OOIR: Observatory of International Research

Papers

(The TQCC of Biotechnology Progress is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Biosurfactants: Production and application prospects in the food industry	87
Microbial biosurfactants: A broad analysis of properties, applications, biosynthesis, and techno‐economical assessment of rhamnolipid production	47
Lignin degradation by microorganisms: A review	42
A novel pH‐responsive nanoniosomal emulsion for sustained release of curcumin from a chitosan‐based nanocarrier: Emphasis on the concurrent improvement of loading, sustained release, and ap	40
Optimization of electroporation and other non‐viral gene delivery strategies for T cells	39
Recent biotechnological tools for diagnosis of corona virus disease: A review	38
Developments of biobased plasticizers for compostable polymers in the green packaging applications: A review	35
Recent advances in domesticating non‐model microorganisms	33
Computational drug repurposing study of the RNA binding domain of SARS‐CoV‐2 nucleocapsid protein with antiviral agents	28
Cell culture process metabolomics together with multivariate data analysis tools opens new routes for bioprocess development and glycosylation prediction	25
In vitro hepatic steatosis model based on gut–liver‐on‐a‐chip	25
Decoration of electrical conductive polyurethane‐polyaniline/polyvinyl alcohol matrixes with mussel‐inspired polydopamine for bone tissue engineering	25
Proliferation and differentiation of primary bovine myoblasts using Chlorella vulgaris extract for sustainable production of cultured meat	24
Synthesis of a novel nanocomposite containing chitosan as a three‐dimensional printed wound dressing technique: Emphasis on gene expression	23
Green and sustainable route for oxidative depolymerization of lignin: New platform for fine chemicals and fuels	23
Tuning monoclonal antibody galactosylation using Raman spectroscopy‐controlled lactic acid feeding	23
Lipase activation by molecular bioimprinting: The role of interactions between fatty acids and enzyme active site	22
Bioremediation of water contaminated with uranium using Penicillium piscarium	22
Economic assessment of continuous processing for manufacturing of biotherapeutics	22
Establishment and characterization of an in vitro 3D ovarian cancer model for drug screening assays	20
Reshaping cell line development and CMC strategy for fast responses to pandemic outbreak	19
Identification and characterization of a residual host cell protein hexosaminidase B associated with N‐glycan degradation during the stability study of a therapeutic recombinant monoclonal anti	19
Deep brain stimulation: Challenges at the tissue‐electrode interface and current solutions	18
Evaluation of exosome loading characteristics in their purification via a glycerol‐assisted hydrophobic interaction chromatography method on a polyester, capillary‐channeled poly	18
Process and operations strategies to enable global access to antibody therapies	18

Biosynthesis of vitamin B12 by Propionibacterium freudenreichii subsp. shermanii ATCC 13673 using liquid acid protein residue of soybean as culture medium	18
Effectiveness of host cell protein removal using depth filtration with a filter containing diatomaceous earth	17
Anti‐epithelial cell adhesion molecule RNA aptamer‐conjugated liposomal doxorubicin as an efficient targeted therapy in mice bearing colon carcinoma tumor model	17
Cross‐scale quality assessment of a mechanistic cation exchange chromatography model	16
High throughput solubility and redissolution screening for antibody purification via combined PEG and zinc chloride precipitation	16
Using microalgae for remediation of crude petroleum oil–water emulsions	16
Exploring the potential of machine learning for more efficient development and production of biopharmaceuticals	16
Spectroscopy integration to miniature bioreactors and large scale production bioreactors–Increasing current capabilities and model transfer	16
Development of a targeted integration Chinese hamster ovary host directly targeting either one or two vectors simultaneously to a single locus using the Cre/Lox recombinase‐mediated cassette exchange	16
Devices and techniques used to obtain and analyze three‐dimensional cell cultures	16
In silico process characterization for biopharmaceutical development following the quality by design concept	15
Mesenchymal stem cells engineered by modified polyethylenimine polymer for targeted cancer gene therapy, in vitro and in vivo	15
The effect of biosynthesized selenium nanoparticles on the expression of CYP51A and HSP90 antifungal resistance genes in Aspergillus fumigatus and Aspergi	15
Nanoparticles in cancer immunotherapies: An innovative strategy	15
Identification and characterization of a Triton X‐100 replacement for virus inactivation	14
Raman‐based dynamic feeding strategies using real‐time glucose concentration monitoring system during adalimumab producing CHO cell cultivation	14
Introducing a delivery system for melanogenesis inhibition in melanoma B16F10 cells mediated by the conjugation of tyrosine ammonia‐lyase and a TAT‐penetrating peptide	14
Molecularly imprinted cryogel cartridges for the selective recognition of tyrosine	14
Characterization of liver zonation‐like transcriptomic patterns in HLCs derived from hiPSCs in a microfluidic biochip environment	14
Advances in 3D printing of composite scaffolds for the repairment of bone tissue associated defects	13
Synthetic biology in biofilms: Tools, challenges, and opportunities	13
Relationship between HETP measurements and breakthrough curves in short chromatography columns	13
Raman based chemometric model development for glycation and glycosylation real time monitoring in a manufacturing scale CHO cell bioreactor process	13
Development of a high cell density transient CHO platform yielding mAb titers greater than 2 g/L in only 7 days	12
Chemistry of lignin and hemicellulose structures interacts with hydrothermal pretreatment severity and affects cellulose conversion	12
Ectoine production in bioreactor by Halomonas elongataDSM2581: Using MWCNT and Fe‐nanoparticle	12
Bioconversion of ferulic acid into aroma compounds by newly isolated yeast strains of the Latin American biodiversity	12
Adapting virus filtration to enable intensified and continuous monoclonal antibody processing	12
Stabilization of immobilized l‐arabinose isomerase for the production of d‐tagatose from d‐galactose	12
Metabolic engineering of Yarrowia lipolytica for the production of isoprene	11
Integration of ion exchange resin materials for a downstream‐processing approach of an imine reductase‐catalyzed reaction	11
Computational fluid dynamics analysis of mixing and gas–liquid mass transfer in wave bag bioreactor	11
Differential responses in EPA and fucoxanthin production by the marine diatom Stauroneis sp. under varying cultivation conditions	11
Hydrolysis of lignocellulose by anaerobic fungi produces free sugars and organic acids for two‐stage fine chemical production with Kluyveromyces marxianus	11
Immobilized enzymes as potent antibiofilm agent	11
Rapid intensification of an established CHO cell fed‐batch process	11
Glycan engineering reveals interrelated effects of terminal galactose and core fucose on antibody‐dependent cell‐mediated cytotoxicity	11
Pumpless, unidirectional microphysiological system for testing metabolism‐dependent chemotherapeutic toxicity	11
Yeast cells for encapsulation of bioactive compounds in food products: A review	11
A rapid novel strategy for screening of antibody phage libraries for production, purification, and functional characterization of amber stop codons containing single‐chain antibody fragments	10
Immunoliposomes bearing lymphocyte activation gene 3 fusion protein and P5 peptide: A novel vaccine for breast cancer	10
Reduction of medium consumption in perfusion mammalian cell cultures using a perfusion rate equivalent concentrated nutrient feed	10
Nanoelicitor based enhancement of camptothecin production in fungi isolated from Ophiorrhiza mungos	10
Model‐based workflow for scale‐up of process strategies developed in miniaturized bioreactor systems	10
Metabolic trends of Chinese hamster ovary cells in biopharmaceutical production under batch and fed‐batch conditions	10
Metabolic profiling of Chinese hamster ovary cell cultures at different working volumes and agitation speeds using spin tube reactors	10
Ionic liquid‐based in situ product removal design exemplified for an acetone–butanol–ethanol fermentation	10
Response surface methodology optimization of polyhydroxyalkanoate production by Burkholderia cepacia BPT1213 using waste glycerol from palm oil‐based biodiesel production	10
Effect of using a nitrogen atmosphere on enzyme hydrolysis at high corn stover loadings in an agitated reactor	10
CRISPR‐Cas9 mediated engineering of Bacillus licheniformis for industrial production of (2R,3S)‐butanediol	10

The function of chitosan/agarose biopolymer on Fe₂O₃ nanoparticles and evaluation of their effects on MCF‐7 breast cancer cell line and expression of B	9
Wound dressing based on PVA nanofiber containing silk fibroin modified with GO/ZnO nanoparticles for superficial wound healing: In vitro and in vivo evaluations	9
Induced pluripotent stem cells can utilize lactate as a metabolic substrate to support proliferation	9
Aptamer‐functionalized quantum dots as theranostic nanotools against cancer and bacterial infections: A comprehensive overview of recent trends	9
Hypoxia preconditioned mesenchymal stem cell‐derived exosomes induce ex vivo expansion of umbilical cord blood hematopoietic stem cells CD133+ by stimulation of Notch signaling pathway	9
PVA based nanofiber containing cellulose modified with graphitic carbon nitride/nettles/trachyspermum accelerates wound healing	9
CHOK1SV GS‐KO SSIexpression system: A combination of theFer1L4locus and glutamine synthetase selection	9
Effects of variable domain orientation on anti‐HER2 single‐chain variable fragment antibody expressed in the Escherichia coli cytoplasm	9
Development of a scale‐up strategy for Chinese hamster ovary cell culture processes using the k_La ratio as a direct indicator of gas stripping conditions	9
A rational approach to improving titer in Escherichia coli‐based cell‐free protein synthesis reactions	8
Bax and Bak knockout apoptosis‐resistant Chinese hamster ovary cell lines significantly improve culture viability and titer in intensified fed‐batch culture process	8
Biophysical analysis of SARS‐CoV‐2 transmission and theranostic development via N protein computational characterization	8
X‐ray sterilization of biopharmaceutical manufacturing equipment—Extractables profile of a film material and copolyester Tritan™ compared to gamma irradiation	8
Protection of human induced pluripotent stem cells against shear stress in suspension culture by Bingham plastic fluid	8
Enhanced filtration performance usingfeed‐and‐bleedconfiguration for purification of antibody precipitates	8
Characterization of Chinese hamster ovary cell culture feed media precipitate	8
Development of virus‐like particles‐based vaccines against coronaviruses	8
Elemental metal variance in cell culture raw materials for process risk profiling	8
Single‐cell oil production by Mortierella isabellinaDSM 1414 using different sugars as carbon source	8
A mechanistic model to account for the Donnan and volume exclusion effects in ultrafiltration/diafiltration process of protein formulations	8
Continuous CTC separation through a DEP‐based contraction–expansion inertial microfluidic channel	8
Development of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performance as a tool to understanding heterogeneity eff	8
Rheology of enzyme liquefied corn stover slurries: The effect of solids concentration on yielding and flow behavior	8
Investigating the role of mechanics in lignocellulosic biomass degradation during hydrolysis: Part II	7
A class of low‐cost alternatives to kifunensine for increasing high mannose N‐linked glycosylation for monoclonal antibody production in Chinese hamster ovary cells	7
Transferability of miRNA‐technology to bioprocessing: Influence of cultivation mode and media	7
Prebiotic peptides, their formation, fermentation in the gut, and health implications	7
Tangential flow filtration of haptoglobin	7
Analysis of fouling and breakthrough of process related impurities during depth filtration using confocal microscopy	7
High throughput screening setup of a scale‐down device for membrane chromatography‐aggregate removal of monoclonal antibodies	7
Molecularly imprinted spongy columns for Angiotensin(II) recognition from human serum	7
Larvicidal potential of cell wall degrading enzymes from Trichoderma asperellum against Aedes aegypti (Diptera: Culicidae)	7
An antiphage Escherichia coli mutant for higher production of L‐threonine obtained by atmospheric and room temperature plasma mutagenesis	7
The pandemic and resilience for the future: AccBio 2021	7
Microfluidic chip‐based single‐cell cloning to accelerate biologic production timelines	7
α‐Acetolactate decarboxylase immobilized in chitosan: A highly stable biocatalyst to prevent off‐flavor in beer	7
Effects of different graphene‐based nanomaterials as elicitors on growth and ganoderic acid production by Ganoderma lucidum	7
Applications of flow cytometry sorting in the pharmaceutical industry: A review	7
Smart process development: Application of machine‐learning and integrated process modeling for inclusion body purification processes	7
Development of targeted gene delivery system based on liposome and PAMAM dendrimer functionalized with hyaluronic acid and TAT peptide: In vitro and in vivo studies	7
Role of membrane structure on the filtrate flux during monoclonal antibody filtration through virus retentive membranes	7
High‐throughput and automation advances for accelerating single‐cell cloning, monoclonality and early phase clone screening steps in mammalian cell line development for biologics production	7
High‐capacity multimodal anion‐exchange membranes for polishing of therapeutic proteins	7