral palsy28
Biological activity is not suppressed in mid-shaft stress fracture of the bowed femoral shaft unlike in “typical” atypical subtrochanteric femoral fracture: A proposed theory of atypical femoral fract27
Effects of supervised high-intensity resistance and impact training or machine-based isometric training on regional bone geometry and strength in middle-aged and older men with low bone mass: The LIFT27
Preoperative hypoalbuminemia: Poor functional outcomes and quality of life after hip fracture surgery27
Lipid metabolism in sarcopenia27
Sirtuin 1 deficiency decreases bone mass and increases bone marrow adiposity in a mouse model of chronic energy deficiency27
The treatment gap: The missed opportunities for osteoporosis therapy27
Activin A does not drive post-traumatic heterotopic ossification27
The effect of exercise intensity on bone in postmenopausal women (part 1): A systematic review27
Challenges in the management of tumor-induced osteomalacia (TIO)27
Fibrodysplasia ossificans progressiva (FOP): A disorder of osteochondrogenesis27
Regulation of mesenchymal stem cell differentiation on microstructured titanium surfaces by semaphorin 3A27
The role of endogenous GIP and GLP-1 in postprandial bone homeostasis27
Early extrapulmonary prognostic features in chest computed tomography in COVID-19 pneumonia: Bone mineral density is a relevant predictor for the clinical outcome - A multicenter feasibility study26
The three-year effect of a single zoledronate infusion on bone mineral density and bone turnover markers following denosumab discontinuation in women with postmenopausal osteoporosis26
Multiple pharmacological inhibitors targeting the epigenetic suppressor enhancer of zeste homolog 2 (Ezh2) accelerate osteoblast differentiation26
Tetracyclines and bone: Unclear actions with potentially lasting effects26
Supramolecular self-assembling peptides to deliver bone morphogenetic proteins for skeletal regeneration25
Selenium status is independently related to bone mineral density, FRAX score, and bone fracture history: NHANES, 2013 to 201425
Bone outcomes following sleeve gastrectomy in adolescents and young adults with obesity versus non-surgical controls25
Lacunar-canalicular bone remodeling: Impacts on bone quality and tools for assessment25
Osteoporosis, fracture, osteoarthritis & sarcopenia: A systematic review of circulating microRNA association25
Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)25
PPARG in osteocytes controls sclerostin expression, bone mass, marrow adiposity and mediates TZD-induced bone loss25
Loading-driven PI3K/Akt signaling and erythropoiesis enhanced angiogenesis and osteogenesis in a postmenopausal osteoporosis mouse model25
Correlation between 18F-Sodium Fluoride positron emission tomography and bone histomorphometry in dialysis patients24
The cytoskeleton and connected elements in bone cell mechano-transduction24
Bisphosphonates and lifespan24
Primary cilia act as microgravity sensors by depolymerizing microtubules to inhibit osteoblastic differentiation and mineralization24
MiR-1-3p regulates the differentiation of mesenchymal stem cells to prevent osteoporosis by targeting secreted frizzled-related protein 124
Abnormal macrophage polarization impedes the healing of diabetes-associated tooth sockets23
Hybrid biofabrication of 3D osteoconductive constructs comprising Mg-based nanocomposites and cell-laden bioinks for bone repair23
Assessing causal relationship from gut microbiota to heel bone mineral density23
TRPV4 calcium influx controls sclerostin protein loss independent of purinergic calcium oscillations23
Learning from BMPs and their biophysical extracellular matrix microenvironment for biomaterial design23
Conventional finite element models estimate the strength of metastatic human vertebrae despite alterations of the bone's tissue and structure23
Multiscale modeling of bone tissue mechanobiology23
Biologic and pathologic aspects of osteocytes in the setting of medication-related osteonecrosis of the jaw (MRONJ)23
Cholesterol metabolism related genes in osteoarthritis23
Impact of magnesium on bone health in older adults: A systematic review and meta-analysis23
The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging23
CDllb+ targeted depletion of macrophages negatively affects bone fracture healing23
MicroRNAs are critical regulators of senescence and aging in mesenchymal stem cells22
Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep22
Amino acid metabolism and autophagy in skeletal development and homeostasis22
Moderate tibial loading and treadmill running, but not overloading, protect adult murine bone from destruction by metastasized breast cancer22
Bisphosphonates for the treatment of fibrous dysplasia of bone22
The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes – A longitudinal nationwide population-based study22
An understanding of bone pain: A narrative review22
Fractures after kidney transplantation: Incidence, predictors, and association with mortality22
What do we know about bone morphogenetic proteins and osteochondroprogenitors in inflammatory conditions?22
Bacteroides vulgatus diminishes colonic microbiota dysbiosis ameliorating lumbar bone loss in ovariectomized mice22
1,25(OH)2D3 ameliorates palmitate-induced lipotoxicity in human primary osteoblasts leading to improved viability and function22
Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization22
Interaction of sexual dimorphism and gene dosage imbalance in skeletal deficits associated with Down syndrome22
miR-99a in bone homeostasis: Regulating osteogenic lineage commitment and osteoclast differentiation22
Association between serum FGF21 level and sarcopenia in older adults22
Taurine, an osteocyte metabolite, protects against oxidative stress-induced cell death and decreases inhibitors of the Wnt/β-catenin signaling pathway21
A novel inhibitor of NF-κB-inducing kinase prevents bone loss by inhibiting osteoclastic bone resorption in ovariectomized mice21
Wireless sensor enables longitudinal monitoring of regenerative niche mechanics during rehabilitation that enhance bone repair21
Increasing fluoride content deteriorates rat bone mechanical properties21
ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages21
Regulation of bone marrow mesenchymal stem cell fate by long non-coding RNA21
Aberrant structure of fibrillar collagen and elevated levels of advanced glycation end products typify delayed fracture healing in the diet-induced obesity mouse model21
Cortical bone mapping improves finite element strain prediction accuracy at the proximal femur21
A cell-based combination product for the repair of large bone defects21
High bone mass from mutation of low-density lipoprotein receptor-related protein 6 (LRP6)21
Pharmacological TNAP inhibition efficiently inhibits arterial media calcification in a warfarin rat model but deserves careful consideration of potential physiological bone formation/mineralization im20
A novel autologous bone graft substitute comprised of rhBMP6 blood coagulum as carrier tested in a randomized and controlled Phase I trial in patients with distal radial fractures20
History of etidronate20
Do polyunsaturated fatty acids protect against bone loss in our aging and osteoporotic population?20
Impact microindentation in men with impaired fasting glucose and type 2 diabetes20
Composition and characteristics of trabecular bone in osteoporosis and osteoarthritis20
Asian ethnicity is associated with atypical femur fractures in an Australian population study20
Osteocalcin and its forms respond similarly to exercise in males and females20
Deletion of SIRT3 inhibits osteoclastogenesis and alleviates aging or estrogen deficiency-induced bone loss in female mice20
Antisense oligonucleotide-based therapies for the treatment of osteoarthritis: Opportunities and roadblocks20
MicroRNAs regulating TGFβ and BMP signaling in the osteoblast lineage20
Siglec-15-targeting therapy protects against glucocorticoid-induced osteoporosis of growing skeleton in juvenile rats20
Glutamine metabolite α-ketoglutarate acts as an epigenetic co-factor to interfere with osteoclast differentiation20
Wnt signaling in chondroprogenitors during long bone development and growth20
Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier19
Inhibition of glycolysis by targeting lactate dehydrogenase A facilitates hyaluronan synthase 2 synthesis in synovial fibroblasts of temporomandibular joint osteoarthritis19
Large-scale quantification of human osteocyte lacunar morphological biomarkers as assessed by ultra-high-resolution desktop micro-computed tomography19
Bisphosphonates in veterinary medicine: The new horizon for use19
Large osteocyte lacunae in iliac crest infantile bone are not associated with impaired mineral distribution or signs of osteocytic osteolysis19
Human dendritic cell-derived osteoclasts with high bone resorption capacity and T cell stimulation ability19
Mind the gap: Incidence of osteoporosis treatment after an osteoporotic fracture – results of the Austrian branch of the International Costs and Utilities Related to Osteoporotic Fractures Study (ICUR19
Dynamic polarization shifting from M1 to M2 macrophages in reduced osteonecrosis of the jaw-like lesions by cessation of anti-RANKL antibody in mice19
“The use of bisphosphonates to treat skeletal complications in solid tumours”19
The effects of acute exercise on bone turnover markers in middle-aged and older adults: A systematic review19
Critical periods of bone health across the lifespan for individuals with cerebral palsy: Informing clinical guidelines for fracture prevention and monitoring19
Musculoskeletal morbidity following spinal cord injury: A longitudinal cohort study of privately-insured beneficiaries19
Practical guidance for the use of bisphosphonates in osteoporosis18
The JAK inhibitor Tofacitinib inhibits structural damage in osteoarthritis by modulating JAK1/TNF-alpha/IL-6 signaling through Mir-149-5p18
miRNAs in osteoclast biology18
Differential risk of fracture attributable to type 2 diabetes mellitus according to skeletal site18
Age and sex effects on FGF23-mediated response to mild phosphate challenge18
Type 2 innate lymphoid cells inhibit the differentiation of osteoclasts and protect from ovariectomy-induced bone loss18
Co-aligned chondrocytes: Zonal morphological variation and structured arrangement of cell lacunae in tessellated cartilage18
Bisphosphonates and the risk of atypical femur fractures18
A search for apatite crystals in the gap zone of collagen fibrils in bone using dark-field illumination18
Bone mineral density in Anorexia Nervosa versus Avoidant Restrictive Food Intake Disorder18
Clinical and biochemical characteristics of adults with hypophosphatasia attending a metabolic bone clinic18
WNT16 is upregulated early in mouse TMJ osteoarthritis and protects fibrochondrocytes against IL-1β induced inflammatory response by regulation of RUNX2/MMP13 cascade18
PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma18
Using confocal imaging approaches to understand the structure and function of osteocytes and the lacunocanalicular network18
Glucose variability and low bone turnover in people with type 2 diabetes18
Incidence of and risk for osteonecrosis of the jaw in Korean osteoporosis patients treated with bisphosphonates: A nationwide cohort-study18
Inhibition of the mitochondrial permeability transition improves bone fracture repair18
Dental defects in the primary dentition associated with hypophosphatasia from biallelic ALPL mutations17
Osteophyte size and location on hip DXA scans are associated with hip pain: Findings from a cross sectional study in UK Biobank17
MRI-derived porosity index is associated with whole-bone stiffness and mineral density in human cadaveric femora17
The epiphyseal secondary ossification center: Evolution, development and function17
Reference intervals in Danish children and adolescents for bone turnover markers carboxy-terminal cross-linked telopeptide of type I collagen (β-CTX), pro-collagen type I N-terminal propeptide (PINP),17
Inhibition of cellular communication network factor 1 (CCN1)-driven senescence slows down cartilage inflammaging and osteoarthritis17
Vascular calcification relationship to vascular biomarkers and bone metabolism in advanced chronic kidney disease17
From hurdle to springboard: The macrophage as target in biomaterial-based bone regeneration strategies17
A deep learning system for automated, multi-modality 2D segmentation of vertebral bodies and intervertebral discs17
Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: Evidence of osteoanabolic and osteoangiogenic effects of the drugs17
Non-endemic skeletal fluorosis: Causes and associated secondary hyperparathyroidism (case report and literature review)17
A review of the skeletal effects of exposure to high altitude and potential mechanisms for hypobaric hypoxia-induced bone loss17
Ex vivo regional gene therapy with human adipose-derived stem cells for bone repair17
Male mice with elevated C-type natriuretic peptide-dependent guanylyl cyclase-B activity have increased osteoblasts, bone mass and bone strength17
Bone healing and reactivation of remodeling under asfotase alfa therapy in adult patients with pediatric-onset hypophosphatasia17
The effect of frailty on outcomes of surgically treated hip fractures in older people17
Burosumab treatment for fibrous dysplasia17
A SMOC2 variant inhibits BMP signaling by competitively binding to BMPR1B and causes growth plate defects17
Gain-of-function variants and overexpression of RUNX2 in patients with nonsyndromic midline craniosynostosis17
The effect of different training frequency on bone mineral density in older adults. A comparative systematic review and meta-analysis17
Self-reported baseline phenotypes from the International Fibrodysplasia Ossificans Progressiva (FOP) Association Global Registry16
Incidence and predictors of fractures in older adults with and without obesity defined by body mass index versus body fat percentage16
Magnesium supplementation enhances mTOR signalling to facilitate myogenic differentiation and improve aged muscle performance16
Methodological quality of systematic reviews on treatments for osteoporosis: A cross-sectional study16
Autosomal recessive hypophosphatemic rickets type 2 (ARHR2) due to ENPP1-deficiency16
Primary cilium-mediated MSC mechanotransduction is dependent on Gpr161 regulation of hedgehog signalling16
Rheumatoid arthritis and osteoimmunology: The adverse impact of a deregulated immune system on bone metabolism16
Cytokine-mediated immunomodulation of osteoclastogenesis16
Quantitative histomorphometric analysis of halved iliac crest bone biopsies yield comparable ROD diagnosis as full 7.5mm wide samples16
Circulating serum microRNAs including senescent miR-31-5p are associated with incident fragility fractures in older postmenopausal women with type 2 diabetes mellitus16
MicroRNA function in craniofacial bone formation, regeneration and repair16
Treatment of osteoporosis after hip fracture is associated with lower all-cause mortality: A nationwide population study16
Osteoblastic Wnt1 regulates periosteal bone formation in adult mice16
High resolution imaging in bone tissue research-review16
Sex differences in the effect of diet, obesity, and exercise on bone quality and fracture toughness15
Increased tissue-level storage modulus and hardness with age in male cortical bone and its association with decreased fracture toughness15
Trabecular bone score and transilial bone trabecular histomorphometry in type 1 diabetes and healthy controls15
Genetic and pharmacologic modulation of cementogenesis via pyrophosphate regulators15
Mouse LGR6 regulates osteogenesis in vitro and in vivo through differential ligand use15
“Which skeletal imaging modality is best for assessing bone health in children and young adults compared to DXA? A systematic review and meta-analysis”15
Secreted BMP antagonists and their role in cancer and bone metastases15
Relevant genetic variants are common in women with pregnancy and lactation-associated osteoporosis (PLO) and predispose to more severe clinical manifestations15
Pharmacodynamics of asfotase alfa in adults with pediatric-onset hypophosphatasia15
At the nuclear envelope of bone mechanobiology15
ZFBONE: An ImageJ toolset for semi-automatic analysis of zebrafish bone structures15
Reciprocal effect of microRNA-224 on osteogenesis and adipogenesis in steroid-induced osteonecrosis of the femoral head15
Bisphosphonates in the management of Paget's disease15
Aerobic and resistance training improve alveolar bone quality and interferes with bone-remodeling during orthodontic tooth movement in mice15
Identification of prevalent vertebral fractures using Vertebral Fracture Assessment (VFA) in asymptomatic postmenopausal women: A systematic review and meta-analysis15
Health service use pathways associated with recovery of quality of life at 12-months for individual fracture sites: Analyses of the International Costs and Utilities Related to Osteoporotic fractures 15
Evaluation of synthetic ceramics as compression resistant matrix to promote osteogenesis of autologous blood coagulum containing recombinant human bone morphogenetic protein 6 in rabbit posterolateral15
Evaluation of patient tissue selection methods for deriving equivalent density calibration for femoral bone quantitative CT analyses15
GATA4 regulates mesenchymal stem cells via direct transcriptional regulation of the WNT signalosome15
The challenge of long-term adherence: The role of bone turnover markers in monitoring bisphosphonate treatment of osteoporosis15
Post-translational modifications in collagen type I of bone in a mouse model of aging15
Tunnels in the rock: Dynamics of osteocyte morphogenesis15
G9a is involved in the regulation of cranial bone formation through activation of Runx2 function during development15
Bone adaptation to mechanical loading in mice is affected by circadian rhythms15
Osteoimmunology in periodontitis; a paradigm for Th17/IL-17 inflammatory bone loss15
Metabolomics-driven of relationships among kidney, bone marrow and bone of rats with postmenopausal osteoporosis15
Low bone mass resulting from impaired estrogen signaling in bone increases severity of load-induced osteoarthritis in female mice14
Differences in the microarchitectural features of the lateral collapsed lesion between osteonecrosis and subchondral insufficiency fracture of the femoral head14
Effects of recreational team handball on bone health, postural balance and body composition in inactive postmenopausal women — A randomised controlled trial14
Bone material properties and response to teriparatide in osteoporosis due to WNT1 and PLS3 mutations14
Epidemiology and the economic burden of pediatric fractures in China: A retrospective study of 14,141 fractures14
The coupling of reduced type H vessels with unloading-induced bone loss and the protection role of Panax quinquefolium saponin in the male mice14
The role of miR-150 regulates bone cell differentiation and function14
Favorable skeletal benefit/risk of long-term denosumab therapy: A virtual-twin analysis of fractures prevented relative to skeletal safety events observed14
Serum vitamin K1 (phylloquinone) is associated with fracture risk and hip strength in post-menopausal osteoporosis: A cross-sectional study14
Assessing bone maturity: Compositional and mechanical properties of rib cortical bone at different ages14
Preventing or controlling periodontitis reduces the occurrence of osteonecrosis of the jaw (ONJ) in rice rats (Oryzomys palustris)14
On the pharmacological evaluation of bisphosphonates in humans14
Causative or associative: A critical review of the role of advanced glycation end-products in bone fragility14
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